The Experts below are selected from a list of 306 Experts worldwide ranked by ideXlab platform
Ulrich Kneser - One of the best experts on this subject based on the ideXlab platform.
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axial Vascularization of a large volume calcium phosphate ceramic bone substitute in the sheep av loop model
Journal of Tissue Engineering and Regenerative Medicine, 2010Co-Authors: Justus P. Beier, Johanna Heinrich, Johanna S Loew, Elias Polykandriotis, Oliver Bleiziffer, Heinz Gulle, Andreas Arkudas, Andreas Hess, Raymund E. Horch, Ulrich KneserAbstract:Vascularization still remains an obstacle to engineering of bone tissue with clinically relevant dimensions. Our aim was to induce axial Vascularization in a large volume of a clinically approved biphasic calcium phosphate ceramic by transferring the arteriovenous (AV) loop approach to a large animal model. HA/β-TCP granula were mixed with fibrin gel for a total volume of 16 cm3, followed by incorporation into an isolation chamber together with an AV loop. The chambers were implanted into the groins of merino sheep and the development of Vascularization was monitored by sequential non-invasive magnetic resonance imaging (MRI). The chambers were explanted after 6 and 12 weeks, the pedicle was perfused with contrast agent and specimens were subjected to micro-computed tomography (µ-CT) scan and histological analysis. Sequential MRI demonstrated a significantly increased perfusion in the HA/β-TCP matrices over time. Micro-CT scans and histology confirmed successful axial Vascularization of HA/β-TCP constructs. This study demonstrates, for the first time, successful axial Vascularization of a clinically approved bone substitute with a significant volume in a large animal model by means of a microsurgically created AV loop, thus paving the way for the first microsurgical transplantation of a tissue-engineered, axially vascularized bone with clinically relevant dimensions. Copyright © 2009 John Wiley & Sons, Ltd.
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Axial Vascularization of a large volume calcium phosphate ceramic bone substitute in the sheep AV loop model.
Journal of tissue engineering and regenerative medicine, 2010Co-Authors: Justus P. Beier, Johanna Heinrich, Johanna S Loew, Elias Polykandriotis, Oliver Bleiziffer, Heinz Gulle, Andreas Arkudas, Andreas Hess, Raymund E. Horch, Ulrich KneserAbstract:Vascularization still remains an obstacle to engineering of bone tissue with clinically relevant dimensions. Our aim was to induce axial Vascularization in a large volume of a clinically approved biphasic calcium phosphate ceramic by transferring the arteriovenous (AV) loop approach to a large animal model. HA/beta-TCP granula were mixed with fibrin gel for a total volume of 16 cm(3), followed by incorporation into an isolation chamber together with an AV loop. The chambers were implanted into the groins of merino sheep and the development of Vascularization was monitored by sequential non-invasive magnetic resonance imaging (MRI). The chambers were explanted after 6 and 12 weeks, the pedicle was perfused with contrast agent and specimens were subjected to micro-computed tomography (micro-CT) scan and histological analysis. Sequential MRI demonstrated a significantly increased perfusion in the HA/beta-TCP matrices over time. Micro-CT scans and histology confirmed successful axial Vascularization of HA/beta-TCP constructs. This study demonstrates, for the first time, successful axial Vascularization of a clinically approved bone substitute with a significant volume in a large animal model by means of a microsurgically created AV loop, thus paving the way for the first microsurgical transplantation of a tissue-engineered, axially vascularized bone with clinically relevant dimensions.
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Engineering of vascularized transplantable bone tissues: induction of axial Vascularization in an osteoconductive matrix using an arteriovenous loop.
Tissue Engineering, 2006Co-Authors: Ulrich Kneser, Elias Polykandriotis, Andreas Hess, Kerstin Amann, J. Ohnolz, Kristina Heidner, Lucia Grabinger, Simon Euler, Kay Brune, Peter GreilAbstract:Introduction: Vascularization remains an obstacle to engineering of larger volume bone tissues. Our aim was to induce axial Vascularization in a processed bovine cancellous bone (PBCB) matrix using...
Andreas Hess - One of the best experts on this subject based on the ideXlab platform.
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axial Vascularization of a large volume calcium phosphate ceramic bone substitute in the sheep av loop model
Journal of Tissue Engineering and Regenerative Medicine, 2010Co-Authors: Justus P. Beier, Johanna Heinrich, Johanna S Loew, Elias Polykandriotis, Oliver Bleiziffer, Heinz Gulle, Andreas Arkudas, Andreas Hess, Raymund E. Horch, Ulrich KneserAbstract:Vascularization still remains an obstacle to engineering of bone tissue with clinically relevant dimensions. Our aim was to induce axial Vascularization in a large volume of a clinically approved biphasic calcium phosphate ceramic by transferring the arteriovenous (AV) loop approach to a large animal model. HA/β-TCP granula were mixed with fibrin gel for a total volume of 16 cm3, followed by incorporation into an isolation chamber together with an AV loop. The chambers were implanted into the groins of merino sheep and the development of Vascularization was monitored by sequential non-invasive magnetic resonance imaging (MRI). The chambers were explanted after 6 and 12 weeks, the pedicle was perfused with contrast agent and specimens were subjected to micro-computed tomography (µ-CT) scan and histological analysis. Sequential MRI demonstrated a significantly increased perfusion in the HA/β-TCP matrices over time. Micro-CT scans and histology confirmed successful axial Vascularization of HA/β-TCP constructs. This study demonstrates, for the first time, successful axial Vascularization of a clinically approved bone substitute with a significant volume in a large animal model by means of a microsurgically created AV loop, thus paving the way for the first microsurgical transplantation of a tissue-engineered, axially vascularized bone with clinically relevant dimensions. Copyright © 2009 John Wiley & Sons, Ltd.
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Axial Vascularization of a large volume calcium phosphate ceramic bone substitute in the sheep AV loop model.
Journal of tissue engineering and regenerative medicine, 2010Co-Authors: Justus P. Beier, Johanna Heinrich, Johanna S Loew, Elias Polykandriotis, Oliver Bleiziffer, Heinz Gulle, Andreas Arkudas, Andreas Hess, Raymund E. Horch, Ulrich KneserAbstract:Vascularization still remains an obstacle to engineering of bone tissue with clinically relevant dimensions. Our aim was to induce axial Vascularization in a large volume of a clinically approved biphasic calcium phosphate ceramic by transferring the arteriovenous (AV) loop approach to a large animal model. HA/beta-TCP granula were mixed with fibrin gel for a total volume of 16 cm(3), followed by incorporation into an isolation chamber together with an AV loop. The chambers were implanted into the groins of merino sheep and the development of Vascularization was monitored by sequential non-invasive magnetic resonance imaging (MRI). The chambers were explanted after 6 and 12 weeks, the pedicle was perfused with contrast agent and specimens were subjected to micro-computed tomography (micro-CT) scan and histological analysis. Sequential MRI demonstrated a significantly increased perfusion in the HA/beta-TCP matrices over time. Micro-CT scans and histology confirmed successful axial Vascularization of HA/beta-TCP constructs. This study demonstrates, for the first time, successful axial Vascularization of a clinically approved bone substitute with a significant volume in a large animal model by means of a microsurgically created AV loop, thus paving the way for the first microsurgical transplantation of a tissue-engineered, axially vascularized bone with clinically relevant dimensions.
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Engineering of vascularized transplantable bone tissues: induction of axial Vascularization in an osteoconductive matrix using an arteriovenous loop.
Tissue Engineering, 2006Co-Authors: Ulrich Kneser, Elias Polykandriotis, Andreas Hess, Kerstin Amann, J. Ohnolz, Kristina Heidner, Lucia Grabinger, Simon Euler, Kay Brune, Peter GreilAbstract:Introduction: Vascularization remains an obstacle to engineering of larger volume bone tissues. Our aim was to induce axial Vascularization in a processed bovine cancellous bone (PBCB) matrix using...
Elias Polykandriotis - One of the best experts on this subject based on the ideXlab platform.
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axial Vascularization of a large volume calcium phosphate ceramic bone substitute in the sheep av loop model
Journal of Tissue Engineering and Regenerative Medicine, 2010Co-Authors: Justus P. Beier, Johanna Heinrich, Johanna S Loew, Elias Polykandriotis, Oliver Bleiziffer, Heinz Gulle, Andreas Arkudas, Andreas Hess, Raymund E. Horch, Ulrich KneserAbstract:Vascularization still remains an obstacle to engineering of bone tissue with clinically relevant dimensions. Our aim was to induce axial Vascularization in a large volume of a clinically approved biphasic calcium phosphate ceramic by transferring the arteriovenous (AV) loop approach to a large animal model. HA/β-TCP granula were mixed with fibrin gel for a total volume of 16 cm3, followed by incorporation into an isolation chamber together with an AV loop. The chambers were implanted into the groins of merino sheep and the development of Vascularization was monitored by sequential non-invasive magnetic resonance imaging (MRI). The chambers were explanted after 6 and 12 weeks, the pedicle was perfused with contrast agent and specimens were subjected to micro-computed tomography (µ-CT) scan and histological analysis. Sequential MRI demonstrated a significantly increased perfusion in the HA/β-TCP matrices over time. Micro-CT scans and histology confirmed successful axial Vascularization of HA/β-TCP constructs. This study demonstrates, for the first time, successful axial Vascularization of a clinically approved bone substitute with a significant volume in a large animal model by means of a microsurgically created AV loop, thus paving the way for the first microsurgical transplantation of a tissue-engineered, axially vascularized bone with clinically relevant dimensions. Copyright © 2009 John Wiley & Sons, Ltd.
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Axial Vascularization of a large volume calcium phosphate ceramic bone substitute in the sheep AV loop model.
Journal of tissue engineering and regenerative medicine, 2010Co-Authors: Justus P. Beier, Johanna Heinrich, Johanna S Loew, Elias Polykandriotis, Oliver Bleiziffer, Heinz Gulle, Andreas Arkudas, Andreas Hess, Raymund E. Horch, Ulrich KneserAbstract:Vascularization still remains an obstacle to engineering of bone tissue with clinically relevant dimensions. Our aim was to induce axial Vascularization in a large volume of a clinically approved biphasic calcium phosphate ceramic by transferring the arteriovenous (AV) loop approach to a large animal model. HA/beta-TCP granula were mixed with fibrin gel for a total volume of 16 cm(3), followed by incorporation into an isolation chamber together with an AV loop. The chambers were implanted into the groins of merino sheep and the development of Vascularization was monitored by sequential non-invasive magnetic resonance imaging (MRI). The chambers were explanted after 6 and 12 weeks, the pedicle was perfused with contrast agent and specimens were subjected to micro-computed tomography (micro-CT) scan and histological analysis. Sequential MRI demonstrated a significantly increased perfusion in the HA/beta-TCP matrices over time. Micro-CT scans and histology confirmed successful axial Vascularization of HA/beta-TCP constructs. This study demonstrates, for the first time, successful axial Vascularization of a clinically approved bone substitute with a significant volume in a large animal model by means of a microsurgically created AV loop, thus paving the way for the first microsurgical transplantation of a tissue-engineered, axially vascularized bone with clinically relevant dimensions.
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Engineering of vascularized transplantable bone tissues: induction of axial Vascularization in an osteoconductive matrix using an arteriovenous loop.
Tissue Engineering, 2006Co-Authors: Ulrich Kneser, Elias Polykandriotis, Andreas Hess, Kerstin Amann, J. Ohnolz, Kristina Heidner, Lucia Grabinger, Simon Euler, Kay Brune, Peter GreilAbstract:Introduction: Vascularization remains an obstacle to engineering of larger volume bone tissues. Our aim was to induce axial Vascularization in a processed bovine cancellous bone (PBCB) matrix using...
Justus P. Beier - One of the best experts on this subject based on the ideXlab platform.
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axial Vascularization of a large volume calcium phosphate ceramic bone substitute in the sheep av loop model
Journal of Tissue Engineering and Regenerative Medicine, 2010Co-Authors: Justus P. Beier, Johanna Heinrich, Johanna S Loew, Elias Polykandriotis, Oliver Bleiziffer, Heinz Gulle, Andreas Arkudas, Andreas Hess, Raymund E. Horch, Ulrich KneserAbstract:Vascularization still remains an obstacle to engineering of bone tissue with clinically relevant dimensions. Our aim was to induce axial Vascularization in a large volume of a clinically approved biphasic calcium phosphate ceramic by transferring the arteriovenous (AV) loop approach to a large animal model. HA/β-TCP granula were mixed with fibrin gel for a total volume of 16 cm3, followed by incorporation into an isolation chamber together with an AV loop. The chambers were implanted into the groins of merino sheep and the development of Vascularization was monitored by sequential non-invasive magnetic resonance imaging (MRI). The chambers were explanted after 6 and 12 weeks, the pedicle was perfused with contrast agent and specimens were subjected to micro-computed tomography (µ-CT) scan and histological analysis. Sequential MRI demonstrated a significantly increased perfusion in the HA/β-TCP matrices over time. Micro-CT scans and histology confirmed successful axial Vascularization of HA/β-TCP constructs. This study demonstrates, for the first time, successful axial Vascularization of a clinically approved bone substitute with a significant volume in a large animal model by means of a microsurgically created AV loop, thus paving the way for the first microsurgical transplantation of a tissue-engineered, axially vascularized bone with clinically relevant dimensions. Copyright © 2009 John Wiley & Sons, Ltd.
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Axial Vascularization of a large volume calcium phosphate ceramic bone substitute in the sheep AV loop model.
Journal of tissue engineering and regenerative medicine, 2010Co-Authors: Justus P. Beier, Johanna Heinrich, Johanna S Loew, Elias Polykandriotis, Oliver Bleiziffer, Heinz Gulle, Andreas Arkudas, Andreas Hess, Raymund E. Horch, Ulrich KneserAbstract:Vascularization still remains an obstacle to engineering of bone tissue with clinically relevant dimensions. Our aim was to induce axial Vascularization in a large volume of a clinically approved biphasic calcium phosphate ceramic by transferring the arteriovenous (AV) loop approach to a large animal model. HA/beta-TCP granula were mixed with fibrin gel for a total volume of 16 cm(3), followed by incorporation into an isolation chamber together with an AV loop. The chambers were implanted into the groins of merino sheep and the development of Vascularization was monitored by sequential non-invasive magnetic resonance imaging (MRI). The chambers were explanted after 6 and 12 weeks, the pedicle was perfused with contrast agent and specimens were subjected to micro-computed tomography (micro-CT) scan and histological analysis. Sequential MRI demonstrated a significantly increased perfusion in the HA/beta-TCP matrices over time. Micro-CT scans and histology confirmed successful axial Vascularization of HA/beta-TCP constructs. This study demonstrates, for the first time, successful axial Vascularization of a clinically approved bone substitute with a significant volume in a large animal model by means of a microsurgically created AV loop, thus paving the way for the first microsurgical transplantation of a tissue-engineered, axially vascularized bone with clinically relevant dimensions.
Heinz Gulle - One of the best experts on this subject based on the ideXlab platform.
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axial Vascularization of a large volume calcium phosphate ceramic bone substitute in the sheep av loop model
Journal of Tissue Engineering and Regenerative Medicine, 2010Co-Authors: Justus P. Beier, Johanna Heinrich, Johanna S Loew, Elias Polykandriotis, Oliver Bleiziffer, Heinz Gulle, Andreas Arkudas, Andreas Hess, Raymund E. Horch, Ulrich KneserAbstract:Vascularization still remains an obstacle to engineering of bone tissue with clinically relevant dimensions. Our aim was to induce axial Vascularization in a large volume of a clinically approved biphasic calcium phosphate ceramic by transferring the arteriovenous (AV) loop approach to a large animal model. HA/β-TCP granula were mixed with fibrin gel for a total volume of 16 cm3, followed by incorporation into an isolation chamber together with an AV loop. The chambers were implanted into the groins of merino sheep and the development of Vascularization was monitored by sequential non-invasive magnetic resonance imaging (MRI). The chambers were explanted after 6 and 12 weeks, the pedicle was perfused with contrast agent and specimens were subjected to micro-computed tomography (µ-CT) scan and histological analysis. Sequential MRI demonstrated a significantly increased perfusion in the HA/β-TCP matrices over time. Micro-CT scans and histology confirmed successful axial Vascularization of HA/β-TCP constructs. This study demonstrates, for the first time, successful axial Vascularization of a clinically approved bone substitute with a significant volume in a large animal model by means of a microsurgically created AV loop, thus paving the way for the first microsurgical transplantation of a tissue-engineered, axially vascularized bone with clinically relevant dimensions. Copyright © 2009 John Wiley & Sons, Ltd.
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Axial Vascularization of a large volume calcium phosphate ceramic bone substitute in the sheep AV loop model.
Journal of tissue engineering and regenerative medicine, 2010Co-Authors: Justus P. Beier, Johanna Heinrich, Johanna S Loew, Elias Polykandriotis, Oliver Bleiziffer, Heinz Gulle, Andreas Arkudas, Andreas Hess, Raymund E. Horch, Ulrich KneserAbstract:Vascularization still remains an obstacle to engineering of bone tissue with clinically relevant dimensions. Our aim was to induce axial Vascularization in a large volume of a clinically approved biphasic calcium phosphate ceramic by transferring the arteriovenous (AV) loop approach to a large animal model. HA/beta-TCP granula were mixed with fibrin gel for a total volume of 16 cm(3), followed by incorporation into an isolation chamber together with an AV loop. The chambers were implanted into the groins of merino sheep and the development of Vascularization was monitored by sequential non-invasive magnetic resonance imaging (MRI). The chambers were explanted after 6 and 12 weeks, the pedicle was perfused with contrast agent and specimens were subjected to micro-computed tomography (micro-CT) scan and histological analysis. Sequential MRI demonstrated a significantly increased perfusion in the HA/beta-TCP matrices over time. Micro-CT scans and histology confirmed successful axial Vascularization of HA/beta-TCP constructs. This study demonstrates, for the first time, successful axial Vascularization of a clinically approved bone substitute with a significant volume in a large animal model by means of a microsurgically created AV loop, thus paving the way for the first microsurgical transplantation of a tissue-engineered, axially vascularized bone with clinically relevant dimensions.
