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Metha Songthamwat - One of the best experts on this subject based on the ideXlab platform.
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Uterine flexion suture: modified B-Lynch Uterine compression suture for the treatment of Uterine Atony during cesarean section.
International journal of women's health, 2018Co-Authors: Srisuda Songthamwat, Metha SongthamwatAbstract:Objective The aim of this study was to report our clinical experience of applying a Uterine flexion suture, which was modified from the B-Lynch Uterine compression suture, for treating Uterine Atony during cesarean section. Materials and methods This is a retrospective descriptive study describing the use of a new technique, Uterine flexion suture, for treating Uterine Atony during cesarean section. The study period was from January 2009 to December 2017 at Udonthani Hospital, Udonthani, Thailand. Uterine Atony during cesarean section was treated by manual compression, intravenous oxytocin, methylergonovine maleate, and prostaglandins and then was observed for 10-15 minutes before applying a Uterine flexion suture in the failed medical treatment cases. The patients were observed for vaginal bleeding, hematometra, and infection after operation. Uterine ultrasound scan results on days 1, 7, and 30 postoperation were also reviewed. Results Fifty-seven patients with Uterine Atony during cesarean delivery received the Uterine flexion suture. The mean age of patients was 27.0 (15-44 years). Thirty-four patients were primipara. The indications for cesarean section were cephalopelvic disproportion in 27 (47.4%) cases, and previous cesarean section in 11 (19.3%) cases. Neither postoperative excessive bleeding nor hysterectomy was observed. There was no hematometra or serious postoperative complication after surgery. The estimated time for Uterine flexion suture is only 2-3 minutes and was very easy to perform. Conclusion Uterine flexion suture technique, which was modified from the B-Lynch suture, was inexpensive, quick, and effective in the treatment of atonic postpartum uterus in women undergoing cesarean section.
Patricia Griffin - One of the best experts on this subject based on the ideXlab platform.
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Double-blind comparison of carbetocin versus oxytocin in prevention of Uterine Atony after cesarean section.
American Journal of Obstetrics and Gynecology, 1999Co-Authors: Jerome Dansereau, Arvind K Joshi, Michael Helewa, Terence A Doran, Ian Lange, Edwin R Luther, Dan Farine, Miklos L Schulz, Gwendolyn L A Horbay, Patricia GriffinAbstract:Abstract Objective: The goal of this study was to compare carbetocin, a long-acting oxytocin analog, with oxytocin in the prevention of Uterine Atony after cesarean section. Study Design: We enrolled 694 patients undergoing elective cesarean section in a Canadian multicenter, double-blind, randomized clinical trial. We compared the effect of a single 100 μg dose of carbetocin with that of a standard 8-hour infusion of oxytocin. The primary outcome was the proportion of patients requiring additional oxytocic intervention for Uterine Atony. A variable sample size, sequential design was used. Results: The overall oxytocic intervention rate was 7.4%. The odds of treatment failure requiring oxytocic intervention was 2.03 (95% confidence interval 1.1 to 2.8) times higher in the oxytocin group compared with the carbetocin group, respectively, 32 of 318 (10.1%) versus 15 of 317 (4.7%), P Conclusions: Carbetocin, a new drug for the prevention of Uterine Atony, appears to be more effective than a continuous infusion of oxytocin and has a similar safety profile. (Am J Obstet Gynecol 1999;180:670-6.)
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Double-blind comparison of carbetocin versus oxytocin in prevention of Uterine Atony after cesarean section.
American journal of obstetrics and gynecology, 1999Co-Authors: Jerome Dansereau, Arvind K Joshi, Michael Helewa, Terence A Doran, Edwin R Luther, Dan Farine, Miklos L Schulz, Gwendolyn L A Horbay, I R Lange, Patricia GriffinAbstract:The goal of this study was to compare carbetocin, a long-acting oxytocin analog, with oxytocin in the prevention of Uterine Atony after cesarean section. We enrolled 694 patients undergoing elective cesarean section in a Canadian multicenter, double-blind, randomized clinical trial. We compared the effect of a single 100 microg dose of carbetocin with that of a standard 8-hour infusion of oxytocin. The primary outcome was the proportion of patients requiring additional oxytocic intervention for Uterine Atony. A variable sample size, sequential design was used. The overall oxytocic intervention rate was 7.4%. The odds of treatment failure requiring oxytocic intervention was 2.03 (95% confidence interval 1.1 to 2.8) times higher in the oxytocin group compared with the carbetocin group, respectively, 32 of 318 (10.1%) versus 15 of 317 (4.7%), P <.05. Carbetocin, a new drug for the prevention of Uterine Atony, appears to be more effective than a continuous infusion of oxytocin and has a similar safety profile.
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double blind comparison of carbetocin versus oxytocin in preventing Uterine Atony post cesarean section
European Journal of Obstetrics & Gynecology and Reproductive Biology, 1996Co-Authors: Jerome Dansereau, Arvind K Joshi, Michael Helewa, Terence A Doran, Ian Lange, Edwin R Luther, Dan Farine, Miklos L Schulz, Gwendolyn L A Horbay, Patricia GriffinAbstract:Objectives : The aim of this study was to compare carbetocin, a long-acting oxytocin analog, to oxytocin in the prevention of post-cesarean Uterine Atony. Material and methods : We enrolled 694 patients going for elective repeat cesarean in a Canadian multicentre double-blind randomized clinical trial. We compared the effect of a single dose of carbetocin (100 mcg.IV) to a standard 8 h IV infusion of oxytocin. The primary outcome was the proportion of patients requiring additional uterotonic drugs. The design used a sequential analysis using the double triangular test. Results : The overall uterotonic intervention rate was 7.4%. The odds of treatment failure was 2.0 times higher in the oxytocin group compared with the carbetocin group (respectively 10.1% vs. 4.7%, P<0.05). Interim safety analysis shows carbetocin to be well tolerated with a safety profile similar to oxytocin. Conclusion : Carbetocin, a new drug to prevent Uterine Atony, appears to be more effective than a continuous infusion of oxytocin in preventing Uterine Atony post-Cesarean.
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Double-blind comparison of carbetocin versus oxytocin in preventing Uterine Atony post cesarean section☆
European Journal of Obstetrics & Gynecology and Reproductive Biology, 1996Co-Authors: Jerome Dansereau, Arvind K Joshi, Michael Helewa, Terence A Doran, Ian Lange, Edwin R Luther, Dan Farine, Miklos L Schulz, Gwendolyn L A Horbay, Patricia GriffinAbstract:Objectives : The aim of this study was to compare carbetocin, a long-acting oxytocin analog, to oxytocin in the prevention of post-cesarean Uterine Atony. Material and methods : We enrolled 694 patients going for elective repeat cesarean in a Canadian multicentre double-blind randomized clinical trial. We compared the effect of a single dose of carbetocin (100 mcg.IV) to a standard 8 h IV infusion of oxytocin. The primary outcome was the proportion of patients requiring additional uterotonic drugs. The design used a sequential analysis using the double triangular test. Results : The overall uterotonic intervention rate was 7.4%. The odds of treatment failure was 2.0 times higher in the oxytocin group compared with the carbetocin group (respectively 10.1% vs. 4.7%, P
Srisuda Songthamwat - One of the best experts on this subject based on the ideXlab platform.
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Uterine flexion suture: modified B-Lynch Uterine compression suture for the treatment of Uterine Atony during cesarean section.
International journal of women's health, 2018Co-Authors: Srisuda Songthamwat, Metha SongthamwatAbstract:Objective The aim of this study was to report our clinical experience of applying a Uterine flexion suture, which was modified from the B-Lynch Uterine compression suture, for treating Uterine Atony during cesarean section. Materials and methods This is a retrospective descriptive study describing the use of a new technique, Uterine flexion suture, for treating Uterine Atony during cesarean section. The study period was from January 2009 to December 2017 at Udonthani Hospital, Udonthani, Thailand. Uterine Atony during cesarean section was treated by manual compression, intravenous oxytocin, methylergonovine maleate, and prostaglandins and then was observed for 10-15 minutes before applying a Uterine flexion suture in the failed medical treatment cases. The patients were observed for vaginal bleeding, hematometra, and infection after operation. Uterine ultrasound scan results on days 1, 7, and 30 postoperation were also reviewed. Results Fifty-seven patients with Uterine Atony during cesarean delivery received the Uterine flexion suture. The mean age of patients was 27.0 (15-44 years). Thirty-four patients were primipara. The indications for cesarean section were cephalopelvic disproportion in 27 (47.4%) cases, and previous cesarean section in 11 (19.3%) cases. Neither postoperative excessive bleeding nor hysterectomy was observed. There was no hematometra or serious postoperative complication after surgery. The estimated time for Uterine flexion suture is only 2-3 minutes and was very easy to perform. Conclusion Uterine flexion suture technique, which was modified from the B-Lynch suture, was inexpensive, quick, and effective in the treatment of atonic postpartum uterus in women undergoing cesarean section.
Jerome Dansereau - One of the best experts on this subject based on the ideXlab platform.
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Double-blind comparison of carbetocin versus oxytocin in prevention of Uterine Atony after cesarean section.
American Journal of Obstetrics and Gynecology, 1999Co-Authors: Jerome Dansereau, Arvind K Joshi, Michael Helewa, Terence A Doran, Ian Lange, Edwin R Luther, Dan Farine, Miklos L Schulz, Gwendolyn L A Horbay, Patricia GriffinAbstract:Abstract Objective: The goal of this study was to compare carbetocin, a long-acting oxytocin analog, with oxytocin in the prevention of Uterine Atony after cesarean section. Study Design: We enrolled 694 patients undergoing elective cesarean section in a Canadian multicenter, double-blind, randomized clinical trial. We compared the effect of a single 100 μg dose of carbetocin with that of a standard 8-hour infusion of oxytocin. The primary outcome was the proportion of patients requiring additional oxytocic intervention for Uterine Atony. A variable sample size, sequential design was used. Results: The overall oxytocic intervention rate was 7.4%. The odds of treatment failure requiring oxytocic intervention was 2.03 (95% confidence interval 1.1 to 2.8) times higher in the oxytocin group compared with the carbetocin group, respectively, 32 of 318 (10.1%) versus 15 of 317 (4.7%), P Conclusions: Carbetocin, a new drug for the prevention of Uterine Atony, appears to be more effective than a continuous infusion of oxytocin and has a similar safety profile. (Am J Obstet Gynecol 1999;180:670-6.)
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Double-blind comparison of carbetocin versus oxytocin in prevention of Uterine Atony after cesarean section.
American journal of obstetrics and gynecology, 1999Co-Authors: Jerome Dansereau, Arvind K Joshi, Michael Helewa, Terence A Doran, Edwin R Luther, Dan Farine, Miklos L Schulz, Gwendolyn L A Horbay, I R Lange, Patricia GriffinAbstract:The goal of this study was to compare carbetocin, a long-acting oxytocin analog, with oxytocin in the prevention of Uterine Atony after cesarean section. We enrolled 694 patients undergoing elective cesarean section in a Canadian multicenter, double-blind, randomized clinical trial. We compared the effect of a single 100 microg dose of carbetocin with that of a standard 8-hour infusion of oxytocin. The primary outcome was the proportion of patients requiring additional oxytocic intervention for Uterine Atony. A variable sample size, sequential design was used. The overall oxytocic intervention rate was 7.4%. The odds of treatment failure requiring oxytocic intervention was 2.03 (95% confidence interval 1.1 to 2.8) times higher in the oxytocin group compared with the carbetocin group, respectively, 32 of 318 (10.1%) versus 15 of 317 (4.7%), P <.05. Carbetocin, a new drug for the prevention of Uterine Atony, appears to be more effective than a continuous infusion of oxytocin and has a similar safety profile.
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double blind comparison of carbetocin versus oxytocin in preventing Uterine Atony post cesarean section
European Journal of Obstetrics & Gynecology and Reproductive Biology, 1996Co-Authors: Jerome Dansereau, Arvind K Joshi, Michael Helewa, Terence A Doran, Ian Lange, Edwin R Luther, Dan Farine, Miklos L Schulz, Gwendolyn L A Horbay, Patricia GriffinAbstract:Objectives : The aim of this study was to compare carbetocin, a long-acting oxytocin analog, to oxytocin in the prevention of post-cesarean Uterine Atony. Material and methods : We enrolled 694 patients going for elective repeat cesarean in a Canadian multicentre double-blind randomized clinical trial. We compared the effect of a single dose of carbetocin (100 mcg.IV) to a standard 8 h IV infusion of oxytocin. The primary outcome was the proportion of patients requiring additional uterotonic drugs. The design used a sequential analysis using the double triangular test. Results : The overall uterotonic intervention rate was 7.4%. The odds of treatment failure was 2.0 times higher in the oxytocin group compared with the carbetocin group (respectively 10.1% vs. 4.7%, P<0.05). Interim safety analysis shows carbetocin to be well tolerated with a safety profile similar to oxytocin. Conclusion : Carbetocin, a new drug to prevent Uterine Atony, appears to be more effective than a continuous infusion of oxytocin in preventing Uterine Atony post-Cesarean.
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Double-blind comparison of carbetocin versus oxytocin in preventing Uterine Atony post cesarean section☆
European Journal of Obstetrics & Gynecology and Reproductive Biology, 1996Co-Authors: Jerome Dansereau, Arvind K Joshi, Michael Helewa, Terence A Doran, Ian Lange, Edwin R Luther, Dan Farine, Miklos L Schulz, Gwendolyn L A Horbay, Patricia GriffinAbstract:Objectives : The aim of this study was to compare carbetocin, a long-acting oxytocin analog, to oxytocin in the prevention of post-cesarean Uterine Atony. Material and methods : We enrolled 694 patients going for elective repeat cesarean in a Canadian multicentre double-blind randomized clinical trial. We compared the effect of a single dose of carbetocin (100 mcg.IV) to a standard 8 h IV infusion of oxytocin. The primary outcome was the proportion of patients requiring additional uterotonic drugs. The design used a sequential analysis using the double triangular test. Results : The overall uterotonic intervention rate was 7.4%. The odds of treatment failure was 2.0 times higher in the oxytocin group compared with the carbetocin group (respectively 10.1% vs. 4.7%, P
Andra H. James - One of the best experts on this subject based on the ideXlab platform.
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oxytocin exposure during labor among women with postpartum hemorrhage secondary to Uterine Atony
American Journal of Obstetrics and Gynecology, 2011Co-Authors: Chad A. Grotegut, Lauren N C Johnson, Betty Thames, Michael J Paglia, Andra H. JamesAbstract:Objective We sought to determine if women with severe postpartum hemorrhage (PPH) secondary to Uterine Atony received greater amounts of oxytocin during labor compared to women without PPH. Study Design Subjects with severe PPH secondary to Uterine Atony, who received a blood transfusion, were compared to matched controls. Total oxytocin exposure was calculated as the area under the concentration curve (mU/min*min). Variables were compared using paired t test, χ 2 , and logistic regression. Results Women with severe PPH had a mean oxytocin area under the curve of 10,054 mU compared to 3762 mU in controls ( P Conclusion Women with severe PPH secondary to Uterine Atony were exposed to significantly more oxytocin during labor compared to matched controls.
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Oxytocin exposure during labor among women with postpartum hemorrhage secondary to Uterine Atony.
American journal of obstetrics and gynecology, 2010Co-Authors: Chad A. Grotegut, Lauren N C Johnson, Betty Thames, Michael J Paglia, Andra H. JamesAbstract:We sought to determine if women with severe postpartum hemorrhage (PPH) secondary to Uterine Atony received greater amounts of oxytocin during labor compared to women without PPH. Subjects with severe PPH secondary to Uterine Atony, who received a blood transfusion, were compared to matched controls. Total oxytocin exposure was calculated as the area under the concentration curve (mU/min*min). Variables were compared using paired t test, χ², and logistic regression. Women with severe PPH had a mean oxytocin area under the curve of 10,054 mU compared to 3762 mU in controls (P < .001). After controlling for race, body mass index, admission hematocrit, induction status, magnesium therapy, and chorioamnionitis using logistic regression, oxytocin area under the curve continued to predict severe PPH. Women with severe PPH secondary to Uterine Atony were exposed to significantly more oxytocin during labor compared to matched controls. Copyright © 2011 Mosby, Inc. All rights reserved.
