The Experts below are selected from a list of 345 Experts worldwide ranked by ideXlab platform

Lee C-p - One of the best experts on this subject based on the ideXlab platform.

  • Outcome of pregnancy in patients with systemic lupus erythematosus: A prospective study
    'American Medical Association (AMA)', 1991
    Co-Authors: Chan F-y, Wong K-l, Lee C-p
    Abstract:

    A prospective study was performed to investigate the outcome and complications of pregnancy in patients with systemic lupus erythematosus. Twenty-nine pregnancies occurred in 22 patients. There were 12 abortions, two spontaneous and 10 induced. Fifteen women had 17 live-born neonates. Neonatal complications included nine premature deliveries, two cases of intrauterine growth retardation, and one of Treacher Collins syndrome. Obstetric complications included threatened abortion (two), placenta previa (two), and preeclampsia (three). Cesarean sections were necessary in five patients. There was no maternal or neonatal mortality. Thirteen episodes of systemic lupus erythematosus relapses were detected by incidents of increasing proteinuria (six), arthritis (four), and Vasculitic Rash (two). There were no statistical differences in changes in hemoglobin level, erythrocyte sedimentation rate, albumin level, antinuclear antibody titer, or C3 or C4 level between the patients who relapsed and those who did not. Pregnancy could induce a flare of systemic lupus erythematosus in previously normal patients or patients with previously inactive disease. The overall neonatal and maternal survival was good, even in patients who presented during pregnancy. Spontaneous fetal loss was low (2/29 [6.9%]); both cases occurred in mothers with inactive lupus.link_to_subscribed_fulltex

R Dattwyler - One of the best experts on this subject based on the ideXlab platform.

  • vasculitis and cd 19 plasma cells is it a reactive process or a plasma cell dyscrasia
    The Journal of Allergy and Clinical Immunology, 2004
    Co-Authors: P A Takach, M Golightly, R Dattwyler
    Abstract:

    Abstract Rationale A 64 year-old WM presenting with fever, Vasculitic Rash and SOB was diagnosed with Chlamydia pneumoniae, cryoglobulinemia, polyclonal gammapathy and an abnormal plasma cell phenotype. Methods SPEP and IFE revealed polyclonal gammapathy. We analyzed bone marrow histology with flow cytometry of peripheral blood and bone marrow and obtained a skin biopsy for histology and immunofluorescence. Results SPEP and IFE revealed polyclonal gammapathy. Bone marrow histology demonstrated increased plasma cells with lymphoplasmacytoid morphology more like that of lymphocytes than plasma cells and occasional binucleated plasma cells. Peripheral blood flow cytometry demonstrated a heteogenous population of mature B and plasmacytoid-like cells, appearing polyclonal. There was a population of polyclonal large cells expressing B cell and plasmacytoid cell markers, expressing CD 19 but not 20, composing 6% of WBC population. Bone marrow flow revealed similar findings. Chromosome analysis demonstrated no clonal abnormalities. Skin biopsy revealed vasculitis with perivascular lymphocytes and plasma cells around small blood vessels consistent with cryoglobulinemia. IgG, IgM and IgE were significantly elevated with elevated titers to C. pneumoniae. Qualitative cryoglobulins were positive. Imaging studies were significant for lung infiltrates, axillary and subcarinal lymph nodes, and soft tissue within the AP window. Conclusions The patient had findings usually associated with a monoclonal process but his abnormal plasma cell phenotype showed no evidence for clonality. The patient initially responded to prednisone but worsened as the drug was tapered. His Rash and cryoglobulinemia resolved with hydroxychloroquine, suggesting a reactive process to infection. This phenotype, however, raises questions about abnormalities in regulation of plasma cell differentiation.

Chan F-y - One of the best experts on this subject based on the ideXlab platform.

  • Outcome of pregnancy in patients with systemic lupus erythematosus: A prospective study
    'American Medical Association (AMA)', 1991
    Co-Authors: Chan F-y, Wong K-l, Lee C-p
    Abstract:

    A prospective study was performed to investigate the outcome and complications of pregnancy in patients with systemic lupus erythematosus. Twenty-nine pregnancies occurred in 22 patients. There were 12 abortions, two spontaneous and 10 induced. Fifteen women had 17 live-born neonates. Neonatal complications included nine premature deliveries, two cases of intrauterine growth retardation, and one of Treacher Collins syndrome. Obstetric complications included threatened abortion (two), placenta previa (two), and preeclampsia (three). Cesarean sections were necessary in five patients. There was no maternal or neonatal mortality. Thirteen episodes of systemic lupus erythematosus relapses were detected by incidents of increasing proteinuria (six), arthritis (four), and Vasculitic Rash (two). There were no statistical differences in changes in hemoglobin level, erythrocyte sedimentation rate, albumin level, antinuclear antibody titer, or C3 or C4 level between the patients who relapsed and those who did not. Pregnancy could induce a flare of systemic lupus erythematosus in previously normal patients or patients with previously inactive disease. The overall neonatal and maternal survival was good, even in patients who presented during pregnancy. Spontaneous fetal loss was low (2/29 [6.9%]); both cases occurred in mothers with inactive lupus.link_to_subscribed_fulltex

P A Takach - One of the best experts on this subject based on the ideXlab platform.

  • vasculitis and cd 19 plasma cells is it a reactive process or a plasma cell dyscrasia
    The Journal of Allergy and Clinical Immunology, 2004
    Co-Authors: P A Takach, M Golightly, R Dattwyler
    Abstract:

    Abstract Rationale A 64 year-old WM presenting with fever, Vasculitic Rash and SOB was diagnosed with Chlamydia pneumoniae, cryoglobulinemia, polyclonal gammapathy and an abnormal plasma cell phenotype. Methods SPEP and IFE revealed polyclonal gammapathy. We analyzed bone marrow histology with flow cytometry of peripheral blood and bone marrow and obtained a skin biopsy for histology and immunofluorescence. Results SPEP and IFE revealed polyclonal gammapathy. Bone marrow histology demonstrated increased plasma cells with lymphoplasmacytoid morphology more like that of lymphocytes than plasma cells and occasional binucleated plasma cells. Peripheral blood flow cytometry demonstrated a heteogenous population of mature B and plasmacytoid-like cells, appearing polyclonal. There was a population of polyclonal large cells expressing B cell and plasmacytoid cell markers, expressing CD 19 but not 20, composing 6% of WBC population. Bone marrow flow revealed similar findings. Chromosome analysis demonstrated no clonal abnormalities. Skin biopsy revealed vasculitis with perivascular lymphocytes and plasma cells around small blood vessels consistent with cryoglobulinemia. IgG, IgM and IgE were significantly elevated with elevated titers to C. pneumoniae. Qualitative cryoglobulins were positive. Imaging studies were significant for lung infiltrates, axillary and subcarinal lymph nodes, and soft tissue within the AP window. Conclusions The patient had findings usually associated with a monoclonal process but his abnormal plasma cell phenotype showed no evidence for clonality. The patient initially responded to prednisone but worsened as the drug was tapered. His Rash and cryoglobulinemia resolved with hydroxychloroquine, suggesting a reactive process to infection. This phenotype, however, raises questions about abnormalities in regulation of plasma cell differentiation.

Wong K-l - One of the best experts on this subject based on the ideXlab platform.

  • Outcome of pregnancy in patients with systemic lupus erythematosus: A prospective study
    'American Medical Association (AMA)', 1991
    Co-Authors: Chan F-y, Wong K-l, Lee C-p
    Abstract:

    A prospective study was performed to investigate the outcome and complications of pregnancy in patients with systemic lupus erythematosus. Twenty-nine pregnancies occurred in 22 patients. There were 12 abortions, two spontaneous and 10 induced. Fifteen women had 17 live-born neonates. Neonatal complications included nine premature deliveries, two cases of intrauterine growth retardation, and one of Treacher Collins syndrome. Obstetric complications included threatened abortion (two), placenta previa (two), and preeclampsia (three). Cesarean sections were necessary in five patients. There was no maternal or neonatal mortality. Thirteen episodes of systemic lupus erythematosus relapses were detected by incidents of increasing proteinuria (six), arthritis (four), and Vasculitic Rash (two). There were no statistical differences in changes in hemoglobin level, erythrocyte sedimentation rate, albumin level, antinuclear antibody titer, or C3 or C4 level between the patients who relapsed and those who did not. Pregnancy could induce a flare of systemic lupus erythematosus in previously normal patients or patients with previously inactive disease. The overall neonatal and maternal survival was good, even in patients who presented during pregnancy. Spontaneous fetal loss was low (2/29 [6.9%]); both cases occurred in mothers with inactive lupus.link_to_subscribed_fulltex