The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Ken Ichi Tobisu - One of the best experts on this subject based on the ideXlab platform.
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transitional cell carcinoma of the urethra in men and women associated with bladder cancer
Japanese Journal of Clinical Oncology, 1998Co-Authors: Tadao Kakizoe, Ken Ichi TobisuAbstract:Multifocal tumor occurrence in the entire urinary tract in time and space is a well-recognized characteristic of transitional cell carcinoma. Synchronous and asynchronous urethral transitional cell carcinoma, in relation to bladder cancer in male and female patients, is the subject of the present mini-review. It is imperative to rule out male and female patients having a high risk for urethral involvement or urethral recurrence. In male patients, prostatic urethral involvement and stromal invasion mainly due to in situ extension of carcinoma seems to be the most important risk factor. In female patients, bladder neck involvement by cancer seems most important. By excluding male and female bladder cancer patients having these characteristics for simultaneous Urethrectomy, other patients are good candidates for reconstruction of the urinary tract after cystectomy by an orthotopic neobladder which will offer a good quality of life to bladder cancer patients.
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urethral involvement in female bladder cancer patients mapping of 47 consecutive cysto Urethrectomy specimens
The Journal of Urology, 1994Co-Authors: P Coloby, Ken Ichi Tobisu, Tadao Kakizoe, Michiie SakamotoAbstract:AbstractWe reviewed 47 consecutive step-sectioned cysto-Urethrectomy specimens of bladder cancer in female patients to determine the incidence and characteristics of urethral involvement. Of the 47 cases 43 were transitional cell carcinoma: 10 (23%) papillary, 9 (21%) papillo-nodular and 18 (42%) nodular cancer, and 6 (14%) primary or secondary carcinoma in situ. There were 23 cases (54%) of invasive carcinoma of more than stage pT1 and 27 (63%) were grade 3 lesions. Urethral cancer was observed in only 3 cases: 1 stage pT4, grade 3 papillo-nodular cancer developed widely in the bladder and, overriding the bladder neck and proximal urethra, stage pTa, grade 2 papillary cancer was detected, while in 2 with nodular invasive lesions of the bladder (including the bladder neck) urethral cancer was detected either as a direct invasive extension via urethral carcinoma in situ or as an intralymphatic spread without urethral mucosal change. These findings indicate the necessity for prophylactic Urethrectomy in cas...
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a ureteral small cell carcinoma mixed with malignant mesodermal and ectodermal elements a clinicopathological morphological and immunohistochemical study
Japanese Journal of Clinical Oncology, 1993Co-Authors: Masakazu Tsutsumi, Michiie Sakamoto, Ken Ichi Tobisu, Masuzo Kamiya, Tadao KakizoeAbstract:A 60-year-old male with a small cell carcinoma of the right lower ureter is presented. The tumor mainly comprised a small cell carcinoma but also included a full variety of histological types such as transitional cell carcinoma, squamous cell carcinoma, adenocarcinoma, leiomyosarcoma and chondrosarcoma. Immunohistochemical staining was positive for neuron specific enolase and cluster 1 small cell lung cancer antigen/N-CAM in the small cell carcinoma and S-100 in the chondrosarcoma component. The patient underwent a right nephroureterectomy, and received prophylactic radiation of the pelvic and para-aortic lymph node regions and cisplatin and etoposide combination chemotherapy. Eight months after the chemotherapy, a transitional cell carcinoma was found in the bladder neck, and a cystectomy with Urethrectomy performed. To our knowledge, this is the second report of a small cell carcinoma originating from the ureter.
Donald G Skinner - One of the best experts on this subject based on the ideXlab platform.
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pathological guidelines for orthotopic urinary diversion in women with bladder cancer a review of the literature
The Journal of Urology, 2007Co-Authors: John P Stein, David F Penson, Donald G SkinnerAbstract:Purpose: Before the early 1990s total Urethrectomy at radical cystectomy for bladder cancer in women was considered the standard of care. As our understanding of the natural history of urethral urothelial carcinoma in women has improved, neobladders have been increasingly created in carefully selected women with bladder cancer. We reviewed the literature regarding the incidence of urethral involvement, the risk factors for urethral involvement and the incidence of urethral recurrence in women undergoing orthotopic urinary diversion for bladder cancer.Materials and Methods: A comprehensive literature review was performed regarding the natural history of urethral tumor involvement by urothelial carcinoma, risk factors and the incidence of urethral recurrence following radical cystectomy and orthotopic diversion in women with bladder cancer.Results: Urethral tumor involvement occurs in approximately 12% of female patients with bladder cancer undergoing radical cystectomy for high grade, invasive urothelial c...
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the management of urethral transitional cell carcinoma after radical cystectomy for invasive bladder cancer
The Journal of Urology, 2004Co-Authors: Peter E Clark, John P Stein, Susan Groshen, Gus Miranda, Gary Lieskovsky, Donald G SkinnerAbstract:ABSTRACTPurpose: Previous reports have identified risk factors for urethral recurrence following radical cystectomy for transitional cell carcinoma (TCC). However, reports of the clinical presentation, treatment and outcome in these patients are lacking. We report our experience with the diagnosis, management and outcome of urethral TCC after radical cystectomy for bladder cancer.Materials and Methods: A database of 1,054 patients who underwent radical cystectomy and urinary diversion for TCC from 1971 to 1997 was retrospectively reviewed. All patients with urethral TCC after surgery were identified.Results: Urethral TCC was diagnosed in 47 men a median of 18.5 months (range 2 to 116) after cystectomy with 20 (42%) diagnosed within 1 year. Symptomatic recurrence developed in 24 of 42 evaluable patients (57%), 21 had bloody urethral discharge and 7 had pain or a palpable mass. A total of 13 patients (31%) were asymptomatic with abnormal cytology. The remaining 5 patients underwent prophylactic Urethrectomy...
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management of the patient with bladder cancer urethral recurrence
Urologic Clinics of North America, 1994Co-Authors: John A Freeman, John P Stein, D Esrig, Donald G SkinnerAbstract:: Urethral recurrence develops in roughly 10% of patients following cystectomy for bladder cancer and appears to be another manifestation of the multicentric nature of TCC. By far the greatest risk factor for recurrence is tumor involvement of the prostate in the radical cystectomy specimen, with prostatic stromal invasion more ominous than either ductal or mucosal involvement. For patients in whom orthotopic diversion is contemplated, precystectomy screening of the prostate is recommended by means of deep transurethral biopsy. Surveillance of the urethra following cystectomy should be done by urethral wash cytology at 6-month to yearly intervals and must be continued for life. Management of documented urethral recurrence should be by total Urethrectomy, including the meatus.
Tadao Kakizoe - One of the best experts on this subject based on the ideXlab platform.
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transitional cell carcinoma of the urethra in men and women associated with bladder cancer
Japanese Journal of Clinical Oncology, 1998Co-Authors: Tadao Kakizoe, Ken Ichi TobisuAbstract:Multifocal tumor occurrence in the entire urinary tract in time and space is a well-recognized characteristic of transitional cell carcinoma. Synchronous and asynchronous urethral transitional cell carcinoma, in relation to bladder cancer in male and female patients, is the subject of the present mini-review. It is imperative to rule out male and female patients having a high risk for urethral involvement or urethral recurrence. In male patients, prostatic urethral involvement and stromal invasion mainly due to in situ extension of carcinoma seems to be the most important risk factor. In female patients, bladder neck involvement by cancer seems most important. By excluding male and female bladder cancer patients having these characteristics for simultaneous Urethrectomy, other patients are good candidates for reconstruction of the urinary tract after cystectomy by an orthotopic neobladder which will offer a good quality of life to bladder cancer patients.
-
urethral involvement in female bladder cancer patients mapping of 47 consecutive cysto Urethrectomy specimens
The Journal of Urology, 1994Co-Authors: P Coloby, Ken Ichi Tobisu, Tadao Kakizoe, Michiie SakamotoAbstract:AbstractWe reviewed 47 consecutive step-sectioned cysto-Urethrectomy specimens of bladder cancer in female patients to determine the incidence and characteristics of urethral involvement. Of the 47 cases 43 were transitional cell carcinoma: 10 (23%) papillary, 9 (21%) papillo-nodular and 18 (42%) nodular cancer, and 6 (14%) primary or secondary carcinoma in situ. There were 23 cases (54%) of invasive carcinoma of more than stage pT1 and 27 (63%) were grade 3 lesions. Urethral cancer was observed in only 3 cases: 1 stage pT4, grade 3 papillo-nodular cancer developed widely in the bladder and, overriding the bladder neck and proximal urethra, stage pTa, grade 2 papillary cancer was detected, while in 2 with nodular invasive lesions of the bladder (including the bladder neck) urethral cancer was detected either as a direct invasive extension via urethral carcinoma in situ or as an intralymphatic spread without urethral mucosal change. These findings indicate the necessity for prophylactic Urethrectomy in cas...
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a ureteral small cell carcinoma mixed with malignant mesodermal and ectodermal elements a clinicopathological morphological and immunohistochemical study
Japanese Journal of Clinical Oncology, 1993Co-Authors: Masakazu Tsutsumi, Michiie Sakamoto, Ken Ichi Tobisu, Masuzo Kamiya, Tadao KakizoeAbstract:A 60-year-old male with a small cell carcinoma of the right lower ureter is presented. The tumor mainly comprised a small cell carcinoma but also included a full variety of histological types such as transitional cell carcinoma, squamous cell carcinoma, adenocarcinoma, leiomyosarcoma and chondrosarcoma. Immunohistochemical staining was positive for neuron specific enolase and cluster 1 small cell lung cancer antigen/N-CAM in the small cell carcinoma and S-100 in the chondrosarcoma component. The patient underwent a right nephroureterectomy, and received prophylactic radiation of the pelvic and para-aortic lymph node regions and cisplatin and etoposide combination chemotherapy. Eight months after the chemotherapy, a transitional cell carcinoma was found in the bladder neck, and a cystectomy with Urethrectomy performed. To our knowledge, this is the second report of a small cell carcinoma originating from the ureter.
John P Stein - One of the best experts on this subject based on the ideXlab platform.
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pathological guidelines for orthotopic urinary diversion in women with bladder cancer a review of the literature
The Journal of Urology, 2007Co-Authors: John P Stein, David F Penson, Donald G SkinnerAbstract:Purpose: Before the early 1990s total Urethrectomy at radical cystectomy for bladder cancer in women was considered the standard of care. As our understanding of the natural history of urethral urothelial carcinoma in women has improved, neobladders have been increasingly created in carefully selected women with bladder cancer. We reviewed the literature regarding the incidence of urethral involvement, the risk factors for urethral involvement and the incidence of urethral recurrence in women undergoing orthotopic urinary diversion for bladder cancer.Materials and Methods: A comprehensive literature review was performed regarding the natural history of urethral tumor involvement by urothelial carcinoma, risk factors and the incidence of urethral recurrence following radical cystectomy and orthotopic diversion in women with bladder cancer.Results: Urethral tumor involvement occurs in approximately 12% of female patients with bladder cancer undergoing radical cystectomy for high grade, invasive urothelial c...
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the management of urethral transitional cell carcinoma after radical cystectomy for invasive bladder cancer
The Journal of Urology, 2004Co-Authors: Peter E Clark, John P Stein, Susan Groshen, Gus Miranda, Gary Lieskovsky, Donald G SkinnerAbstract:ABSTRACTPurpose: Previous reports have identified risk factors for urethral recurrence following radical cystectomy for transitional cell carcinoma (TCC). However, reports of the clinical presentation, treatment and outcome in these patients are lacking. We report our experience with the diagnosis, management and outcome of urethral TCC after radical cystectomy for bladder cancer.Materials and Methods: A database of 1,054 patients who underwent radical cystectomy and urinary diversion for TCC from 1971 to 1997 was retrospectively reviewed. All patients with urethral TCC after surgery were identified.Results: Urethral TCC was diagnosed in 47 men a median of 18.5 months (range 2 to 116) after cystectomy with 20 (42%) diagnosed within 1 year. Symptomatic recurrence developed in 24 of 42 evaluable patients (57%), 21 had bloody urethral discharge and 7 had pain or a palpable mass. A total of 13 patients (31%) were asymptomatic with abnormal cytology. The remaining 5 patients underwent prophylactic Urethrectomy...
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management of the patient with bladder cancer urethral recurrence
Urologic Clinics of North America, 1994Co-Authors: John A Freeman, John P Stein, D Esrig, Donald G SkinnerAbstract:: Urethral recurrence develops in roughly 10% of patients following cystectomy for bladder cancer and appears to be another manifestation of the multicentric nature of TCC. By far the greatest risk factor for recurrence is tumor involvement of the prostate in the radical cystectomy specimen, with prostatic stromal invasion more ominous than either ductal or mucosal involvement. For patients in whom orthotopic diversion is contemplated, precystectomy screening of the prostate is recommended by means of deep transurethral biopsy. Surveillance of the urethra following cystectomy should be done by urethral wash cytology at 6-month to yearly intervals and must be continued for life. Management of documented urethral recurrence should be by total Urethrectomy, including the meatus.
Chester B Algood - One of the best experts on this subject based on the ideXlab platform.
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urothelial carcinoma recurrence in ileal orthotopic neobladder Urethrectomy and creation of ileal conduit
Urology, 2007Co-Authors: Christopher D Moore, Kenneth A Iczkowski, Kenneth M Blue, Chester B AlgoodAbstract:A patient who had previously undergone radical cystoprostatectomy and ileal neobladder with the Studer technique presented with a recurrence of urothelial carcinoma in the neobladder and urethra. Surgical treatment consisted of resection of the neobladder, Urethrectomy, and creation of an ileal conduit using a separately isolated segment of ileum. Pathologic analysis revealed high-grade urothelial carcinoma implants to the Studer pouch and urethra, with spread to the mesenteric lymph nodes draining the pouch. Intraluminal tumor cell seeding appears to be an important mechanism of metachronous transitional cell carcinoma recurrence in the urethra and ileal mucosa of a neobladder.
