The Experts below are selected from a list of 30111 Experts worldwide ranked by ideXlab platform
Yingying Gao - One of the best experts on this subject based on the ideXlab platform.
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recombinant dna Vaccine against neurite outgrowth inhibitors attenuates behavioral deficits and decreases abeta in an alzheimer s disease mouse model
Neuropharmacology, 2013Co-Authors: Lingling Zhang, Wulin Yang, Zhigang Yao, Ying Liu, Liang Liang, Xiang Wang, Lan Huang, Hua Zhu, Wei Deng, Yingying GaoAbstract:Alzheimer's disease (AD) is a chronic neurodegenerative disease that causes a progressive loss in learning and memory capabilities and eventually results in dementia. The non-renewable nature of neurons in the central nervous system leads to the basic pathological changes that are related to the various behavioral and psychological symptoms of AD. Oligodendrocyte- and myelin-related neurite outgrowth inhibitors (NOIs) tend to hinder the regeneration of neurons. We designed a recombinant DNA Vaccine composed of multiple specific inhibitory domains of NOIs. Vaccination induced effective antibodies against the specific domains in the sera of mice treated with a DNA primed-vaccinia virus boost regimen. The Vaccine Attenuated neuronal degeneration in the mouse brain and protected the model mice from behavioral deficits. Vaccination also decreased the formation of soluble Aβ oligomer and amyloid plaques in the co-transgenic mice brain. What's more, astrocytosis in brains of APP/PS1 co-transgenic mice was also relieved. The results suggested that immunotherapy with multiple specific domains of myelin- and oligodendrocyte-related NOIs may be a promising approach for Alzheimer's disease and other degenerative central nervous system diseases.
Lingling Zhang - One of the best experts on this subject based on the ideXlab platform.
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recombinant dna Vaccine against neurite outgrowth inhibitors attenuates behavioral deficits and decreases abeta in an alzheimer s disease mouse model
Neuropharmacology, 2013Co-Authors: Lingling Zhang, Wulin Yang, Zhigang Yao, Ying Liu, Liang Liang, Xiang Wang, Lan Huang, Hua Zhu, Wei Deng, Yingying GaoAbstract:Alzheimer's disease (AD) is a chronic neurodegenerative disease that causes a progressive loss in learning and memory capabilities and eventually results in dementia. The non-renewable nature of neurons in the central nervous system leads to the basic pathological changes that are related to the various behavioral and psychological symptoms of AD. Oligodendrocyte- and myelin-related neurite outgrowth inhibitors (NOIs) tend to hinder the regeneration of neurons. We designed a recombinant DNA Vaccine composed of multiple specific inhibitory domains of NOIs. Vaccination induced effective antibodies against the specific domains in the sera of mice treated with a DNA primed-vaccinia virus boost regimen. The Vaccine Attenuated neuronal degeneration in the mouse brain and protected the model mice from behavioral deficits. Vaccination also decreased the formation of soluble Aβ oligomer and amyloid plaques in the co-transgenic mice brain. What's more, astrocytosis in brains of APP/PS1 co-transgenic mice was also relieved. The results suggested that immunotherapy with multiple specific domains of myelin- and oligodendrocyte-related NOIs may be a promising approach for Alzheimer's disease and other degenerative central nervous system diseases.
Xiang Wang - One of the best experts on this subject based on the ideXlab platform.
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recombinant dna Vaccine against neurite outgrowth inhibitors attenuates behavioral deficits and decreases abeta in an alzheimer s disease mouse model
Neuropharmacology, 2013Co-Authors: Lingling Zhang, Wulin Yang, Zhigang Yao, Ying Liu, Liang Liang, Xiang Wang, Lan Huang, Hua Zhu, Wei Deng, Yingying GaoAbstract:Alzheimer's disease (AD) is a chronic neurodegenerative disease that causes a progressive loss in learning and memory capabilities and eventually results in dementia. The non-renewable nature of neurons in the central nervous system leads to the basic pathological changes that are related to the various behavioral and psychological symptoms of AD. Oligodendrocyte- and myelin-related neurite outgrowth inhibitors (NOIs) tend to hinder the regeneration of neurons. We designed a recombinant DNA Vaccine composed of multiple specific inhibitory domains of NOIs. Vaccination induced effective antibodies against the specific domains in the sera of mice treated with a DNA primed-vaccinia virus boost regimen. The Vaccine Attenuated neuronal degeneration in the mouse brain and protected the model mice from behavioral deficits. Vaccination also decreased the formation of soluble Aβ oligomer and amyloid plaques in the co-transgenic mice brain. What's more, astrocytosis in brains of APP/PS1 co-transgenic mice was also relieved. The results suggested that immunotherapy with multiple specific domains of myelin- and oligodendrocyte-related NOIs may be a promising approach for Alzheimer's disease and other degenerative central nervous system diseases.
Hua Zhu - One of the best experts on this subject based on the ideXlab platform.
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recombinant dna Vaccine against neurite outgrowth inhibitors attenuates behavioral deficits and decreases abeta in an alzheimer s disease mouse model
Neuropharmacology, 2013Co-Authors: Lingling Zhang, Wulin Yang, Zhigang Yao, Ying Liu, Liang Liang, Xiang Wang, Lan Huang, Hua Zhu, Wei Deng, Yingying GaoAbstract:Alzheimer's disease (AD) is a chronic neurodegenerative disease that causes a progressive loss in learning and memory capabilities and eventually results in dementia. The non-renewable nature of neurons in the central nervous system leads to the basic pathological changes that are related to the various behavioral and psychological symptoms of AD. Oligodendrocyte- and myelin-related neurite outgrowth inhibitors (NOIs) tend to hinder the regeneration of neurons. We designed a recombinant DNA Vaccine composed of multiple specific inhibitory domains of NOIs. Vaccination induced effective antibodies against the specific domains in the sera of mice treated with a DNA primed-vaccinia virus boost regimen. The Vaccine Attenuated neuronal degeneration in the mouse brain and protected the model mice from behavioral deficits. Vaccination also decreased the formation of soluble Aβ oligomer and amyloid plaques in the co-transgenic mice brain. What's more, astrocytosis in brains of APP/PS1 co-transgenic mice was also relieved. The results suggested that immunotherapy with multiple specific domains of myelin- and oligodendrocyte-related NOIs may be a promising approach for Alzheimer's disease and other degenerative central nervous system diseases.
Lan Huang - One of the best experts on this subject based on the ideXlab platform.
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recombinant dna Vaccine against neurite outgrowth inhibitors attenuates behavioral deficits and decreases abeta in an alzheimer s disease mouse model
Neuropharmacology, 2013Co-Authors: Lingling Zhang, Wulin Yang, Zhigang Yao, Ying Liu, Liang Liang, Xiang Wang, Lan Huang, Hua Zhu, Wei Deng, Yingying GaoAbstract:Alzheimer's disease (AD) is a chronic neurodegenerative disease that causes a progressive loss in learning and memory capabilities and eventually results in dementia. The non-renewable nature of neurons in the central nervous system leads to the basic pathological changes that are related to the various behavioral and psychological symptoms of AD. Oligodendrocyte- and myelin-related neurite outgrowth inhibitors (NOIs) tend to hinder the regeneration of neurons. We designed a recombinant DNA Vaccine composed of multiple specific inhibitory domains of NOIs. Vaccination induced effective antibodies against the specific domains in the sera of mice treated with a DNA primed-vaccinia virus boost regimen. The Vaccine Attenuated neuronal degeneration in the mouse brain and protected the model mice from behavioral deficits. Vaccination also decreased the formation of soluble Aβ oligomer and amyloid plaques in the co-transgenic mice brain. What's more, astrocytosis in brains of APP/PS1 co-transgenic mice was also relieved. The results suggested that immunotherapy with multiple specific domains of myelin- and oligodendrocyte-related NOIs may be a promising approach for Alzheimer's disease and other degenerative central nervous system diseases.
