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Tore Midtvedt - One of the best experts on this subject based on the ideXlab platform.
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Biochemical Intestinal Parameters in Germ‐free Minipigs and Rats and in Ex‐germ‐free Minipigs and Rats Monoassociated with Escherichia coli
Journal of veterinary medicine. A Physiology pathology clinical medicine, 2005Co-Authors: Maria E. Cardona, Tore Midtvedt, H. Kozakova, Eje Collinder, A.-k. Persson, Elisabeth NorinAbstract:Summary Intestinal contents of newborn and young germ-free minipigs and germ-free rats were investigated for the following biochemical parameters – conversion of cholesterol to coprostanol, degradation of β-aspartylglycine, level of tryptic activity, formation of Urobilinogen and the profile of short-chain fatty acids. Additionally, germ-free minipigs and germ-free rats were monoassociated with non-pathogenic strains of Escherichia coli and were investigated for the same biochemical parameters. The conversion of cholesterol to coprostanol, degradation of β-aspartylglycine, tryptic activity and the short-chain fatty acid profile were similar to those found in previous studies in germ-free animals. Slightly higher amounts of Urobilinogen than in the other species investigated so far were found in samples from germ-free and monoassociated minipigs. Except for the total amount of short-chain fatty acids in rats, monoassociation with E. coli did not alter any of the parameters either in the minipigs or in the rats.
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Biochemical Intestinal Parameters in Germ‐free Minipigs and Rats and in Ex‐germ‐free Minipigs and Rats Monoassociated with Escherichia coli
Journal of veterinary medicine. A Physiology pathology clinical medicine, 2005Co-Authors: Maria E. Cardona, Tore Midtvedt, H. Kozakova, Eje Collinder, A.-k. Persson, Elisabeth NorinAbstract:Intestinal contents of newborn and young germ-free minipigs and germ-free rats were investigated for the following biochemical parameters - conversion of cholesterol to coprostanol, degradation of beta-aspartylglycine, level of tryptic activity, formation of Urobilinogen and the profile of short-chain fatty acids. Additionally, germ-free minipigs and germ-free rats were monoassociated with non-pathogenic strains of Escherichia coli and were investigated for the same biochemical parameters. The conversion of cholesterol to coprostanol, degradation of beta-aspartylglycine, tryptic activity and the short-chain fatty acid profile were similar to those found in previous studies in germ-free animals. Slightly higher amounts of Urobilinogen than in the other species investigated so far were found in samples from germ-free and monoassociated minipigs. Except for the total amount of short-chain fatty acids in rats, monoassociation with E. coli did not alter any of the parameters either in the minipigs or in the rats.
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Effect of Olestra Upon Intestinal Microecology as Reflected by Five Microflora Associated Characteristics in Man
Microbial Ecology in Health and Disease, 1996Co-Authors: U. Siigur, K. E. Norin, G. Allgood, T. Schlagheck, Tore MidtvedtAbstract:To determine the effect of olestra on microbial ecology of the gut five microflora associated characteristics (MACs) were assessed in 93 subjects in a 36 d parallel, placebo-controlled, double-blind study. Degradation of tryptic activity, β-aspartylglycine and mucin, and conversion of cholesterol to coprostanol and bilirubin to Urobilinogen were determined in faecal samples collected at the end of an 8 d low fibre baseline period and 28 d treatment period. The test meal consisted of either a moderate (7 g) or high (24 g) level of fibre and olestra (24 g) or an equivalent amount of conventional fat. Olestra had no effect on degradation of tryptic activity or β-aspartylglycine, and no consistent effect on mucin degradation. Olestra reduced significantly the conversion of cholesterol to coprostanol and urobilin to Urobilinogen although the individual values were all within the range of healthy population after treatment. The lipophilic nature of cholesterol and urobilin is the most likely reason for the find...
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Abnormal colonic microbial function in patients with rheumatoid arthritis.
Scandinavian journal of rheumatology, 1994Co-Authors: Peter Benno, Elisabeth Norin, A Uribe, M. Alam, K Henriksson, Tore MidtvedtAbstract:The aim of this study was to examine the mieroflora-associated characteristics (MACs) of faecal samples of patients with rheumatoid arthritis (RA) and to evaluate the actions of sulphasalazine (SASP) on these MACs. The conversion of cholesterol to coprostanol, the production of Urobilinogen, the degradation of faecal tryptic activity (FTA) and of β-aspartylglycine were measured in faecal samples from 19 patients treated with SASP and 21 patients not treated with this medication. A control group of 21 healthy subjects was sex-and age-matched with the untreated patients.The conversion of cholesterol to coprostanol showed a bimodal distribution. The frequency of high converters in patients without SASP treatment was higher than in healthy subjects (p < 0.05). Treatment with SASP markedly increased the FTA and reduced the Urobilinogen values, as compared to the untreated patients (p < 0.05). Beta-aspartylglycine was not found in any faecal samples.The results indicate that patients with RA have an abnormal fo...
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Functional Alterations of the Microflora in Patients with Ulcerative Colitis
Scandinavian journal of gastroenterology, 1993Co-Authors: Peter Benno, C. E. Leijonmarck, U. Monsen, A Uribe, Tore MidtvedtAbstract:The aim of the study was to examine microflora-associated characteristics in patients with inactive ulcerative colitis, receiving sulphasalazine, in relation to the spread of the disease. The conversion of cholesterol to coprostanol, the production of Urobilinogen, and the degradation of tryptic activity (FTA) and beta-aspartylglycine were measured in faecal samples from patients with proctitis or left-sided or total ulcerative colitis and in age- and sex-matched controls. No significant differences in the results were observed in patients with various degrees of extension of inflammatory bowel disease. However, the coprostanol ratio and the Urobilinogen level were lower and the FTA was higher in patients with colitis than in the controls (p < 0.05). Beta-aspartylglycine was not found in any faecal sample. The results indicate that patients with ulcerative colitis taking sulphasalazine have a microflora with abnormal metabolic characteristics.
Peter Benno - One of the best experts on this subject based on the ideXlab platform.
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Abnormal colonic microbial function in patients with rheumatoid arthritis.
Scandinavian journal of rheumatology, 1994Co-Authors: Peter Benno, Elisabeth Norin, A Uribe, M. Alam, K Henriksson, Tore MidtvedtAbstract:The aim of this study was to examine the mieroflora-associated characteristics (MACs) of faecal samples of patients with rheumatoid arthritis (RA) and to evaluate the actions of sulphasalazine (SASP) on these MACs. The conversion of cholesterol to coprostanol, the production of Urobilinogen, the degradation of faecal tryptic activity (FTA) and of β-aspartylglycine were measured in faecal samples from 19 patients treated with SASP and 21 patients not treated with this medication. A control group of 21 healthy subjects was sex-and age-matched with the untreated patients.The conversion of cholesterol to coprostanol showed a bimodal distribution. The frequency of high converters in patients without SASP treatment was higher than in healthy subjects (p < 0.05). Treatment with SASP markedly increased the FTA and reduced the Urobilinogen values, as compared to the untreated patients (p < 0.05). Beta-aspartylglycine was not found in any faecal samples.The results indicate that patients with RA have an abnormal fo...
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Functional Alterations of the Microflora in Patients with Ulcerative Colitis
Scandinavian journal of gastroenterology, 1993Co-Authors: Peter Benno, C. E. Leijonmarck, U. Monsen, A Uribe, Tore MidtvedtAbstract:The aim of the study was to examine microflora-associated characteristics in patients with inactive ulcerative colitis, receiving sulphasalazine, in relation to the spread of the disease. The conversion of cholesterol to coprostanol, the production of Urobilinogen, and the degradation of tryptic activity (FTA) and beta-aspartylglycine were measured in faecal samples from patients with proctitis or left-sided or total ulcerative colitis and in age- and sex-matched controls. No significant differences in the results were observed in patients with various degrees of extension of inflammatory bowel disease. However, the coprostanol ratio and the Urobilinogen level were lower and the FTA was higher in patients with colitis than in the controls (p < 0.05). Beta-aspartylglycine was not found in any faecal sample. The results indicate that patients with ulcerative colitis taking sulphasalazine have a microflora with abnormal metabolic characteristics.
Craig L. Anderson - One of the best experts on this subject based on the ideXlab platform.
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Analysis of Urobilinogen and Urine Bilirubin for Intra-Abdominal Injury in Blunt Trauma Patients
The western journal of emergency medicine, 2009Co-Authors: Julie Gorchynski, Kevin Dean, Craig L. AndersonAbstract:Objective: To determine the point prevalence of urine bilirubin, urine hemoglobin and Urobilinogen in blunt trauma patients, and to evaluate its utility as a screening tool for intra-abdominal injury.
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Or i g i n a l Re s e a r c h Analysis of Urobilinogen and Urine Bilirubin for Intra-Abdominal Injury in Blunt Trauma Patients
2007Co-Authors: Julie Gorchynski, Kevin Dean, Craig L. AndersonAbstract:Reprints available through open access at www.westjem.org Objective: To determine the point prevalence of urine bilirubin, urine hemoglobin and Urobilinogen in blunt trauma patients, and to evaluate its utility as a screening tool for intra-abdominal injury. Methods: Data analysis of 986 consecutive trauma patients of which 698 were adult blunt trauma patients. Five-hundred sixteen subjects had a urinalysis and a CT scan of the abdomen/pelvis or exploratory laparotomy. We reviewed initial urinalysis results from trauma patients in the emergency department (ED) for the presence of urine hemoglobin, uroblinogen and urine bilirubin. Computed tomography (CT) scan results and operative reports were reviewed from the trauma registry for evidence of liver laceration, spleen laceration, bowel or mesenteric injuries. Results: There were 73 injuries and 57/516 patients (11%) with intra-abdominal injury. Urinalysis was positive for Urobilinogen in 28/516 (5.4%) patients, urine bilirubin in 15/516 (2.9%) patients and urine hemoglobin in 313/516 (61%) patients. Nineteen/forty-seven (4%) subjects had liver lacerations, 28/56 (5%) splenic lacerations, and 15/5 (3%) bowel or mesenteric injury. Comparing the proportion of patients that had Urobilinogen detected in the group with and without intra-abdominal injury, 8/28 (29%) subjects with Urobilinogen, 5/15 (33%) subjects with bilirubin and 47/313 (15%) subjects wit
A Uribe - One of the best experts on this subject based on the ideXlab platform.
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Abnormal colonic microbial function in patients with rheumatoid arthritis.
Scandinavian journal of rheumatology, 1994Co-Authors: Peter Benno, Elisabeth Norin, A Uribe, M. Alam, K Henriksson, Tore MidtvedtAbstract:The aim of this study was to examine the mieroflora-associated characteristics (MACs) of faecal samples of patients with rheumatoid arthritis (RA) and to evaluate the actions of sulphasalazine (SASP) on these MACs. The conversion of cholesterol to coprostanol, the production of Urobilinogen, the degradation of faecal tryptic activity (FTA) and of β-aspartylglycine were measured in faecal samples from 19 patients treated with SASP and 21 patients not treated with this medication. A control group of 21 healthy subjects was sex-and age-matched with the untreated patients.The conversion of cholesterol to coprostanol showed a bimodal distribution. The frequency of high converters in patients without SASP treatment was higher than in healthy subjects (p < 0.05). Treatment with SASP markedly increased the FTA and reduced the Urobilinogen values, as compared to the untreated patients (p < 0.05). Beta-aspartylglycine was not found in any faecal samples.The results indicate that patients with RA have an abnormal fo...
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Functional Alterations of the Microflora in Patients with Ulcerative Colitis
Scandinavian journal of gastroenterology, 1993Co-Authors: Peter Benno, C. E. Leijonmarck, U. Monsen, A Uribe, Tore MidtvedtAbstract:The aim of the study was to examine microflora-associated characteristics in patients with inactive ulcerative colitis, receiving sulphasalazine, in relation to the spread of the disease. The conversion of cholesterol to coprostanol, the production of Urobilinogen, and the degradation of tryptic activity (FTA) and beta-aspartylglycine were measured in faecal samples from patients with proctitis or left-sided or total ulcerative colitis and in age- and sex-matched controls. No significant differences in the results were observed in patients with various degrees of extension of inflammatory bowel disease. However, the coprostanol ratio and the Urobilinogen level were lower and the FTA was higher in patients with colitis than in the controls (p < 0.05). Beta-aspartylglycine was not found in any faecal sample. The results indicate that patients with ulcerative colitis taking sulphasalazine have a microflora with abnormal metabolic characteristics.
Mayer F. Wowor - One of the best experts on this subject based on the ideXlab platform.
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Gambaran bilirubin dan Urobilinogen urin pada pasien tuberkulosis paru dewasa di RSUP Prof. Dr. R. D. Kandou Manado
Jurnal e-Biomedik, 2016Co-Authors: Faleriano Makay, Glady I. Rambert, Mayer F. WoworAbstract:Abstract: Tuberculosis is an infectious disease caused by the bacillus Mycobacterium tuberculosis. Antituberculosis drugs prescribed to TB patients is hepatotoxic drug. Liver damage caused by side effects of the drugs will cause an alteration in urinary bilirubin and Urobilinogen level. This study was aimed to obtain the profile of urinary bilirubin and Urobilinogen in adult pulmonary tuberculosis patients at Prof. Dr. R. D. Kandou Hospital Manado from October to November 2016. This was an observational descriptive study. Samples obtained by using random sampling urine from all pulmonary tuberculosis patient that met the inclusion criteria. The results showed that according to urinary bilirubin and Urobilinogen examination in 30 patients, most of them were in normal level. Only 6 out of 30 patients has bilirubinuria in this urinary bilirubin examination. In urinary Urobilinogen examination, all results is in normal level. Conclusion: Urinary bilirubin and Urobilinogen examination in this research was normal in general, bilirubinemia was found only in some patients. Keywords: pulmonary tuberculosis, urinary bilirubin, urinary Urobilinogen Abstrak: Tuberkulosis (TB) merupakan penyakit menular yang disebabkan oleh basil Mycobacterium tuberculosis. Obat antituberkulosis yang diberikan pada pasien TB bersifat hepatotoksik. Kerusakan hepar yang disebabkan oleh efek samping obat tersebut akan menyebabkan perubahan pada kadar bilirubin dan Urobilinogen urin. Tujuan penelitian untuk mengetahui gambaran bilirubin dan Urobilinogen urin pada pasien tuberkulosis paru dewasa di RSUP Prof. Dr. R. D. Kandou Manado. Jenis penelitian ialah deskriptif observasional, untuk mendapatkan data tentang bilirubin dan Urobilinogen urin pada pasien tuberkulosis paru dewasa di RSUP. Prof. Dr. R. D. Kandou Manado pada Oktober-November 2016. Sampel penelitian adalah sampel urin sewaktu dari semua pasien tuberkulosis paru yang memenuhi kriteria inklusi. Hasil penelitian memperlihatkan berdasarkan pemeriksaan bilirubin dan Urobilinogen urin pada 30 pasien, sebagian besar kadarnya normal. Hanya 6 dari 30 pasien yang mengalami bilirubinuria pada pemeriksaan bilirubin urin. Pada pemeriksaan Urobilinogen urin semua hasil dalam batas normal. Simpulan: Pemeriksaan bilirubin dan Urobilinogen urin pada umumnya normal, hanya beberapa pasien yang mengalami bilirubinuria. Kata kunci: tuberkulosis paru, bilirubin urin, Urobilinogen urin
