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Robert R Myers - One of the best experts on this subject based on the ideXlab platform.
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effect of acute nerve root compression on endoneurial fluid pressure and blood flow in rat dorsal root ganglia
Journal of Orthopaedic Research, 2005Co-Authors: Tamaki Igarashi, Shoji Yabuki, Shinichi Kikuchi, Robert R MyersAbstract:Abstract The objective of the current study was to test the hypothesis that crush injury to nerve root increases endoneurial fluid pressure (EFP) and decreases blood flow in the associated dorsal root ganglion (DRG). A total of 21 adult, female Sprague–Dawley rats had their left L5 nerve root and DRG exposed. The L5 nerve root was clamped for 2 s with a Vascular Suture clip just proximal to the DRG (compression group). Sham-operated animals without compression were used for control (control group). EFP was recorded with a servo-null micropipette system using a glass micropipette with tip diameter of 4 μm before and after 3 h of treatment. After the final measurement of EFP, DRG was excised and processed for histology. Blood flow in the DRG was continuously monitored by laser Doppler flow meter for 3 h. Three hours after treatment, EFP was 4.7 ± 2.7 cm H 2 O in the compression group and 2.2 ± 1.2 cm H 2 O in the control group ( P P
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effect of acute nerve root compression on endoneurial fluid pressure and blood flow in rat dorsal root ganglia
Journal of Orthopaedic Research, 2005Co-Authors: Tamaki Igarashi, Shoji Yabuki, Shinichi Kikuchi, Robert R MyersAbstract:The objective of the current study was to test the hypothesis that crush injury to nerve root increases endoneurial fluid pressure (EFP) and decreases blood flow in the associated dorsal root ganglion (DRG). A total of 21 adult, female Sprague-Dawley rats had their left L5 nerve root and DRG exposed. The L5 nerve root was clamped for 2 s with a Vascular Suture clip just proximal to the DRG (compression group). Sham-operated animals without compression were used for control (control group). EFP was recorded with a servo-null micropipette system using a glass micropipette with tip diameter of 4 mum before and after 3 h of treatment. After the final measurement of EFP, DRG was excised and processed for histology. Blood flow in the DRG was continuously monitored by laser Doppler flow meter for 3 h. Three hours after treatment, EFP was 4.7+/-2.7 cm H(2)O in the compression group and 2.2+/-1.2 cm H(2)O in the control group (P<0.05). Edema was the principal pathologic findings seen consistently in the DRG from animals in the compression group. Blood flow in the compression group was reduced 10 min after compression. This reduction was statistically significant compared with that of the control (P<0.01). An acute compression to the nerve root increased endoneurial edema, increased EFP in the associated DRG, and reduced DRG blood flow. This combination of increased EFP and decreased blood flow in the DRG may result in neuronal ischemia and sensory dysfunction. These acute pathophysiologic changes may thus have a role in the pathogenesis of low back pain and sciatica due to disc herniation and spinal canal stenosis.
Shoji Yabuki - One of the best experts on this subject based on the ideXlab platform.
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effect of acute nerve root compression on endoneurial fluid pressure and blood flow in rat dorsal root ganglia
Journal of Orthopaedic Research, 2005Co-Authors: Tamaki Igarashi, Shoji Yabuki, Shinichi Kikuchi, Robert R MyersAbstract:Abstract The objective of the current study was to test the hypothesis that crush injury to nerve root increases endoneurial fluid pressure (EFP) and decreases blood flow in the associated dorsal root ganglion (DRG). A total of 21 adult, female Sprague–Dawley rats had their left L5 nerve root and DRG exposed. The L5 nerve root was clamped for 2 s with a Vascular Suture clip just proximal to the DRG (compression group). Sham-operated animals without compression were used for control (control group). EFP was recorded with a servo-null micropipette system using a glass micropipette with tip diameter of 4 μm before and after 3 h of treatment. After the final measurement of EFP, DRG was excised and processed for histology. Blood flow in the DRG was continuously monitored by laser Doppler flow meter for 3 h. Three hours after treatment, EFP was 4.7 ± 2.7 cm H 2 O in the compression group and 2.2 ± 1.2 cm H 2 O in the control group ( P P
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effect of acute nerve root compression on endoneurial fluid pressure and blood flow in rat dorsal root ganglia
Journal of Orthopaedic Research, 2005Co-Authors: Tamaki Igarashi, Shoji Yabuki, Shinichi Kikuchi, Robert R MyersAbstract:The objective of the current study was to test the hypothesis that crush injury to nerve root increases endoneurial fluid pressure (EFP) and decreases blood flow in the associated dorsal root ganglion (DRG). A total of 21 adult, female Sprague-Dawley rats had their left L5 nerve root and DRG exposed. The L5 nerve root was clamped for 2 s with a Vascular Suture clip just proximal to the DRG (compression group). Sham-operated animals without compression were used for control (control group). EFP was recorded with a servo-null micropipette system using a glass micropipette with tip diameter of 4 mum before and after 3 h of treatment. After the final measurement of EFP, DRG was excised and processed for histology. Blood flow in the DRG was continuously monitored by laser Doppler flow meter for 3 h. Three hours after treatment, EFP was 4.7+/-2.7 cm H(2)O in the compression group and 2.2+/-1.2 cm H(2)O in the control group (P<0.05). Edema was the principal pathologic findings seen consistently in the DRG from animals in the compression group. Blood flow in the compression group was reduced 10 min after compression. This reduction was statistically significant compared with that of the control (P<0.01). An acute compression to the nerve root increased endoneurial edema, increased EFP in the associated DRG, and reduced DRG blood flow. This combination of increased EFP and decreased blood flow in the DRG may result in neuronal ischemia and sensory dysfunction. These acute pathophysiologic changes may thus have a role in the pathogenesis of low back pain and sciatica due to disc herniation and spinal canal stenosis.
Shinichi Kikuchi - One of the best experts on this subject based on the ideXlab platform.
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effect of acute nerve root compression on endoneurial fluid pressure and blood flow in rat dorsal root ganglia
Journal of Orthopaedic Research, 2005Co-Authors: Tamaki Igarashi, Shoji Yabuki, Shinichi Kikuchi, Robert R MyersAbstract:Abstract The objective of the current study was to test the hypothesis that crush injury to nerve root increases endoneurial fluid pressure (EFP) and decreases blood flow in the associated dorsal root ganglion (DRG). A total of 21 adult, female Sprague–Dawley rats had their left L5 nerve root and DRG exposed. The L5 nerve root was clamped for 2 s with a Vascular Suture clip just proximal to the DRG (compression group). Sham-operated animals without compression were used for control (control group). EFP was recorded with a servo-null micropipette system using a glass micropipette with tip diameter of 4 μm before and after 3 h of treatment. After the final measurement of EFP, DRG was excised and processed for histology. Blood flow in the DRG was continuously monitored by laser Doppler flow meter for 3 h. Three hours after treatment, EFP was 4.7 ± 2.7 cm H 2 O in the compression group and 2.2 ± 1.2 cm H 2 O in the control group ( P P
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effect of acute nerve root compression on endoneurial fluid pressure and blood flow in rat dorsal root ganglia
Journal of Orthopaedic Research, 2005Co-Authors: Tamaki Igarashi, Shoji Yabuki, Shinichi Kikuchi, Robert R MyersAbstract:The objective of the current study was to test the hypothesis that crush injury to nerve root increases endoneurial fluid pressure (EFP) and decreases blood flow in the associated dorsal root ganglion (DRG). A total of 21 adult, female Sprague-Dawley rats had their left L5 nerve root and DRG exposed. The L5 nerve root was clamped for 2 s with a Vascular Suture clip just proximal to the DRG (compression group). Sham-operated animals without compression were used for control (control group). EFP was recorded with a servo-null micropipette system using a glass micropipette with tip diameter of 4 mum before and after 3 h of treatment. After the final measurement of EFP, DRG was excised and processed for histology. Blood flow in the DRG was continuously monitored by laser Doppler flow meter for 3 h. Three hours after treatment, EFP was 4.7+/-2.7 cm H(2)O in the compression group and 2.2+/-1.2 cm H(2)O in the control group (P<0.05). Edema was the principal pathologic findings seen consistently in the DRG from animals in the compression group. Blood flow in the compression group was reduced 10 min after compression. This reduction was statistically significant compared with that of the control (P<0.01). An acute compression to the nerve root increased endoneurial edema, increased EFP in the associated DRG, and reduced DRG blood flow. This combination of increased EFP and decreased blood flow in the DRG may result in neuronal ischemia and sensory dysfunction. These acute pathophysiologic changes may thus have a role in the pathogenesis of low back pain and sciatica due to disc herniation and spinal canal stenosis.
Tamaki Igarashi - One of the best experts on this subject based on the ideXlab platform.
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effect of acute nerve root compression on endoneurial fluid pressure and blood flow in rat dorsal root ganglia
Journal of Orthopaedic Research, 2005Co-Authors: Tamaki Igarashi, Shoji Yabuki, Shinichi Kikuchi, Robert R MyersAbstract:Abstract The objective of the current study was to test the hypothesis that crush injury to nerve root increases endoneurial fluid pressure (EFP) and decreases blood flow in the associated dorsal root ganglion (DRG). A total of 21 adult, female Sprague–Dawley rats had their left L5 nerve root and DRG exposed. The L5 nerve root was clamped for 2 s with a Vascular Suture clip just proximal to the DRG (compression group). Sham-operated animals without compression were used for control (control group). EFP was recorded with a servo-null micropipette system using a glass micropipette with tip diameter of 4 μm before and after 3 h of treatment. After the final measurement of EFP, DRG was excised and processed for histology. Blood flow in the DRG was continuously monitored by laser Doppler flow meter for 3 h. Three hours after treatment, EFP was 4.7 ± 2.7 cm H 2 O in the compression group and 2.2 ± 1.2 cm H 2 O in the control group ( P P
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effect of acute nerve root compression on endoneurial fluid pressure and blood flow in rat dorsal root ganglia
Journal of Orthopaedic Research, 2005Co-Authors: Tamaki Igarashi, Shoji Yabuki, Shinichi Kikuchi, Robert R MyersAbstract:The objective of the current study was to test the hypothesis that crush injury to nerve root increases endoneurial fluid pressure (EFP) and decreases blood flow in the associated dorsal root ganglion (DRG). A total of 21 adult, female Sprague-Dawley rats had their left L5 nerve root and DRG exposed. The L5 nerve root was clamped for 2 s with a Vascular Suture clip just proximal to the DRG (compression group). Sham-operated animals without compression were used for control (control group). EFP was recorded with a servo-null micropipette system using a glass micropipette with tip diameter of 4 mum before and after 3 h of treatment. After the final measurement of EFP, DRG was excised and processed for histology. Blood flow in the DRG was continuously monitored by laser Doppler flow meter for 3 h. Three hours after treatment, EFP was 4.7+/-2.7 cm H(2)O in the compression group and 2.2+/-1.2 cm H(2)O in the control group (P<0.05). Edema was the principal pathologic findings seen consistently in the DRG from animals in the compression group. Blood flow in the compression group was reduced 10 min after compression. This reduction was statistically significant compared with that of the control (P<0.01). An acute compression to the nerve root increased endoneurial edema, increased EFP in the associated DRG, and reduced DRG blood flow. This combination of increased EFP and decreased blood flow in the DRG may result in neuronal ischemia and sensory dysfunction. These acute pathophysiologic changes may thus have a role in the pathogenesis of low back pain and sciatica due to disc herniation and spinal canal stenosis.
Ahmed Mousa - One of the best experts on this subject based on the ideXlab platform.
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Vascular Suture line wrapping for aortoiliac anastomoses following open surgical repair of infrarenal behcet s aortoiliac aneurysms
Orphanet Journal of Rare Diseases, 2019Co-Authors: Ahmed Mousa, Ibrahim Hanbal, Alaa Sharabi, Mohammed A. Nasr, Abdelfattah K. Nassar, Mai A. ElkallaAbstract:This study was conducted to evaluate our local experiences of adjunctive mechanical prosthetic wrapping for aortoiliac Vascular anastomoses as a prophylactic measure following surgical repair of Behcet’s aortoiliac aneurysms. The goal of prosthetic wrapping to reinforce the Vascular anastomoses by mechanical protection to reduce the bleeding complications, and consequently pseudoaneurysm formation. This was aided by the administration of pre- and postoperative immunosuppressive therapy as an adjuvant treatment. A seven-year retrospective study was conducted between January 2006 and December 2012, retrieving data of patients with Behcet’s aortoiliac aneurysms. All patients underwent open surgical repair using a heparin-bonded synthetic Dacron® graft. Data for all patients were retrieved and analyzed for diagnostic procedures, graft selection, as well as, different methods of surgical repair. Graft-related complications such as anastomotic pseudoaneurysms, occlusion, and thrombosis were also reported. Sixteen patients were recruited in this study. There were 11 (69%) males and 5 (31%) females with the male to female ratio 2:1. The patients’ age ranged between 25 and 47 years with the mean of 36.4 ± 7.3. All Behcet’s aortic/aortoiliac aneurysms were repaired by the application of heparin-bonded Dacron® tube and bifurcated grafts. The anastomotic wrapping technique was performed for both the proximal and the distal Vascular anastomoses. The technical success of aortoiliac aneurysm and wrapping techniques was achieved in 100% of patients. All patients were given pre- and postoperative systemic immunosuppressive therapy. No graft-related complications were reported except for only one anastomotic pseudoaneurysm that developed at one of the right iliac anastomoses, that developed within 24 months after follow up. Mechanical prosthetic wrapping for Vascular anastomoses in patients with Behcet’s aortic/aortoiliac aneurysms is a feasible, simple, and reliable technique with low morbidity and mortality. It was performed as a prophylactic measure to avoid the development of postoperative anastomotic pseudoaneurysms. It must be performed for all patients with Behcet’s arterial aneurysms whenever possible. Furthermore, the supplemental administration of pre- and postoperative systemic immunosuppressive therapy should be considered as an important factor for the prophylaxis and prevention of anastomotic pseudoaneurysms and other graft-related complications.
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Correction to: Vascular Suture line wrapping for aortoiliac anastomoses following open surgical repair of infrarenal Behçet’s aortoiliac aneurysms
BMC, 2019Co-Authors: Ahmed Mousa, Ibrahim Hanbal, Alaa Sharabi, Mohammed A. Nasr, Abdelfattah K. Nassar, Mai A. ElkallaAbstract:Following the publication of this article [1], the authors informed us of a typographical error in the spelling of “ePET-Dacron®” in the Background section. The sentence to be corrected is the following: “While anastomosing graft to host artery, Vascular Suture lines has been reinforced with expanded polyethylene terephthalate (ePTE - Dacron®), polytetrafluoroethylene (ePTFE), omentum, an autogenous vein, or mesh to wrap the Vascular anastomoses.
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Vascular Suture line wrapping for Aortoiliac anastomoses following open surgical repair of Infrarenal Behçet’s Aortoiliac aneurysms
BMC, 2019Co-Authors: Ahmed Mousa, Ibrahim Hanbal, Alaa Sharabi, Mohammed A. Nasr, Abdelfattah K. Nassar, Mai A. ElkallaAbstract:Abstract Background This study was conducted to evaluate our local experiences of adjunctive mechanical prosthetic wrapping for aortoiliac Vascular anastomoses as a prophylactic measure following surgical repair of Behçet’s aortoiliac aneurysms. The goal of prosthetic wrapping to reinforce the Vascular anastomoses by mechanical protection to reduce the bleeding complications, and consequently pseudoaneurysm formation. This was aided by the administration of pre- and postoperative immunosuppressive therapy as an adjuvant treatment. Methods A seven-year retrospective study was conducted between January 2006 and December 2012, retrieving data of patients with Behçet’s aortoiliac aneurysms. All patients underwent open surgical repair using a heparin-bonded synthetic Dacron® graft. Data for all patients were retrieved and analyzed for diagnostic procedures, graft selection, as well as, different methods of surgical repair. Graft-related complications such as anastomotic pseudoaneurysms, occlusion, and thrombosis were also reported. Results Sixteen patients were recruited in this study. There were 11 (69%) males and 5 (31%) females with the male to female ratio 2:1. The patients’ age ranged between 25 and 47 years with the mean of 36.4 ± 7.3. All Behçet’s aortic/aortoiliac aneurysms were repaired by the application of heparin-bonded Dacron® tube and bifurcated grafts. The anastomotic wrapping technique was performed for both the proximal and the distal Vascular anastomoses. The technical success of aortoiliac aneurysm and wrapping techniques was achieved in 100% of patients. All patients were given pre- and postoperative systemic immunosuppressive therapy. No graft-related complications were reported except for only one anastomotic pseudoaneurysm that developed at one of the right iliac anastomoses, that developed within 24 months after follow up. Conclusions Mechanical prosthetic wrapping for Vascular anastomoses in patients with Behçet’s aortic/aortoiliac aneurysms is a feasible, simple, and reliable technique with low morbidity and mortality. It was performed as a prophylactic measure to avoid the development of postoperative anastomotic pseudoaneurysms. It must be performed for all patients with Behçet’s arterial aneurysms whenever possible. Furthermore, the supplemental administration of pre- and postoperative systemic immunosuppressive therapy should be considered as an important factor for the prophylaxis and prevention of anastomotic pseudoaneurysms and other graft-related complications
