The Experts below are selected from a list of 54 Experts worldwide ranked by ideXlab platform
Bo Lindström - One of the best experts on this subject based on the ideXlab platform.
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Unscheduled DNA Synthesis in lens epithelium after in vivo exposure to UV radiation in the 300 nm wavelength region.
Acta ophthalmologica, 2009Co-Authors: Per G. Söderberg, Bo Philipson, Bo LindströmAbstract:A quantitative autoradiographic method was developed to study the pattern of DNA Synthesis in the rat lens epithelium after in vivo exposure to UV radiation in the 300 nm wavelength region. It was found that UV radiation (peak transmission = 298 nm, half-width = +/- 10 nm) induces Unscheduled DNA Synthesis and that the proportion of nuclei in S-phase concurrently is reduced indicating an inhibition of the scheduled DNA Synthesis. The registered Unscheduled DNA Synthesis is believed to be excision repair of DNA damage induced by the UV radiation. Excision repair in lens epithelial cells could be one mechanism involved in the correlation between exposure to sunlight and cataracts.
D Bootsma - One of the best experts on this subject based on the ideXlab platform.
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prenatal diagnosis of xeroderma pigmentosum group c using assays of Unscheduled DNA Synthesis and postreplication repair
Clinical Genetics, 2008Co-Authors: D J J Halley, W Keijzer, Nicolaas G J Jaspers, M F Niermeuer, W J Rleijer, J Boue, A Boue, D BootsmaAbstract:The analysis of DNA repair processes is described in two pregnancies at risk for xeroderma pigmentosum. In both cases, excision repair (measured by Unscheduled DNA Synthesis) and postreplication repair were analyzed. An affected and an unaffected fetus were identified within 3 weeks after amniocentesis. The cells from the affected fetus were found to be deficient in excision DNA repair, whereas the PRR patterns were intermediate between those of normal and PRR deficient cells. This indicates the possibility of prenatal diagnosis of PRR deficient XP patients (XP variants).
Per G. Söderberg - One of the best experts on this subject based on the ideXlab platform.
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Unscheduled DNA Synthesis in lens epithelium after in vivo exposure to UV radiation in the 300 nm wavelength region.
Acta ophthalmologica, 2009Co-Authors: Per G. Söderberg, Bo Philipson, Bo LindströmAbstract:A quantitative autoradiographic method was developed to study the pattern of DNA Synthesis in the rat lens epithelium after in vivo exposure to UV radiation in the 300 nm wavelength region. It was found that UV radiation (peak transmission = 298 nm, half-width = +/- 10 nm) induces Unscheduled DNA Synthesis and that the proportion of nuclei in S-phase concurrently is reduced indicating an inhibition of the scheduled DNA Synthesis. The registered Unscheduled DNA Synthesis is believed to be excision repair of DNA damage induced by the UV radiation. Excision repair in lens epithelial cells could be one mechanism involved in the correlation between exposure to sunlight and cataracts.
D J J Halley - One of the best experts on this subject based on the ideXlab platform.
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prenatal diagnosis of xeroderma pigmentosum group c using assays of Unscheduled DNA Synthesis and postreplication repair
Clinical Genetics, 2008Co-Authors: D J J Halley, W Keijzer, Nicolaas G J Jaspers, M F Niermeuer, W J Rleijer, J Boue, A Boue, D BootsmaAbstract:The analysis of DNA repair processes is described in two pregnancies at risk for xeroderma pigmentosum. In both cases, excision repair (measured by Unscheduled DNA Synthesis) and postreplication repair were analyzed. An affected and an unaffected fetus were identified within 3 weeks after amniocentesis. The cells from the affected fetus were found to be deficient in excision DNA repair, whereas the PRR patterns were intermediate between those of normal and PRR deficient cells. This indicates the possibility of prenatal diagnosis of PRR deficient XP patients (XP variants).
Huigang Zhu - One of the best experts on this subject based on the ideXlab platform.
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Study on the Unscheduled DNA Synthesis in primary rat hepatocyte induced by source water, tap water and active carbon-treated tap water
Wei sheng yan jiu = Journal of hygiene research, 2003Co-Authors: Songhui Jiang, Wei Shi, Huigang ZhuAbstract:To study the mutagenicity of source water with different turbidities, tap water and active carbon-treated tap water, Unscheduled DNA Synthesis in primary rat hepatocyte was detected. Increased Unscheduled DNA Synthesis was found in a dose-depend manner inducted by tap water, source water and tap water treated with 5, 10 and 15 milligrammes active carbon per liter water. The results also showed that the mutagenicity of the source water increased with the increasing of its turbidity, and mutagenicity of the tap water is higher than that of the source water as well. There was no Unscheduled DNA Synthesis in tap water followed by the treatment with 20 milligrammes active carbon per liter water. It is suggested that the development of the water treatment technics including sedimentation, filtration and treatment with active carbon is needed for decreasing or eliminating the mutagenicity of tap water.
