The Experts below are selected from a list of 219 Experts worldwide ranked by ideXlab platform
Francesco Giannessi - One of the best experts on this subject based on the ideXlab platform.
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Immunohistochemical localization of 3-nitrotyrosine in the nasal respiratory mucosa of patients with Vasomotor Rhinitis.
Acta oto-laryngologica, 2005Co-Authors: Francesco Giannessi, Francesco Ursino, Bruno Fattori, M. Anita Giambelluca, Maria Concetta Scavuzzo, Francesca Ceccarelli, Riccardo RuffoliAbstract:Conclusion This study demonstrates that, in the nasal respiratory mucosa of patients with Vasomotor Rhinitis, oxidative stress following peroxynitrite formation is confined to the respiratory epithelium. This suggests that the role of peroxynitrite in Vasomotor Rhinitis differs from its role in other diseases of the respiratory tract. The results of this study also support the concept that different pathogenetic mechanisms are probably involved in Vasomotor Rhinitis. Objective Previous studies indicated that nitric oxide (NO) is involved in the pathogenesis of Vasomotor Rhinitis, strong expression of NO synthase being detected in the smooth muscle cells of the cavernous sinuses and in the respiratory epithelium. However, most adverse effects of high levels of NO originate from the reaction of NO with superoxide anions to form peroxynitrite. Therefore, in this study we evaluated the involvement of peroxynitrite in the pathogenesis of Vasomotor Rhinitis. Material and methods Sites of peroxynitrite formation...
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ultracytochemical localization of the nadph d activity in the human nasal respiratory mucosa in Vasomotor Rhinitis
Laryngoscope, 2000Co-Authors: Riccardo Ruffoli, M. Anita Giambelluca, Bruno Fattori, Paola Soldani, Francesco GiannessiAbstract:Objectives Description of the ultrastructural localization of nitric oxide synthase in the blood vessels of the nasal respiratory mucosa in patients with Vasomotor Rhinitis. Study Design This research was conducted on seven patients—men and women, ages 20 to 45 years—suffering from Vasomotor Rhinitis and who had undergone surgical therapy for reduction of the inferior turbinates. Methods To study the ultrastructural localization of nitric oxide synthase, NADPH-diaphorase cytochemistry was employed. Samples of the nasal mucosa were obtained from inferior turbinates. Results The endothelial cells of the arterioles, capillaries , venules and cavernous sinuses revealed a distribution of the enzymatic activity similar to that found in unaffected subjects. A strong enzymatic activity was recognized in the smooth muscle cells of the cavernous sinuses. The smooth muscle cells of arterioles and venules were generally found to be negative to enzymatic reaction. Conclusions This study suggests that the vascular disorders of the Vasomotor Rhinitis depend, at least in part, from nitric oxide synthase induction in the smooth muscle cells of the cavernous sinuses.
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Ultracytochemical Localization of the NADPH‐d Activity in the Human Nasal Respiratory Mucosa in Vasomotor Rhinitis
The Laryngoscope, 2000Co-Authors: Riccardo Ruffoli, M. Anita Giambelluca, Bruno Fattori, Paola Soldani, Francesco GiannessiAbstract:Objectives Description of the ultrastructural localization of nitric oxide synthase in the blood vessels of the nasal respiratory mucosa in patients with Vasomotor Rhinitis. Study Design This research was conducted on seven patients—men and women, ages 20 to 45 years—suffering from Vasomotor Rhinitis and who had undergone surgical therapy for reduction of the inferior turbinates. Methods To study the ultrastructural localization of nitric oxide synthase, NADPH-diaphorase cytochemistry was employed. Samples of the nasal mucosa were obtained from inferior turbinates. Results The endothelial cells of the arterioles, capillaries , venules and cavernous sinuses revealed a distribution of the enzymatic activity similar to that found in unaffected subjects. A strong enzymatic activity was recognized in the smooth muscle cells of the cavernous sinuses. The smooth muscle cells of arterioles and venules were generally found to be negative to enzymatic reaction. Conclusions This study suggests that the vascular disorders of the Vasomotor Rhinitis depend, at least in part, from nitric oxide synthase induction in the smooth muscle cells of the cavernous sinuses.
Riccardo Ruffoli - One of the best experts on this subject based on the ideXlab platform.
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Immunohistochemical localization of 3-nitrotyrosine in the nasal respiratory mucosa of patients with Vasomotor Rhinitis.
Acta oto-laryngologica, 2005Co-Authors: Francesco Giannessi, Francesco Ursino, Bruno Fattori, M. Anita Giambelluca, Maria Concetta Scavuzzo, Francesca Ceccarelli, Riccardo RuffoliAbstract:Conclusion This study demonstrates that, in the nasal respiratory mucosa of patients with Vasomotor Rhinitis, oxidative stress following peroxynitrite formation is confined to the respiratory epithelium. This suggests that the role of peroxynitrite in Vasomotor Rhinitis differs from its role in other diseases of the respiratory tract. The results of this study also support the concept that different pathogenetic mechanisms are probably involved in Vasomotor Rhinitis. Objective Previous studies indicated that nitric oxide (NO) is involved in the pathogenesis of Vasomotor Rhinitis, strong expression of NO synthase being detected in the smooth muscle cells of the cavernous sinuses and in the respiratory epithelium. However, most adverse effects of high levels of NO originate from the reaction of NO with superoxide anions to form peroxynitrite. Therefore, in this study we evaluated the involvement of peroxynitrite in the pathogenesis of Vasomotor Rhinitis. Material and methods Sites of peroxynitrite formation...
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ultracytochemical localization of the nadph d activity in the human nasal respiratory mucosa in Vasomotor Rhinitis
Laryngoscope, 2000Co-Authors: Riccardo Ruffoli, M. Anita Giambelluca, Bruno Fattori, Paola Soldani, Francesco GiannessiAbstract:Objectives Description of the ultrastructural localization of nitric oxide synthase in the blood vessels of the nasal respiratory mucosa in patients with Vasomotor Rhinitis. Study Design This research was conducted on seven patients—men and women, ages 20 to 45 years—suffering from Vasomotor Rhinitis and who had undergone surgical therapy for reduction of the inferior turbinates. Methods To study the ultrastructural localization of nitric oxide synthase, NADPH-diaphorase cytochemistry was employed. Samples of the nasal mucosa were obtained from inferior turbinates. Results The endothelial cells of the arterioles, capillaries , venules and cavernous sinuses revealed a distribution of the enzymatic activity similar to that found in unaffected subjects. A strong enzymatic activity was recognized in the smooth muscle cells of the cavernous sinuses. The smooth muscle cells of arterioles and venules were generally found to be negative to enzymatic reaction. Conclusions This study suggests that the vascular disorders of the Vasomotor Rhinitis depend, at least in part, from nitric oxide synthase induction in the smooth muscle cells of the cavernous sinuses.
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Ultracytochemical Localization of the NADPH‐d Activity in the Human Nasal Respiratory Mucosa in Vasomotor Rhinitis
The Laryngoscope, 2000Co-Authors: Riccardo Ruffoli, M. Anita Giambelluca, Bruno Fattori, Paola Soldani, Francesco GiannessiAbstract:Objectives Description of the ultrastructural localization of nitric oxide synthase in the blood vessels of the nasal respiratory mucosa in patients with Vasomotor Rhinitis. Study Design This research was conducted on seven patients—men and women, ages 20 to 45 years—suffering from Vasomotor Rhinitis and who had undergone surgical therapy for reduction of the inferior turbinates. Methods To study the ultrastructural localization of nitric oxide synthase, NADPH-diaphorase cytochemistry was employed. Samples of the nasal mucosa were obtained from inferior turbinates. Results The endothelial cells of the arterioles, capillaries , venules and cavernous sinuses revealed a distribution of the enzymatic activity similar to that found in unaffected subjects. A strong enzymatic activity was recognized in the smooth muscle cells of the cavernous sinuses. The smooth muscle cells of arterioles and venules were generally found to be negative to enzymatic reaction. Conclusions This study suggests that the vascular disorders of the Vasomotor Rhinitis depend, at least in part, from nitric oxide synthase induction in the smooth muscle cells of the cavernous sinuses.
P.s.n. Murthy - One of the best experts on this subject based on the ideXlab platform.
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Vasomotor Rhinitis and sphenopalatine ganglion block
Journal of Pain and Symptom Management, 1997Co-Authors: Athma Prasanna, P.s.n. MurthyAbstract:Abstract The effectiveness of the sphenopalatine ganglion (SPG) block for the relief of symptoms inchronic Vasomotor Rhinitis was assessed in 30 patients of both genders. The number of blocks required for complete relief was three (range from two to four) at weekly intervals in 66.7% of volunteers. There was no recurrence of symptoms during a follow-up period of 12–20 months in 29 patients, and one patient was symptom free for 8 months. The technique is simple and can be performed as an outpatient procedure without side effects.
M. Anita Giambelluca - One of the best experts on this subject based on the ideXlab platform.
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Immunohistochemical localization of 3-nitrotyrosine in the nasal respiratory mucosa of patients with Vasomotor Rhinitis.
Acta oto-laryngologica, 2005Co-Authors: Francesco Giannessi, Francesco Ursino, Bruno Fattori, M. Anita Giambelluca, Maria Concetta Scavuzzo, Francesca Ceccarelli, Riccardo RuffoliAbstract:Conclusion This study demonstrates that, in the nasal respiratory mucosa of patients with Vasomotor Rhinitis, oxidative stress following peroxynitrite formation is confined to the respiratory epithelium. This suggests that the role of peroxynitrite in Vasomotor Rhinitis differs from its role in other diseases of the respiratory tract. The results of this study also support the concept that different pathogenetic mechanisms are probably involved in Vasomotor Rhinitis. Objective Previous studies indicated that nitric oxide (NO) is involved in the pathogenesis of Vasomotor Rhinitis, strong expression of NO synthase being detected in the smooth muscle cells of the cavernous sinuses and in the respiratory epithelium. However, most adverse effects of high levels of NO originate from the reaction of NO with superoxide anions to form peroxynitrite. Therefore, in this study we evaluated the involvement of peroxynitrite in the pathogenesis of Vasomotor Rhinitis. Material and methods Sites of peroxynitrite formation...
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ultracytochemical localization of the nadph d activity in the human nasal respiratory mucosa in Vasomotor Rhinitis
Laryngoscope, 2000Co-Authors: Riccardo Ruffoli, M. Anita Giambelluca, Bruno Fattori, Paola Soldani, Francesco GiannessiAbstract:Objectives Description of the ultrastructural localization of nitric oxide synthase in the blood vessels of the nasal respiratory mucosa in patients with Vasomotor Rhinitis. Study Design This research was conducted on seven patients—men and women, ages 20 to 45 years—suffering from Vasomotor Rhinitis and who had undergone surgical therapy for reduction of the inferior turbinates. Methods To study the ultrastructural localization of nitric oxide synthase, NADPH-diaphorase cytochemistry was employed. Samples of the nasal mucosa were obtained from inferior turbinates. Results The endothelial cells of the arterioles, capillaries , venules and cavernous sinuses revealed a distribution of the enzymatic activity similar to that found in unaffected subjects. A strong enzymatic activity was recognized in the smooth muscle cells of the cavernous sinuses. The smooth muscle cells of arterioles and venules were generally found to be negative to enzymatic reaction. Conclusions This study suggests that the vascular disorders of the Vasomotor Rhinitis depend, at least in part, from nitric oxide synthase induction in the smooth muscle cells of the cavernous sinuses.
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Ultracytochemical Localization of the NADPH‐d Activity in the Human Nasal Respiratory Mucosa in Vasomotor Rhinitis
The Laryngoscope, 2000Co-Authors: Riccardo Ruffoli, M. Anita Giambelluca, Bruno Fattori, Paola Soldani, Francesco GiannessiAbstract:Objectives Description of the ultrastructural localization of nitric oxide synthase in the blood vessels of the nasal respiratory mucosa in patients with Vasomotor Rhinitis. Study Design This research was conducted on seven patients—men and women, ages 20 to 45 years—suffering from Vasomotor Rhinitis and who had undergone surgical therapy for reduction of the inferior turbinates. Methods To study the ultrastructural localization of nitric oxide synthase, NADPH-diaphorase cytochemistry was employed. Samples of the nasal mucosa were obtained from inferior turbinates. Results The endothelial cells of the arterioles, capillaries , venules and cavernous sinuses revealed a distribution of the enzymatic activity similar to that found in unaffected subjects. A strong enzymatic activity was recognized in the smooth muscle cells of the cavernous sinuses. The smooth muscle cells of arterioles and venules were generally found to be negative to enzymatic reaction. Conclusions This study suggests that the vascular disorders of the Vasomotor Rhinitis depend, at least in part, from nitric oxide synthase induction in the smooth muscle cells of the cavernous sinuses.
Bruno Fattori - One of the best experts on this subject based on the ideXlab platform.
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Immunohistochemical localization of 3-nitrotyrosine in the nasal respiratory mucosa of patients with Vasomotor Rhinitis.
Acta oto-laryngologica, 2005Co-Authors: Francesco Giannessi, Francesco Ursino, Bruno Fattori, M. Anita Giambelluca, Maria Concetta Scavuzzo, Francesca Ceccarelli, Riccardo RuffoliAbstract:Conclusion This study demonstrates that, in the nasal respiratory mucosa of patients with Vasomotor Rhinitis, oxidative stress following peroxynitrite formation is confined to the respiratory epithelium. This suggests that the role of peroxynitrite in Vasomotor Rhinitis differs from its role in other diseases of the respiratory tract. The results of this study also support the concept that different pathogenetic mechanisms are probably involved in Vasomotor Rhinitis. Objective Previous studies indicated that nitric oxide (NO) is involved in the pathogenesis of Vasomotor Rhinitis, strong expression of NO synthase being detected in the smooth muscle cells of the cavernous sinuses and in the respiratory epithelium. However, most adverse effects of high levels of NO originate from the reaction of NO with superoxide anions to form peroxynitrite. Therefore, in this study we evaluated the involvement of peroxynitrite in the pathogenesis of Vasomotor Rhinitis. Material and methods Sites of peroxynitrite formation...
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ultracytochemical localization of the nadph d activity in the human nasal respiratory mucosa in Vasomotor Rhinitis
Laryngoscope, 2000Co-Authors: Riccardo Ruffoli, M. Anita Giambelluca, Bruno Fattori, Paola Soldani, Francesco GiannessiAbstract:Objectives Description of the ultrastructural localization of nitric oxide synthase in the blood vessels of the nasal respiratory mucosa in patients with Vasomotor Rhinitis. Study Design This research was conducted on seven patients—men and women, ages 20 to 45 years—suffering from Vasomotor Rhinitis and who had undergone surgical therapy for reduction of the inferior turbinates. Methods To study the ultrastructural localization of nitric oxide synthase, NADPH-diaphorase cytochemistry was employed. Samples of the nasal mucosa were obtained from inferior turbinates. Results The endothelial cells of the arterioles, capillaries , venules and cavernous sinuses revealed a distribution of the enzymatic activity similar to that found in unaffected subjects. A strong enzymatic activity was recognized in the smooth muscle cells of the cavernous sinuses. The smooth muscle cells of arterioles and venules were generally found to be negative to enzymatic reaction. Conclusions This study suggests that the vascular disorders of the Vasomotor Rhinitis depend, at least in part, from nitric oxide synthase induction in the smooth muscle cells of the cavernous sinuses.
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Ultracytochemical Localization of the NADPH‐d Activity in the Human Nasal Respiratory Mucosa in Vasomotor Rhinitis
The Laryngoscope, 2000Co-Authors: Riccardo Ruffoli, M. Anita Giambelluca, Bruno Fattori, Paola Soldani, Francesco GiannessiAbstract:Objectives Description of the ultrastructural localization of nitric oxide synthase in the blood vessels of the nasal respiratory mucosa in patients with Vasomotor Rhinitis. Study Design This research was conducted on seven patients—men and women, ages 20 to 45 years—suffering from Vasomotor Rhinitis and who had undergone surgical therapy for reduction of the inferior turbinates. Methods To study the ultrastructural localization of nitric oxide synthase, NADPH-diaphorase cytochemistry was employed. Samples of the nasal mucosa were obtained from inferior turbinates. Results The endothelial cells of the arterioles, capillaries , venules and cavernous sinuses revealed a distribution of the enzymatic activity similar to that found in unaffected subjects. A strong enzymatic activity was recognized in the smooth muscle cells of the cavernous sinuses. The smooth muscle cells of arterioles and venules were generally found to be negative to enzymatic reaction. Conclusions This study suggests that the vascular disorders of the Vasomotor Rhinitis depend, at least in part, from nitric oxide synthase induction in the smooth muscle cells of the cavernous sinuses.