The Experts below are selected from a list of 261 Experts worldwide ranked by ideXlab platform
Katja Kollewe - One of the best experts on this subject based on the ideXlab platform.
-
lower motor neuron involvement in als assessed by motor unit number index mUnix long term changes and reproducibility p6 254
Neurology, 2016Co-Authors: Davood Fathi, Bahram Mohammadi, Reinhard Dengler, Sebastian Boselt, Susanne Petri, Katja KolleweAbstract:Objective and Background: Motor unit number estimation (MUNE) techniques such as motor unit number index (MUnix) have been used to quantify lower motor neuron loss and disease progression in amyotrophic lateral sclerosis (ALS). In this study we investigated the consistency of reproducibility of MUnix in 30 ALS-patients during the course of the disease. Methods: MUnix was recorded in abductor pollicis brevis and tibialis anterior muscles bilaterally in ALS-patients in two measurements in first and follow-up visit and in healthy controls. Intra-rater reproducibility of MUnix was evaluated by three statistical methods: interclass correlation coefficient (ICC), correlation coefficient analysis (CCA), and coefficient of variation (CV). Results: We found significant correlation between the first and second measurement of MUnix in all tested muscles and in the follow-up visit (r ≥ 0.891, p < 0.01). In the ICC analysis, we found good statistically significant reproducibility of MUnix in all four measured muscles at the follow-up visit (ICC ≥ 0.946, p < 0.01). In the CV analysis at the follow-up visit, there was a CV of MUnix ranging from 13.90[percnt] to 32.95[percnt]. Conclusions: This study shows good consistency of reproducibility of MUnix in the course of ALS and highlights its value as a reliable disease progression index. Disclosure: Dr. Fathi has nothing to disclose. Dr. Mohammadi has nothing to disclose. Dr. Dengler has nothing to disclose. Dr. Boselt has nothing to disclose. Dr. Petri has nothing to disclose. Dr. Kollewe has nothing to disclose.
-
lower motor neuron involvement in als assessed by motor unit number index mUnix long term changes and reproducibility
Clinical Neurophysiology, 2016Co-Authors: Davood Fathi, Bahram Mohammadi, Reinhard Dengler, Sebastian Boselt, Susanne Petri, Katja KolleweAbstract:Abstract Objective Motor unit number estimation (MUNE) techniques such as motor unit number index (MUnix) have been used to quantify lower motor neuron loss and disease progression in amyotrophic lateral sclerosis (ALS). We investigated the consistency of reproducibility of MUnix in 30 ALS-patients during the course of the disorder. Methods MUnix was recorded in abductor pollicis brevis and tibialis anterior muscles bilaterally in ALS-patients by two measurements at the first and at one follow-up visit and once in healthy controls. Intra-rater reproducibility was evaluated by three statistical methods: interclass correlation coefficient (ICC), correlation coefficient analysis (CCA), and coefficient of variation (CV). Results We found significant correlation between the first and second measurement of MUnix in all tested muscles and at the follow-up visit (r ⩾ 0.891, p Conclusions This study shows good consistency of reproducibility of MUnix in the course of ALS. Significance This study suggests that MUnix can be used to track the progression of the disorder both in clinical routine and in treatment trials.
Davood Fathi - One of the best experts on this subject based on the ideXlab platform.
-
lower motor neuron involvement in als assessed by motor unit number index mUnix long term changes and reproducibility p6 254
Neurology, 2016Co-Authors: Davood Fathi, Bahram Mohammadi, Reinhard Dengler, Sebastian Boselt, Susanne Petri, Katja KolleweAbstract:Objective and Background: Motor unit number estimation (MUNE) techniques such as motor unit number index (MUnix) have been used to quantify lower motor neuron loss and disease progression in amyotrophic lateral sclerosis (ALS). In this study we investigated the consistency of reproducibility of MUnix in 30 ALS-patients during the course of the disease. Methods: MUnix was recorded in abductor pollicis brevis and tibialis anterior muscles bilaterally in ALS-patients in two measurements in first and follow-up visit and in healthy controls. Intra-rater reproducibility of MUnix was evaluated by three statistical methods: interclass correlation coefficient (ICC), correlation coefficient analysis (CCA), and coefficient of variation (CV). Results: We found significant correlation between the first and second measurement of MUnix in all tested muscles and in the follow-up visit (r ≥ 0.891, p < 0.01). In the ICC analysis, we found good statistically significant reproducibility of MUnix in all four measured muscles at the follow-up visit (ICC ≥ 0.946, p < 0.01). In the CV analysis at the follow-up visit, there was a CV of MUnix ranging from 13.90[percnt] to 32.95[percnt]. Conclusions: This study shows good consistency of reproducibility of MUnix in the course of ALS and highlights its value as a reliable disease progression index. Disclosure: Dr. Fathi has nothing to disclose. Dr. Mohammadi has nothing to disclose. Dr. Dengler has nothing to disclose. Dr. Boselt has nothing to disclose. Dr. Petri has nothing to disclose. Dr. Kollewe has nothing to disclose.
-
lower motor neuron involvement in als assessed by motor unit number index mUnix long term changes and reproducibility
Clinical Neurophysiology, 2016Co-Authors: Davood Fathi, Bahram Mohammadi, Reinhard Dengler, Sebastian Boselt, Susanne Petri, Katja KolleweAbstract:Abstract Objective Motor unit number estimation (MUNE) techniques such as motor unit number index (MUnix) have been used to quantify lower motor neuron loss and disease progression in amyotrophic lateral sclerosis (ALS). We investigated the consistency of reproducibility of MUnix in 30 ALS-patients during the course of the disorder. Methods MUnix was recorded in abductor pollicis brevis and tibialis anterior muscles bilaterally in ALS-patients by two measurements at the first and at one follow-up visit and once in healthy controls. Intra-rater reproducibility was evaluated by three statistical methods: interclass correlation coefficient (ICC), correlation coefficient analysis (CCA), and coefficient of variation (CV). Results We found significant correlation between the first and second measurement of MUnix in all tested muscles and at the follow-up visit (r ⩾ 0.891, p Conclusions This study shows good consistency of reproducibility of MUnix in the course of ALS. Significance This study suggests that MUnix can be used to track the progression of the disorder both in clinical routine and in treatment trials.
Bahram Mohammadi - One of the best experts on this subject based on the ideXlab platform.
-
lower motor neuron involvement in als assessed by motor unit number index mUnix long term changes and reproducibility p6 254
Neurology, 2016Co-Authors: Davood Fathi, Bahram Mohammadi, Reinhard Dengler, Sebastian Boselt, Susanne Petri, Katja KolleweAbstract:Objective and Background: Motor unit number estimation (MUNE) techniques such as motor unit number index (MUnix) have been used to quantify lower motor neuron loss and disease progression in amyotrophic lateral sclerosis (ALS). In this study we investigated the consistency of reproducibility of MUnix in 30 ALS-patients during the course of the disease. Methods: MUnix was recorded in abductor pollicis brevis and tibialis anterior muscles bilaterally in ALS-patients in two measurements in first and follow-up visit and in healthy controls. Intra-rater reproducibility of MUnix was evaluated by three statistical methods: interclass correlation coefficient (ICC), correlation coefficient analysis (CCA), and coefficient of variation (CV). Results: We found significant correlation between the first and second measurement of MUnix in all tested muscles and in the follow-up visit (r ≥ 0.891, p < 0.01). In the ICC analysis, we found good statistically significant reproducibility of MUnix in all four measured muscles at the follow-up visit (ICC ≥ 0.946, p < 0.01). In the CV analysis at the follow-up visit, there was a CV of MUnix ranging from 13.90[percnt] to 32.95[percnt]. Conclusions: This study shows good consistency of reproducibility of MUnix in the course of ALS and highlights its value as a reliable disease progression index. Disclosure: Dr. Fathi has nothing to disclose. Dr. Mohammadi has nothing to disclose. Dr. Dengler has nothing to disclose. Dr. Boselt has nothing to disclose. Dr. Petri has nothing to disclose. Dr. Kollewe has nothing to disclose.
-
lower motor neuron involvement in als assessed by motor unit number index mUnix long term changes and reproducibility
Clinical Neurophysiology, 2016Co-Authors: Davood Fathi, Bahram Mohammadi, Reinhard Dengler, Sebastian Boselt, Susanne Petri, Katja KolleweAbstract:Abstract Objective Motor unit number estimation (MUNE) techniques such as motor unit number index (MUnix) have been used to quantify lower motor neuron loss and disease progression in amyotrophic lateral sclerosis (ALS). We investigated the consistency of reproducibility of MUnix in 30 ALS-patients during the course of the disorder. Methods MUnix was recorded in abductor pollicis brevis and tibialis anterior muscles bilaterally in ALS-patients by two measurements at the first and at one follow-up visit and once in healthy controls. Intra-rater reproducibility was evaluated by three statistical methods: interclass correlation coefficient (ICC), correlation coefficient analysis (CCA), and coefficient of variation (CV). Results We found significant correlation between the first and second measurement of MUnix in all tested muscles and at the follow-up visit (r ⩾ 0.891, p Conclusions This study shows good consistency of reproducibility of MUnix in the course of ALS. Significance This study suggests that MUnix can be used to track the progression of the disorder both in clinical routine and in treatment trials.
Reinhard Dengler - One of the best experts on this subject based on the ideXlab platform.
-
lower motor neuron involvement in als assessed by motor unit number index mUnix long term changes and reproducibility p6 254
Neurology, 2016Co-Authors: Davood Fathi, Bahram Mohammadi, Reinhard Dengler, Sebastian Boselt, Susanne Petri, Katja KolleweAbstract:Objective and Background: Motor unit number estimation (MUNE) techniques such as motor unit number index (MUnix) have been used to quantify lower motor neuron loss and disease progression in amyotrophic lateral sclerosis (ALS). In this study we investigated the consistency of reproducibility of MUnix in 30 ALS-patients during the course of the disease. Methods: MUnix was recorded in abductor pollicis brevis and tibialis anterior muscles bilaterally in ALS-patients in two measurements in first and follow-up visit and in healthy controls. Intra-rater reproducibility of MUnix was evaluated by three statistical methods: interclass correlation coefficient (ICC), correlation coefficient analysis (CCA), and coefficient of variation (CV). Results: We found significant correlation between the first and second measurement of MUnix in all tested muscles and in the follow-up visit (r ≥ 0.891, p < 0.01). In the ICC analysis, we found good statistically significant reproducibility of MUnix in all four measured muscles at the follow-up visit (ICC ≥ 0.946, p < 0.01). In the CV analysis at the follow-up visit, there was a CV of MUnix ranging from 13.90[percnt] to 32.95[percnt]. Conclusions: This study shows good consistency of reproducibility of MUnix in the course of ALS and highlights its value as a reliable disease progression index. Disclosure: Dr. Fathi has nothing to disclose. Dr. Mohammadi has nothing to disclose. Dr. Dengler has nothing to disclose. Dr. Boselt has nothing to disclose. Dr. Petri has nothing to disclose. Dr. Kollewe has nothing to disclose.
-
lower motor neuron involvement in als assessed by motor unit number index mUnix long term changes and reproducibility
Clinical Neurophysiology, 2016Co-Authors: Davood Fathi, Bahram Mohammadi, Reinhard Dengler, Sebastian Boselt, Susanne Petri, Katja KolleweAbstract:Abstract Objective Motor unit number estimation (MUNE) techniques such as motor unit number index (MUnix) have been used to quantify lower motor neuron loss and disease progression in amyotrophic lateral sclerosis (ALS). We investigated the consistency of reproducibility of MUnix in 30 ALS-patients during the course of the disorder. Methods MUnix was recorded in abductor pollicis brevis and tibialis anterior muscles bilaterally in ALS-patients by two measurements at the first and at one follow-up visit and once in healthy controls. Intra-rater reproducibility was evaluated by three statistical methods: interclass correlation coefficient (ICC), correlation coefficient analysis (CCA), and coefficient of variation (CV). Results We found significant correlation between the first and second measurement of MUnix in all tested muscles and at the follow-up visit (r ⩾ 0.891, p Conclusions This study shows good consistency of reproducibility of MUnix in the course of ALS. Significance This study suggests that MUnix can be used to track the progression of the disorder both in clinical routine and in treatment trials.
Sebastian Boselt - One of the best experts on this subject based on the ideXlab platform.
-
lower motor neuron involvement in als assessed by motor unit number index mUnix long term changes and reproducibility p6 254
Neurology, 2016Co-Authors: Davood Fathi, Bahram Mohammadi, Reinhard Dengler, Sebastian Boselt, Susanne Petri, Katja KolleweAbstract:Objective and Background: Motor unit number estimation (MUNE) techniques such as motor unit number index (MUnix) have been used to quantify lower motor neuron loss and disease progression in amyotrophic lateral sclerosis (ALS). In this study we investigated the consistency of reproducibility of MUnix in 30 ALS-patients during the course of the disease. Methods: MUnix was recorded in abductor pollicis brevis and tibialis anterior muscles bilaterally in ALS-patients in two measurements in first and follow-up visit and in healthy controls. Intra-rater reproducibility of MUnix was evaluated by three statistical methods: interclass correlation coefficient (ICC), correlation coefficient analysis (CCA), and coefficient of variation (CV). Results: We found significant correlation between the first and second measurement of MUnix in all tested muscles and in the follow-up visit (r ≥ 0.891, p < 0.01). In the ICC analysis, we found good statistically significant reproducibility of MUnix in all four measured muscles at the follow-up visit (ICC ≥ 0.946, p < 0.01). In the CV analysis at the follow-up visit, there was a CV of MUnix ranging from 13.90[percnt] to 32.95[percnt]. Conclusions: This study shows good consistency of reproducibility of MUnix in the course of ALS and highlights its value as a reliable disease progression index. Disclosure: Dr. Fathi has nothing to disclose. Dr. Mohammadi has nothing to disclose. Dr. Dengler has nothing to disclose. Dr. Boselt has nothing to disclose. Dr. Petri has nothing to disclose. Dr. Kollewe has nothing to disclose.
-
lower motor neuron involvement in als assessed by motor unit number index mUnix long term changes and reproducibility
Clinical Neurophysiology, 2016Co-Authors: Davood Fathi, Bahram Mohammadi, Reinhard Dengler, Sebastian Boselt, Susanne Petri, Katja KolleweAbstract:Abstract Objective Motor unit number estimation (MUNE) techniques such as motor unit number index (MUnix) have been used to quantify lower motor neuron loss and disease progression in amyotrophic lateral sclerosis (ALS). We investigated the consistency of reproducibility of MUnix in 30 ALS-patients during the course of the disorder. Methods MUnix was recorded in abductor pollicis brevis and tibialis anterior muscles bilaterally in ALS-patients by two measurements at the first and at one follow-up visit and once in healthy controls. Intra-rater reproducibility was evaluated by three statistical methods: interclass correlation coefficient (ICC), correlation coefficient analysis (CCA), and coefficient of variation (CV). Results We found significant correlation between the first and second measurement of MUnix in all tested muscles and at the follow-up visit (r ⩾ 0.891, p Conclusions This study shows good consistency of reproducibility of MUnix in the course of ALS. Significance This study suggests that MUnix can be used to track the progression of the disorder both in clinical routine and in treatment trials.
