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Javier P. Gisbert - One of the best experts on this subject based on the ideXlab platform.
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Accuracy of Urea Breath Test performed immediately after emergency endoscopy in peptic ulcer bleeding.
Digestive Diseases and Sciences, 2012Co-Authors: Benito Velayos, Luis Fernández-salazar, Fernando Pons-renedo, Maria Fe Muñoz, A. Almaraz, Rocío Aller, Lourdes Ruiz, Lourdes Del Olmo, Javier P. Gisbert, José Manuel González-hernándezAbstract:Aims The aim of this work is to investigate the accuracy of the Urea Breath Test (UBT) performed immediately after emergency endoscopy in peptic ulcer bleeding (PUB).
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Long‐term follow‐up of 13C‐Urea Breath Test results after Helicobacter pylori eradication: frequency and significance of borderline δ13CO2 values
Alimentary pharmacology & therapeutics, 2006Co-Authors: Javier P. Gisbert, I. Jimenez, David Olivares, J.m. PajaresAbstract:BACKGROUND The precise choice of cut-off point for the 13C-Urea Breath Test to define whether it is positive or negative represents a controversial issue. AIM To quantify the 13C-Urea Breath Test result for several years following Helicobacter pylori eradication, and to evaluate the frequency and the significance of borderline delta13CO2 values. METHODS Two-hundred H. pylori eradicated patients confirmed by 13C-Urea Breath Test (100 mg of Urea, citric acid), and having had repeated this Test yearly up to 5 years, were studied. Delta13CO2 values between 2 and 5/1000 were considered as borderline results. RESULTS Eight H. pylori recurrences were observed during 406 patient-years of follow-up (1.97% yearly). In two of eight reinfected patients, the reinfection was preceded by a negative delta13CO2 value >2/1000. Borderline delta13CO2 values were detected in 4% of the 606 Urea Breath Tests performed, and in 25% when only patients in whom H. pylori recurrence was detected in subsequent Urea Breath Tests were included (P 2/1000 for the diagnosis of H. pylori recurrence was 99%. CONCLUSIONS Positive and negative Urea Breath Test results tend to cluster outside the range between 2/1000 and 5/1000. Nevertheless, a borderline Urea Breath Test delta value (e.g. very close to the selected cut-off point) should be interpreted cautiously, and the result should probably be confirmed either by repeating the Urea Breath Test or by other diagnostic methods. On the contrary, a delta13CO2 value
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long term follow up of 13c Urea Breath Test results after helicobacter pylori eradication frequency and significance of borderline delta13co2 values
Alimentary Pharmacology & Therapeutics, 2006Co-Authors: Javier P. Gisbert, I. Jimenez, David Olivares, J M PajaresAbstract:BACKGROUND The precise choice of cut-off point for the 13C-Urea Breath Test to define whether it is positive or negative represents a controversial issue. AIM To quantify the 13C-Urea Breath Test result for several years following Helicobacter pylori eradication, and to evaluate the frequency and the significance of borderline delta13CO2 values. METHODS Two-hundred H. pylori eradicated patients confirmed by 13C-Urea Breath Test (100 mg of Urea, citric acid), and having had repeated this Test yearly up to 5 years, were studied. Delta13CO2 values between 2 and 5/1000 were considered as borderline results. RESULTS Eight H. pylori recurrences were observed during 406 patient-years of follow-up (1.97% yearly). In two of eight reinfected patients, the reinfection was preceded by a negative delta13CO2 value >2/1000. Borderline delta13CO2 values were detected in 4% of the 606 Urea Breath Tests performed, and in 25% when only patients in whom H. pylori recurrence was detected in subsequent Urea Breath Tests were included (P 2/1000 for the diagnosis of H. pylori recurrence was 99%. CONCLUSIONS Positive and negative Urea Breath Test results tend to cluster outside the range between 2/1000 and 5/1000. Nevertheless, a borderline Urea Breath Test delta value (e.g. very close to the selected cut-off point) should be interpreted cautiously, and the result should probably be confirmed either by repeating the Urea Breath Test or by other diagnostic methods. On the contrary, a delta13CO2 value <2/1000 very confidently confirms H. pylori eradication.
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Review article: 13C-Urea Breath Test in the diagnosis of Helicobacter pylori infection -- a critical review.
Alimentary pharmacology & therapeutics, 2004Co-Authors: Javier P. Gisbert, J.m. PajaresAbstract:Summary The Urea Breath Test is a non-invasive, simple and safe Test which provides excellent accuracy both for the initial diagnosis of Helicobacter pylori infection and for the confirmation of its eradication after treatment. Some studies have found no differences between Urea Breath Test performed under non-fasting conditions. The simplicity, good tolerance and economy of the citric acid Test meal probably make its systematic use advisable. The Urea Breath Test protocol may be performed with relatively low doses (
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review article 13c Urea Breath Test in the diagnosis of helicobacter pylori infection a critical review
Alimentary Pharmacology & Therapeutics, 2004Co-Authors: Javier P. Gisbert, J.m. PajaresAbstract:Summary The Urea Breath Test is a non-invasive, simple and safe Test which provides excellent accuracy both for the initial diagnosis of Helicobacter pylori infection and for the confirmation of its eradication after treatment. Some studies have found no differences between Urea Breath Test performed under non-fasting conditions. The simplicity, good tolerance and economy of the citric acid Test meal probably make its systematic use advisable. The Urea Breath Test protocol may be performed with relatively low doses (<100 mg) of Urea: 75 mg or even 50 mg seem to be sufficient. With the most widely used protocol (with citric acid and 75 mg of Urea), excellent accuracy is obtained when Breath samples are collected as early as 10–15 min after Urea ingestion. A unique and generally proposed cut-off level is not possible because it has to be adapted to different factors, such as the Test meal, the dose and type of Urea, or the pre-/post-treatment setting. Fortunately, because positive and negative Urea Breath Test results tend to cluster outside of the range between 2 and 5‰, a change in cut-off value within this range would be expected to have little effect on clinical accuracy of the Test.
F Parente - One of the best experts on this subject based on the ideXlab platform.
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Different effects of short‐term omeprazole, lansoprazole or pantoprazole on the accuracy of the 13C‐Urea Breath Test
Alimentary pharmacology & therapeutics, 2002Co-Authors: F Parente, M Sainaghi, O Sangaletti, V Imbesi, G Maconi, A Anderloni, G. Bianchi PorroAbstract:Background: Proton pump inhibitors may interfere with the accuracy of the 13C-Urea Breath Test, but little information is available on the effect of standard doses of various proton pump inhibitors on this Test. Aim: To evaluate the effect of short-term standard doses of omeprazole, lansoprazole and pantoprazole on the accuracy of the standardized 13C-Urea Breath Test. Methods: A total of 124 patients with Helicobacter pylori infection, diagnosed on the basis of gastric histology, rapid Urease Test and 13C-Urea Breath Test, were studied. These patients received omeprazole, 20 mg/day, lansoprazole, 30 mg/day, or pantoprazole, 40 mg/day, for 2 weeks according to a randomized protocol. 13C-Urea Breath Test was repeated on days 4, 7 and 14 while on therapy and 7 days after proton pump inhibitor withdrawal. Results: Of the patients receiving omeprazole and lansoprazole, 30% (12/40) and 20% (8/41), respectively, became 13C-Urea Breath Test negative during therapy, compared with none of the 42 patients treated with pantoprazole (P
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different effects of short term omeprazole lansoprazole or pantoprazole on the accuracy of the 13c Urea Breath Test
Alimentary Pharmacology & Therapeutics, 2002Co-Authors: F Parente, M Sainaghi, O Sangaletti, V Imbesi, G Maconi, A Anderloni, Bianchi G PorroAbstract:Background: Proton pump inhibitors may interfere with the accuracy of the 13C-Urea Breath Test, but little information is available on the effect of standard doses of various proton pump inhibitors on this Test. Aim: To evaluate the effect of short-term standard doses of omeprazole, lansoprazole and pantoprazole on the accuracy of the standardized 13C-Urea Breath Test. Methods: A total of 124 patients with Helicobacter pylori infection, diagnosed on the basis of gastric histology, rapid Urease Test and 13C-Urea Breath Test, were studied. These patients received omeprazole, 20 mg/day, lansoprazole, 30 mg/day, or pantoprazole, 40 mg/day, for 2 weeks according to a randomized protocol. 13C-Urea Breath Test was repeated on days 4, 7 and 14 while on therapy and 7 days after proton pump inhibitor withdrawal. Results: Of the patients receiving omeprazole and lansoprazole, 30% (12/40) and 20% (8/41), respectively, became 13C-Urea Breath Test negative during therapy, compared with none of the 42 patients treated with pantoprazole (P < 0.05). All the false negative 13C-Urea Breath Test results returned to positive within 1 week of drug withdrawal, with a mean recovery to 84.7 ± 15.6% of baseline δ13CO2. Conclusions: Short-term omeprazole and lansoprazole interfere with the 13C-Urea Breath Test, although a return to positive Test results invariably occurs within 1 week of proton pump inhibitor withdrawal. In contrast, the accuracy of the 13C-Urea Breath Test does not appear to be significantly impaired by short-term pantoprazole, which therefore may not necessarily be withdrawn before this Test.
J.m. Pajares - One of the best experts on this subject based on the ideXlab platform.
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Long‐term follow‐up of 13C‐Urea Breath Test results after Helicobacter pylori eradication: frequency and significance of borderline δ13CO2 values
Alimentary pharmacology & therapeutics, 2006Co-Authors: Javier P. Gisbert, I. Jimenez, David Olivares, J.m. PajaresAbstract:BACKGROUND The precise choice of cut-off point for the 13C-Urea Breath Test to define whether it is positive or negative represents a controversial issue. AIM To quantify the 13C-Urea Breath Test result for several years following Helicobacter pylori eradication, and to evaluate the frequency and the significance of borderline delta13CO2 values. METHODS Two-hundred H. pylori eradicated patients confirmed by 13C-Urea Breath Test (100 mg of Urea, citric acid), and having had repeated this Test yearly up to 5 years, were studied. Delta13CO2 values between 2 and 5/1000 were considered as borderline results. RESULTS Eight H. pylori recurrences were observed during 406 patient-years of follow-up (1.97% yearly). In two of eight reinfected patients, the reinfection was preceded by a negative delta13CO2 value >2/1000. Borderline delta13CO2 values were detected in 4% of the 606 Urea Breath Tests performed, and in 25% when only patients in whom H. pylori recurrence was detected in subsequent Urea Breath Tests were included (P 2/1000 for the diagnosis of H. pylori recurrence was 99%. CONCLUSIONS Positive and negative Urea Breath Test results tend to cluster outside the range between 2/1000 and 5/1000. Nevertheless, a borderline Urea Breath Test delta value (e.g. very close to the selected cut-off point) should be interpreted cautiously, and the result should probably be confirmed either by repeating the Urea Breath Test or by other diagnostic methods. On the contrary, a delta13CO2 value
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13C-Urea Breath Test in the management of Helicobacter pylori infection
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2005Co-Authors: J.p. Gisbert, J.m. PajaresAbstract:The Urea Breath Test is a noninvasive and very accurate Test for the diagnosis of Helicobacter pylori infection. However, false negative Urea Breath Test results have been reported to occur in a considerable percentage of the individuals taking proton pump inhibitors; the interval needed to be completely confident that false negative Tests had been excluded has varied among the different studies between 6 and 14 days. The impact of H(2)-receptor antagonists on the accuracy of Urea Breath Test remains controversial, although, in contrast with proton pump inhibitors, the data suggest that H(2)-receptor antagonists, for the most part, have little effect on the result of the Urea Breath Test. The Urea Breath Test does not represent a suitable tool for estimating the density of H. pylori colonization. The only quantitative information to be obtained from the Urea Breath Test is that the higher the delta value, the lower the probability of a false-positive Urea Breath Test result. Although some authors have demonstrated a correlation between Urea Breath Test values and histological lesions of the gastric mucosa, the practical utility of this relationship remains unclear. It has been suggested that the pretreatment Urea Breath Test has the potential to identify patients who require modification of the standard therapeutic regimen (for example, prolonging the duration of treatment or increasing the pharmacological dose when bacterial density is high), but other studies could not confirm this relationship. Some studies have shown that the Urea Breath Test is less accurate in patients who have undergone partial gastrectomy. Finally, in contrast with biopsy-based methods, which are responsible for a high number of false-negative results when used to diagnose H. pylori infection in patients with upper gastroinTestinal bleeding, Urea Breath Test seems not to be negatively influenced by the presence of this complication.
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Review article: 13C-Urea Breath Test in the diagnosis of Helicobacter pylori infection -- a critical review.
Alimentary pharmacology & therapeutics, 2004Co-Authors: Javier P. Gisbert, J.m. PajaresAbstract:Summary The Urea Breath Test is a non-invasive, simple and safe Test which provides excellent accuracy both for the initial diagnosis of Helicobacter pylori infection and for the confirmation of its eradication after treatment. Some studies have found no differences between Urea Breath Test performed under non-fasting conditions. The simplicity, good tolerance and economy of the citric acid Test meal probably make its systematic use advisable. The Urea Breath Test protocol may be performed with relatively low doses (
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review article 13c Urea Breath Test in the diagnosis of helicobacter pylori infection a critical review
Alimentary Pharmacology & Therapeutics, 2004Co-Authors: Javier P. Gisbert, J.m. PajaresAbstract:Summary The Urea Breath Test is a non-invasive, simple and safe Test which provides excellent accuracy both for the initial diagnosis of Helicobacter pylori infection and for the confirmation of its eradication after treatment. Some studies have found no differences between Urea Breath Test performed under non-fasting conditions. The simplicity, good tolerance and economy of the citric acid Test meal probably make its systematic use advisable. The Urea Breath Test protocol may be performed with relatively low doses (<100 mg) of Urea: 75 mg or even 50 mg seem to be sufficient. With the most widely used protocol (with citric acid and 75 mg of Urea), excellent accuracy is obtained when Breath samples are collected as early as 10–15 min after Urea ingestion. A unique and generally proposed cut-off level is not possible because it has to be adapted to different factors, such as the Test meal, the dose and type of Urea, or the pre-/post-treatment setting. Fortunately, because positive and negative Urea Breath Test results tend to cluster outside of the range between 2 and 5‰, a change in cut-off value within this range would be expected to have little effect on clinical accuracy of the Test.
Bianchi G Porro - One of the best experts on this subject based on the ideXlab platform.
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different effects of short term omeprazole lansoprazole or pantoprazole on the accuracy of the 13c Urea Breath Test
Alimentary Pharmacology & Therapeutics, 2002Co-Authors: F Parente, M Sainaghi, O Sangaletti, V Imbesi, G Maconi, A Anderloni, Bianchi G PorroAbstract:Background: Proton pump inhibitors may interfere with the accuracy of the 13C-Urea Breath Test, but little information is available on the effect of standard doses of various proton pump inhibitors on this Test. Aim: To evaluate the effect of short-term standard doses of omeprazole, lansoprazole and pantoprazole on the accuracy of the standardized 13C-Urea Breath Test. Methods: A total of 124 patients with Helicobacter pylori infection, diagnosed on the basis of gastric histology, rapid Urease Test and 13C-Urea Breath Test, were studied. These patients received omeprazole, 20 mg/day, lansoprazole, 30 mg/day, or pantoprazole, 40 mg/day, for 2 weeks according to a randomized protocol. 13C-Urea Breath Test was repeated on days 4, 7 and 14 while on therapy and 7 days after proton pump inhibitor withdrawal. Results: Of the patients receiving omeprazole and lansoprazole, 30% (12/40) and 20% (8/41), respectively, became 13C-Urea Breath Test negative during therapy, compared with none of the 42 patients treated with pantoprazole (P < 0.05). All the false negative 13C-Urea Breath Test results returned to positive within 1 week of drug withdrawal, with a mean recovery to 84.7 ± 15.6% of baseline δ13CO2. Conclusions: Short-term omeprazole and lansoprazole interfere with the 13C-Urea Breath Test, although a return to positive Test results invariably occurs within 1 week of proton pump inhibitor withdrawal. In contrast, the accuracy of the 13C-Urea Breath Test does not appear to be significantly impaired by short-term pantoprazole, which therefore may not necessarily be withdrawn before this Test.
M Sainaghi - One of the best experts on this subject based on the ideXlab platform.
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Different effects of short‐term omeprazole, lansoprazole or pantoprazole on the accuracy of the 13C‐Urea Breath Test
Alimentary pharmacology & therapeutics, 2002Co-Authors: F Parente, M Sainaghi, O Sangaletti, V Imbesi, G Maconi, A Anderloni, G. Bianchi PorroAbstract:Background: Proton pump inhibitors may interfere with the accuracy of the 13C-Urea Breath Test, but little information is available on the effect of standard doses of various proton pump inhibitors on this Test. Aim: To evaluate the effect of short-term standard doses of omeprazole, lansoprazole and pantoprazole on the accuracy of the standardized 13C-Urea Breath Test. Methods: A total of 124 patients with Helicobacter pylori infection, diagnosed on the basis of gastric histology, rapid Urease Test and 13C-Urea Breath Test, were studied. These patients received omeprazole, 20 mg/day, lansoprazole, 30 mg/day, or pantoprazole, 40 mg/day, for 2 weeks according to a randomized protocol. 13C-Urea Breath Test was repeated on days 4, 7 and 14 while on therapy and 7 days after proton pump inhibitor withdrawal. Results: Of the patients receiving omeprazole and lansoprazole, 30% (12/40) and 20% (8/41), respectively, became 13C-Urea Breath Test negative during therapy, compared with none of the 42 patients treated with pantoprazole (P
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different effects of short term omeprazole lansoprazole or pantoprazole on the accuracy of the 13c Urea Breath Test
Alimentary Pharmacology & Therapeutics, 2002Co-Authors: F Parente, M Sainaghi, O Sangaletti, V Imbesi, G Maconi, A Anderloni, Bianchi G PorroAbstract:Background: Proton pump inhibitors may interfere with the accuracy of the 13C-Urea Breath Test, but little information is available on the effect of standard doses of various proton pump inhibitors on this Test. Aim: To evaluate the effect of short-term standard doses of omeprazole, lansoprazole and pantoprazole on the accuracy of the standardized 13C-Urea Breath Test. Methods: A total of 124 patients with Helicobacter pylori infection, diagnosed on the basis of gastric histology, rapid Urease Test and 13C-Urea Breath Test, were studied. These patients received omeprazole, 20 mg/day, lansoprazole, 30 mg/day, or pantoprazole, 40 mg/day, for 2 weeks according to a randomized protocol. 13C-Urea Breath Test was repeated on days 4, 7 and 14 while on therapy and 7 days after proton pump inhibitor withdrawal. Results: Of the patients receiving omeprazole and lansoprazole, 30% (12/40) and 20% (8/41), respectively, became 13C-Urea Breath Test negative during therapy, compared with none of the 42 patients treated with pantoprazole (P < 0.05). All the false negative 13C-Urea Breath Test results returned to positive within 1 week of drug withdrawal, with a mean recovery to 84.7 ± 15.6% of baseline δ13CO2. Conclusions: Short-term omeprazole and lansoprazole interfere with the 13C-Urea Breath Test, although a return to positive Test results invariably occurs within 1 week of proton pump inhibitor withdrawal. In contrast, the accuracy of the 13C-Urea Breath Test does not appear to be significantly impaired by short-term pantoprazole, which therefore may not necessarily be withdrawn before this Test.
