The Experts below are selected from a list of 228 Experts worldwide ranked by ideXlab platform
Gerald S Berenson - One of the best experts on this subject based on the ideXlab platform.
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association of fasting insulin level with serum lipid and Lipoprotein levels in children adolescents and young adults the bogalusa heart study
JAMA Internal Medicine, 1995Co-Authors: Xiaozhang Jiang, Sathanur R Srinivasan, Larry S Webber, Wendy A Wattigney, Gerald S BerensonAbstract:Objective: To assess whether circulating insulin is a major contributor to adverse lipid profiles during the transition from adolescence to young adulthood. Methods: The association between fasting insulin levels and serum lipid and Lipoprotein levels was examined in a cross-sectional survey of 4136 young individuals aged 5 to 30 years from a biracial community. Results: Fasting insulin levels were strongly and positively correlated with serum triglyceride and Very-Low-Density Lipoprotein Cholesterol levels and negatively correlated with high-density Lipoprotein Cholesterol levels in all age groups (5 to 11, 12 to 17, 19 to 24, and 25 to 30 years). An increasing impact of insulin level on low-density Lipoprotein Cholesterol level was observed in young adults aged 25 to 30 years. In multivariate analysis, fasting insulin level was associated with Very-Low-Density Lipoprotein Cholesterol level for most of the age groups in both races independently of age, sex, glucose levels, obesity, cigarette smoking, and alcohol intake. The independent relationship to low-density Lipoprotein Cholesterol level persisted in young adults aged 25 to 30 years. The independent and negative association with high-density Lipoprotein Cholesterol level remained in whites aged 5 to 24 years and blacks aged 19 to 24 years. When individuals were divided into tertiles according to insulin concentration and subscapular skinfold thickness, the independent effect of insulin level and obesity on Lipoprotein fractions was also noted. Furthermore, a stronger association of insulin level with Lipoprotein fractions was observed in obese than in lean white males. Conclusions: These data indicate that an increasing association of insulin levels with adverse Lipoprotein levels in young adults, especially obese individuals, may have adverse consequence for adult cardiovascular diseases. (Arch Intern Med. 1995;155:190-196)
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Coexistence of increased levels of adiposity, insulin, and blood pressure in a young adult cohort with elevated Very-Low-Density Lipoprotein Cholesterol : the Bogalusa heart study
Metabolism: clinical and experimental, 1993Co-Authors: Sathanur R Srinivasan, Weihang Bao, Gerald S BerensonAbstract:Clustering and interrelationships of elevated levels (>75th percentile) of adiposity, insulin, blood pressure, and Very-Low-Density Lipoprotein Cholesterol (VLDL-C) were examined in a selected subset (n = 89) of a young adult cohort aged 18 to 26 years, whose childhood (ages 10 to 18 years) VLDL-C and/or low-density Lipoprotein Cholesterol (LDL-C) levels were in the upper or lower percentiles of the distribution. Among the young adults with elevated VLDL-C and LDL-C levels, 23% had increased adiposity and systolic blood pressure, 17% had increased insulin levels and systolic blood pressure, 17% had increased insulin levels and adiposity, and 13% had increased insulin levels, adiposity, and systolic blood pressure; corresponding values among those with elevated VLDL-C and normal (
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Race and gender differences in serum Lipoproteins of children, adolescents, and young adults--emergence of an adverse Lipoprotein pattern in white males: the Bogalusa Heart Study.
Preventive medicine, 1991Co-Authors: Sathanur R Srinivasan, Larry S Webber, Wendy A Wattigney, Gerald S BerensonAbstract:Abstract Methods. Serum Lipoprotein profiles in 4,231 individuals, ages 5–26 years, were studied cross-sectionally in a biracial community to describe the race- and gender-specific changes from adolescence into young adulthood. Results. White children and adolescents of both genders showed significantly higher covariates—adjusted triglycerides (9–11 mg/dl) and Very-Low-Density Lipoprotein Cholesterol (1–2 mg/dl)—and lower total Cholesterol (3–14 mg/dl) and high-density Lipoprotein Cholesterol (6–10 mg/dl) levels than their black counterparts. These black-white differences persisted among young adults of both genders with the exception of total Cholesterol levels (higher triglycerides: 23–32 mg/dl; higher Very-Low-Density Lipoprotein Cholesterol: 5–7 mg/dl; lower high-density Lipoprotein Cholesterol: 9–11 mg/dl); in addition, white young adult males began to show higher levels of low-density Lipoprotein Cholesterol (14 mg/dl) than black young adult males. A consistent gender-related pattern emerged only among white young adults with males showing higher triglyceride levels (22 mg/dl), Very-Low-Density Lipoprotein Cholesterol (5 mg/dl), and low-density Lipoprotein Cholesterol (10 mg/dl) and lower high-density Lipoprotein Cholesterol (10 mg/dl) than females. Lipoprotein changes from adolescence into young adulthood were more pronounced among white males than other race-gender groups, resulting in higher triglyceride, Very-Low-Density Lipoprotein Cholesterol, and low-density Lipoprotein Cholesterol, a higher total Cholesterol/high-density Lipoprotein Cholesterol ratio, and a lower high-density Lipoprotein Cholesterol in their young adulthood. According to the National Cholesterol Education Program criteria, a relatively higher proportion of young adult white males was classified as borderline-high (22.6%) or high (9.1%) for low-density Lipoprotein Cholesterol. Adiposity was the major contributor to the adverse Lipoprotein pattern, especially among white males. Sexual maturation and age influenced the Lipoprotein levels to a greater extent among white males. Cigarette smoking, alcohol intake, and oral contraceptive use began to emerge as minor but significant factors contributing to the Lipoprotein levels in adolescents and young adults. Conclusion. These results underscore the desirability of early targeting for primary prevention.
Sathanur R Srinivasan - One of the best experts on this subject based on the ideXlab platform.
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association of fasting insulin level with serum lipid and Lipoprotein levels in children adolescents and young adults the bogalusa heart study
JAMA Internal Medicine, 1995Co-Authors: Xiaozhang Jiang, Sathanur R Srinivasan, Larry S Webber, Wendy A Wattigney, Gerald S BerensonAbstract:Objective: To assess whether circulating insulin is a major contributor to adverse lipid profiles during the transition from adolescence to young adulthood. Methods: The association between fasting insulin levels and serum lipid and Lipoprotein levels was examined in a cross-sectional survey of 4136 young individuals aged 5 to 30 years from a biracial community. Results: Fasting insulin levels were strongly and positively correlated with serum triglyceride and Very-Low-Density Lipoprotein Cholesterol levels and negatively correlated with high-density Lipoprotein Cholesterol levels in all age groups (5 to 11, 12 to 17, 19 to 24, and 25 to 30 years). An increasing impact of insulin level on low-density Lipoprotein Cholesterol level was observed in young adults aged 25 to 30 years. In multivariate analysis, fasting insulin level was associated with Very-Low-Density Lipoprotein Cholesterol level for most of the age groups in both races independently of age, sex, glucose levels, obesity, cigarette smoking, and alcohol intake. The independent relationship to low-density Lipoprotein Cholesterol level persisted in young adults aged 25 to 30 years. The independent and negative association with high-density Lipoprotein Cholesterol level remained in whites aged 5 to 24 years and blacks aged 19 to 24 years. When individuals were divided into tertiles according to insulin concentration and subscapular skinfold thickness, the independent effect of insulin level and obesity on Lipoprotein fractions was also noted. Furthermore, a stronger association of insulin level with Lipoprotein fractions was observed in obese than in lean white males. Conclusions: These data indicate that an increasing association of insulin levels with adverse Lipoprotein levels in young adults, especially obese individuals, may have adverse consequence for adult cardiovascular diseases. (Arch Intern Med. 1995;155:190-196)
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Coexistence of increased levels of adiposity, insulin, and blood pressure in a young adult cohort with elevated Very-Low-Density Lipoprotein Cholesterol : the Bogalusa heart study
Metabolism: clinical and experimental, 1993Co-Authors: Sathanur R Srinivasan, Weihang Bao, Gerald S BerensonAbstract:Clustering and interrelationships of elevated levels (>75th percentile) of adiposity, insulin, blood pressure, and Very-Low-Density Lipoprotein Cholesterol (VLDL-C) were examined in a selected subset (n = 89) of a young adult cohort aged 18 to 26 years, whose childhood (ages 10 to 18 years) VLDL-C and/or low-density Lipoprotein Cholesterol (LDL-C) levels were in the upper or lower percentiles of the distribution. Among the young adults with elevated VLDL-C and LDL-C levels, 23% had increased adiposity and systolic blood pressure, 17% had increased insulin levels and systolic blood pressure, 17% had increased insulin levels and adiposity, and 13% had increased insulin levels, adiposity, and systolic blood pressure; corresponding values among those with elevated VLDL-C and normal (
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Race and gender differences in serum Lipoproteins of children, adolescents, and young adults--emergence of an adverse Lipoprotein pattern in white males: the Bogalusa Heart Study.
Preventive medicine, 1991Co-Authors: Sathanur R Srinivasan, Larry S Webber, Wendy A Wattigney, Gerald S BerensonAbstract:Abstract Methods. Serum Lipoprotein profiles in 4,231 individuals, ages 5–26 years, were studied cross-sectionally in a biracial community to describe the race- and gender-specific changes from adolescence into young adulthood. Results. White children and adolescents of both genders showed significantly higher covariates—adjusted triglycerides (9–11 mg/dl) and Very-Low-Density Lipoprotein Cholesterol (1–2 mg/dl)—and lower total Cholesterol (3–14 mg/dl) and high-density Lipoprotein Cholesterol (6–10 mg/dl) levels than their black counterparts. These black-white differences persisted among young adults of both genders with the exception of total Cholesterol levels (higher triglycerides: 23–32 mg/dl; higher Very-Low-Density Lipoprotein Cholesterol: 5–7 mg/dl; lower high-density Lipoprotein Cholesterol: 9–11 mg/dl); in addition, white young adult males began to show higher levels of low-density Lipoprotein Cholesterol (14 mg/dl) than black young adult males. A consistent gender-related pattern emerged only among white young adults with males showing higher triglyceride levels (22 mg/dl), Very-Low-Density Lipoprotein Cholesterol (5 mg/dl), and low-density Lipoprotein Cholesterol (10 mg/dl) and lower high-density Lipoprotein Cholesterol (10 mg/dl) than females. Lipoprotein changes from adolescence into young adulthood were more pronounced among white males than other race-gender groups, resulting in higher triglyceride, Very-Low-Density Lipoprotein Cholesterol, and low-density Lipoprotein Cholesterol, a higher total Cholesterol/high-density Lipoprotein Cholesterol ratio, and a lower high-density Lipoprotein Cholesterol in their young adulthood. According to the National Cholesterol Education Program criteria, a relatively higher proportion of young adult white males was classified as borderline-high (22.6%) or high (9.1%) for low-density Lipoprotein Cholesterol. Adiposity was the major contributor to the adverse Lipoprotein pattern, especially among white males. Sexual maturation and age influenced the Lipoprotein levels to a greater extent among white males. Cigarette smoking, alcohol intake, and oral contraceptive use began to emerge as minor but significant factors contributing to the Lipoprotein levels in adolescents and young adults. Conclusion. These results underscore the desirability of early targeting for primary prevention.
Muredach P. Reilly - One of the best experts on this subject based on the ideXlab platform.
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Very low density Lipoprotein Cholesterol associates with coronary artery calcification in type 2 diabetes beyond circulating levels of triglycerides
Atherosclerosis, 2014Co-Authors: Stuart B. Prenner, Claire K. Mulvey, Jane F. Ferguson, Michael R. Rickels, Anish B. Bhatt, Muredach P. ReillyAbstract:Objective While recent genomic studies have focused attention on triglyceride (TG) rich Lipoproteins in cardiovascular disease (CVD), little is known of very low-density Lipoprotein Cholesterol (VLDL-C) relationship with atherosclerosis and CVD. We examined, in a high-risk type-2 diabetic population, the association of plasma VLDL-C with coronary artery calcification (CAC).
Yongyan Song - One of the best experts on this subject based on the ideXlab platform.
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Very low-density Lipoprotein Cholesterol is associated with extent and severity of coronary artery disease in patients with type 2 diabetes mellitus.
SAGE open medicine, 2019Co-Authors: Aimei Jia, Wei Zeng, Huirun Zeng, Yongyan SongAbstract:Objective:Patients with type 2 diabetes mellitus usually have multiple cardiovascular disease risk factors. The objective of this study was to examine the severity and associated risk factors in co...
Paul M. Ridker - One of the best experts on this subject based on the ideXlab platform.
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Safety Profile of Subjects Treated to Very Low Low-Density Lipoprotein Cholesterol Levels (
The American journal of cardiology, 2014Co-Authors: Brendan M. Everett, Samia Mora, Robert J. Glynn, Jean G. Macfadyen, Paul M. RidkerAbstract:Recent US guidelines expand the indications for high-intensity statin therapy, yet data on the safety of attaining very low-density Lipoprotein Cholesterol (LDL-C) levels are scarce. Among 16,304 participants in the Justification for the Use of Statins in Prevention: An Intervention Trial Evaluating Rosuvastatin (JUPITER) with on-treatment LDL-C levels, we identified 767 who did and 7,387 who did not achieve LDL-C
