The Experts below are selected from a list of 753 Experts worldwide ranked by ideXlab platform
Lubbe Wiesner - One of the best experts on this subject based on the ideXlab platform.
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Severe Acute Malnutrition Results in Lower Lumefantrine Exposure in Children Treated With Artemether‐Lumefantrine for Uncomplicated Malaria
Clinical Pharmacology and Therapeutics, 2019Co-Authors: Palang Chotsiri, Ousmane Guindo, Lise Denoeud-ndam, Elisabeth Baudin, Halimatou Diawara, Oumar Attaher, Michiel Smit, Philippe J Guerin, Ogobara K Doumbo, Lubbe WiesnerAbstract:Severe acute malnutrition (SAM) has been reported to be associated with increased malaria morbidity in Sub-Saharan African children and may affect the pharmacology of antimalarial drugs. This population pharmacokinetic (PK)-pharmacodynamic study included 131 SAM and 266 non-SAM children administered artemether-lumefantrine twice daily for 3 days. Lumefantrine capillary plasma concentrations were adequately described by two transit-absorption compartments followed by two distribution compartments. Allometrically scaled body weight and an enzymatic maturation effect were included in the PK model. Mid-upper arm circumference was associated with decreased absorption of lumefantrine (25.4% decreased absorption per 1 cm reduction). Risk of recurrent malaria episodes (i.e., reinfection) were characterized by an interval-censored time-to-event model with a sigmoid maximum-effect model describing the effect of lumefantrine. SAM children were at risk of Underexposure to lumefantrine and an increased risk of malaria reinfection compared with well-nourished children. Research on optimized regimens should be considered for malaria treatment in malnourished children.
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severe acute malnutrition results in lower lumefantrine exposure in children treated with artemether lumefantrine for uncomplicated malaria
Clinical Pharmacology & Therapeutics, 2019Co-Authors: Palang Chotsiri, Ousmane Guindo, Elisabeth Baudin, Halimatou Diawara, Oumar Attaher, Michiel Smit, Philippe J Guerin, Ogobara K Doumbo, Lise Denoeudndam, Lubbe WiesnerAbstract:Severe acute malnutrition (SAM) has been reported to be associated with increased malaria morbidity in Sub-Saharan African children and may affect the pharmacology of antimalarial drugs. This population pharmacokinetic (PK)-pharmacodynamic study included 131 SAM and 266 non-SAM children administered artemether-lumefantrine twice daily for 3 days. Lumefantrine capillary plasma concentrations were adequately described by two transit-absorption compartments followed by two distribution compartments. Allometrically scaled body weight and an enzymatic maturation effect were included in the PK model. Mid-upper arm circumference was associated with decreased absorption of lumefantrine (25.4% decreased absorption per 1 cm reduction). Risk of recurrent malaria episodes (i.e., reinfection) were characterized by an interval-censored time-to-event model with a sigmoid maximum-effect model describing the effect of lumefantrine. SAM children were at risk of Underexposure to lumefantrine and an increased risk of malaria reinfection compared with well-nourished children. Research on optimized regimens should be considered for malaria treatment in malnourished children.
Erik M Van Maarseveen - One of the best experts on this subject based on the ideXlab platform.
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quantification of active infliximab in human serum with liquid chromatography tandem mass spectrometry using a tumor necrosis factor alpha based pre analytical sample purification and a stable isotopic labeled infliximab bio similar as internal standard a target based sensitive and cost effective method
Journal of Chromatography A, 2016Co-Authors: Mohsin El Amrani, Marcel P H Van Den Broek, Camiel Gobel, Erik M Van MaarseveenAbstract:Abstract The therapeutic monoclonal antibody Infliximab (IFX) is a widely used drug for the treatment of several inflammatory autoimmune diseases. However, approximately 10% of patients develop anti-infliximab antibodies (ATIs) rendering the treatment ineffective. Early detection of Underexposure to unbound IFX would result in a timely switch of therapy which could aid in the treatment of this disease. Streptavidin coated 96 well plates were used to capture biotinylated-tumor necrosis factor -alpha (b-TNF-α), which in turn was used to selectively extract the active form of IFX in human serum. After elution, IFX was digested using trypsin and one signature peptide was selected for subsequent analysis on liquid chromatography − tandem mass spectrometry (LC–MS/MS). The internal standard used was a stable isotopic labeled IFX bio-similar. The assay was successfully validated according to European Medicines Agency (EMA) guidelines and was found to be linear in a range of 0.5–20 μg/mL (r 2 = 0.994). Lower limit of quantification for the assay ( 2 = 0.95 with a ρ c = 0.83) and the accuracy was in line with previously published results. In conclusion, a sensitive, robust and cost-effective method was developed for the bio-analysis of IFX with LC–MS/MS by means of a target-based pre-analytical sample purification. Moreover, low volume and costs of consumables per sample promote its feasibility in (pre)clinical studies and in therapeutic drug monitoring. This method should be considered as first choice due to its accuracy and multiple degree of selectivity.
Karel Allegaert - One of the best experts on this subject based on the ideXlab platform.
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pregnancy related pharmacokinetics and antimicrobial prophylaxis during fetal surgery cefazolin and clindamycin as examples
Prenatal Diagnosis, 2020Co-Authors: Karel Allegaert, Anouk E Muller, Francesca Russo, Sam Schoenmakers, Jan Deprest, Birgit Cp KochAbstract:Antimicrobial prophylaxis during surgery aims to prevent post-operative site infections. For fetal surgery, this includes the fetal and amniotic compartments. Both are deep compartments as drug equilibrium with maternal blood is achieved relatively late. Despite prophylaxis, chorio-amnionitis or endometritis following ex utero intrapartum treatment or fetoscopy occur in 4.13% and 1.45% respectively of the interventions. This review summarizes the observations on two commonly administered antimicrobials (cefazolin, clindamycin) for surgical prophylaxis during pregnancy, with emphasis on the deep compartments. For both compounds, antimicrobial exposure is on target when we consider the maternal and fetal plasma compartment. In contrast, amniotic fluid concentrations-time profiles display a delayed and much more blunted pattern, behaving as deep compartment. For cefazolin, there are data that document further dilution in the setting of polyhydramnios. Along this deep compartment concept, there is some accumulation during repeated administration, modeled for cefazolin and observed for clindamycin. The relative Underexposure to antimicrobials in amniotic fluid may be reflected in the pattern of maternal-fetal complications after fetal surgery, and suggest that antimicrobial prophylaxis practices for fetal surgery should be reconsidered. Further studies should be designed by a multidisciplinary team (fetal surgeons, clinical pharmacologists and microbiologists) to facilitate efficient evaluation of antimicrobial prophylaxis.
Palang Chotsiri - One of the best experts on this subject based on the ideXlab platform.
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Severe Acute Malnutrition Results in Lower Lumefantrine Exposure in Children Treated With Artemether‐Lumefantrine for Uncomplicated Malaria
Clinical Pharmacology and Therapeutics, 2019Co-Authors: Palang Chotsiri, Ousmane Guindo, Lise Denoeud-ndam, Elisabeth Baudin, Halimatou Diawara, Oumar Attaher, Michiel Smit, Philippe J Guerin, Ogobara K Doumbo, Lubbe WiesnerAbstract:Severe acute malnutrition (SAM) has been reported to be associated with increased malaria morbidity in Sub-Saharan African children and may affect the pharmacology of antimalarial drugs. This population pharmacokinetic (PK)-pharmacodynamic study included 131 SAM and 266 non-SAM children administered artemether-lumefantrine twice daily for 3 days. Lumefantrine capillary plasma concentrations were adequately described by two transit-absorption compartments followed by two distribution compartments. Allometrically scaled body weight and an enzymatic maturation effect were included in the PK model. Mid-upper arm circumference was associated with decreased absorption of lumefantrine (25.4% decreased absorption per 1 cm reduction). Risk of recurrent malaria episodes (i.e., reinfection) were characterized by an interval-censored time-to-event model with a sigmoid maximum-effect model describing the effect of lumefantrine. SAM children were at risk of Underexposure to lumefantrine and an increased risk of malaria reinfection compared with well-nourished children. Research on optimized regimens should be considered for malaria treatment in malnourished children.
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severe acute malnutrition results in lower lumefantrine exposure in children treated with artemether lumefantrine for uncomplicated malaria
Clinical Pharmacology & Therapeutics, 2019Co-Authors: Palang Chotsiri, Ousmane Guindo, Elisabeth Baudin, Halimatou Diawara, Oumar Attaher, Michiel Smit, Philippe J Guerin, Ogobara K Doumbo, Lise Denoeudndam, Lubbe WiesnerAbstract:Severe acute malnutrition (SAM) has been reported to be associated with increased malaria morbidity in Sub-Saharan African children and may affect the pharmacology of antimalarial drugs. This population pharmacokinetic (PK)-pharmacodynamic study included 131 SAM and 266 non-SAM children administered artemether-lumefantrine twice daily for 3 days. Lumefantrine capillary plasma concentrations were adequately described by two transit-absorption compartments followed by two distribution compartments. Allometrically scaled body weight and an enzymatic maturation effect were included in the PK model. Mid-upper arm circumference was associated with decreased absorption of lumefantrine (25.4% decreased absorption per 1 cm reduction). Risk of recurrent malaria episodes (i.e., reinfection) were characterized by an interval-censored time-to-event model with a sigmoid maximum-effect model describing the effect of lumefantrine. SAM children were at risk of Underexposure to lumefantrine and an increased risk of malaria reinfection compared with well-nourished children. Research on optimized regimens should be considered for malaria treatment in malnourished children.
Mohsin El Amrani - One of the best experts on this subject based on the ideXlab platform.
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quantification of active infliximab in human serum with liquid chromatography tandem mass spectrometry using a tumor necrosis factor alpha based pre analytical sample purification and a stable isotopic labeled infliximab bio similar as internal standard a target based sensitive and cost effective method
Journal of Chromatography A, 2016Co-Authors: Mohsin El Amrani, Marcel P H Van Den Broek, Camiel Gobel, Erik M Van MaarseveenAbstract:Abstract The therapeutic monoclonal antibody Infliximab (IFX) is a widely used drug for the treatment of several inflammatory autoimmune diseases. However, approximately 10% of patients develop anti-infliximab antibodies (ATIs) rendering the treatment ineffective. Early detection of Underexposure to unbound IFX would result in a timely switch of therapy which could aid in the treatment of this disease. Streptavidin coated 96 well plates were used to capture biotinylated-tumor necrosis factor -alpha (b-TNF-α), which in turn was used to selectively extract the active form of IFX in human serum. After elution, IFX was digested using trypsin and one signature peptide was selected for subsequent analysis on liquid chromatography − tandem mass spectrometry (LC–MS/MS). The internal standard used was a stable isotopic labeled IFX bio-similar. The assay was successfully validated according to European Medicines Agency (EMA) guidelines and was found to be linear in a range of 0.5–20 μg/mL (r 2 = 0.994). Lower limit of quantification for the assay ( 2 = 0.95 with a ρ c = 0.83) and the accuracy was in line with previously published results. In conclusion, a sensitive, robust and cost-effective method was developed for the bio-analysis of IFX with LC–MS/MS by means of a target-based pre-analytical sample purification. Moreover, low volume and costs of consumables per sample promote its feasibility in (pre)clinical studies and in therapeutic drug monitoring. This method should be considered as first choice due to its accuracy and multiple degree of selectivity.
