The Experts below are selected from a list of 231 Experts worldwide ranked by ideXlab platform
Rinat O Esenaliev - One of the best experts on this subject based on the ideXlab platform.
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optoacoustic monitoring of cerebral Venous Blood oxygenation though intact scalp in large animals
Optics Express, 2012Co-Authors: Irene Y Petrov, Yuriy Petrov, Donald S Prough, Inga Cicenaite, Donald J Deyo, Rinat O EsenalievAbstract:Monitoring (currently invasive) of cerebral Venous Blood oxygenation is a key to avoiding hypoxia-induced brain injury resulting in death or severe disability. Noninvasive, optoacoustic monitoring of cerebral Venous Blood oxygenation can potentially replace existing invasive methods. To the best of our knowledge, we report for the first time noninvasive monitoring of cerebral Venous Blood oxygenation through intact scalp that was validated with invasive, “gold standard” measurements. We performed an in vivo study in the sheep superior sagittal sinus (SSS), a large midline cerebral vein, using our novel, multi-wavelength optoacoustic system. The study results demonstrated that: 1) the optoacoustic signal from the sheep SSS is detectable through the thick, intact scalp and skull; 2) the SSS signal amplitude correlated well with wavelength and actual SSS Blood oxygenation measured invasively using SSS catheterization, Blood sampling, and measurement with “gold standard” CO-Oximeter; 3) the optoacoustically predicted oxygenation strongly correlated with that measured with the CO-Oximeter. Our results indicate that monitoring of cerebral Venous Blood oxygenation may be performed in humans noninvasively and accurately through the intact scalp using optoacoustic systems because the sheep scalp and skull thickness is comparable to that of humans whereas the sheep SSS is much smaller than that of humans.
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optoacoustic monitoring of cerebral Venous Blood oxygenation through extracerebral Blood
Biomedical Optics Express, 2012Co-Authors: Irene Y Petrov, Yuriy Petrov, Donald S Prough, Inga Cicenaite, Donald J Deyo, Rinat O EsenalievAbstract:There is strong clinical evidence that controlling cerebral Venous oxygenation (oxyhemoglobin saturation) is critically important for patients with severe traumatic brain injury as well as for patients undergoing cardiac surgery. However, the only available method for cerebral Venous Blood oxygenation monitoring is invasive and requires catheterization of the internal jugular vein. We designed and built a novel optoacoustic monitor of cerebral Venous oxygenation as measured in the superior sagittal sinus (SSS), the large midline cerebral vein. To the best of our knowledge, optical monitoring of cerebral Venous Blood oxygenation through overlying extracerebral Blood is reported for the first time in this paper. The system was capable of detecting SSS signals in vivo at 700, 800, and 1064 nm through the thick (5–6 mm) sheep skull containing the circulating Blood. The high (submillimeter) in-depth resolution of the system provided identification of the SSS peaks in the optoacoustic signals. The SSS peak amplitude closely followed the actual SSS Blood oxygenation measured invasively using catheterization, Blood sampling, and “gold standard” CO-Oximetry. Our data indicate the system may provide accurate measurement of the SSS Blood oxygenation in patients with extracerebral Blood over the SSS.
Irene Y Petrov - One of the best experts on this subject based on the ideXlab platform.
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optoacoustic monitoring of cerebral Venous Blood oxygenation though intact scalp in large animals
Optics Express, 2012Co-Authors: Irene Y Petrov, Yuriy Petrov, Donald S Prough, Inga Cicenaite, Donald J Deyo, Rinat O EsenalievAbstract:Monitoring (currently invasive) of cerebral Venous Blood oxygenation is a key to avoiding hypoxia-induced brain injury resulting in death or severe disability. Noninvasive, optoacoustic monitoring of cerebral Venous Blood oxygenation can potentially replace existing invasive methods. To the best of our knowledge, we report for the first time noninvasive monitoring of cerebral Venous Blood oxygenation through intact scalp that was validated with invasive, “gold standard” measurements. We performed an in vivo study in the sheep superior sagittal sinus (SSS), a large midline cerebral vein, using our novel, multi-wavelength optoacoustic system. The study results demonstrated that: 1) the optoacoustic signal from the sheep SSS is detectable through the thick, intact scalp and skull; 2) the SSS signal amplitude correlated well with wavelength and actual SSS Blood oxygenation measured invasively using SSS catheterization, Blood sampling, and measurement with “gold standard” CO-Oximeter; 3) the optoacoustically predicted oxygenation strongly correlated with that measured with the CO-Oximeter. Our results indicate that monitoring of cerebral Venous Blood oxygenation may be performed in humans noninvasively and accurately through the intact scalp using optoacoustic systems because the sheep scalp and skull thickness is comparable to that of humans whereas the sheep SSS is much smaller than that of humans.
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optoacoustic monitoring of cerebral Venous Blood oxygenation through extracerebral Blood
Biomedical Optics Express, 2012Co-Authors: Irene Y Petrov, Yuriy Petrov, Donald S Prough, Inga Cicenaite, Donald J Deyo, Rinat O EsenalievAbstract:There is strong clinical evidence that controlling cerebral Venous oxygenation (oxyhemoglobin saturation) is critically important for patients with severe traumatic brain injury as well as for patients undergoing cardiac surgery. However, the only available method for cerebral Venous Blood oxygenation monitoring is invasive and requires catheterization of the internal jugular vein. We designed and built a novel optoacoustic monitor of cerebral Venous oxygenation as measured in the superior sagittal sinus (SSS), the large midline cerebral vein. To the best of our knowledge, optical monitoring of cerebral Venous Blood oxygenation through overlying extracerebral Blood is reported for the first time in this paper. The system was capable of detecting SSS signals in vivo at 700, 800, and 1064 nm through the thick (5–6 mm) sheep skull containing the circulating Blood. The high (submillimeter) in-depth resolution of the system provided identification of the SSS peaks in the optoacoustic signals. The SSS peak amplitude closely followed the actual SSS Blood oxygenation measured invasively using catheterization, Blood sampling, and “gold standard” CO-Oximetry. Our data indicate the system may provide accurate measurement of the SSS Blood oxygenation in patients with extracerebral Blood over the SSS.
Donald S Prough - One of the best experts on this subject based on the ideXlab platform.
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optoacoustic monitoring of cerebral Venous Blood oxygenation though intact scalp in large animals
Optics Express, 2012Co-Authors: Irene Y Petrov, Yuriy Petrov, Donald S Prough, Inga Cicenaite, Donald J Deyo, Rinat O EsenalievAbstract:Monitoring (currently invasive) of cerebral Venous Blood oxygenation is a key to avoiding hypoxia-induced brain injury resulting in death or severe disability. Noninvasive, optoacoustic monitoring of cerebral Venous Blood oxygenation can potentially replace existing invasive methods. To the best of our knowledge, we report for the first time noninvasive monitoring of cerebral Venous Blood oxygenation through intact scalp that was validated with invasive, “gold standard” measurements. We performed an in vivo study in the sheep superior sagittal sinus (SSS), a large midline cerebral vein, using our novel, multi-wavelength optoacoustic system. The study results demonstrated that: 1) the optoacoustic signal from the sheep SSS is detectable through the thick, intact scalp and skull; 2) the SSS signal amplitude correlated well with wavelength and actual SSS Blood oxygenation measured invasively using SSS catheterization, Blood sampling, and measurement with “gold standard” CO-Oximeter; 3) the optoacoustically predicted oxygenation strongly correlated with that measured with the CO-Oximeter. Our results indicate that monitoring of cerebral Venous Blood oxygenation may be performed in humans noninvasively and accurately through the intact scalp using optoacoustic systems because the sheep scalp and skull thickness is comparable to that of humans whereas the sheep SSS is much smaller than that of humans.
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optoacoustic monitoring of cerebral Venous Blood oxygenation through extracerebral Blood
Biomedical Optics Express, 2012Co-Authors: Irene Y Petrov, Yuriy Petrov, Donald S Prough, Inga Cicenaite, Donald J Deyo, Rinat O EsenalievAbstract:There is strong clinical evidence that controlling cerebral Venous oxygenation (oxyhemoglobin saturation) is critically important for patients with severe traumatic brain injury as well as for patients undergoing cardiac surgery. However, the only available method for cerebral Venous Blood oxygenation monitoring is invasive and requires catheterization of the internal jugular vein. We designed and built a novel optoacoustic monitor of cerebral Venous oxygenation as measured in the superior sagittal sinus (SSS), the large midline cerebral vein. To the best of our knowledge, optical monitoring of cerebral Venous Blood oxygenation through overlying extracerebral Blood is reported for the first time in this paper. The system was capable of detecting SSS signals in vivo at 700, 800, and 1064 nm through the thick (5–6 mm) sheep skull containing the circulating Blood. The high (submillimeter) in-depth resolution of the system provided identification of the SSS peaks in the optoacoustic signals. The SSS peak amplitude closely followed the actual SSS Blood oxygenation measured invasively using catheterization, Blood sampling, and “gold standard” CO-Oximetry. Our data indicate the system may provide accurate measurement of the SSS Blood oxygenation in patients with extracerebral Blood over the SSS.
Yuriy Petrov - One of the best experts on this subject based on the ideXlab platform.
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optoacoustic monitoring of cerebral Venous Blood oxygenation though intact scalp in large animals
Optics Express, 2012Co-Authors: Irene Y Petrov, Yuriy Petrov, Donald S Prough, Inga Cicenaite, Donald J Deyo, Rinat O EsenalievAbstract:Monitoring (currently invasive) of cerebral Venous Blood oxygenation is a key to avoiding hypoxia-induced brain injury resulting in death or severe disability. Noninvasive, optoacoustic monitoring of cerebral Venous Blood oxygenation can potentially replace existing invasive methods. To the best of our knowledge, we report for the first time noninvasive monitoring of cerebral Venous Blood oxygenation through intact scalp that was validated with invasive, “gold standard” measurements. We performed an in vivo study in the sheep superior sagittal sinus (SSS), a large midline cerebral vein, using our novel, multi-wavelength optoacoustic system. The study results demonstrated that: 1) the optoacoustic signal from the sheep SSS is detectable through the thick, intact scalp and skull; 2) the SSS signal amplitude correlated well with wavelength and actual SSS Blood oxygenation measured invasively using SSS catheterization, Blood sampling, and measurement with “gold standard” CO-Oximeter; 3) the optoacoustically predicted oxygenation strongly correlated with that measured with the CO-Oximeter. Our results indicate that monitoring of cerebral Venous Blood oxygenation may be performed in humans noninvasively and accurately through the intact scalp using optoacoustic systems because the sheep scalp and skull thickness is comparable to that of humans whereas the sheep SSS is much smaller than that of humans.
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optoacoustic monitoring of cerebral Venous Blood oxygenation through extracerebral Blood
Biomedical Optics Express, 2012Co-Authors: Irene Y Petrov, Yuriy Petrov, Donald S Prough, Inga Cicenaite, Donald J Deyo, Rinat O EsenalievAbstract:There is strong clinical evidence that controlling cerebral Venous oxygenation (oxyhemoglobin saturation) is critically important for patients with severe traumatic brain injury as well as for patients undergoing cardiac surgery. However, the only available method for cerebral Venous Blood oxygenation monitoring is invasive and requires catheterization of the internal jugular vein. We designed and built a novel optoacoustic monitor of cerebral Venous oxygenation as measured in the superior sagittal sinus (SSS), the large midline cerebral vein. To the best of our knowledge, optical monitoring of cerebral Venous Blood oxygenation through overlying extracerebral Blood is reported for the first time in this paper. The system was capable of detecting SSS signals in vivo at 700, 800, and 1064 nm through the thick (5–6 mm) sheep skull containing the circulating Blood. The high (submillimeter) in-depth resolution of the system provided identification of the SSS peaks in the optoacoustic signals. The SSS peak amplitude closely followed the actual SSS Blood oxygenation measured invasively using catheterization, Blood sampling, and “gold standard” CO-Oximetry. Our data indicate the system may provide accurate measurement of the SSS Blood oxygenation in patients with extracerebral Blood over the SSS.
Donald J Deyo - One of the best experts on this subject based on the ideXlab platform.
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optoacoustic monitoring of cerebral Venous Blood oxygenation though intact scalp in large animals
Optics Express, 2012Co-Authors: Irene Y Petrov, Yuriy Petrov, Donald S Prough, Inga Cicenaite, Donald J Deyo, Rinat O EsenalievAbstract:Monitoring (currently invasive) of cerebral Venous Blood oxygenation is a key to avoiding hypoxia-induced brain injury resulting in death or severe disability. Noninvasive, optoacoustic monitoring of cerebral Venous Blood oxygenation can potentially replace existing invasive methods. To the best of our knowledge, we report for the first time noninvasive monitoring of cerebral Venous Blood oxygenation through intact scalp that was validated with invasive, “gold standard” measurements. We performed an in vivo study in the sheep superior sagittal sinus (SSS), a large midline cerebral vein, using our novel, multi-wavelength optoacoustic system. The study results demonstrated that: 1) the optoacoustic signal from the sheep SSS is detectable through the thick, intact scalp and skull; 2) the SSS signal amplitude correlated well with wavelength and actual SSS Blood oxygenation measured invasively using SSS catheterization, Blood sampling, and measurement with “gold standard” CO-Oximeter; 3) the optoacoustically predicted oxygenation strongly correlated with that measured with the CO-Oximeter. Our results indicate that monitoring of cerebral Venous Blood oxygenation may be performed in humans noninvasively and accurately through the intact scalp using optoacoustic systems because the sheep scalp and skull thickness is comparable to that of humans whereas the sheep SSS is much smaller than that of humans.
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optoacoustic monitoring of cerebral Venous Blood oxygenation through extracerebral Blood
Biomedical Optics Express, 2012Co-Authors: Irene Y Petrov, Yuriy Petrov, Donald S Prough, Inga Cicenaite, Donald J Deyo, Rinat O EsenalievAbstract:There is strong clinical evidence that controlling cerebral Venous oxygenation (oxyhemoglobin saturation) is critically important for patients with severe traumatic brain injury as well as for patients undergoing cardiac surgery. However, the only available method for cerebral Venous Blood oxygenation monitoring is invasive and requires catheterization of the internal jugular vein. We designed and built a novel optoacoustic monitor of cerebral Venous oxygenation as measured in the superior sagittal sinus (SSS), the large midline cerebral vein. To the best of our knowledge, optical monitoring of cerebral Venous Blood oxygenation through overlying extracerebral Blood is reported for the first time in this paper. The system was capable of detecting SSS signals in vivo at 700, 800, and 1064 nm through the thick (5–6 mm) sheep skull containing the circulating Blood. The high (submillimeter) in-depth resolution of the system provided identification of the SSS peaks in the optoacoustic signals. The SSS peak amplitude closely followed the actual SSS Blood oxygenation measured invasively using catheterization, Blood sampling, and “gold standard” CO-Oximetry. Our data indicate the system may provide accurate measurement of the SSS Blood oxygenation in patients with extracerebral Blood over the SSS.
