The Experts below are selected from a list of 9135 Experts worldwide ranked by ideXlab platform
Senthil Kannan - One of the best experts on this subject based on the ideXlab platform.
-
circulating cxcr5 pd 1 response predicts influenza Vaccine antibody responses in young adults but not elderly adults
Journal of Immunology, 2014Co-Authors: Ramin S Herati, Morgan A Reuter, Douglas V Dolfi, Kathleen D Mansfield, Raj K Kurupati, Htin Aung, Osama Z Badwan, Senthil KannanAbstract:Although influenza vaccination is recommended for all adults annually, the incidence of Vaccine Failure, defined as weak or absent increase in neutralizing Ab titers, is increased in the elderly compared with young adults. The T follicular helper cell (Tfh) subset of CD4 T cells provides B cell help in germinal centers and is necessary for class-switched Ab responses. Previous studies suggested a role for circulating Tfh cells (cTfh) following influenza vaccination in adults, but cTfh have not been studied in elderly adults in whom weak Vaccine responses are often observed. In this study, we studied cTfh expressing CXCR5 and programmed death-1 (PD-1). cTfh from elderly adults were present at reduced frequency, had decreased in vitro B cell help ability, and had greater expression of ICOS compared with young adults. At 7 d after inactivated influenza vaccination, cTfh correlated with influenza Vaccine–specific IgM and IgG responses in young adults but not in elderly adults. In sum, we have identified aging-related changes in cTfh that correlated with reduced influenza Vaccine responses. Future rational Vaccine design efforts should incorporate Tfh measurement as an immune correlate of protection, particularly in the setting of aging.
-
circulating cxcr5 pd 1 response predicts influenza Vaccine antibody responses in young adults but not older adults vac2p 936
Journal of Immunology, 2014Co-Authors: David H Canaday, Ramin S Herati, Morgan A Reuter, Douglas V Dolfi, Kathleen D Mansfield, Raj K Kurupati, Hildegund C J Ertl, Kenneth E Schmader, Senthil Kannan, Michael R BettsAbstract:Although influenza vaccination is recommend for all adults annually, the incidence of Vaccine Failure, defined as weak or absent increase in neutralizing antibody titers, is increased in the elderly compared to young adults. The T follicular helper subset of CD4+ T cells provide B cell help in germinal centers and are necessary for class-switched antibody responses. Previous studies suggested a role for circulating T follicular helper cells (cTfh) following influenza vaccination in adults, but cTfh have not been studied in elderly adults where weak Vaccine responses are often observed. Here, we studied cTfh expressing CXCR5 and Programmed Death 1 (PD-1). cTfh from elderly adults were present at reduced frequency, had decreased in vitro B cell help ability, and greater expression of activation marker inducible costimulator (ICOS) compared to young adults. At seven days after inactivated influenza vaccination, cTfh correlated with influenza Vaccine-specific IgM and IgG responses in young adults but not in elderly adults. In sum, we have identified aging-related changes in cTfh which manifested as reduced influenza Vaccine responses. Future rational Vaccine design efforts should incorporate Tfh measurement as an immune correlate of protection, particularly in the setting of aging.
Douglas V Dolfi - One of the best experts on this subject based on the ideXlab platform.
-
circulating cxcr5 pd 1 response predicts influenza Vaccine antibody responses in young adults but not elderly adults
Journal of Immunology, 2014Co-Authors: Ramin S Herati, Morgan A Reuter, Douglas V Dolfi, Kathleen D Mansfield, Raj K Kurupati, Htin Aung, Osama Z Badwan, Senthil KannanAbstract:Although influenza vaccination is recommended for all adults annually, the incidence of Vaccine Failure, defined as weak or absent increase in neutralizing Ab titers, is increased in the elderly compared with young adults. The T follicular helper cell (Tfh) subset of CD4 T cells provides B cell help in germinal centers and is necessary for class-switched Ab responses. Previous studies suggested a role for circulating Tfh cells (cTfh) following influenza vaccination in adults, but cTfh have not been studied in elderly adults in whom weak Vaccine responses are often observed. In this study, we studied cTfh expressing CXCR5 and programmed death-1 (PD-1). cTfh from elderly adults were present at reduced frequency, had decreased in vitro B cell help ability, and had greater expression of ICOS compared with young adults. At 7 d after inactivated influenza vaccination, cTfh correlated with influenza Vaccine–specific IgM and IgG responses in young adults but not in elderly adults. In sum, we have identified aging-related changes in cTfh that correlated with reduced influenza Vaccine responses. Future rational Vaccine design efforts should incorporate Tfh measurement as an immune correlate of protection, particularly in the setting of aging.
-
circulating cxcr5 pd 1 response predicts influenza Vaccine antibody responses in young adults but not older adults vac2p 936
Journal of Immunology, 2014Co-Authors: David H Canaday, Ramin S Herati, Morgan A Reuter, Douglas V Dolfi, Kathleen D Mansfield, Raj K Kurupati, Hildegund C J Ertl, Kenneth E Schmader, Senthil Kannan, Michael R BettsAbstract:Although influenza vaccination is recommend for all adults annually, the incidence of Vaccine Failure, defined as weak or absent increase in neutralizing antibody titers, is increased in the elderly compared to young adults. The T follicular helper subset of CD4+ T cells provide B cell help in germinal centers and are necessary for class-switched antibody responses. Previous studies suggested a role for circulating T follicular helper cells (cTfh) following influenza vaccination in adults, but cTfh have not been studied in elderly adults where weak Vaccine responses are often observed. Here, we studied cTfh expressing CXCR5 and Programmed Death 1 (PD-1). cTfh from elderly adults were present at reduced frequency, had decreased in vitro B cell help ability, and greater expression of activation marker inducible costimulator (ICOS) compared to young adults. At seven days after inactivated influenza vaccination, cTfh correlated with influenza Vaccine-specific IgM and IgG responses in young adults but not in elderly adults. In sum, we have identified aging-related changes in cTfh which manifested as reduced influenza Vaccine responses. Future rational Vaccine design efforts should incorporate Tfh measurement as an immune correlate of protection, particularly in the setting of aging.
Kathleen D Mansfield - One of the best experts on this subject based on the ideXlab platform.
-
circulating cxcr5 pd 1 response predicts influenza Vaccine antibody responses in young adults but not elderly adults
Journal of Immunology, 2014Co-Authors: Ramin S Herati, Morgan A Reuter, Douglas V Dolfi, Kathleen D Mansfield, Raj K Kurupati, Htin Aung, Osama Z Badwan, Senthil KannanAbstract:Although influenza vaccination is recommended for all adults annually, the incidence of Vaccine Failure, defined as weak or absent increase in neutralizing Ab titers, is increased in the elderly compared with young adults. The T follicular helper cell (Tfh) subset of CD4 T cells provides B cell help in germinal centers and is necessary for class-switched Ab responses. Previous studies suggested a role for circulating Tfh cells (cTfh) following influenza vaccination in adults, but cTfh have not been studied in elderly adults in whom weak Vaccine responses are often observed. In this study, we studied cTfh expressing CXCR5 and programmed death-1 (PD-1). cTfh from elderly adults were present at reduced frequency, had decreased in vitro B cell help ability, and had greater expression of ICOS compared with young adults. At 7 d after inactivated influenza vaccination, cTfh correlated with influenza Vaccine–specific IgM and IgG responses in young adults but not in elderly adults. In sum, we have identified aging-related changes in cTfh that correlated with reduced influenza Vaccine responses. Future rational Vaccine design efforts should incorporate Tfh measurement as an immune correlate of protection, particularly in the setting of aging.
-
circulating cxcr5 pd 1 response predicts influenza Vaccine antibody responses in young adults but not older adults vac2p 936
Journal of Immunology, 2014Co-Authors: David H Canaday, Ramin S Herati, Morgan A Reuter, Douglas V Dolfi, Kathleen D Mansfield, Raj K Kurupati, Hildegund C J Ertl, Kenneth E Schmader, Senthil Kannan, Michael R BettsAbstract:Although influenza vaccination is recommend for all adults annually, the incidence of Vaccine Failure, defined as weak or absent increase in neutralizing antibody titers, is increased in the elderly compared to young adults. The T follicular helper subset of CD4+ T cells provide B cell help in germinal centers and are necessary for class-switched antibody responses. Previous studies suggested a role for circulating T follicular helper cells (cTfh) following influenza vaccination in adults, but cTfh have not been studied in elderly adults where weak Vaccine responses are often observed. Here, we studied cTfh expressing CXCR5 and Programmed Death 1 (PD-1). cTfh from elderly adults were present at reduced frequency, had decreased in vitro B cell help ability, and greater expression of activation marker inducible costimulator (ICOS) compared to young adults. At seven days after inactivated influenza vaccination, cTfh correlated with influenza Vaccine-specific IgM and IgG responses in young adults but not in elderly adults. In sum, we have identified aging-related changes in cTfh which manifested as reduced influenza Vaccine responses. Future rational Vaccine design efforts should incorporate Tfh measurement as an immune correlate of protection, particularly in the setting of aging.
Mary P. E. Slack - One of the best experts on this subject based on the ideXlab platform.
-
association between single nucleotide polymorphisms in mal tirap and interleukin 10 genes and susceptibility to invasive haemophilus influenzae serotype b infection in immunized children
Clinical Infectious Diseases, 2010Co-Authors: Andrew J. Pollard, Mary P. E. Slack, Shamez N Ladhani, Paul T Heath, Mary Ramsay, Robert Booy, Sonia Davila, Martin L HibberdAbstract:Background. The development of invasive Haemophilus influenzae serotype b (Hib) disease after prior immunization with the Hib conjugate Vaccine (ie, Hib Vaccine Failure) is extremely rare, suggesting that affected children may have an underlying genetic susceptibility in their immune response. The objective of this study was to investigate single-nucleotide polymorphisms (SNPs) known to affect function in biologically plausible genes in relation to the risk of Hib Vaccine Failure and its clinical manifestations. Methods. The families of UK children with Hib Vaccine Failure diagnosed during the period October 1992 through December 2005 were identified through enhanced national surveillance and approached for the study at a median interval of 4 years after invasive disease. The Wellcome Trust Case Control Consortium data sets were used as controls. Nineteen functional SNPs in 14 immune response genes were investigated in 172 white children. Results. The recessive homozygous genotype for a SNP in the TIRAP (also known as MAL) gene (rs1893352) that is in strong linkage disequilibrium (r(2) = 0.93) with the known functional Ser180Leu polymorphism in white persons was strongly associated with nonmeningitis cases of Hib Vaccine Failure (odds ratio, 5.6; 95% confidence interval, 2.7-11.5; P = 1.2 x 10(-7)). In addition, the recessive homozygous genotype for another SNP (rs1554286) in strong linkage disequilibrium with both the C-819T (r(2) = 0.87) and C-592A (r(2)=0.75) promoter polymorphisms in the interleukin-10 gene was associated with epiglottitis only (odds ratio, 5.8; 95% confidence interval, 2.4-14.2; P = 1.1 x 10(-5)). Conclusions. Our findings strongly suggest that the development of invasive Hib disease after prior immunization is in part genetically determined and may direct the immune response to specific clinical manifestations.
-
haemophilus influenzae serotype b conjugate Vaccine Failure in twelve countries with established national childhood immunization programmes
Clinical Microbiology and Infection, 2010Co-Authors: Shamez N Ladhani, Mary P. E. Slack, Paul T Heath, Peter Mcintyre, Javier Diezdomingo, Jose Campos, Ron Dagan, Mary RamsayAbstract:Abstract The present study describes the clinical and immunological features of children with Hib Vaccine Failure, who were identified through national surveillance between 1996 and 2001 in Europe, Israel and Australia. True Vaccine Failure was defined as invasive Hib disease occurring ≥2 weeks after one dose, given after the first birthday, or ≥1 week after ≥2 doses, given at
-
long term immunological follow up of children with haemophilus influenzae serotype b Vaccine Failure in the united kingdom
Clinical Infectious Diseases, 2009Co-Authors: Andrew J. Pollard, Mary P. E. Slack, Shamez N Ladhani, Paul T Heath, Mary Ramsay, Elizabeth Kibwana, Robert BooyAbstract:BACKGROUND It is not known how long children with Haemophilus influenzae serotype b (Hib) Vaccine Failure retain protective Hib antibody concentrations after infection. The objective of this study was to determine Hib antibody concentrations in children several years after infection and to identify risk factors for low antibody concentrations. METHODS The families of children from the United Kingdom who developed invasive Hib disease after prior immunization with Hib conjugate Vaccine (i.e., Hib Vaccine Failure) from October 1992 through December 2005 were asked to complete a questionnaire. A blood sample was also obtained from each child. RESULTS Of 323 families approached, 260 (80.5%) returned a completed questionnaire, and 175 (54.2%) children provided a blood sample. The median age at follow-up was 8.4 years (interquartile range [IQR], 6.2-15.4 years), and the median duration of follow-up was 4.1 years (IQR, 3.5-9.7 years). Twenty-seven children (16.1%) had been born prematurely and/or had an underlying medical condition, and 18 (10.8%) had immunoglobulin deficiency. The median Hib antibody concentration was 0.70 microg/mL (IQR, 0.22-5.8 microg/mL). Overall, 95 children (56.9%) had antibody concentrations <1.0 microg/mL, and 27 (16.2%) had antibody concentrations <0.15 microg/mL. All 3 children with Down syndrome and 10 (42%) of 24 children aged <5 years at follow-up had Hib antibody concentrations <0.15 microg/mL. An antibody concentration <0.15 microg/mL was independently associated with underlying conditions, young age at onset of Hib disease, and shorter time from Hib disease to follow-up. CONCLUSIONS More than one-half of the children with Hib Vaccine Failure had antibody concentrations below those considered to confer long-term protection, which suggests that these children might be at further risk of invasive Hib disease and would benefit from another dose of Hib Vaccine.
-
presence of multiple copies of the capsulation b locus in invasive haemophilus influenzae type b hib strains isolated from children with hib conjugate Vaccine Failure
The Journal of Infectious Diseases, 2005Co-Authors: Marina Cerquetti, Rita Cardines, Marta Luisa Ciofi Degli Atti, Maria Giufre, Antonino Bella, Tonino Sofia, Paola Mastrantonio, Mary P. E. SlackAbstract:Most invasive Haemophilus influenzae type b strains possess a duplication of the capsulation locus. Further amplification resulting in as many as 5 copies has been described. To verify whether amplification is involved in Vaccine Failure, the number of copies of the locus was determined by Southern blotting in 90 strains from children with true Vaccine Failure (TVF) between 1993 and 1999 and in 139 strains from unvaccinated children (50 collected between 1993 and 1999 and 89 collected between 1991 and 1992, before routine immunization was introduced). A significantly greater proportion of strains from TVFs contained multiple copies, compared with strains from control children (24% vs. 10%; P = .0379), which suggests that amplification of the capb locus may be a contributory factor in Vaccine Failure. The presence of multiple-copy strains was associated with disease other than meningitis.
-
risk of Vaccine Failure after haemophilus influenzae type b hib combination Vaccines with acellular pertussis
The Lancet, 2003Co-Authors: Jodie Mcvernon, Mary P. E. Slack, N Andrews, Mary RamsayAbstract:Summary An increase in invasive Hib disease incidence in the UK has coincided with the distribution of combination Vaccines that contain acellular pertussis (DTaP-Hib). These Vaccines have been associated with reduced immunogenicity of the Hib component, although there is little agreement on the clinical relevance of this finding. We retrospectively compared Vaccine formulations given to fully vaccinated Hib cases with those administered to fully immunised age-matched controls using conditional logistic regression. More cases than controls received all three doses of their infant primary course as DTaP-Hib, compared with two or three doses of another Hib Vaccine (conditional odds ratio 6·77 [95% CI 3·26–14·07])
Ramin S Herati - One of the best experts on this subject based on the ideXlab platform.
-
circulating cxcr5 pd 1 response predicts influenza Vaccine antibody responses in young adults but not elderly adults
Journal of Immunology, 2014Co-Authors: Ramin S Herati, Morgan A Reuter, Douglas V Dolfi, Kathleen D Mansfield, Raj K Kurupati, Htin Aung, Osama Z Badwan, Senthil KannanAbstract:Although influenza vaccination is recommended for all adults annually, the incidence of Vaccine Failure, defined as weak or absent increase in neutralizing Ab titers, is increased in the elderly compared with young adults. The T follicular helper cell (Tfh) subset of CD4 T cells provides B cell help in germinal centers and is necessary for class-switched Ab responses. Previous studies suggested a role for circulating Tfh cells (cTfh) following influenza vaccination in adults, but cTfh have not been studied in elderly adults in whom weak Vaccine responses are often observed. In this study, we studied cTfh expressing CXCR5 and programmed death-1 (PD-1). cTfh from elderly adults were present at reduced frequency, had decreased in vitro B cell help ability, and had greater expression of ICOS compared with young adults. At 7 d after inactivated influenza vaccination, cTfh correlated with influenza Vaccine–specific IgM and IgG responses in young adults but not in elderly adults. In sum, we have identified aging-related changes in cTfh that correlated with reduced influenza Vaccine responses. Future rational Vaccine design efforts should incorporate Tfh measurement as an immune correlate of protection, particularly in the setting of aging.
-
circulating cxcr5 pd 1 response predicts influenza Vaccine antibody responses in young adults but not older adults vac2p 936
Journal of Immunology, 2014Co-Authors: David H Canaday, Ramin S Herati, Morgan A Reuter, Douglas V Dolfi, Kathleen D Mansfield, Raj K Kurupati, Hildegund C J Ertl, Kenneth E Schmader, Senthil Kannan, Michael R BettsAbstract:Although influenza vaccination is recommend for all adults annually, the incidence of Vaccine Failure, defined as weak or absent increase in neutralizing antibody titers, is increased in the elderly compared to young adults. The T follicular helper subset of CD4+ T cells provide B cell help in germinal centers and are necessary for class-switched antibody responses. Previous studies suggested a role for circulating T follicular helper cells (cTfh) following influenza vaccination in adults, but cTfh have not been studied in elderly adults where weak Vaccine responses are often observed. Here, we studied cTfh expressing CXCR5 and Programmed Death 1 (PD-1). cTfh from elderly adults were present at reduced frequency, had decreased in vitro B cell help ability, and greater expression of activation marker inducible costimulator (ICOS) compared to young adults. At seven days after inactivated influenza vaccination, cTfh correlated with influenza Vaccine-specific IgM and IgG responses in young adults but not in elderly adults. In sum, we have identified aging-related changes in cTfh which manifested as reduced influenza Vaccine responses. Future rational Vaccine design efforts should incorporate Tfh measurement as an immune correlate of protection, particularly in the setting of aging.
