The Experts below are selected from a list of 327 Experts worldwide ranked by ideXlab platform
Niels Klarskov - One of the best experts on this subject based on the ideXlab platform.
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the manchester procedure versus vaginal hysterectomy in the treatment of Uterine Prolapse a review
International Urogynecology Journal, 2017Co-Authors: Caecilie Krogsgaard Tolstrup, Gunnar Lose, Niels KlarskovAbstract:Introduction and hypothesis Uterine Prolapse is a common health problem and the number of surgical procedures is increasing. No consensus regarding the surgical strategy for repair of Uterine Prolapse exists. Vaginal hysterectomy (VH) is the preferred surgical procedure worldwide, but uterus-preserving alternatives including the Manchester procedure (MP) are available. The objective was to evaluate if VH and the MP are equally efficient treatments for Uterine Prolapse with regard to anatomical and symptomatic outcome, quality of life score, functional outcome, re-operation and conservative re-intervention rate, complications and operative outcomes.
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The Manchester procedure versus vaginal hysterectomy in the treatment of Uterine Prolapse: a review
International Urogynecology Journal, 2017Co-Authors: Caecilie Krogsgaard Tolstrup, Gunnar Lose, Niels KlarskovAbstract:Introduction and hypothesis Uterine Prolapse is a common health problem and the number of surgical procedures is increasing. No consensus regarding the surgical strategy for repair of Uterine Prolapse exists. Vaginal hysterectomy (VH) is the preferred surgical procedure worldwide, but uterus-preserving alternatives including the Manchester procedure (MP) are available. The objective was to evaluate if VH and the MP are equally efficient treatments for Uterine Prolapse with regard to anatomical and symptomatic outcome, quality of life score, functional outcome, re-operation and conservative re-intervention rate, complications and operative outcomes. Methods We systematically searched Embase, PubMed, the Cochrane databases, Clinicaltrials and Clinical trials register using the MeSh terms “Uterine Prolapse”, “uterus Prolapse”, “vaginal Prolapse” “pelvic organ Prolapse”, “Prolapsed uterus”, “Manchester procedure” and “vaginal hysterectomy”. No limitations regarding language, study design or methodology were applied. In total, nine studies published from 1966 to 2014 comparing the MP to VH were included. Results The anatomical recurrence rate for the middle compartment was 4–7 % after VH, whereas recurrence was very rare after the MP. The re-operation rate because of symptomatic recurrence was higher after VH (9–13.1 %) compared with MP (3.3–9.5 %) and more patients needed conservative re-intervention (14–15 %) than after MP (10–11 %). After VH, postoperative bleeding and blood loss tended to be greater, bladder lesions and infections more frequent and the operating time longer. Conclusions This review is in favour of the MP, which seems to be an efficient and safe treatment for Uterine Prolapse. We suggest that the MP might be considered a durable alternative to VH in Uterine Prolapse repair.
Carlos A Medina - One of the best experts on this subject based on the ideXlab platform.
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differential expression of smooth muscle regulatory proteins in the uterosacral ligaments of women with Uterine Prolapse
American Journal of Obstetrics and Gynecology, 2010Co-Authors: Peter Takacs, Marc Gualtieri, Mehdi Nassiri, Keith A Candiotti, Alessia Fornoni, Carlos A MedinaAbstract:Objective To compare smooth muscle regulatory protein expression in the uterosacral ligament (USL) of women with and without Uterine Prolapse. Study Design USLs ligament were sampled in women with (n = 9) or without (n = 9) Uterine Prolapse. Caldesmon, smooth muscle actin (SMA), myosin heavy chain, and zinc finger protein messenger RNA expression was assessed by quantitative real-time polymerase chain reaction. Immunohistochemistry and digital image analysis were used to determine protein expression. Results Caldesmon messenger RNA expression and the ratio of caldesmon-SMA messenger RNA expression was significantly increased in the USL from women with Uterine Prolapse compared with women without Prolapse (caldesmon mean ± standard deviation messenger RNA, 0.81 ± 0.46 vs 0.39 ± 0.16; P = .01 and caldesmon-SMA messenger RNA ratio, mean ± standard deviation, 0.11 ± 0.04 vs 0.07 ± 0.02; P = .01). In addition, the ratio of caldesmon-SMA staining was significantly increased in women with Uterine Prolapse compared with women without Prolapse (mean ± standard deviation, 0.44 ± 0.28 vs 0.28 ± 0.16; P = .03). Conclusion Uterine Prolapse is associated with an increased ratio of caldesmon-SMA actin expression.
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uterosacral ligament smooth muscle cell apoptosis is increased in women with Uterine Prolapse
Reproductive Sciences, 2009Co-Authors: Peter Takacs, Marc Gualtieri, Mehdi Nassiri, Keith A Candiotti, Carlos A MedinaAbstract:Purpose: The purpose of this study was to compare the smooth muscle content and apoptosis of the uterosacral ligament in women with and without Uterine Prolapse. Study Design: Uterosacral ligaments were sampled in women with (n = 9) or without (n = 9) Uterine Prolapse undergoing hysterectomy. Smooth muscle of the uterosacral ligament was identified by immunohistochemistry. Digital image analysis was used to determine the fractional area of smooth muscle in the histologic cross sections. Apoptosis was assessed by terminal deoxynucelotidyl-transferase-mediated dUTP nick-end-labeling method. Results: The fractional area of nonvascular smooth muscle in the uterosacral ligament of women with Uterine Prolapse was significantly decreased compared to women without Prolapse (0.32 + 0.12 vs. 0.42 + 0.03, P = .02) and the apoptotic index was significantly higher compared to women without Prolapse (0.20 + 0.06 vs. 0.08 + 0.04, P < .01). Conclusion: The fraction of smooth muscle in the uterosacral ligaments is signifi...
Caecilie Krogsgaard Tolstrup - One of the best experts on this subject based on the ideXlab platform.
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the manchester procedure versus vaginal hysterectomy in the treatment of Uterine Prolapse a review
International Urogynecology Journal, 2017Co-Authors: Caecilie Krogsgaard Tolstrup, Gunnar Lose, Niels KlarskovAbstract:Introduction and hypothesis Uterine Prolapse is a common health problem and the number of surgical procedures is increasing. No consensus regarding the surgical strategy for repair of Uterine Prolapse exists. Vaginal hysterectomy (VH) is the preferred surgical procedure worldwide, but uterus-preserving alternatives including the Manchester procedure (MP) are available. The objective was to evaluate if VH and the MP are equally efficient treatments for Uterine Prolapse with regard to anatomical and symptomatic outcome, quality of life score, functional outcome, re-operation and conservative re-intervention rate, complications and operative outcomes.
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The Manchester procedure versus vaginal hysterectomy in the treatment of Uterine Prolapse: a review
International Urogynecology Journal, 2017Co-Authors: Caecilie Krogsgaard Tolstrup, Gunnar Lose, Niels KlarskovAbstract:Introduction and hypothesis Uterine Prolapse is a common health problem and the number of surgical procedures is increasing. No consensus regarding the surgical strategy for repair of Uterine Prolapse exists. Vaginal hysterectomy (VH) is the preferred surgical procedure worldwide, but uterus-preserving alternatives including the Manchester procedure (MP) are available. The objective was to evaluate if VH and the MP are equally efficient treatments for Uterine Prolapse with regard to anatomical and symptomatic outcome, quality of life score, functional outcome, re-operation and conservative re-intervention rate, complications and operative outcomes. Methods We systematically searched Embase, PubMed, the Cochrane databases, Clinicaltrials and Clinical trials register using the MeSh terms “Uterine Prolapse”, “uterus Prolapse”, “vaginal Prolapse” “pelvic organ Prolapse”, “Prolapsed uterus”, “Manchester procedure” and “vaginal hysterectomy”. No limitations regarding language, study design or methodology were applied. In total, nine studies published from 1966 to 2014 comparing the MP to VH were included. Results The anatomical recurrence rate for the middle compartment was 4–7 % after VH, whereas recurrence was very rare after the MP. The re-operation rate because of symptomatic recurrence was higher after VH (9–13.1 %) compared with MP (3.3–9.5 %) and more patients needed conservative re-intervention (14–15 %) than after MP (10–11 %). After VH, postoperative bleeding and blood loss tended to be greater, bladder lesions and infections more frequent and the operating time longer. Conclusions This review is in favour of the MP, which seems to be an efficient and safe treatment for Uterine Prolapse. We suggest that the MP might be considered a durable alternative to VH in Uterine Prolapse repair.
Gunnar Lose - One of the best experts on this subject based on the ideXlab platform.
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the manchester procedure versus vaginal hysterectomy in the treatment of Uterine Prolapse a review
International Urogynecology Journal, 2017Co-Authors: Caecilie Krogsgaard Tolstrup, Gunnar Lose, Niels KlarskovAbstract:Introduction and hypothesis Uterine Prolapse is a common health problem and the number of surgical procedures is increasing. No consensus regarding the surgical strategy for repair of Uterine Prolapse exists. Vaginal hysterectomy (VH) is the preferred surgical procedure worldwide, but uterus-preserving alternatives including the Manchester procedure (MP) are available. The objective was to evaluate if VH and the MP are equally efficient treatments for Uterine Prolapse with regard to anatomical and symptomatic outcome, quality of life score, functional outcome, re-operation and conservative re-intervention rate, complications and operative outcomes.
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The Manchester procedure versus vaginal hysterectomy in the treatment of Uterine Prolapse: a review
International Urogynecology Journal, 2017Co-Authors: Caecilie Krogsgaard Tolstrup, Gunnar Lose, Niels KlarskovAbstract:Introduction and hypothesis Uterine Prolapse is a common health problem and the number of surgical procedures is increasing. No consensus regarding the surgical strategy for repair of Uterine Prolapse exists. Vaginal hysterectomy (VH) is the preferred surgical procedure worldwide, but uterus-preserving alternatives including the Manchester procedure (MP) are available. The objective was to evaluate if VH and the MP are equally efficient treatments for Uterine Prolapse with regard to anatomical and symptomatic outcome, quality of life score, functional outcome, re-operation and conservative re-intervention rate, complications and operative outcomes. Methods We systematically searched Embase, PubMed, the Cochrane databases, Clinicaltrials and Clinical trials register using the MeSh terms “Uterine Prolapse”, “uterus Prolapse”, “vaginal Prolapse” “pelvic organ Prolapse”, “Prolapsed uterus”, “Manchester procedure” and “vaginal hysterectomy”. No limitations regarding language, study design or methodology were applied. In total, nine studies published from 1966 to 2014 comparing the MP to VH were included. Results The anatomical recurrence rate for the middle compartment was 4–7 % after VH, whereas recurrence was very rare after the MP. The re-operation rate because of symptomatic recurrence was higher after VH (9–13.1 %) compared with MP (3.3–9.5 %) and more patients needed conservative re-intervention (14–15 %) than after MP (10–11 %). After VH, postoperative bleeding and blood loss tended to be greater, bladder lesions and infections more frequent and the operating time longer. Conclusions This review is in favour of the MP, which seems to be an efficient and safe treatment for Uterine Prolapse. We suggest that the MP might be considered a durable alternative to VH in Uterine Prolapse repair.
Peter Takacs - One of the best experts on this subject based on the ideXlab platform.
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differential expression of smooth muscle regulatory proteins in the uterosacral ligaments of women with Uterine Prolapse
American Journal of Obstetrics and Gynecology, 2010Co-Authors: Peter Takacs, Marc Gualtieri, Mehdi Nassiri, Keith A Candiotti, Alessia Fornoni, Carlos A MedinaAbstract:Objective To compare smooth muscle regulatory protein expression in the uterosacral ligament (USL) of women with and without Uterine Prolapse. Study Design USLs ligament were sampled in women with (n = 9) or without (n = 9) Uterine Prolapse. Caldesmon, smooth muscle actin (SMA), myosin heavy chain, and zinc finger protein messenger RNA expression was assessed by quantitative real-time polymerase chain reaction. Immunohistochemistry and digital image analysis were used to determine protein expression. Results Caldesmon messenger RNA expression and the ratio of caldesmon-SMA messenger RNA expression was significantly increased in the USL from women with Uterine Prolapse compared with women without Prolapse (caldesmon mean ± standard deviation messenger RNA, 0.81 ± 0.46 vs 0.39 ± 0.16; P = .01 and caldesmon-SMA messenger RNA ratio, mean ± standard deviation, 0.11 ± 0.04 vs 0.07 ± 0.02; P = .01). In addition, the ratio of caldesmon-SMA staining was significantly increased in women with Uterine Prolapse compared with women without Prolapse (mean ± standard deviation, 0.44 ± 0.28 vs 0.28 ± 0.16; P = .03). Conclusion Uterine Prolapse is associated with an increased ratio of caldesmon-SMA actin expression.
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uterosacral ligament smooth muscle cell apoptosis is increased in women with Uterine Prolapse
Reproductive Sciences, 2009Co-Authors: Peter Takacs, Marc Gualtieri, Mehdi Nassiri, Keith A Candiotti, Carlos A MedinaAbstract:Purpose: The purpose of this study was to compare the smooth muscle content and apoptosis of the uterosacral ligament in women with and without Uterine Prolapse. Study Design: Uterosacral ligaments were sampled in women with (n = 9) or without (n = 9) Uterine Prolapse undergoing hysterectomy. Smooth muscle of the uterosacral ligament was identified by immunohistochemistry. Digital image analysis was used to determine the fractional area of smooth muscle in the histologic cross sections. Apoptosis was assessed by terminal deoxynucelotidyl-transferase-mediated dUTP nick-end-labeling method. Results: The fractional area of nonvascular smooth muscle in the uterosacral ligament of women with Uterine Prolapse was significantly decreased compared to women without Prolapse (0.32 + 0.12 vs. 0.42 + 0.03, P = .02) and the apoptotic index was significantly higher compared to women without Prolapse (0.20 + 0.06 vs. 0.08 + 0.04, P < .01). Conclusion: The fraction of smooth muscle in the uterosacral ligaments is signifi...
