The Experts below are selected from a list of 174810 Experts worldwide ranked by ideXlab platform
Dominique Heymann - One of the best experts on this subject based on the ideXlab platform.
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rankl rank osteoprotegerin key partners of osteoimmunology and Vascular Diseases
Cellular and Molecular Life Sciences, 2007Co-Authors: Marc Baudhuin, Francois Lamoureux, Laurence Duplomb, Francoise Redini, Dominique HeymannAbstract:1997 saw the identification of a novel set of proteins within the tumor necrosis factor (TNF)/TNF receptor families that are required for the control of bone remodeling. Therefore, these receptors, receptor activator of nuclear factor kappa B (RANK), osteoprotegerin (OPG) and their ligand RANK ligand (RANKL) became the critical molecular triad controlling osteoclastogenesis and pathophysiologic bone remodeling. However, the establishment of the corresponding knock-out and transgenic mice revealed unexpected results, most particularly, the involvement of these factors in the Vascular system and immunity. Thus, the OPG/RANK/RANKL molecular triad appears to be associated with Vascular calcifications and plays a pivotal function in the development of the immune system through dendritic cells. OPG/RANK/RANKL thus constitute a molecular bridge spanning bone metabolism, Vascular biology and immunity. This review summarizes recent knowledge of OPG/RANK/RANKL interactions and activities as well as the current evidence for their participation in osteoimmunology and Vascular Diseases. In fine, the targeting of the OPG/RANK/RANKL axis as novel therapeutic approaches will be discussed.
Sanjeev Bhalla - One of the best experts on this subject based on the ideXlab platform.
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Cardiopulmonary Manifestations of Collagen Vascular Diseases
Current Rheumatology Reports, 2017Co-Authors: Hamza Jawad, Sebastian R. Mcwilliams, Sanjeev BhallaAbstract:Purpose of Review The study aimed to illustrate the cardiopulmonary findings of the following collagen Vascular Diseases on cross-sectional imaging: rheumatoid arthritis, scleroderma (progressive systemic sclerosis), systemic lupus erythematosus, the inflammatory myopathies (polymyositis/dermatomyositis), and Sjögren’s syndrome. Recent Findings Although collagen Vascular Diseases can affect any part of the body, interstitial lung disease and pulmonary hypertension are the two most important cardiopulmonary complications and are responsible for the majority of morbidity and mortality in this patient population. Interstitial pneumonia with autoimmune features (IPAF) is a newly described entity that encompasses interstitial lung disease in patients with clinical, serologic, or morphologic features suggestive of but not diagnostic of collagen Vascular disease; these patients are thought to have better outcomes than idiopathic interstitial pneumonias. Summary Interstitial lung disease and pulmonary hypertension determine the prognosis in collagen Vascular disease patients. IPAF is a new term to label patients with possible collagen Vascular disease-related interstitial lung disease. Collagen Vascular disease patients are at increased risk for various malignancies.
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Pulmonary Vascular Diseases.
Clinics in chest medicine, 2015Co-Authors: Kristopher W. Cummings, Sanjeev BhallaAbstract:Pulmonary Vascular Diseases encompass a large and diverse group of underlying pathologies ranging from venous thromboembolism to congenital malformations to inflammatory vasculitides. As a result, patients can present either acutely with dyspnea and chest pain or chronically with dyspnea on exertion, hypoxia, and right heart failure. Imaging, particularly with multidetector CT, plays a key role in the evaluation and management of patients with suspected pulmonary Vascular disease and, given the widespread routine use of high-quality CT pulmonary angiography, it is imperative that radiologists be familiar these pathologies.
Huaming Sheng - One of the best experts on this subject based on the ideXlab platform.
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synthesis biology and clinical significance of pentacyclic triterpenes a multi target approach to prevention and treatment of metabolic and Vascular Diseases
Natural Product Reports, 2011Co-Authors: Huaming Sheng, Hongbin SunAbstract:This review (with 335 references cited) is devoted to pentacyclic triterpenes. The total synthesis, semi-synthesis, structural modification, and metabolic behavior of naturally occurring pentacyclic triterpenes are described. We also cover the in vivo evidence, mechanistic studies, and clinical significance of pentacyclic triterpenes as multi-target therapeutic agents for the prevention and treatment of metabolic and Vascular Diseases.
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Synthesis, biology and clinical significance of pentacyclic triterpenes: a multi-target approach to prevention and treatment of metabolic and Vascular Diseases
Natural Product Reports, 2011Co-Authors: Huaming ShengAbstract:Covering: up to May 2010 This review (with 335 references cited) is devoted to pentacyclic triterpenes. The total synthesis, semi-synthesis, structural modification, and metabolic behavior of naturally occurring pentacyclic triterpenes are described. We also cover the in vivo evidence, mechanistic studies, and clinical significance of pentacyclic triterpenes as multi-target therapeutic agents for the prevention and treatment of metabolic and Vascular Diseases.
Marc Baudhuin - One of the best experts on this subject based on the ideXlab platform.
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rankl rank osteoprotegerin key partners of osteoimmunology and Vascular Diseases
Cellular and Molecular Life Sciences, 2007Co-Authors: Marc Baudhuin, Francois Lamoureux, Laurence Duplomb, Francoise Redini, Dominique HeymannAbstract:1997 saw the identification of a novel set of proteins within the tumor necrosis factor (TNF)/TNF receptor families that are required for the control of bone remodeling. Therefore, these receptors, receptor activator of nuclear factor kappa B (RANK), osteoprotegerin (OPG) and their ligand RANK ligand (RANKL) became the critical molecular triad controlling osteoclastogenesis and pathophysiologic bone remodeling. However, the establishment of the corresponding knock-out and transgenic mice revealed unexpected results, most particularly, the involvement of these factors in the Vascular system and immunity. Thus, the OPG/RANK/RANKL molecular triad appears to be associated with Vascular calcifications and plays a pivotal function in the development of the immune system through dendritic cells. OPG/RANK/RANKL thus constitute a molecular bridge spanning bone metabolism, Vascular biology and immunity. This review summarizes recent knowledge of OPG/RANK/RANKL interactions and activities as well as the current evidence for their participation in osteoimmunology and Vascular Diseases. In fine, the targeting of the OPG/RANK/RANKL axis as novel therapeutic approaches will be discussed.
Hongbin Sun - One of the best experts on this subject based on the ideXlab platform.
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synthesis biology and clinical significance of pentacyclic triterpenes a multi target approach to prevention and treatment of metabolic and Vascular Diseases
Natural Product Reports, 2011Co-Authors: Huaming Sheng, Hongbin SunAbstract:This review (with 335 references cited) is devoted to pentacyclic triterpenes. The total synthesis, semi-synthesis, structural modification, and metabolic behavior of naturally occurring pentacyclic triterpenes are described. We also cover the in vivo evidence, mechanistic studies, and clinical significance of pentacyclic triterpenes as multi-target therapeutic agents for the prevention and treatment of metabolic and Vascular Diseases.
