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Lucia Corina Dimacozma - One of the best experts on this subject based on the ideXlab platform.
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distinct activation of the sympathetic adreno medullar system and hypothalamus pituitary adrenal axis following the caloric Vestibular Test in healthy subjects
PLOS ONE, 2018Co-Authors: Sebastian Cozma, Cristina Mihaela Ghiciuc, Lisandra Damian, Vittorio Pasquali, Angelo Saponaro, Elena Catalina Lupusoru, Francesca Romana Patacchioli, Lucia Corina DimacozmaAbstract:Introduction The Vestibular acute stress induces reversible alert-like reactions that involve the sympathetic adrenal-medullar system and hypothalamic-pituitary-adrenal axis responses. The present study aimed to evaluate salivary α-amylase and salivary cortisol production in relation with cardiovascular reactivity induced by acute stress in healthy subjects. Material and methods Forty-eight young healthy male volunteers were examined under basal conditions and at various times after reaching the maximal nystagmic reaction following air caloric Vestibular Test. Heart rate, systolic blood pressure, diastolic blood pressure and mean arterial pressure were recorded at the same time as measurement of the salivary α-amylase and salivary cortisol. At the end of the caloric Vestibular Test session, perceived stress scale questionnaires were administered to measure the self-perceived stress impact induced by the task, and individual scores were compared with those measured on the enrollment day. Results Following caloric Vestibular Test-evoked vertigo, salivary α-amylase and cortisol showed distinct trends in their production after acute stress: Student’s t-Test was used to compare the α-amylase vs cortisol slopes of the respective interpolated regression lines, and the difference was significant (t = -3.283; p<0.001); an increase in salivary cortisol production corresponded with a decrease in the salivary α-amylase concentration. In addition, salivary biomarker modifications were associated with consistent changes in the heart rate, systolic blood pressure and mean arterial pressure. Conclusions Using the air caloric Vestibular Test task as a stressor, the present study demonstrated a connection between the acute hormonal stress response to Vestibular stimulation and cardiovascular output. However, further research is needed before we can define the potential importance of the consistent cardiovascular activity changes evoked by Vestibular stimulation and the possible functional consequences for cardiovascular regulation and orthostatic tolerance in humans.
Leonard R Proctor - One of the best experts on this subject based on the ideXlab platform.
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benign paroxysmal positional vertigo
Laryngoscope, 1997Co-Authors: C A Hughes, Leonard R ProctorAbstract:Benign paroxysmal positional vertigo (BPPV) has received renewed clinical interest. At the Johns Hopkins Otological Vestibular Laboratory, 781 patients were Tested on more than one occasion between September 1976 and November 1992. Of these patients, 187 (24%) were found to have positional nystagmus consistent with a diagnosis of BPPV. A retrospective analysis of these patients' records, including Vestibular Test and eye movement reports, audiograms, questionnaires, and hospital charts was performed After this review, the nystagmus, initially diagnosed as due to BPPV, was believed to be a manifestation of another disease process in 36 cases. Of the remaining 151 cases, 52 (34%) presented with no significant preceding disorder and have been termed primary BPPV. In the remaining 99 patients we found coexisting or associated disorders which included Meniere's disease, head trauma, prior ear surgery, Vestibular neuronitis, migraine, and others. Forty-five of these 151 patients (31%) had an associated diagnosis of Meniere's disease. To our knowledge a significant association between Meniere's disease and BPPV has not been reported. A review of the literature with discussion of BPPV and the associated disorders is offered.
Sebastian Cozma - One of the best experts on this subject based on the ideXlab platform.
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distinct activation of the sympathetic adreno medullar system and hypothalamus pituitary adrenal axis following the caloric Vestibular Test in healthy subjects
PLOS ONE, 2018Co-Authors: Sebastian Cozma, Cristina Mihaela Ghiciuc, Lisandra Damian, Vittorio Pasquali, Angelo Saponaro, Elena Catalina Lupusoru, Francesca Romana Patacchioli, Lucia Corina DimacozmaAbstract:Introduction The Vestibular acute stress induces reversible alert-like reactions that involve the sympathetic adrenal-medullar system and hypothalamic-pituitary-adrenal axis responses. The present study aimed to evaluate salivary α-amylase and salivary cortisol production in relation with cardiovascular reactivity induced by acute stress in healthy subjects. Material and methods Forty-eight young healthy male volunteers were examined under basal conditions and at various times after reaching the maximal nystagmic reaction following air caloric Vestibular Test. Heart rate, systolic blood pressure, diastolic blood pressure and mean arterial pressure were recorded at the same time as measurement of the salivary α-amylase and salivary cortisol. At the end of the caloric Vestibular Test session, perceived stress scale questionnaires were administered to measure the self-perceived stress impact induced by the task, and individual scores were compared with those measured on the enrollment day. Results Following caloric Vestibular Test-evoked vertigo, salivary α-amylase and cortisol showed distinct trends in their production after acute stress: Student’s t-Test was used to compare the α-amylase vs cortisol slopes of the respective interpolated regression lines, and the difference was significant (t = -3.283; p<0.001); an increase in salivary cortisol production corresponded with a decrease in the salivary α-amylase concentration. In addition, salivary biomarker modifications were associated with consistent changes in the heart rate, systolic blood pressure and mean arterial pressure. Conclusions Using the air caloric Vestibular Test task as a stressor, the present study demonstrated a connection between the acute hormonal stress response to Vestibular stimulation and cardiovascular output. However, further research is needed before we can define the potential importance of the consistent cardiovascular activity changes evoked by Vestibular stimulation and the possible functional consequences for cardiovascular regulation and orthostatic tolerance in humans.
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Distinct activation of the sympathetic adreno-medullar system and hypothalamus pituitary adrenal axis following the caloric Vestibular Test in healthy subjects
2018Co-Authors: Sebastian Cozma, Cristina Mihaela Ghiciuc, Lisandra Damian, Vittorio Pasquali, Angelo Saponaro, Elena Catalina Lupusoru, Francesca Romana Patacchioli, Lucia Corina Dima-cozmaAbstract:IntroductionThe Vestibular acute stress induces reversible alert-like reactions that involve the sympathetic adrenal-medullar system and hypothalamic-pituitary-adrenal axis responses. The present study aimed to evaluate salivary α-amylase and salivary cortisol production in relation with cardiovascular reactivity induced by acute stress in healthy subjects.Material and methodsForty-eight young healthy male volunteers were examined under basal conditions and at various times after reaching the maximal nystagmic reaction following air caloric Vestibular Test. Heart rate, systolic blood pressure, diastolic blood pressure and mean arterial pressure were recorded at the same time as measurement of the salivary α-amylase and salivary cortisol. At the end of the caloric Vestibular Test session, perceived stress scale questionnaires were administered to measure the self-perceived stress impact induced by the task, and individual scores were compared with those measured on the enrollment day.ResultsFollowing caloric Vestibular Test-evoked vertigo, salivary α-amylase and cortisol showed distinct trends in their production after acute stress: Student’s t-Test was used to compare the α-amylase vs cortisol slopes of the respective interpolated regression lines, and the difference was significant (t = -3.283; p
Katherine D. Heidenreich - One of the best experts on this subject based on the ideXlab platform.
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Nystagmus Discordance with 2-Dimensional Videonystagmography in Posterior Semicircular Canal Benign Paroxysmal Positional Vertigo
Otolaryngology–Head and Neck Surgery, 2015Co-Authors: Crystal M. Vanderheyden, Wendy J. Carender, Katherine D. HeidenreichAbstract:ObjectiveThe Dix-Hallpike Test is a standard component of the videonystagmography Test battery and can diagnose posterior semicircular canal benign paroxysmal positional vertigo. The purpose of this study is to determine the prevalence of discordant, equivocal, and concordant nystagmus tracings in active posterior semicircular canal benign paroxysmal positional vertigo when compared directly with the eye video.Study DesignCase series with chart review of patients diagnosed with posterior semicircular canal benign paroxysmal positional vertigo by 2-dimensional videonystagmography from August 1, 2007, to August 1, 2012.SettingA tertiary Vestibular Test laboratory.Subjects and MethodsNinety-six adults (4 had bilateral involvement) with posterior semicircular canal benign paroxysmal positional vertigo were included. A total of 100 videos with accompanying videonystagmography tracings were reviewed to determine nystagmus trajectory as well as globe position. Descriptive statistics were used to describe prevale...
Miriam S Welgampola - One of the best experts on this subject based on the ideXlab platform.
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clinical oculographic and Vestibular Test characteristics of meniere s disease
Journal of Neurology, 2021Co-Authors: Allison S Young, Benjamin Nham, Andrew P Bradshaw, Zeljka Calic, Jacob M Pogson, Michael G Halmagyi, W P R Gibson, Miriam S WelgampolaAbstract:Seventy Meniere’s disease (MD) patients with spontaneous vertigo (100%), unilateral aural fullness (57.1%), tinnitus (78.6%), and subjective hearing loss (75.7%) self-recorded nystagmus during their episodes of vertigo using portable video oculography goggles. All demonstrated ictal spontaneous nystagmus, horizontal in 94.3% (n = 66) and vertical in 5.7% (n = 4), with a mean slow-phase velocity (SPV) of 42.8 ± 31.1°/s (range 5.3–160.1). Direction reversal of spontaneous horizontal nystagmus was captured in 58.6%, within the same episode in 34.3%, and over different days in 24.3%. In 18.6%, we observed ipsiversive then contraversive nystagmus, and in 12.9% contraversive to ipsiversive direction reversal. Ictal nystagmus SPV (42.8 ± 31.1°/s) was significantly faster than interictal (1.4 ± 3.1°/s, p 40%). Using ictal nystagmus findings of SPV > 12°/s, and a caloric canal paresis > 25%, we correctly separated a diagnosis MD from Vestibular Migraine with a sensitivity and specificity of 95.7% and 85.1% (CI 0.89–0.97).
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clinical oculographic and Vestibular Test characteristics of Vestibular migraine
Cephalalgia, 2021Co-Authors: Allison S Young, Benjamin Nham, Andrew P Bradshaw, Zeljka Calic, Jacob M Pogson, Mario Dsouza, Michael G Halmagyi, Miriam S WelgampolaAbstract:BackgroundWe characterise the history, Vestibular Tests, ictal and interictal nystagmus in Vestibular migraine.MethodWe present our observations on 101 adult-patients presenting to an outpatient fa...
