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Murray R Gray - One of the best experts on this subject based on the ideXlab platform.
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new Vanadium Compounds in venezuela heavy crude oil detected by positive ion electrospray ionization fourier transform ion cyclotron resonance mass spectrometry
Scientific Reports, 2015Co-Authors: Xu Zhao, Quan Shi, Murray R GrayAbstract:Metalloporphyrins are ubiquitous in nature, particularly iron porphyrins (hemes) and magnesium dihydroporphyrins or chlorophylls. OxoVanadium (IV) complexes of alkyl porphyrins are widely distributed in petroleum, oil shales and maturing sedimentary bitumen. Here we identify new Vanadium Compounds in Venezuela Orinoco heavy crude oil detected by Fourier transform-ion cyclotron resonance mass spectrometry (FT-ICR MS). These Compounds likely have the main structure of porphyrin, with the addition of more aromatic rings, thiophene and amino functional groups, corresponding to molecular series of C(n)H(2n-40)N(4)V(1)O(1) (36 ≤ n ≤ 58),C(n)H(2n-42)N(4)V(1)O(1) (37 ≤ n ≤ 57),C(n)H(2n-44)N(4)V(1)O(1) (38 ≤ n ≤ 59),C(n)H(2n-46)N(4)V(1)O(1) (43 ≤ n ≤ 54),C(n)H(2n-48)N(4)V(1)O(1) (45 ≤ n ≤ 55),C(n)H(2n-38)N(4)V(1)S(1)O(1) (36 ≤ n ≤ 41),C(n)H(2n-40)N(4)V(1)S(1)O(1) (35 ≤ n ≤ 51),C(n)H(2n-42)N(4)V(1)S(1)O(1) (36 ≤ n ≤ 54),C(n)H(2n-44)N(4)V(1)S(1)O(1) (41 ≤ n ≤ 55),C(n)H(2n-46)N(4)V(1)S(1)O(1) (39 ≤ n ≤ 55),C(n)H(2n-27)N(5)V(1)O(1) (29 ≤ n ≤ 40),C(n)H(2n-29)N(5)V(1)O(1) (34 ≤ n ≤ 42),C(n)H(2n-33)N(5)V(1)O(1) (31 ≤ n ≤ 38),C(n)H(2n-35)N(5)V(1)O(1) (32 ≤ n ≤ 41),C(n)H(2n-27)N(5)V(1)O(2) (32 ≤ n ≤ 41) and C(n)H(2n-29)N(5)V(1)O(2) (33 ≤ n ≤ 42). These findings are significant for the understanding of the existing form of Vanadium species in nature, and are helpful for enhancing the amount of information on palaeoenvironments and improving the level of applied basic theory for the processing technologies of heavy oils.
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new Vanadium Compounds in venezuela heavy crude oil detected by positive ion electrospray ionization
2014Co-Authors: Xu Zhao, Quan Shi, Murray R GrayAbstract:Metalloporphyrins are ubiquitous in nature, particularly iron porphyrins (hemes) and magnesium dihydroporphyrins or chlorophylls. OxoVanadium (IV) complexes of alkyl porphyrins are widely distributed in petroleum, oil shales and maturing sedimentary bitumen. Here we identify new Vanadium Compounds in Venezuela Orinoco heavy crude oil detected by Fourier transform-ion cyclotron resonance mass spectrometry (FT-ICR MS). These Compounds likely have the main structure of porphyrin, with the addition of more aromatic rings, thiophene and amino functional groups, corresponding to molecular series of CnH2n-40N4V1O1 (36 # n # 58),CnH2n-42N4V1O1 (37 # n # 57),CnH2n-44N4V1O1 (38 # n # 59),CnH2n-46N4V1O1 (43 # n # 54),CnH2n-48N4V1O1 (45 # n # 55),CnH2n-38N4V1S1O1 (36 # n # 41),CnH2n-40N4V1S1O1 (35 # n # 51),CnH2n-42N4V1S1O1 (36 # n # 54),CnH2n-44N4V1S1O1 (41 # n # 55),CnH2n-46N4V1S1O1 (39 # n # 55),CnH2n-27N5V1O1 (29 # n # 40),CnH2n-29N5V1O1 (34 # n # 42),CnH2n-33N5V1O1 (31 # n # 38),CnH2n-35N5V1O1 (32 # n # 41),CnH2n-27N5V1O2 (32 # n # 41) and CnH2n-29N5V1O2 (33 # n # 42). These findings are significant for the understanding of the existing form of Vanadium species in nature, and are helpful for enhancing the amount of information on palaeoenvironments and improving the level of applied basic theory for the processing technologies of heavy oils.
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chemistry and association of Vanadium Compounds in heavy oil and bitumen and implications for their selective removal
Energy & Fuels, 2010Co-Authors: Greg P Dechaine, Murray R GrayAbstract:Most crude oils contain traces of Vanadium, which cause significant detrimental impact during catalytic conversion and combustion. The concentrations in bitumen and vacuum residue are generally much higher, which poses a problem for the economical upgrading of these feedstocks. These problems are relevant since the world reserves of conventional light oils are dwindling and being replaced by an increasing amount of heavier feedstocks. In this article, the current understanding of the distribution and form of Vanadium Compounds within vacuum residue is critically discussed. The implications of this chemistry on prospects for new separation methods, other than deasphalting, are considered. Although only a small fraction of the Vanadium is contained within the polar resin fraction (i.e., maltenes), this fraction has been most often characterized to determine the chemical form of the Vanadium Compounds. Various spectroscopic techniques have been used to determine that these resin soluble Vanadium Compounds ex...
Debbie C Crans - One of the best experts on this subject based on the ideXlab platform.
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antidiabetic chemical and physical properties of organic vanadates as presumed transition state inhibitors for phosphatases
ChemInform, 2016Co-Authors: Debbie C CransAbstract:Studies of antidiabetic Vanadium Compounds, specifically the organic vanadate esters, are reviewed with regard to their chemistry and biological properties. The Compounds are described from the perspective of how the fundamental chemistry and properties of organic vanadate esters impact their effects as inhibitors for phosphatases based on the structural information obtained from Vanadium-phosphatase complexes. Vanadium Compounds have been reported to have antidiabetic properties for more than a century. The structures and properties of organic vanadate complexes are reviewed, and the potency of such Vanadium coordination complexes as antidiabetic agents is described. Because such Compounds form spontaneously in aqueous environments, the reactions with most components in any assay or cellular environment has potential to be important and should be considered. Generally, the active form of Vanadium remains elusive, although studies have been reported of a number of promising Vanadium Compounds. The description of the antidiabetic properties of Vanadium Compounds is described here in the context of recent characterization of vanadate-phosphatase protein structures by data mining. Organic vanadate ester Compounds are generally four coordinate or five coordinate with the former being substrate analogues and the latter being transition-state analogue inhibitors. These studies demonstrated a framework for characterization of five-coordinate trigonal bipyramidal Vanadium inhibitors by comparison with the reported Vanadium-protein phosphatase complexes. The binding of the Vanadium to the phosphatases is either as a five-coordinate exploded transition-state analogue or as a high energy intermediate, respectively. Even if potency as an inhibitor requires trigonal bipyramidal geometry of the Vanadium when bound to the protein, such geometry can be achieved upon binding from Compounds with other geometries. Desirable properties of ligands are identified and analyzed. Ligand interactions, as reported in one peptidic substrate, are favorable so that complementarity between phosphatase and coordinating ligand to the Vanadium can be established resulting in a dramatic enhancement of the inhibitory potency. These considerations point to a frameshift in ligand design for Vanadium complexes as phosphatase inhibitors and are consistent with other small molecule having much lower affinities. Combined, these studies do suggest that if effective delivery of potentially active antidiabetic compound such a the organic vanadate peptidic substrate was possible the toxicity problems currently reported for the salts and some of the complexes may be alleviated and dramatic enhancement of antidiabetic Vanadium Compounds may result.
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effects of Vanadium iii iv v chlorodipicolinate on glycolysis and antioxidant status in the liver of stz induced diabetic rats
Journal of Inorganic Biochemistry, 2014Co-Authors: Mingxia Xie, Deliang Chen, Fang Zhang, Gail R Willsky, Debbie C Crans, Wenjun DingAbstract:Abstract Vanadium Compounds exert various insulin-mimetic and anti-diabetic effects both in vitro and in vivo . Vanadium(III, IV, V)-chlorodipicolinate (Vdipic-Cl) Compounds, including H[V III (dipic-Cl) 2 ] · 5H 2 O (V 3 dipic-Cl), V IV O(dipic-Cl)(H 2 O) 2 (V 4 dipic-Cl) and K[V V O 2 (dipic-Cl)] (V 5 dipic-Cl), were synthesized with the indicated oxidation states. The present study was conducted to investigate if chemical valence and anti-oxidation effects of Vanadium Compounds are involved in the anti-diabetic effects observed in streptozotocin (STZ)-induced diabetic rats treated with these Vanadium Compounds. V 3 dipic-Cl, V 4 dipic-Cl, V 5 dipic-Cl, inorganic Vanadium salts vanadyl sulfate (VOSO 4 ) or sodium metavanadate (NaVO 3 ) were orally administered in drinking water (50 μgV/ml) to STZ-induced diabetic rats for 28 days. The results showed that Vdipic-Cl treatment significantly improved hyperglycemia and glucose intolerance, as well as increased hepatic glycogen synthesis in diabetic rats. The mRNA levels of key glycolytic enzymes in liver, phosphoenolpyruvate carboxykinase (PEPCK), glucokinase (GK), and L-pyruvate kinase (L-PK) altered in diabetic animals were significantly restored towards normal values by treatment with some of the Vanadium Compounds. Moreover, the diabetes elevated activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) in serum were significantly decreased after treatment with Vdipic-Cl complexes. Furthermore, treatment of diabetic rats with V 4 dipic-Cl and V 5 dipic-Cl Compounds significantly reduced malondialdehyde (MDA) production and increased glutathione peroxidase (GSH-Px) and catalase (CAT) activities. These data suggest that Vanadium Compounds with the indicated chemical valence promote glycogen synthesis and recover suppressed glycolysis in the liver of diabetic rats due to their capacity to reduce oxidative stress by stimulating antioxidant enzymes.
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structural and redox requirements for the action of anti diabetic Vanadium Compounds
Dalton Transactions, 2014Co-Authors: Yutaka Yoshikawa, Debbie C Crans, Giovanni Micera, Hiromu Sakurai, Eugenio GarribbaAbstract:This study presents the first systematic investigation of the anti-diabetic properties of non-oxido V(IV) complexes. In particular, the insulin-mimetic activity of [V(IV)(taci)2](4+), [V(IV)(inoH-3)2](2-), [V(IV)(dhab)2], [V(IV)(hyph(Ph))2], [V(IV)(cat)3](2-) and [V(IV)(pdbh)2]--where taci is 1,3,5-triamino-1,3,5-trideoxy-cis-inositol, ino is cis-inositol, H2dhab is 2,2'-dihydroxyazobenzene, H2hyph(Ph) is 3,5-bis(2-hydroxyphenyl)-1H-1,2,4-triazole, H2cat is catechol and H2pdbh is pentan-2,4-dione benzoylhydrazone--was evaluated in terms of free fatty acid (FFA) release. Among the six Compounds examined, only [V(IV)(pdbh)2], [V(IV)(cat)3](2-) and [V(IV)(hyph(Ph))2], which at the physiological pH convert to the corresponding V(IV)O complexes, were found to exhibit a significant insulin-mimetic activity compared to VOSO4. In contrast, [V(taci)2](4+), [V(inoH-3)2](2-) and [V(dhab)2], which at pH 7.4 keep their 'bare' non-oxido structure, did not cause any inhibition of FFA. The results, therefore, suggest that a V(IV)O functionality is necessary for Vanadium complexes to exhibit anti-diabetic effects. This agrees with the notion that the biotransformations of V Compounds in the organism are more important than the nature of the species.
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effects of decavanadate and insulin enhancing Vanadium Compounds on glucose uptake in isolated rat adipocytes
Journal of Inorganic Biochemistry, 2009Co-Authors: Maria J Pereira, Debbie C Crans, Eugenia Carvalho, Jan W Eriksson, Manuel AurelianoAbstract:The effects of different Vanadium Compounds namely pyridine-2,6-dicarboxylatedioxoVanadium(V) (V5-dipic), bis(maltolato) oxoVanadium(IV) (BMOV) and amavadine, and oligovanadates namely metavanadate and decavanadate were analysed on basal and insulin stimulated glucose uptake in rat adipocytes. Decavanadate (50 microM), manifest a higher increases (6-fold) on glucose uptake compared with basal, followed by BMOV (1 mM) and metavanadate (1 mM) solutions (3-fold) whereas V5 dipic and amavadine had no effect. Decavanadate (100 microM) also shows the highest insulin like activity when compared with the others Compounds studied. In the presence of insulin (10 nM), only decavanadate increases (50%) the glucose uptake when compared with insulin stimulated glucose uptake whereas BMOV and metavanadate, had no effect and V5 dipic and amavadine prevent the stimulation to about half of the basal value. Decavanadate is also able to reduce or eradicate the suppressor effect caused by dexamethasone on glucose uptake at the level of the adipocytes. Altogether, Vanadium Compounds and oligovanadates with several structures and coordination spheres reveal different effects on glucose uptake in rat primary adipocytes.
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diabetes altered gene expression in rat skeletal muscle corrected by oral administration of vanadyl sulfate
Physiological Genomics, 2006Co-Authors: Gail R Willsky, Laihar Chi, Yulan Liang, Daniel P Gaile, Debbie C CransAbstract:Treatment with Vanadium, a representative of a class of antidiabetic Compounds, alleviates diabetic hyperglycemia and hyperlipidemia. Oral administration of Vanadium Compounds in animal models and ...
Xu Zhao - One of the best experts on this subject based on the ideXlab platform.
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new Vanadium Compounds in venezuela heavy crude oil detected by positive ion electrospray ionization fourier transform ion cyclotron resonance mass spectrometry
Scientific Reports, 2015Co-Authors: Xu Zhao, Quan Shi, Murray R GrayAbstract:Metalloporphyrins are ubiquitous in nature, particularly iron porphyrins (hemes) and magnesium dihydroporphyrins or chlorophylls. OxoVanadium (IV) complexes of alkyl porphyrins are widely distributed in petroleum, oil shales and maturing sedimentary bitumen. Here we identify new Vanadium Compounds in Venezuela Orinoco heavy crude oil detected by Fourier transform-ion cyclotron resonance mass spectrometry (FT-ICR MS). These Compounds likely have the main structure of porphyrin, with the addition of more aromatic rings, thiophene and amino functional groups, corresponding to molecular series of C(n)H(2n-40)N(4)V(1)O(1) (36 ≤ n ≤ 58),C(n)H(2n-42)N(4)V(1)O(1) (37 ≤ n ≤ 57),C(n)H(2n-44)N(4)V(1)O(1) (38 ≤ n ≤ 59),C(n)H(2n-46)N(4)V(1)O(1) (43 ≤ n ≤ 54),C(n)H(2n-48)N(4)V(1)O(1) (45 ≤ n ≤ 55),C(n)H(2n-38)N(4)V(1)S(1)O(1) (36 ≤ n ≤ 41),C(n)H(2n-40)N(4)V(1)S(1)O(1) (35 ≤ n ≤ 51),C(n)H(2n-42)N(4)V(1)S(1)O(1) (36 ≤ n ≤ 54),C(n)H(2n-44)N(4)V(1)S(1)O(1) (41 ≤ n ≤ 55),C(n)H(2n-46)N(4)V(1)S(1)O(1) (39 ≤ n ≤ 55),C(n)H(2n-27)N(5)V(1)O(1) (29 ≤ n ≤ 40),C(n)H(2n-29)N(5)V(1)O(1) (34 ≤ n ≤ 42),C(n)H(2n-33)N(5)V(1)O(1) (31 ≤ n ≤ 38),C(n)H(2n-35)N(5)V(1)O(1) (32 ≤ n ≤ 41),C(n)H(2n-27)N(5)V(1)O(2) (32 ≤ n ≤ 41) and C(n)H(2n-29)N(5)V(1)O(2) (33 ≤ n ≤ 42). These findings are significant for the understanding of the existing form of Vanadium species in nature, and are helpful for enhancing the amount of information on palaeoenvironments and improving the level of applied basic theory for the processing technologies of heavy oils.
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distribution of Vanadium Compounds in petroleum vacuum residuum and their transformations in hydrodemetallization
Energy & Fuels, 2015Co-Authors: Tingting Liu, Xu Zhao, Yasong Zhou, Qiang Wei, Yahe Zhang, Sijia Ding, Tao Zhang, Xiujuan Tao, Quan ShiAbstract:The distribution of Vanadium (V) Compounds in the petroleum vacuum residuum (VR) and their transformations in hydrodemetallization (HDM) were investigated. V Compounds in the VR and its hydrotreated products were extracted by different solvents in sequence to obtain methanol, dimethylformamide (DMF), and toluene extract fractions. The extracts were further separated into several subfractions using silica gel chromatography with various polar solvents. Positive-ion electrospray ionization (ESI) Fourier transform-ion cyclotron resonance mass spectrometry (FT-ICR MS) analyses was used to characterize V Compounds before and after HDM. The contents of V Compounds in the methanol, DMF, and toluene extracts were 9.04, 22.19, and 62.58%, respectively. The V Compounds in the methanol extract were mainly porphyrin with a molecular formula of CnHmN4V1O1, which were found undergoing side-chain cracking and could be removed through hydrotreating. CnHmN5V1O2 species were found in the DMF extracts, which can be easily c...
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new Vanadium Compounds in venezuela heavy crude oil detected by positive ion electrospray ionization
2014Co-Authors: Xu Zhao, Quan Shi, Murray R GrayAbstract:Metalloporphyrins are ubiquitous in nature, particularly iron porphyrins (hemes) and magnesium dihydroporphyrins or chlorophylls. OxoVanadium (IV) complexes of alkyl porphyrins are widely distributed in petroleum, oil shales and maturing sedimentary bitumen. Here we identify new Vanadium Compounds in Venezuela Orinoco heavy crude oil detected by Fourier transform-ion cyclotron resonance mass spectrometry (FT-ICR MS). These Compounds likely have the main structure of porphyrin, with the addition of more aromatic rings, thiophene and amino functional groups, corresponding to molecular series of CnH2n-40N4V1O1 (36 # n # 58),CnH2n-42N4V1O1 (37 # n # 57),CnH2n-44N4V1O1 (38 # n # 59),CnH2n-46N4V1O1 (43 # n # 54),CnH2n-48N4V1O1 (45 # n # 55),CnH2n-38N4V1S1O1 (36 # n # 41),CnH2n-40N4V1S1O1 (35 # n # 51),CnH2n-42N4V1S1O1 (36 # n # 54),CnH2n-44N4V1S1O1 (41 # n # 55),CnH2n-46N4V1S1O1 (39 # n # 55),CnH2n-27N5V1O1 (29 # n # 40),CnH2n-29N5V1O1 (34 # n # 42),CnH2n-33N5V1O1 (31 # n # 38),CnH2n-35N5V1O1 (32 # n # 41),CnH2n-27N5V1O2 (32 # n # 41) and CnH2n-29N5V1O2 (33 # n # 42). These findings are significant for the understanding of the existing form of Vanadium species in nature, and are helpful for enhancing the amount of information on palaeoenvironments and improving the level of applied basic theory for the processing technologies of heavy oils.
Quan Shi - One of the best experts on this subject based on the ideXlab platform.
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new Vanadium Compounds in venezuela heavy crude oil detected by positive ion electrospray ionization fourier transform ion cyclotron resonance mass spectrometry
Scientific Reports, 2015Co-Authors: Xu Zhao, Quan Shi, Murray R GrayAbstract:Metalloporphyrins are ubiquitous in nature, particularly iron porphyrins (hemes) and magnesium dihydroporphyrins or chlorophylls. OxoVanadium (IV) complexes of alkyl porphyrins are widely distributed in petroleum, oil shales and maturing sedimentary bitumen. Here we identify new Vanadium Compounds in Venezuela Orinoco heavy crude oil detected by Fourier transform-ion cyclotron resonance mass spectrometry (FT-ICR MS). These Compounds likely have the main structure of porphyrin, with the addition of more aromatic rings, thiophene and amino functional groups, corresponding to molecular series of C(n)H(2n-40)N(4)V(1)O(1) (36 ≤ n ≤ 58),C(n)H(2n-42)N(4)V(1)O(1) (37 ≤ n ≤ 57),C(n)H(2n-44)N(4)V(1)O(1) (38 ≤ n ≤ 59),C(n)H(2n-46)N(4)V(1)O(1) (43 ≤ n ≤ 54),C(n)H(2n-48)N(4)V(1)O(1) (45 ≤ n ≤ 55),C(n)H(2n-38)N(4)V(1)S(1)O(1) (36 ≤ n ≤ 41),C(n)H(2n-40)N(4)V(1)S(1)O(1) (35 ≤ n ≤ 51),C(n)H(2n-42)N(4)V(1)S(1)O(1) (36 ≤ n ≤ 54),C(n)H(2n-44)N(4)V(1)S(1)O(1) (41 ≤ n ≤ 55),C(n)H(2n-46)N(4)V(1)S(1)O(1) (39 ≤ n ≤ 55),C(n)H(2n-27)N(5)V(1)O(1) (29 ≤ n ≤ 40),C(n)H(2n-29)N(5)V(1)O(1) (34 ≤ n ≤ 42),C(n)H(2n-33)N(5)V(1)O(1) (31 ≤ n ≤ 38),C(n)H(2n-35)N(5)V(1)O(1) (32 ≤ n ≤ 41),C(n)H(2n-27)N(5)V(1)O(2) (32 ≤ n ≤ 41) and C(n)H(2n-29)N(5)V(1)O(2) (33 ≤ n ≤ 42). These findings are significant for the understanding of the existing form of Vanadium species in nature, and are helpful for enhancing the amount of information on palaeoenvironments and improving the level of applied basic theory for the processing technologies of heavy oils.
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distribution of Vanadium Compounds in petroleum vacuum residuum and their transformations in hydrodemetallization
Energy & Fuels, 2015Co-Authors: Tingting Liu, Xu Zhao, Yasong Zhou, Qiang Wei, Yahe Zhang, Sijia Ding, Tao Zhang, Xiujuan Tao, Quan ShiAbstract:The distribution of Vanadium (V) Compounds in the petroleum vacuum residuum (VR) and their transformations in hydrodemetallization (HDM) were investigated. V Compounds in the VR and its hydrotreated products were extracted by different solvents in sequence to obtain methanol, dimethylformamide (DMF), and toluene extract fractions. The extracts were further separated into several subfractions using silica gel chromatography with various polar solvents. Positive-ion electrospray ionization (ESI) Fourier transform-ion cyclotron resonance mass spectrometry (FT-ICR MS) analyses was used to characterize V Compounds before and after HDM. The contents of V Compounds in the methanol, DMF, and toluene extracts were 9.04, 22.19, and 62.58%, respectively. The V Compounds in the methanol extract were mainly porphyrin with a molecular formula of CnHmN4V1O1, which were found undergoing side-chain cracking and could be removed through hydrotreating. CnHmN5V1O2 species were found in the DMF extracts, which can be easily c...
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new Vanadium Compounds in venezuela heavy crude oil detected by positive ion electrospray ionization
2014Co-Authors: Xu Zhao, Quan Shi, Murray R GrayAbstract:Metalloporphyrins are ubiquitous in nature, particularly iron porphyrins (hemes) and magnesium dihydroporphyrins or chlorophylls. OxoVanadium (IV) complexes of alkyl porphyrins are widely distributed in petroleum, oil shales and maturing sedimentary bitumen. Here we identify new Vanadium Compounds in Venezuela Orinoco heavy crude oil detected by Fourier transform-ion cyclotron resonance mass spectrometry (FT-ICR MS). These Compounds likely have the main structure of porphyrin, with the addition of more aromatic rings, thiophene and amino functional groups, corresponding to molecular series of CnH2n-40N4V1O1 (36 # n # 58),CnH2n-42N4V1O1 (37 # n # 57),CnH2n-44N4V1O1 (38 # n # 59),CnH2n-46N4V1O1 (43 # n # 54),CnH2n-48N4V1O1 (45 # n # 55),CnH2n-38N4V1S1O1 (36 # n # 41),CnH2n-40N4V1S1O1 (35 # n # 51),CnH2n-42N4V1S1O1 (36 # n # 54),CnH2n-44N4V1S1O1 (41 # n # 55),CnH2n-46N4V1S1O1 (39 # n # 55),CnH2n-27N5V1O1 (29 # n # 40),CnH2n-29N5V1O1 (34 # n # 42),CnH2n-33N5V1O1 (31 # n # 38),CnH2n-35N5V1O1 (32 # n # 41),CnH2n-27N5V1O2 (32 # n # 41) and CnH2n-29N5V1O2 (33 # n # 42). These findings are significant for the understanding of the existing form of Vanadium species in nature, and are helpful for enhancing the amount of information on palaeoenvironments and improving the level of applied basic theory for the processing technologies of heavy oils.
Spustová Kristína - One of the best experts on this subject based on the ideXlab platform.
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Hodnotenie biologického účinku vanadocén dithiokarbamátových komplexov na línií buniek akútnej lymfoblastickej leukémie
'Univerzita Pardubice', 2018Co-Authors: Spustová KristínaAbstract:Bakalárska práca obsahuje teoretickú časť v ktorej je zahrnutá teória o vanáde, zlúčeninách vanádu, vanadocenových komplexoch a mechanizmoch antitumorovej aktivity vanádu. V experimentálnej časti je uvedené testovanie cytotoxickej aktivity 10 vanadocen dithiokarbamátových komplexov na nádorovej línií buniek MOLT-4, pomocou stanovenia polovičnej inhibičnej koncentrácie (IC50). Najaktívnejšími testovanými komplexmi boli zlúčeniny s chelátovo viazaným piperidindithiokarbamátom (4, 9) u ktorých bola hodnota IC50 v rozmedzí 0,9 - 1,0 umol/l.The bachelor thesis contains a theoretical part in which is included the theory of Vanadium, Vanadium Compounds, vanadocene complexes and mechanisms of Vanadium antitumor activity. The theoretical part is followed by an experimental part, which describe the testing of the cytotoxic activity of vanadocene dithiocarbamate complexes on tumor cell line the MOLT-4 by determining the half inhibitory concentration (IC50) in selected 10 complexes. The most potent test complexes were chelate-bound piperidinedithiocarbamate (4. 9) whose IC50 was in the range of 0.9 - 1.0 umol /l.Fakulta chemicko-technologická1. Prezentace výsledků bakalářské práce. 2. Diskuze k posudku vedoucího bakalářské práce. 3. Studentka zodpověděla všechny dotazy a připomínky k BP
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Hodnotenie biologického účinku vanadocén dithiokarbamátových komplexov na línií buniek akútnej lymfoblastickej leukémie
'Univerzita Pardubice', 2018Co-Authors: Spustová KristínaAbstract:Bakalárska práca obsahuje teoretickú časť v ktorej je zahrnutá teória o vanáde, zlúčeninách vanádu, vanadocenových komplexoch a mechanizmoch antitumorovej aktivity vanádu. V experimentálnej časti je uvedené testovanie cytotoxickej aktivity 10 vanadocen dithiokarbamátových komplexov na nádorovej línií buniek MOLT-4, pomocou stanovenia polovičnej inhibičnej koncentrácie (IC50). Najaktívnejšími testovanými komplexmi boli zlúčeniny s chelátovo viazaným piperidindithiokarbamátom (4, 9) u ktorých bola hodnota IC50 v rozmedzí 0,9 - 1,0 umol/l.The bachelor thesis contains a theoretical part in which is included the theory of Vanadium, Vanadium Compounds, vanadocene complexes and mechanisms of Vanadium antitumor activity. The theoretical part is followed by an experimental part, which describe the testing of the cytotoxic activity of vanadocene dithiocarbamate complexes on tumor cell line the MOLT-4 by determining the half inhibitory concentration (IC50) in selected 10 complexes. The most potent test complexes were chelate-bound piperidinedithiocarbamate (4. 9) whose IC50 was in the range of 0.9 - 1.0 umol /l.Fakulta chemicko-technologická1. Prezentace výsledků bakalářské práce. 2. Diskuze k posudku vedoucího bakalářské práce. 3. Studentka zodpověděla všechny dotazy a připomínky k BP.Dokončená práce s úspěšnou obhajobo
