The Experts below are selected from a list of 306 Experts worldwide ranked by ideXlab platform
R Marre - One of the best experts on this subject based on the ideXlab platform.
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In vitro activities of the lichen secondary metabolites vulpinic Acid, (+)-Usnic Acid, and (-)-Usnic Acid against aerobic and anaerobic microorganisms.
Antimicrobial agents and chemotherapy, 1995Co-Authors: M Lauterwein, M Oethinger, K Belsner, T Peters, R MarreAbstract:Secondary metabolites of different species of lichen were tested for their activities against a variety of microbial species. While gram-negative rods and fungi were not inhibited by these compounds, Staphylococcus aureus, Enterococcus faecalis, Enterococcus faecium, and some anaerobic species (Bacteroides and Clostridium species) were susceptible at the concentrations tested. Vulpinic Acid generally was less active than Usnic Acid, regardless of its stereochemistry. The susceptibility to Usnic Acid was not impaired in clinical isolates of S. aureus resistant to methicillin and/or mupirocin.
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in vitro activities of the lichen secondary metabolites vulpinic Acid Usnic Acid and Usnic Acid against aerobic and anaerobic microorganisms
Antimicrobial Agents and Chemotherapy, 1995Co-Authors: M Lauterwein, M Oethinger, K Belsner, T Peters, R MarreAbstract:Secondary metabolites of different species of lichen were tested for their activities against a variety of microbial species. While gram-negative rods and fungi were not inhibited by these compounds, Staphylococcus aureus, Enterococcus faecalis, Enterococcus faecium, and some anaerobic species (Bacteroides and Clostridium species) were susceptible at the concentrations tested. Vulpinic Acid generally was less active than Usnic Acid, regardless of its stereochemistry. The susceptibility to Usnic Acid was not impaired in clinical isolates of S. aureus resistant to methicillin and/or mupirocin.
M Lauterwein - One of the best experts on this subject based on the ideXlab platform.
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In vitro activities of the lichen secondary metabolites vulpinic Acid, (+)-Usnic Acid, and (-)-Usnic Acid against aerobic and anaerobic microorganisms.
Antimicrobial agents and chemotherapy, 1995Co-Authors: M Lauterwein, M Oethinger, K Belsner, T Peters, R MarreAbstract:Secondary metabolites of different species of lichen were tested for their activities against a variety of microbial species. While gram-negative rods and fungi were not inhibited by these compounds, Staphylococcus aureus, Enterococcus faecalis, Enterococcus faecium, and some anaerobic species (Bacteroides and Clostridium species) were susceptible at the concentrations tested. Vulpinic Acid generally was less active than Usnic Acid, regardless of its stereochemistry. The susceptibility to Usnic Acid was not impaired in clinical isolates of S. aureus resistant to methicillin and/or mupirocin.
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in vitro activities of the lichen secondary metabolites vulpinic Acid Usnic Acid and Usnic Acid against aerobic and anaerobic microorganisms
Antimicrobial Agents and Chemotherapy, 1995Co-Authors: M Lauterwein, M Oethinger, K Belsner, T Peters, R MarreAbstract:Secondary metabolites of different species of lichen were tested for their activities against a variety of microbial species. While gram-negative rods and fungi were not inhibited by these compounds, Staphylococcus aureus, Enterococcus faecalis, Enterococcus faecium, and some anaerobic species (Bacteroides and Clostridium species) were susceptible at the concentrations tested. Vulpinic Acid generally was less active than Usnic Acid, regardless of its stereochemistry. The susceptibility to Usnic Acid was not impaired in clinical isolates of S. aureus resistant to methicillin and/or mupirocin.
Hayrettin Türk - One of the best experts on this subject based on the ideXlab platform.
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in vitro cytotoxic activities of Usnic Acid and Usnic Acid on v79 a549 and human lymphocyte cells and their non genotoxicity on human lymphocytes
Natural Product Research, 2006Co-Authors: A.t. Koparal, Ayaz B Tuylu, Hayrettin TürkAbstract:This study investigates cytotoxic and genotoxic activities of (+)-Usnic Acid and (−)-Usnic Acid isolated from the lichen Ramalina farinacea and the lichen Cladonia foliacea, respectively. To determine the activities of these Acids, we used the MTT assay on V79 (Chinese hamster lung fibroblast like) and A549 (human lung carcinoma epithelial like) cell lines and cytokinesis-blocked micronucleus (CBMN) assay in human lymphocytes in vitro. Our results suggest that both enantiomers of Usnic Acid are non-genotoxic shown by the absence of micronucleus induction in human lymphocytes and have significant cytotoxic and apoptotic effects to induce cell killing in cultured human lymphocytes, V79 and A549 cell lines. Even low doses of (+)-Usnic Acid showed high cytotoxic activity against cancerous cells. The MTT results and cell proliferation index (CPI) values based on the CBMN test results are found in good agreement.
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In vitro cytotoxic activities of (+)-Usnic Acid and (−)-Usnic Acid on V79, A549, and human lymphocyte cells and their non-genotoxicity on human lymphocytes
Natural product research, 2006Co-Authors: A.t. Koparal, B. Ayaz Tuylu, Hayrettin TürkAbstract:This study investigates cytotoxic and genotoxic activities of (+)-Usnic Acid and (−)-Usnic Acid isolated from the lichen Ramalina farinacea and the lichen Cladonia foliacea, respectively. To determine the activities of these Acids, we used the MTT assay on V79 (Chinese hamster lung fibroblast like) and A549 (human lung carcinoma epithelial like) cell lines and cytokinesis-blocked micronucleus (CBMN) assay in human lymphocytes in vitro. Our results suggest that both enantiomers of Usnic Acid are non-genotoxic shown by the absence of micronucleus induction in human lymphocytes and have significant cytotoxic and apoptotic effects to induce cell killing in cultured human lymphocytes, V79 and A549 cell lines. Even low doses of (+)-Usnic Acid showed high cytotoxic activity against cancerous cells. The MTT results and cell proliferation index (CPI) values based on the CBMN test results are found in good agreement.
K Belsner - One of the best experts on this subject based on the ideXlab platform.
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In vitro activities of the lichen secondary metabolites vulpinic Acid, (+)-Usnic Acid, and (-)-Usnic Acid against aerobic and anaerobic microorganisms.
Antimicrobial agents and chemotherapy, 1995Co-Authors: M Lauterwein, M Oethinger, K Belsner, T Peters, R MarreAbstract:Secondary metabolites of different species of lichen were tested for their activities against a variety of microbial species. While gram-negative rods and fungi were not inhibited by these compounds, Staphylococcus aureus, Enterococcus faecalis, Enterococcus faecium, and some anaerobic species (Bacteroides and Clostridium species) were susceptible at the concentrations tested. Vulpinic Acid generally was less active than Usnic Acid, regardless of its stereochemistry. The susceptibility to Usnic Acid was not impaired in clinical isolates of S. aureus resistant to methicillin and/or mupirocin.
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in vitro activities of the lichen secondary metabolites vulpinic Acid Usnic Acid and Usnic Acid against aerobic and anaerobic microorganisms
Antimicrobial Agents and Chemotherapy, 1995Co-Authors: M Lauterwein, M Oethinger, K Belsner, T Peters, R MarreAbstract:Secondary metabolites of different species of lichen were tested for their activities against a variety of microbial species. While gram-negative rods and fungi were not inhibited by these compounds, Staphylococcus aureus, Enterococcus faecalis, Enterococcus faecium, and some anaerobic species (Bacteroides and Clostridium species) were susceptible at the concentrations tested. Vulpinic Acid generally was less active than Usnic Acid, regardless of its stereochemistry. The susceptibility to Usnic Acid was not impaired in clinical isolates of S. aureus resistant to methicillin and/or mupirocin.
M Oethinger - One of the best experts on this subject based on the ideXlab platform.
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In vitro activities of the lichen secondary metabolites vulpinic Acid, (+)-Usnic Acid, and (-)-Usnic Acid against aerobic and anaerobic microorganisms.
Antimicrobial agents and chemotherapy, 1995Co-Authors: M Lauterwein, M Oethinger, K Belsner, T Peters, R MarreAbstract:Secondary metabolites of different species of lichen were tested for their activities against a variety of microbial species. While gram-negative rods and fungi were not inhibited by these compounds, Staphylococcus aureus, Enterococcus faecalis, Enterococcus faecium, and some anaerobic species (Bacteroides and Clostridium species) were susceptible at the concentrations tested. Vulpinic Acid generally was less active than Usnic Acid, regardless of its stereochemistry. The susceptibility to Usnic Acid was not impaired in clinical isolates of S. aureus resistant to methicillin and/or mupirocin.
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in vitro activities of the lichen secondary metabolites vulpinic Acid Usnic Acid and Usnic Acid against aerobic and anaerobic microorganisms
Antimicrobial Agents and Chemotherapy, 1995Co-Authors: M Lauterwein, M Oethinger, K Belsner, T Peters, R MarreAbstract:Secondary metabolites of different species of lichen were tested for their activities against a variety of microbial species. While gram-negative rods and fungi were not inhibited by these compounds, Staphylococcus aureus, Enterococcus faecalis, Enterococcus faecium, and some anaerobic species (Bacteroides and Clostridium species) were susceptible at the concentrations tested. Vulpinic Acid generally was less active than Usnic Acid, regardless of its stereochemistry. The susceptibility to Usnic Acid was not impaired in clinical isolates of S. aureus resistant to methicillin and/or mupirocin.
