The Experts below are selected from a list of 6525 Experts worldwide ranked by ideXlab platform
Bingsheng Huang - One of the best experts on this subject based on the ideXlab platform.
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patterns of gray matter abnormalities in idiopathic generalized epilepsy a meta analysis of voxel based morphology studies
PLOS ONE, 2017Co-Authors: Tianfu Wang, Hongwu Zeng, Xiaoming He, Feng Li, Bingsheng HuangAbstract:Objective We aimed to identify the consistent regions of gray matter volume (GMV) abnormalities in idiopathic generalized epilepsy (IGE), and to study the difference of GMV abnormalities among IGE subsyndromes by applying activation likelihood estimation (ALE) meta-analysis. Methods A systematic review of VBM studies on GMV of patients with absence epilepsy (AE), juvenile myoclonic epilepsy (JME), IGE and controls indexed in PubMed and ScienceDirect from January 1999 to June 2016 was conducted. A total of 12 IGE studies, including 7 JME and 3 AE studies, were selected. Meta-analysis was performed on these studies by using the pooled and within-subtypes analysis (www.brainmap.org). Based on the above results, between-subtypes contrast analysis was carried out to detect the abnormal GMV regions common in and unique to each subtype as well. Results IGE demonstrated significant GMV increase in right Ventral Lateral Nucleus (VL) and right medial frontal gyrus, and significant GMV decrease in biLateral pulvinar. For JME, significant GMV increase was seen in right medial frontal gyrus, right anterior cingulate cortex (ACC), while significant GMV decrease was found in right pulvinar. In AE, the most significant GMV increase was found in right VL, and slight GMV reduction was seen in right medial dorsal Nucleus, right subcallosal gyrus, left caudate and left precuneus. No overlapped and unique regions with significant GMV abnormalities were found between JME and AE. Significance This meta-analysis demonstrated that thalamo-frontal network was a structure with significant GMV abnormality in IGE, and the IGE subsyndromes showed different GMV abnormal regions. These observations may provide instructions on the clinical diagnosis of IGE.
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Results of ALE meta-analysis with GMV increase.
2017Co-Authors: Guo Bin, Hongwu Zeng, Tianfu Wang, Jian Zhang, Bingsheng HuangAbstract:Significant GMV increase was found in: for IGE, right Ventral Lateral Nucleus and right medial frontal gyrus; for JME, right medial frontal gyrus and right anterior cingulate; and for AE, right Ventral Lateral Nucleus. IGE, idiopathic generalized epilepsy; JME, juvenile myoclonic epilepsy; AE, absence epilepsy; ALE, activation likelihood estimation; GMV, gray matter volume.
Tianfu Wang - One of the best experts on this subject based on the ideXlab platform.
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patterns of gray matter abnormalities in idiopathic generalized epilepsy a meta analysis of voxel based morphology studies
PLOS ONE, 2017Co-Authors: Tianfu Wang, Hongwu Zeng, Xiaoming He, Feng Li, Bingsheng HuangAbstract:Objective We aimed to identify the consistent regions of gray matter volume (GMV) abnormalities in idiopathic generalized epilepsy (IGE), and to study the difference of GMV abnormalities among IGE subsyndromes by applying activation likelihood estimation (ALE) meta-analysis. Methods A systematic review of VBM studies on GMV of patients with absence epilepsy (AE), juvenile myoclonic epilepsy (JME), IGE and controls indexed in PubMed and ScienceDirect from January 1999 to June 2016 was conducted. A total of 12 IGE studies, including 7 JME and 3 AE studies, were selected. Meta-analysis was performed on these studies by using the pooled and within-subtypes analysis (www.brainmap.org). Based on the above results, between-subtypes contrast analysis was carried out to detect the abnormal GMV regions common in and unique to each subtype as well. Results IGE demonstrated significant GMV increase in right Ventral Lateral Nucleus (VL) and right medial frontal gyrus, and significant GMV decrease in biLateral pulvinar. For JME, significant GMV increase was seen in right medial frontal gyrus, right anterior cingulate cortex (ACC), while significant GMV decrease was found in right pulvinar. In AE, the most significant GMV increase was found in right VL, and slight GMV reduction was seen in right medial dorsal Nucleus, right subcallosal gyrus, left caudate and left precuneus. No overlapped and unique regions with significant GMV abnormalities were found between JME and AE. Significance This meta-analysis demonstrated that thalamo-frontal network was a structure with significant GMV abnormality in IGE, and the IGE subsyndromes showed different GMV abnormal regions. These observations may provide instructions on the clinical diagnosis of IGE.
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Results of ALE meta-analysis with GMV increase.
2017Co-Authors: Guo Bin, Hongwu Zeng, Tianfu Wang, Jian Zhang, Bingsheng HuangAbstract:Significant GMV increase was found in: for IGE, right Ventral Lateral Nucleus and right medial frontal gyrus; for JME, right medial frontal gyrus and right anterior cingulate; and for AE, right Ventral Lateral Nucleus. IGE, idiopathic generalized epilepsy; JME, juvenile myoclonic epilepsy; AE, absence epilepsy; ALE, activation likelihood estimation; GMV, gray matter volume.
Marina A J Tijssen - One of the best experts on this subject based on the ideXlab platform.
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functional mri study of response inhibition in myoclonus dystonia
Experimental Neurology, 2013Co-Authors: Sandra M A Van Der Salm, Johan N Van Der Meer, Aart J Nederveen, Dick J Veltman, Anne Fleur Van Rootselaar, Marina A J TijssenAbstract:Background: Myoclonus-dystonia (MD) is a movement disorder characterized by myoclonic jerks, dystonic postures and psychiatric co-morbidity. A mutation in the DYT11 gene underlies half of MD cases. We hypothesize that MD results from a dysfunctional basal ganglia network causing insufficient inhibitory motor control. To test this hypothesis functional MRI (fMRI) was performed using a validated "Go/No go" task, in order to localize blood-oxygen-level dependence (BOLD) effects corresponding to Response Inhibition (RI). Methods: Twenty-four MD patients (fifteen DYT11 positive) and 24 matched controls responded with a button press to Go (Go-Response) or No go (referred to as 'Stop') cues, resulting in analyses of accurate response suppression to Stop cues (Stop-Inhibit), and incorrect responses to Go cues (Go-Inhibit), or to Stop cues (Stop-Response). Results: Response accuracy in patients was impaired due to frequent Go-Inhibit errors. Image analysis of the Stop-Inhibit contrast demonstrated frontal, caudate and cingular activity in both groups. Compared to controls, MD patients showed increased primary motor cortex and insular activation. During Go-Inhibit trials, patients revealed increased activity in the contraLateral thalamus (Ventral Lateral Nucleus) and dorso-Lateral-prefrontal cortex. In a post-hoc analysis comparing MD patients, DYT11 positive patients demonstrated anterior cerebellum hyperactivation on all contrasts and increased putaminal activation in the Stop-Response contrast. Conclusions: This study demonstrates a distinct association of motor symptoms in MD with the Ventral Lateral Nucleus of the thalamus. Cerebellar dysfunction distinguishes DYT11 positive from negative patients. We suggest that MD might be best considered as a disorder of the cortico-ponto-cerebello-thalamo-cortical system. (C) 2013 Elsevier Inc. All rights reserved.
R. C. Miall - One of the best experts on this subject based on the ideXlab platform.
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Temporary inactivation in the primate motor thalamus during visually triggered and internally generated limb movements.
2000Co-Authors: Van Donkelaar P, Richard E. Passingham, Jf Stein, R. C. MiallAbstract:To better understand the contribution of cerebellar- and basal ganglia-receiving areas of the thalamus [Ventral posteroLateral Nucleus, pars oralis (VPLo), area X, Ventral Lateral Nucleus, pars oralis (VLo), or Ventral anterior Nucleus, pars parvicellularis (VApc)] to movements based on external versus internal cues, we temporarily inactivated these individual nuclei in two monkeys trained to make visually triggered (VT) and internally generated (IG) limb movements. Infusions of lignocaine centered within VPLo caused hemiplegia during which movements of the contraLateral arm rarely were performed in either task for a short period of time ( approximately 5-30 min). When VT responses were produced, they had prolonged reaction times and movement times and a higher incidence of trajectory abnormalities compared with responses produced during the preinfusion baseline period. In contrast, those IG responses that were produced remained relatively normal. Infusions centered within area X never caused hemiplegia. The only deficits observed were an increase in reaction time and movement amplitude variability and a higher incidence of trajectory abnormalities during VT trials. Every other aspect of both the VT and IG movements remained unchanged. Infusions centered within VLo reduced the number of movements attempted during each block of trials. This did not appear to be due to hemiplegia, however, as voluntary movements easily could be elicited outside of the trained tasks. The other main deficit resulting from inactivation of VLo was an increased reaction time in the VT task. Finally, infusions centered within VApc caused IG movements to become slower and smaller in amplitude, whereas VT movements remained unchanged. Control infusions with saline did not cause any consistent deficits. This pattern of results implies that VPLo and VLo play a role in the production of movements in general regardless of the context under which they are performed. They also suggest that VPLo contributes more specifically to the execution of movements that are visually triggered and guided, whereas area X contributes specifically to the initiation of such movements. In contrast, VApc appears to play a role in the execution of movements based on internal cues. These results are consistent with the hypothesis that specific subcircuits within the cerebello- and basal ganglio-thalamo-cortical systems preferentially contribute to movements based on external versus internal cues
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Temporary inactivation in the primate motor thalamus during visually triggered and internally generated limb movements
2000Co-Authors: P. Van Donkelaar, John F. Stein, Richard E. Passingham, R. C. MiallAbstract:Temporary inactivation in the primate motor thalamus during visually triggered and internally generated limb movements. J. Neurophysiol. 83: 2780–2790, 2000. To better understand the contribution of cerebellar-and basal ganglia-receiving areas of the thalamus [Ventral posteroLateral Nucleus, pars oralis (VPLo), area X, Ventral Lateral Nucleus, pars oralis (VLo), or Ventral anterior Nucleus, pars parvicellularis (VApc)] to movements based on external versus internal cues, we temporarily inactivated these individual nuclei in two monkeys trained to make visually triggered (VT) and internally generated (IG) limb movements. Infusions of lignocaine centered within VPLo caused hemiplegia during which movements of the contraLateral arm rarely were performed in either task for a short period of time (�5–30 min). When VT responses were produced, they had prolonged reaction times and movement times and a higher incidence of trajectory abnormalities compared with responses produced during the preinfusio
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Neuronal activity in the primate motor thalamus during visually triggered and internally generated limb movements.
1999Co-Authors: Van Donkelaar P, Richard E. Passingham, Jf Stein, R. C. MiallAbstract:Single-unit recordings were made from the basal-ganglia- and cerebellar-receiving areas of the thalamus in two monkeys trained to make arm movements that were either visually triggered (VT) or internally generated (IG). A total of 203 neurons displaying movement-related changes in activity were examined in detail. Most of these cells (69%) showed an increase in firing rate in relation to the onset of movement and could be categorized according to whether they fired in the VT task exclusively, in the IG task exclusively, or in both tasks. The proportion of cells in each category was found to vary between each of the cerebellar-receiving [oral portion of the Ventral posteroLateral Nucleus (VPLo) and area X] and basal-ganglia-receiving [oral portion of the Ventral Lateral Nucleus (VLo) and parvocellular portion of the Ventral anterior Nucleus (VApc)] nuclei that were examined. In particular, in area X the largest group of cells (52%) showed an increase in activity during the VT task only, whereas in VApc the largest group of cells (53%) fired in the IG task only. In contrast to this, relatively high degree of task specificity, in both VPLo and VLo the largest group of cells ( approximately 55%) burst in relation to both tasks. Of the cells that were active in both tasks, a higher proportion were preferentially active in the VT task in VPLo and area X, and the IG task in VLo and VApc. In addition, cells in all four nuclei became active earlier relative to movement onset in the IG task compared with the VT task. These results demonstrate that functional distinctions do exist in the cerebellar- and basal-ganglia-receiving portions of the primate motor thalamus in relation to the types of cues used to initiate and control movement. These distinctions are most clear in area X and VApc, and are much less apparent in VPLo and VLo
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Neuronal activity in the primate motor thalamus during visually triggered and internally generated limb movements
1999Co-Authors: P. Van Donkelaar, Richard E. Passingham, R. C. Miall, Jf Stein, Van DonkelaarAbstract:Neuronal activity in the primate motor thalamus during visually triggered and internally generated limb movements. J. Neurophysiol. 82: 934–945, 1999. Single-unit recordings were made from the basalganglia-and cerebellar-receiving areas of the thalamus in two monkeys trained to make arm movements that were either visually triggered (VT) or internally generated (IG). A total of 203 neurons displaying movement-related changes in activity were examined in detail. Most of these cells (69%) showed an increase in firing rate in relation to the onset of movement and could be categorized according to whether they fired in the VT task exclusively, in the IG task exclusively, or in both tasks. The proportion of cells in each category was found to vary between each of the cerebellar-receiving [oral portion of the Ventral posteroLateral Nucleus (VPLo) and area X] and basal-ganglia-receiving [oral portion of the Ventral Lateral Nucleus (VLo) and parvocellular portion of the Ventral anterior Nucleus (VApc)] nuclei that were examined. In particular, in area X the largest group of cells (52%) showed an increase in activity during the VT task only, whereas in VApc the largest group of cells (53%) fired in the IG task only. In contrast to this, relatively high degree of task specificity, in both VPLo and VLo the largest group of cells (�55%) burst in relation to both tasks. Of the cells that were active in both tasks, a higher proportion were preferentially active in the VT task in VPLo and area X, and the IG task in VLo and VApc. In addition, cells in all four nuclei became active earlier relative to movement onset in the IG task compared with the VT task. These results demonstrate that functional distinctions do exist in the cerebellar- and basal-gangliareceiving portions of the primate motor thalamus in relation to the types of cues used to initiate and control movement. These distinctions are most clear in area X and VApc, and are much less apparent in VPLo and VLo
Hongwu Zeng - One of the best experts on this subject based on the ideXlab platform.
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patterns of gray matter abnormalities in idiopathic generalized epilepsy a meta analysis of voxel based morphology studies
PLOS ONE, 2017Co-Authors: Tianfu Wang, Hongwu Zeng, Xiaoming He, Feng Li, Bingsheng HuangAbstract:Objective We aimed to identify the consistent regions of gray matter volume (GMV) abnormalities in idiopathic generalized epilepsy (IGE), and to study the difference of GMV abnormalities among IGE subsyndromes by applying activation likelihood estimation (ALE) meta-analysis. Methods A systematic review of VBM studies on GMV of patients with absence epilepsy (AE), juvenile myoclonic epilepsy (JME), IGE and controls indexed in PubMed and ScienceDirect from January 1999 to June 2016 was conducted. A total of 12 IGE studies, including 7 JME and 3 AE studies, were selected. Meta-analysis was performed on these studies by using the pooled and within-subtypes analysis (www.brainmap.org). Based on the above results, between-subtypes contrast analysis was carried out to detect the abnormal GMV regions common in and unique to each subtype as well. Results IGE demonstrated significant GMV increase in right Ventral Lateral Nucleus (VL) and right medial frontal gyrus, and significant GMV decrease in biLateral pulvinar. For JME, significant GMV increase was seen in right medial frontal gyrus, right anterior cingulate cortex (ACC), while significant GMV decrease was found in right pulvinar. In AE, the most significant GMV increase was found in right VL, and slight GMV reduction was seen in right medial dorsal Nucleus, right subcallosal gyrus, left caudate and left precuneus. No overlapped and unique regions with significant GMV abnormalities were found between JME and AE. Significance This meta-analysis demonstrated that thalamo-frontal network was a structure with significant GMV abnormality in IGE, and the IGE subsyndromes showed different GMV abnormal regions. These observations may provide instructions on the clinical diagnosis of IGE.
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Results of ALE meta-analysis with GMV increase.
2017Co-Authors: Guo Bin, Hongwu Zeng, Tianfu Wang, Jian Zhang, Bingsheng HuangAbstract:Significant GMV increase was found in: for IGE, right Ventral Lateral Nucleus and right medial frontal gyrus; for JME, right medial frontal gyrus and right anterior cingulate; and for AE, right Ventral Lateral Nucleus. IGE, idiopathic generalized epilepsy; JME, juvenile myoclonic epilepsy; AE, absence epilepsy; ALE, activation likelihood estimation; GMV, gray matter volume.
