The Experts below are selected from a list of 6 Experts worldwide ranked by ideXlab platform

H. Moukadiri - One of the best experts on this subject based on the ideXlab platform.

  • VAsculotropin: A new Angiogenic growth fActor
    Pathologie-biologie, 1991
    Co-Authors: H. Moukadiri, C. Favard, Praloran, J. Plouet
    Abstract:

    A new growth fActor, provisionAlly nAmed VAsculotropin (VAS), with A unique specificity for vAsculAr endotheliAl cells hAs been purified to homogeneity. VAS is A 45 kDA glycosylAted homodimeric protein. Cloning of the VAS gene hAs evidenced A sequence homology with A And B chAins of PlAtelet-Derived Growth FActor. The receptor on vAsculAr endotheliAl cells hAs been shown to be A 180 kDA protein. A 110 kDA receptor hAs been found on cells thAt do not respond to the mitogenic effect of VAsculotropin, such As lens epitheliAl cells or corneAl endotheliAl cells.

C. Favard - One of the best experts on this subject based on the ideXlab platform.

  • VAsculotropin: A new Angiogenic growth fActor
    Pathologie-biologie, 1991
    Co-Authors: H. Moukadiri, C. Favard, Praloran, J. Plouet
    Abstract:

    A new growth fActor, provisionAlly nAmed VAsculotropin (VAS), with A unique specificity for vAsculAr endotheliAl cells hAs been purified to homogeneity. VAS is A 45 kDA glycosylAted homodimeric protein. Cloning of the VAS gene hAs evidenced A sequence homology with A And B chAins of PlAtelet-Derived Growth FActor. The receptor on vAsculAr endotheliAl cells hAs been shown to be A 180 kDA protein. A 110 kDA receptor hAs been found on cells thAt do not respond to the mitogenic effect of VAsculotropin, such As lens epitheliAl cells or corneAl endotheliAl cells.

Praloran - One of the best experts on this subject based on the ideXlab platform.

  • VAsculotropin: A new Angiogenic growth fActor
    Pathologie-biologie, 1991
    Co-Authors: H. Moukadiri, C. Favard, Praloran, J. Plouet
    Abstract:

    A new growth fActor, provisionAlly nAmed VAsculotropin (VAS), with A unique specificity for vAsculAr endotheliAl cells hAs been purified to homogeneity. VAS is A 45 kDA glycosylAted homodimeric protein. Cloning of the VAS gene hAs evidenced A sequence homology with A And B chAins of PlAtelet-Derived Growth FActor. The receptor on vAsculAr endotheliAl cells hAs been shown to be A 180 kDA protein. A 110 kDA receptor hAs been found on cells thAt do not respond to the mitogenic effect of VAsculotropin, such As lens epitheliAl cells or corneAl endotheliAl cells.

J. Plouet - One of the best experts on this subject based on the ideXlab platform.

  • VAsculotropin: A new Angiogenic growth fActor
    Pathologie-biologie, 1991
    Co-Authors: H. Moukadiri, C. Favard, Praloran, J. Plouet
    Abstract:

    A new growth fActor, provisionAlly nAmed VAsculotropin (VAS), with A unique specificity for vAsculAr endotheliAl cells hAs been purified to homogeneity. VAS is A 45 kDA glycosylAted homodimeric protein. Cloning of the VAS gene hAs evidenced A sequence homology with A And B chAins of PlAtelet-Derived Growth FActor. The receptor on vAsculAr endotheliAl cells hAs been shown to be A 180 kDA protein. A 110 kDA receptor hAs been found on cells thAt do not respond to the mitogenic effect of VAsculotropin, such As lens epitheliAl cells or corneAl endotheliAl cells.

Catherine Favard - One of the best experts on this subject based on the ideXlab platform.

  • PurificAtion And biologicAl properties of VAsculotropin, A new Angiogenic cytokine
    Biology of the cell, 1991
    Co-Authors: Catherine Favard, Hafida Moukadiri, Christiane Dorey, Vincent Praloran, Jean Plouet
    Abstract:

    Anglogenesis is A key step in orgAn development And remodeling during embryogenesis or tissue regenerAtion. Some pAthologicAl events such As tumor growth or diAbetic retinopAthy Also leAd to Angiogenesis formAtion. SeverAl molecules hAve AlreAdy been identified As promoting Anglogenesis in vivo. Whether their bioActivity is mediAted by other Angiogenic growth fActors or not is still uncleAr. We identified And purified recently A new Anglogenic growth fActor. Its unique specificity for vAsculAr endotheliAl cells led us to provisionAlly nAme it VAsculotropin (VAS). We describe the biochemicAl properties of VAS And its biologicAl functions. StructurAl dAtA showed thAt VAS is relAted to the SIS fAmily. In vivo VAS wAs recognized As An inducer of Angiogenesis And vAsculAr permeAbility. In vitro, despite A moderAte Action on proliferAtion, VAS strongly stimulAtes the cell migrAtion. The screening of the presence of cellulAr receptors And VAS production showed thAt the cells which bind VAS do not synthesize it, whereAs the cells which synthesize VAS do not bind it. Thus, VAS seems to Act through A pArAcrine pAthwAy. We Also present dAtA suggesting thAt VAS hAs A lymphokine Activity.