The Experts below are selected from a list of 39 Experts worldwide ranked by ideXlab platform
Charles Erlichman - One of the best experts on this subject based on the ideXlab platform.
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Large cell carcinoma with calcitonin and vasoactive intestinal polypeptide-associated Verner-Morrison Syndrome
Mayo Clinic proceedings, 2005Co-Authors: Keith W. Pratz, Cynthia X., Marie Christine Aubry, Terri J. Vrtiska, Charles ErlichmanAbstract:Verner-Morrison Syndrome, characterized by diarrhea, hypokalemia, and hypochlorhydria, is caused most commonly by vasoactive intestinal polypeptide–secreting islet cell tumors of the pancreas. Verner-Morrison Syndrome has not been described as a paraneoplastic Syndrome in non–small cell lung cancer. We describe a 38-year-old man with metastatic non–small cell lung cancer of large cell carcinoma with neuroendocrine differentiation who presented with bone metastasis and intractable secretory diarrhea that was unresponsive to pharmacological treatment, including octreotide. Laboratory evaluation indicated elevated serum calcitonin and vasoactive intestinal polypeptide levels. Chemotherapy resulted in a transient response in the patient's diarrhea and neuroendocrine markers. The patient did not respond to further therapy and died 5 months after onset of back pain. To our knowledge, this is the first published case of large cell carcinoma with neuroendocrine differentiation associated with treatmentresponsive paraneoplastic Verner-Morrison Syndrome.
Keith W. Pratz - One of the best experts on this subject based on the ideXlab platform.
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Large cell carcinoma with calcitonin and vasoactive intestinal polypeptide-associated Verner-Morrison Syndrome
Mayo Clinic proceedings, 2005Co-Authors: Keith W. Pratz, Cynthia X., Marie Christine Aubry, Terri J. Vrtiska, Charles ErlichmanAbstract:Verner-Morrison Syndrome, characterized by diarrhea, hypokalemia, and hypochlorhydria, is caused most commonly by vasoactive intestinal polypeptide–secreting islet cell tumors of the pancreas. Verner-Morrison Syndrome has not been described as a paraneoplastic Syndrome in non–small cell lung cancer. We describe a 38-year-old man with metastatic non–small cell lung cancer of large cell carcinoma with neuroendocrine differentiation who presented with bone metastasis and intractable secretory diarrhea that was unresponsive to pharmacological treatment, including octreotide. Laboratory evaluation indicated elevated serum calcitonin and vasoactive intestinal polypeptide levels. Chemotherapy resulted in a transient response in the patient's diarrhea and neuroendocrine markers. The patient did not respond to further therapy and died 5 months after onset of back pain. To our knowledge, this is the first published case of large cell carcinoma with neuroendocrine differentiation associated with treatmentresponsive paraneoplastic Verner-Morrison Syndrome.
Marie Christine Aubry - One of the best experts on this subject based on the ideXlab platform.
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Large cell carcinoma with calcitonin and vasoactive intestinal polypeptide-associated Verner-Morrison Syndrome
Mayo Clinic proceedings, 2005Co-Authors: Keith W. Pratz, Cynthia X., Marie Christine Aubry, Terri J. Vrtiska, Charles ErlichmanAbstract:Verner-Morrison Syndrome, characterized by diarrhea, hypokalemia, and hypochlorhydria, is caused most commonly by vasoactive intestinal polypeptide–secreting islet cell tumors of the pancreas. Verner-Morrison Syndrome has not been described as a paraneoplastic Syndrome in non–small cell lung cancer. We describe a 38-year-old man with metastatic non–small cell lung cancer of large cell carcinoma with neuroendocrine differentiation who presented with bone metastasis and intractable secretory diarrhea that was unresponsive to pharmacological treatment, including octreotide. Laboratory evaluation indicated elevated serum calcitonin and vasoactive intestinal polypeptide levels. Chemotherapy resulted in a transient response in the patient's diarrhea and neuroendocrine markers. The patient did not respond to further therapy and died 5 months after onset of back pain. To our knowledge, this is the first published case of large cell carcinoma with neuroendocrine differentiation associated with treatmentresponsive paraneoplastic Verner-Morrison Syndrome.
Cynthia X. - One of the best experts on this subject based on the ideXlab platform.
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Large cell carcinoma with calcitonin and vasoactive intestinal polypeptide-associated Verner-Morrison Syndrome
Mayo Clinic proceedings, 2005Co-Authors: Keith W. Pratz, Cynthia X., Marie Christine Aubry, Terri J. Vrtiska, Charles ErlichmanAbstract:Verner-Morrison Syndrome, characterized by diarrhea, hypokalemia, and hypochlorhydria, is caused most commonly by vasoactive intestinal polypeptide–secreting islet cell tumors of the pancreas. Verner-Morrison Syndrome has not been described as a paraneoplastic Syndrome in non–small cell lung cancer. We describe a 38-year-old man with metastatic non–small cell lung cancer of large cell carcinoma with neuroendocrine differentiation who presented with bone metastasis and intractable secretory diarrhea that was unresponsive to pharmacological treatment, including octreotide. Laboratory evaluation indicated elevated serum calcitonin and vasoactive intestinal polypeptide levels. Chemotherapy resulted in a transient response in the patient's diarrhea and neuroendocrine markers. The patient did not respond to further therapy and died 5 months after onset of back pain. To our knowledge, this is the first published case of large cell carcinoma with neuroendocrine differentiation associated with treatmentresponsive paraneoplastic Verner-Morrison Syndrome.
Terri J. Vrtiska - One of the best experts on this subject based on the ideXlab platform.
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Large cell carcinoma with calcitonin and vasoactive intestinal polypeptide-associated Verner-Morrison Syndrome
Mayo Clinic proceedings, 2005Co-Authors: Keith W. Pratz, Cynthia X., Marie Christine Aubry, Terri J. Vrtiska, Charles ErlichmanAbstract:Verner-Morrison Syndrome, characterized by diarrhea, hypokalemia, and hypochlorhydria, is caused most commonly by vasoactive intestinal polypeptide–secreting islet cell tumors of the pancreas. Verner-Morrison Syndrome has not been described as a paraneoplastic Syndrome in non–small cell lung cancer. We describe a 38-year-old man with metastatic non–small cell lung cancer of large cell carcinoma with neuroendocrine differentiation who presented with bone metastasis and intractable secretory diarrhea that was unresponsive to pharmacological treatment, including octreotide. Laboratory evaluation indicated elevated serum calcitonin and vasoactive intestinal polypeptide levels. Chemotherapy resulted in a transient response in the patient's diarrhea and neuroendocrine markers. The patient did not respond to further therapy and died 5 months after onset of back pain. To our knowledge, this is the first published case of large cell carcinoma with neuroendocrine differentiation associated with treatmentresponsive paraneoplastic Verner-Morrison Syndrome.
