The Experts below are selected from a list of 3765 Experts worldwide ranked by ideXlab platform
René H.m. Verheijen - One of the best experts on this subject based on the ideXlab platform.
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Sentinel lymph node detection in early stage Uterine Cervix Carcinoma: a systematic review.
Gynecologic oncology, 2007Co-Authors: Jonas Van De Lande, Bas Torrenga, Pieter G. Raijmakers, Otto S. Hoekstra, Marchien W. Van Baal, Hans A.m. Brölmann, René H.m. VerheijenAbstract:Abstract Objective. The aim of this study was to systematically review the diagnostic performance of Sentinel Node (SN) detection for assessing the nodal status in early stage cervical Carcinoma, and to determine which technique (using blue dye, Technetium-99m colloid ( 99m Tc), or the combined method) had the highest success rate in terms of detection rate and sensitivity. Methods. A comprehensive computer literature search of English language studies in human subjects on Sentinel Node procedures was performed in MEDLINE and EMBASE databases up to July 2006. For each article two reviewers independently performed a methodological qualitative analysis and data extraction using a standard form. Pooled values of the SN detection rate and pooled sensitivity values of the SN procedure are presented with a 95% confidence interval (95% CI) for the three different SN detection techniques. Results. We identified 98 articles, and 23 met the inclusion criteria, comprising a total of 842 patients. Ultimately, 12 studies used the combined technique with a sensitivity of 92% (95% CI: 84–98%). Five studies used 99m Tc-colloid, with a pooled sensitivity of 92% (95% CI: 79–98%; p =0.71 vs. combined technique), and four used blue dye with a pooled sensitivity of 81% (67–92%, p =0.17 vs. combined technique). The SN detection rate was highest for the combined technique: 97% (95% CI: 95–98%), vs. 84% for blue dye (95% CI: 79–89%; p p =0.0018) for 99m Tc colloid. Conclusion. SN biopsy has the highest SN detection rate when 99m Tc is used in combination with blue dye (97%), and a sensitivity of 92%. Hence, according to the present evidence in literature the combination of 99m Tc and a blue dye for SN biopsy in patients with early stage cervical cancer is a reliable method to detect lymph node metastases in early stage cervical cancer.
Michael T Deavers - One of the best experts on this subject based on the ideXlab platform.
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ultrastaging improves detection of metastases in sentinel lymph nodes of Uterine Cervix squamous cell Carcinoma
The American Journal of Surgical Pathology, 2008Co-Authors: Elizabeth D Euscher, Anais Malpica, Edward N Atkinson, Charles F Levenback, Michael Frumovitz, Michael T DeaversAbstract:The technique of sentinel lymph node (SLN) detection is increasingly being applied in patients with Uterine Cervix Carcinoma. This study presents the pathologic findings of SLNs in 48 such patients. The institutional pathology files were searched for all patients with a diagnosis of cervical squamous cell Carcinoma who had SLNs reported. Patient age, follow-up, tumor size, presence/absence of lymphatic invasion, number and status of SLNs and non-SLNs, location of SLNs, and size of metastases in SLNs were recorded. All SLNs were sectioned in 2-mm slices perpendicular to the long axis and submitted entirely for microscopic examination. For all SLNs negative on the initial hematoxylin and eosin (HE level 3 for 1 patient); in 1 patient, the metastasis was detected only by immunohistochemistry and consisted of a single cell. Of the 15 patients with positive SLNs, 3 patients had a total of 6 positive non-SLNs. All of the patients with a positive SLN are currently living. Thirty-three (69%) patients had negative SLNs. Of these, 1 patient had a single positive non-SLN for a false negative rate of 6.25%. Negative SLN predicts negative non-SLN. For most patients with a positive SLN, the SLN will be the only metastasis detected; a minority of patients with a positive SLN may have a positive non-SLN.
Jonas Van De Lande - One of the best experts on this subject based on the ideXlab platform.
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Sentinel lymph node detection in early stage Uterine Cervix Carcinoma: a systematic review.
Gynecologic oncology, 2007Co-Authors: Jonas Van De Lande, Bas Torrenga, Pieter G. Raijmakers, Otto S. Hoekstra, Marchien W. Van Baal, Hans A.m. Brölmann, René H.m. VerheijenAbstract:Abstract Objective. The aim of this study was to systematically review the diagnostic performance of Sentinel Node (SN) detection for assessing the nodal status in early stage cervical Carcinoma, and to determine which technique (using blue dye, Technetium-99m colloid ( 99m Tc), or the combined method) had the highest success rate in terms of detection rate and sensitivity. Methods. A comprehensive computer literature search of English language studies in human subjects on Sentinel Node procedures was performed in MEDLINE and EMBASE databases up to July 2006. For each article two reviewers independently performed a methodological qualitative analysis and data extraction using a standard form. Pooled values of the SN detection rate and pooled sensitivity values of the SN procedure are presented with a 95% confidence interval (95% CI) for the three different SN detection techniques. Results. We identified 98 articles, and 23 met the inclusion criteria, comprising a total of 842 patients. Ultimately, 12 studies used the combined technique with a sensitivity of 92% (95% CI: 84–98%). Five studies used 99m Tc-colloid, with a pooled sensitivity of 92% (95% CI: 79–98%; p =0.71 vs. combined technique), and four used blue dye with a pooled sensitivity of 81% (67–92%, p =0.17 vs. combined technique). The SN detection rate was highest for the combined technique: 97% (95% CI: 95–98%), vs. 84% for blue dye (95% CI: 79–89%; p p =0.0018) for 99m Tc colloid. Conclusion. SN biopsy has the highest SN detection rate when 99m Tc is used in combination with blue dye (97%), and a sensitivity of 92%. Hence, according to the present evidence in literature the combination of 99m Tc and a blue dye for SN biopsy in patients with early stage cervical cancer is a reliable method to detect lymph node metastases in early stage cervical cancer.
Elizabeth D Euscher - One of the best experts on this subject based on the ideXlab platform.
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ultrastaging improves detection of metastases in sentinel lymph nodes of Uterine Cervix squamous cell Carcinoma
The American Journal of Surgical Pathology, 2008Co-Authors: Elizabeth D Euscher, Anais Malpica, Edward N Atkinson, Charles F Levenback, Michael Frumovitz, Michael T DeaversAbstract:The technique of sentinel lymph node (SLN) detection is increasingly being applied in patients with Uterine Cervix Carcinoma. This study presents the pathologic findings of SLNs in 48 such patients. The institutional pathology files were searched for all patients with a diagnosis of cervical squamous cell Carcinoma who had SLNs reported. Patient age, follow-up, tumor size, presence/absence of lymphatic invasion, number and status of SLNs and non-SLNs, location of SLNs, and size of metastases in SLNs were recorded. All SLNs were sectioned in 2-mm slices perpendicular to the long axis and submitted entirely for microscopic examination. For all SLNs negative on the initial hematoxylin and eosin (HE level 3 for 1 patient); in 1 patient, the metastasis was detected only by immunohistochemistry and consisted of a single cell. Of the 15 patients with positive SLNs, 3 patients had a total of 6 positive non-SLNs. All of the patients with a positive SLN are currently living. Thirty-three (69%) patients had negative SLNs. Of these, 1 patient had a single positive non-SLN for a false negative rate of 6.25%. Negative SLN predicts negative non-SLN. For most patients with a positive SLN, the SLN will be the only metastasis detected; a minority of patients with a positive SLN may have a positive non-SLN.
Bas Torrenga - One of the best experts on this subject based on the ideXlab platform.
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Sentinel lymph node detection in early stage Uterine Cervix Carcinoma: a systematic review.
Gynecologic oncology, 2007Co-Authors: Jonas Van De Lande, Bas Torrenga, Pieter G. Raijmakers, Otto S. Hoekstra, Marchien W. Van Baal, Hans A.m. Brölmann, René H.m. VerheijenAbstract:Abstract Objective. The aim of this study was to systematically review the diagnostic performance of Sentinel Node (SN) detection for assessing the nodal status in early stage cervical Carcinoma, and to determine which technique (using blue dye, Technetium-99m colloid ( 99m Tc), or the combined method) had the highest success rate in terms of detection rate and sensitivity. Methods. A comprehensive computer literature search of English language studies in human subjects on Sentinel Node procedures was performed in MEDLINE and EMBASE databases up to July 2006. For each article two reviewers independently performed a methodological qualitative analysis and data extraction using a standard form. Pooled values of the SN detection rate and pooled sensitivity values of the SN procedure are presented with a 95% confidence interval (95% CI) for the three different SN detection techniques. Results. We identified 98 articles, and 23 met the inclusion criteria, comprising a total of 842 patients. Ultimately, 12 studies used the combined technique with a sensitivity of 92% (95% CI: 84–98%). Five studies used 99m Tc-colloid, with a pooled sensitivity of 92% (95% CI: 79–98%; p =0.71 vs. combined technique), and four used blue dye with a pooled sensitivity of 81% (67–92%, p =0.17 vs. combined technique). The SN detection rate was highest for the combined technique: 97% (95% CI: 95–98%), vs. 84% for blue dye (95% CI: 79–89%; p p =0.0018) for 99m Tc colloid. Conclusion. SN biopsy has the highest SN detection rate when 99m Tc is used in combination with blue dye (97%), and a sensitivity of 92%. Hence, according to the present evidence in literature the combination of 99m Tc and a blue dye for SN biopsy in patients with early stage cervical cancer is a reliable method to detect lymph node metastases in early stage cervical cancer.
