The Experts below are selected from a list of 243 Experts worldwide ranked by ideXlab platform
Vincenzo Gentile - One of the best experts on this subject based on the ideXlab platform.
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Management of Urethral Stent Failure for Recurrent Anterior Urethral Strictures
'Elsevier BV', 2010Co-Authors: Enzo Palminteri, Mauro Gacci, Elisa Berdondini, Maurizio Poluzzi, Giorgio Franco, Vincenzo GentileAbstract:Background: Urethral stent placement for recurrent anterior urethral strictures may cause restenosis and complications. Objective: To describe our experience with patients who had restenoses and complications following urethral stent placement for the treatment of recurrent anterior urethral strictures. Design, setting, and participants: We evaluated retrospectively the records of 13 men with anterior urethral stricture who experienced restenosis and complications after stent insertion. We recorded stent position, prestent and poststent urethral procedures, restenosis location, stent-related complications, and management of stent failures. Surgical procedure: The stent was removed en bloc with the whole strictured urethral segment or wire by wire after a ventral or a double-ventral plus dorsal-sagittal Urethrotomy and stent section. Measurements: Successful outcome was defined as standard voiding, without need of any postoperative procedure, and full recovery from complications. Results and limitations: Four patients did not undergo surgery and the stent was left in situ. Of these patients, two required permanent suprapubic cystostomy. Nine patients underwent challenging surgical stent removal and salvage urethrostomy: After the first stage, three patients are waiting for further reconstructive steps, five elected the urethrostomy as a permanent diversion, and one completed the staged reconstruction using a buccal mucosa graft at the second stage. After surgery, seven of the nine patients (77.8%) were free of strictures and stent-related complications, while a restenosis occurred in two of the nine (22.2%) cases. Conclusions: The management of urethral stent failure represents a therapeutic challenge. The stent risks converting a simple stenosis into a complex stenosis requiring a staged urethroplasty, a definitive urethrostomy, or a permanent suprapubic diversion. (c) 2009 European Association of Urology. Published by Elsevier B. V. All rights reserved
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Management of Urethral Stent Failure for Recurrent Anterior Urethral Strictures
European urology, 2009Co-Authors: Enzo Palminteri, Mauro Gacci, Elisa Berdondini, Maurizio Poluzzi, Giorgio Franco, Vincenzo GentileAbstract:Abstract Background Urethral stent placement for recurrent anterior urethral strictures may cause restenosis and complications. Objective To describe our experience with patients who had restenoses and complications following urethral stent placement for the treatment of recurrent anterior urethral strictures. Design, setting, and participants We evaluated retrospectively the records of 13 men with anterior urethral stricture who experienced restenosis and complications after stent insertion. We recorded stent position, prestent and poststent urethral procedures, restenosis location, stent-related complications, and management of stent failures. Surgical procedure The stent was removed en bloc with the whole strictured urethral segment or wire by wire after a ventral or a double-ventral plus dorsal-sagittal Urethrotomy and stent section. Measurements Successful outcome was defined as standard voiding, without need of any postoperative procedure, and full recovery from complications. Results and limitations Four patients did not undergo surgery and the stent was left in situ. Of these patients, two required permanent suprapubic cystostomy. Nine patients underwent challenging surgical stent removal and salvage urethrostomy: After the first stage, three patients are waiting for further reconstructive steps, five elected the urethrostomy as a permanent diversion, and one completed the staged reconstruction using a buccal mucosa graft at the second stage. After surgery, seven of the nine patients (77.8%) were free of strictures and stent-related complications, while a restenosis occurred in two of the nine (22.2%) cases. Conclusions The management of urethral stent failure represents a therapeutic challenge. The stent risks converting a simple stenosis into a complex stenosis requiring a staged urethroplasty, a definitive urethrostomy, or a permanent suprapubic diversion.
Ju Yuquan - One of the best experts on this subject based on the ideXlab platform.
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Treatment of arethral stricture with in ternal Urethrotomy and electrolomy
Journal of Modern Urology, 2002Co-Authors: Ju YuquanAbstract:Objective To evaluate the effect of internal Urethrotomy with transurethral electrotomy on urethral stricture. Method 21 cases with urethral stricture were treated with internal urethrotemy and transurethral electrotomy. Resulls All patients achieved no-mal niicturination postperaton, 4 cases of which have light incontinence,3 cases had hematuria or microscopic hematuria.Conelusion Internal Urethrotomy and electrotomy is a safe and effective method for the treatment of urethral stricture.
Rozhin Badiei - One of the best experts on this subject based on the ideXlab platform.
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The effect of platelet-rich plasma injection on post-internal Urethrotomy stricture recurrence.
World journal of urology, 2018Co-Authors: Mehran Rezaei, Rozhin BadieiAbstract:Local injection of platelet-rich plasma (PRP) is postulated to work by delivering growth factors and cytokines that recruit healer cells and enhance recovery process at the injection site. As new scar formation leads to stricture recurrence after internal Urethrotomy, we proposed to improve post-internal Urethrotomy stricture recurrence rate by injecting local submucosal PRP at the time of Urethrotomy. From July 2015 to June 2018, 87 male patients with symptomatic bulbar urethral stricture (diagnosed by retrograde urethrography) randomized into two groups of internal Urethrotomy and submucosal normal saline injection (control group, 43 patients), and internal Urethrotomy with submucosal autologous platelet-rich plasma injection (PRP injection group, 44 patients). According to the endpoint, which happened sooner, each patient was followed at 3-month intervals for 2 years after internal Urethrotomy or until urethral stricture recurrence. Twelve-month recurrence rates were 26.82 and 9.09% in the control and the PRP injection groups, respectively (p 0.032). After 2 years of follow-up, stricture recurrence was identified in 18 (43.90%) and 9 (21.95%) patients in the control and the PRP injection groups, respectively (p 0.34). In our study, submucosal PRP injection at the site of internal Urethrotomy decreased the rate of stricture recurrence a year after the intervention. This protective effect lasted for 24 months, at least. Submucosal PRP injection at the time of internal Urethrotomy also decreased the length of stricture in case of recurrence.
Zhang Rong-gui - One of the best experts on this subject based on the ideXlab platform.
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Optical Urethrotomy for anterior urethral stricture under a new local anesthesia: intracorpus spongiosum anesthesia
Journal of Chongqing Medical University, 2006Co-Authors: Zhang Rong-guiAbstract:Objectives:To determine the feasibility of routinely performing internal Urethrotomy for anterior urethral stricture under intracorpus spongiosum anesthesia in an outpatient setting.Methods:In a consecutive series of 18 patients with anterior urethral stricture,a dosage of 2~3 ml of 1%~2% lidocaine was slowly injected into the glans penis.Next,optical Urethrotomy was performed immediately with a cold-cutting knife.According to pain scale,the effect of this anesthetic technique was assessed by questionnaire.Results:Internal Urethrotomy was successfully completed in all the patients.All patients had no pain or discomfort.All the minor procedures varying from 15 to 45 minutes in duration were successfully completed under the new local anesthesia without any additional IV sedation.The anesthesia was very satisfactory without any complications.Conclusions:Under intracorpus spongiosum anesthesia,optical Urethrotomy can be routinely performed in an outpatient setting.With this new local anesthesia,internal Urethrotomy is a safe,effective,simple,and inexpensive procedure for treatment of anterior urethral stricture.
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Optical Urethrotomy for anterior urethral stricture under a new local anesthesia: intracorpus spongiosum anesthesia.
Urology, 2002Co-Authors: Zhang Rong-guiAbstract:Objectives. To determine the feasibility of routinely performing internal Urethrotomy for anterior urethral stricture under intracorpus spongiosum anesthesia in an outpatient setting. Methods. In a consecutive series of 23 patients with anterior urethral stricture, a dosage of 3 mL of 1% lidocaine was slowly injected into the glans penis. Next, optical Urethrotomy was performed immediately with a cold-cutting knife. The effect of this anesthetic technique was evaluated by questionnaire. Results. Internal Urethrotomy was successfully completed in all the patients. Twenty-two patients (95.7%) had no pain or discomfort. One patient reported minimal but tolerable discomfort while the tissue above the stricture was being cut. The anesthesia lasted for about 1.5 hours and was very satisfactory without any complications. Conclusions. Under intracorpus spongiosum anesthesia, optical Urethrotomy can be routinely performed in an outpatient setting. With this new local anesthesia, internal Urethrotomy is a safe, effective, simple, and inexpensive procedure for treatment of anterior urethral stricture.
Hamid Mazdak - One of the best experts on this subject based on the ideXlab platform.
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Internal Urethrotomy and intraurethral submucosal injection of triamcinolone in short bulbar urethral strictures
International Urology and Nephrology, 2010Co-Authors: Hamid Mazdak, Mohammad Hossein Izadpanahi, Asghar Ghalamkari, Mahmoud Kabiri, Mohammad-hatef Khorrami, Kia Nouri-mahdavi, Farshid Alizadeh, Mahtab Zargham, Farhad Tadayyon, Ahmad MohammadiAbstract:Objectives In clinical practice, internal Urethrotomy is an easy procedure and is offered as a first modality for treatment of short urethral strictures. Internal Urethrotomy refers to any procedure that opens the stricture by incising or ablating it transurethrally. The most common complication of internal Urethrotomy is stricture recurrence. The curative success rate of internal Urethrotomy is approximately 20%. Triamcinolone has antifibroblast and anticollagen properties. This study evaluated the efficacy of triamcinolone in the prevention of anterior urethral stricture recurrence after internal Urethrotomy. Methods Fifty male patients with anterior urethral stricture were randomized to undergo internal Urethrotomy with or without urethral submucosal injection of triamcinolone. Using general anesthesia Urethrotomy was performed. Triamcinolone (40 mg) was injected submucosally at the Urethrotomy site in 25 patients. The patients were followed for at least 12 months and the stricture recurrence rate was compared between the two groups. Results 23 patients in the triamcinolone group and 22 in the control group completed the study. There were no significant differences in the baseline characteristics of the patients or the etiology of the stricture between the two groups. Mean follow-up time was 13.7 ± 5.5 months (range: 1–25 months). Urethral stricture recurred in five patients (21.7%) in the triamcinolone group and in 11 patients (50%) in the control group ( P = 0.04). Conclusions Injection of triamcinolone significantly reduced stricture recurrence after internal Urethrotomy. Further investigations are warranted to confirm its efficacy and safety.
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Internal Urethrotomy and intraurethral submucosal injection of triamcinolone in short bulbar urethral strictures
International urology and nephrology, 2009Co-Authors: Hamid Mazdak, Mohammad Hossein Izadpanahi, Asghar Ghalamkari, Mahmoud Kabiri, Mohammad-hatef Khorrami, Kia Nouri-mahdavi, Farshid Alizadeh, Mahtab Zargham, Farhad Tadayyon, Ahmad MohammadiAbstract:Objectives In clinical practice, internal Urethrotomy is an easy procedure and is offered as a first modality for treatment of short urethral strictures. Internal Urethrotomy refers to any procedure that opens the stricture by incising or ablating it transurethrally. The most common complication of internal Urethrotomy is stricture recurrence. The curative success rate of internal Urethrotomy is approximately 20%. Triamcinolone has antifibroblast and anticollagen properties. This study evaluated the efficacy of triamcinolone in the prevention of anterior urethral stricture recurrence after internal Urethrotomy.
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effect of mitomycin c on anterior urethral stricture recurrence after internal Urethrotomy
European Urology, 2007Co-Authors: Hamid Mazdak, Iraj Meshki, Fatemeh GhassamiAbstract:Abstract Objectives Urethral stricture is one of the oldest known urologic diseases and remains a common problem with high morbidity. Internal Urethrotomy refers to any procedure that opens the stricture by incising or ablating it transurethrally. The most common complication of internal Urethrotomy is stricture recurrence. The curative success rate of internal Urethrotomy is approximately 20%. Mitomycin C has antifibroblast and anticollagen properties and in sporadic reports of animal and clinical studies it has increased the success rate of trabeculectomy and myringotomy. This study evaluated the efficacy of mitomycin C in the prevention of anterior urethral stricture recurrence after internal Urethrotomy. Patients and methods Forty male patients with anterior urethral strictures were randomized to undergo internal Urethrotomy with or without urethral submucosal mitomycin C injection. Using general anaesthesia, the Urethrotomy was performed under direct vision. Mitomycin C (0.1mg) was injected submucosally at the Urethrotomy site in 20 patients. The patients were re-evaluated after 6 mo and the stricture recurrence rate was compared between the two groups (χ 2 analysis). Results Urethral stricture recurred in 2 patients (10%) in the mitomycin C-treated group and in 10 patients (50%) in the other group. This difference in stricture recurrence between the two groups was statistically significant ( p =0.006). Conclusions To our knowledge, this is the first prospective, randomized, clinical trial to evaluate the efficacy of mitomycin C application in internal Urethrotomy. Submucosal injection of mitomycin C significantly reduced stricture recurrence after internal Urethrotomy. Further investigations are warranted to confirm its efficacy and safety.
