Veterinary Ophthalmology

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Kirk Gelatt - One of the best experts on this subject based on the ideXlab platform.

Caryn E. Plummer - One of the best experts on this subject based on the ideXlab platform.

  • Prophylactic anti-glaucoma therapy in dogs with primary glaucoma: A practitioner survey of current medical protocols.
    Veterinary ophthalmology, 2020
    Co-Authors: Caryn E. Plummer, Paul E. Miller, Dineli Bras, Sinisa D. Grozdanic, András M. Komáromy, Gillian J. Mclellan, John S. Sapienza, Leandro B. C. Teixeira, Terah R. Webb
    Abstract:

    Aim To examine the use of prophylactic anti‐glaucoma medications in the normotensive fellow eye in dogs with unilateral overt primary glaucoma by Veterinary Ophthalmology clinicians. Methods A survey of Veterinary Ophthalmology clinicians was distributed over two international list serves servicing Veterinary ophthalmologists, trainees, and individuals whose practice consisted primarily of ophthalmic patients. The survey was developed following analysis of historical and currently available medical options for control of intraocular pressure and for neuroprotection. Results Responses from 199 Veterinary Ophthalmology clinicians were evaluated. While a large variety of topical anti‐hypertensive drugs and protocols were used, the most commonly used medications were aqueous humor production suppressors such as dorzolamide 2.0% ophthalmic solution, timolol 0.5% ophthalmic solution, and a combination product containing both drugs. Latanoprost 0.005% ophthalmic solution was used infrequently for prophylaxis by comparison. The majority of respondents do not use concurrent anti‐inflammatory medications (61.22%), although a sizeable minority used prednisolone acetate, dexamethasone, or ketorolac as prophylactic treatment. Systemically administered ocular anti‐hypertensive agents were rarely used. Only 40% of respondents used neuroprotectant agents; the most commonly prescribed were the calcium channel blocker amlodipine and the nutraceutical Ocu‐Glo™. Recommended intervals between re‐examination by the clinician ranged from one month to one year, with most re‐evaluations occurring every 3 to 6 months. The majority of respondents recommended more frequent assessments of IOP at intervals between once monthly and once every 3 months. Conclusions Data analysis of medical therapy for the normotensive fellow eye of dogs previously diagnosed with primary glaucoma suggests that there is a great need for well‐designed, prospective, controlled, multi‐center studies to determine which protocols have the greatest efficacy in delaying an overt attack in the previously normotensive eye in dogs with a genetic predisposition to glaucoma. Prospective studies utilizing a carbonic anhydrase inhibitor such as dorzolamide and a prostaglandin analogue such as latanoprost would be reasonable as these two drugs are widely used in the treatment of overt glaucoma and would allow for an exploration of the impact of different mechanisms of action of lowering IOP on the pathophysiology of primary glaucoma.

  • Comprar Color Atlas Of Veterinary Ophthalmology 2nd Ed. | Kirk N. Gelatt | 9781119239444 | Wiley
    2017
    Co-Authors: Kirk Gelatt, Caryn E. Plummer
    Abstract:

    Tienda online donde Comprar Color Atlas Of Veterinary Ophthalmology 2nd Ed. al precio 132,63 € de Kirk N. Gelatt | Caryn E. Plummer, tienda de Libros de Medicina, Libros de Veterinaria - Medicina y Cirugia Animal

  • comprar color atlas of Veterinary Ophthalmology 2nd ed kirk n gelatt 9781119239444 wiley
    2017
    Co-Authors: Kirk Gelatt, Caryn E. Plummer
    Abstract:

    Tienda online donde Comprar Color Atlas Of Veterinary Ophthalmology 2nd Ed. al precio 132,63 € de Kirk N. Gelatt | Caryn E. Plummer, tienda de Libros de Medicina, Libros de Veterinaria - Medicina y Cirugia Animal

  • Bilateral microphthalmos with cyst in a neonatal foal
    Veterinary ophthalmology, 2015
    Co-Authors: Shari M. Greenberg, Caryn E. Plummer, Dodd Sledge, Misa Komine, Serena L. M. Craft, Julia A. Conway
    Abstract:

    A 1-day-old miniature horse filly was presented to the University of Florida Veterinary Ophthalmology service for evaluation of multiple ocular anomalies which were present from birth. Protruding from the right orbit was a large, fluctuant, red, dry and variably ulcerated mass. A globe could not be appreciated clinically in the left orbit. Ocular ultrasound of both orbits was performed. This revealed a lobular, hypo-echoic structure filling the right orbit, with multiple hyperechoic septations; normal ocular structures were not identified. Ultrasound of the left orbit revealed a microphthalmic eye, with a well-defined, hyperechoic structure in the vitreous that was thought to be the lens. Due to irreversible blindness, the foal was humanely euthanized. Histopathology and immunohistochemistry of the orbital contents revealed bilateral microphthalmos with cyst, a congenital defect rarely reported in the Veterinary literature.

  • color atlas of Veterinary Ophthalmology
    2001
    Co-Authors: Caryn E. Plummer, Kirk Gelatt
    Abstract:

    Preface. Clinical Signs and Their Interpretations. Canine Orbit. Canine Eyelids. Canine Tears and Nasolacrimal Systems. Canine Conjunctiva and Nictitans. Canine Cornea/Sclera. Canine Glaucomas. Canine Anterior Uvea. Disease of the Canine Lens and Cataract Formation. Canine Vitreous. Canine Ocular Fundus and Optic Nerve. Feline Ophthalmology. Equine Ophthalmology. Food Animal Ophthalmology. Ophthalmology in Exotic Pet Species. Systemic Diseases with Ophthalmic Manifestations. Neuro-Ophthalmic Syndromes.

Christopher R Helps - One of the best experts on this subject based on the ideXlab platform.

  • The in vitro effects of proxymetacaine, fluorescein, and fusidic acid on real-time PCR assays used for the diagnosis of Feline herpesvirus 1 and Chlamydophila felis infections.
    Veterinary Ophthalmology, 2011
    Co-Authors: Sergi Segarra, Kostas Papasouliotis, Christopher R Helps
    Abstract:

    Purpose  To investigate the possible inhibition of qPCR assays used for the diagnosis of ocular infections in cats by proxymetacaine, fluorescein, and fusidic acid, which are commonly used in Veterinary Ophthalmology. Methods  Fluorescein, proxymetacaine, and fusidic acid were tested for possible inhibition of a triplex qPCR assay designed to detect Chamydophila felis, Feline herpesvirus 1 (FHV-1), and the feline 28S ribosomal DNA (28S rDNA) gene by comparing threshold cycle (Ct) values of samples with and without the three products. A second experiment was carried out to measure the effects of various dilutions of fusidic acid. Results  No statistically significant differences were detected between the C. felis, FHV-1, and 28S rDNA Ct values with and without proxymetacaine or fluorescein. However, there was a statistically significant increase in FHV-1 (P 

  • the in vitro effects of proxymetacaine fluorescein and fusidic acid on real time pcr assays used for the diagnosis of feline herpesvirus 1 and chlamydophila felis infections
    Veterinary Ophthalmology, 2011
    Co-Authors: Sergi Segarra, Kostas Papasouliotis, Christopher R Helps
    Abstract:

    Purpose  To investigate the possible inhibition of qPCR assays used for the diagnosis of ocular infections in cats by proxymetacaine, fluorescein, and fusidic acid, which are commonly used in Veterinary Ophthalmology. Methods  Fluorescein, proxymetacaine, and fusidic acid were tested for possible inhibition of a triplex qPCR assay designed to detect Chamydophila felis, Feline herpesvirus 1 (FHV-1), and the feline 28S ribosomal DNA (28S rDNA) gene by comparing threshold cycle (Ct) values of samples with and without the three products. A second experiment was carried out to measure the effects of various dilutions of fusidic acid. Results  No statistically significant differences were detected between the C. felis, FHV-1, and 28S rDNA Ct values with and without proxymetacaine or fluorescein. However, there was a statistically significant increase in FHV-1 (P < 0.01), C. felis (P < 0.01), and 28S rDNA (P < 0.05) Ct values when fusidic acid was used. When dilutions of fusidic acid were tested, the results revealed that only the 1:2 dilution caused a statistically significant increase (P < 0.01) in the FHV-1 Ct values. Conclusion  Proxymetacaine and fluorescein did not interfere with our qPCR assays for the detection of C. felis and FHV-1. The presence of fusidic acid caused a small inhibitory effect of doubtful clinical significance. In vivo studies are required to establish the clinical relevance of this study and to confirm our findings.

  • The in vitro effects of proxymetacaine, fluorescein, and fusidic acid on real-time PCR assays used for the diagnosis of Feline herpesvirus 1 and Chlamydophila felis infections.
    Veterinary ophthalmology, 2011
    Co-Authors: Sergi Segarra, Kostas Papasouliotis, Christopher R Helps
    Abstract:

    To investigate the possible inhibition of qPCR assays used for the diagnosis of ocular infections in cats by proxymetacaine, fluorescein, and fusidic acid, which are commonly used in Veterinary Ophthalmology. Fluorescein, proxymetacaine, and fusidic acid were tested for possible inhibition of a triplex qPCR assay designed to detect Chlamydophila felis, Feline herpesvirus 1 (FHV-1), and the feline 28S ribosomal DNA (28S rDNA) gene by comparing threshold cycle (C(t) ) values of samples with and without the three products. A second experiment was carried out to measure the effects of various dilutions of fusidic acid. No statistically significant differences were detected between the C. felis, FHV-1, and 28S rDNA C(t) values with and without proxymetacaine or fluorescein. However, there was a statistically significant increase in FHV-1 (P < 0.01), C. felis (P < 0.01), and 28S rDNA (P < 0.05) C(t) values when fusidic acid was used. When dilutions of fusidic acid were tested, the results revealed that only the 1:2 dilution caused a statistically significant increase (P < 0.01) in the FHV-1 Ct values. Proxymetacaine and fluorescein did not interfere with our qPCR assays for the detection of C. felis and FHV-1. The presence of fusidic acid caused a small inhibitory effect of doubtful clinical significance. In vivo studies are required to establish the clinical relevance of this study and to confirm our findings. © 2011 American College of Veterinary Ophthalmologists.

Ron Ofri - One of the best experts on this subject based on the ideXlab platform.

  • Factors affecting peer‐reviewed publication of abstracts presented at meetings of the European College of Veterinary Ophthalmologists (2008–2012)
    Veterinary ophthalmology, 2017
    Co-Authors: Ron Ofri, Tali Bdolah-abram, Nadav Yair
    Abstract:

    PURPOSE: To review abstracts presented at five consecutive meetings of the European College of Veterinary Ophthalmologists (ECVO), and identify abstract characteristics that affect the probability of their publication in peer‐reviewed journals. METHODS: An online search was conducted for peer‐reviewed publications (PRPs) stemming from abstracts from five ECVO meetings (2008–2012). Time to publication and journal were noted. Effects of ocular tissue/discipline, species, type of presentation and study, funding acknowledgment and affiliation, professional qualifications, and nationality of the first and last authors on probability of publication were analyzed. RESULTS: Of presented abstracts, 29% (87/299) were published as PRPs in Veterinary Ophthalmology (n = 50), other Veterinary journals (n = 22), and nonVeterinary journals (n = 15). During the 5 years studied, there was no significant difference between the impact factor of Veterinary Ophthalmology and the 25 other journals in which PRPs were published (P = 0.369). Median time to PRP acceptance or publication was 468 days. Independent variables most significant in determining the probability of PRP were oral presentation (P = 0.002), resident authorship (P < 0.0001), and species (P = 0.002), with food animal abstracts having the highest odds ratio. Ocular tissue/discipline (P = 0.13) and type of study (P = 0.33) did not affect publication probability. Funding acknowledgment (P = 0.02), author nationality (P = 0.02), and academic affiliation (P = 0.04) were also significant factors. CONCLUSIONS: Publication rate of ECVO abstracts is lower, but time to publication is similar, compared with most biomedical meetings.

  • Slatter's fundamentals of Veterinary Ophthalmology
    2008
    Co-Authors: David J. Maggs, Paul E. Miller, Ron Ofri
    Abstract:

    1. Structure and Function of the Eye 2. Development and Congenital Abnormalities 3. Ocular Pharmacology and Therapeutics 4. General Pathology of the Eye 5. Basic Diagnostic Techniques 6. Eyelids 7. Conjunctiva 8. Third Eyelid 9. Lacrimal System 10. Cornea and Sclera 11. Uvea 12. The Glaucomas 13. Lens 14. Vitreous 15. Retina 16. Neuro-Ophthalmology 17. Orbit 18. Ocular Manifestations of Systemic Diseases NEW 19. Ocular Emergencies 20. Ophthalmology of Exotic Pets NEW Appendices: A. Breed Predispositions to Eye Disorders B. Glossary of Ophthalmological Terms

  • Guidelines for clinical electroretinography in the dog
    Documenta Ophthalmologica, 2002
    Co-Authors: Kristina Narfström, Bernhard M. Spiess, Christine L. Percicot, Björn Ekesten, Serge G. Rosolen, Ron Ofri
    Abstract:

    These procedures described for the dog ERG were approved at the 1st European Conference on Veterinary Visual Electrophysiology in Vienna, Austria, May 30, 2000. Dr. Narfström was Chair of the Committee for a Harmonized ERG Protocol, appointed by the European College of Veterinary Ophthalmology (ECVO), and Dr. Ofri was secretary. The other coauthors are committee members. Guidelines for ERG procedures in other animal species for clinical and laboratory studies are planned for in the future and the present guidelines are planned to be revised on a biannual basis. A brief report of the recommended procedures is available in the Conference Proceedings book.

  • Clinical electrophysiology in Veterinary Ophthalmology – the past, present and future
    Documenta Ophthalmologica, 2002
    Co-Authors: Ron Ofri
    Abstract:

    The aim of this review is to introduce the reader to the world of clinical Veterinary electroretinography. An important indication for ERG recordings in the dog is the early diagnosis of progressive retinal atrophy, an inherited form of photoreceptor degeneration, analogous to retinitis pigmentosa in humans. In most of the 20 canine breeds in which the disease has been studied electrophysiologically, changes in the ERG appear long before the appearance of clinical signs. This early diagnosis is a vital tool in efforts to eradicate the disease through preventive breeding. Pre-operative screening of canine cataract patients is another common indication for electroretinography in the dog. The ERG is also used to diagnose inherited and nutritional photoreceptor degenerations in the cat, and retinal disorders in a number of other animal species. The abundance of animal species (and breeds) seen by the Veterinary ophthalmologist lends additional importance to the problem of a harmonized ERG recording protocol. The European College of Veterinary Ophthalmologists has set up a special committee to formulate guidelines for such a protocol. International meetings and wetlabs are also being organized as part of an effort to improve the quality of electrophysiological diagnosis that Veterinary ophthalmologists provide their patients.

  • Clinical electrophysiology in Veterinary Ophthalmology--the past, present and future.
    Documenta ophthalmologica. Advances in ophthalmology, 2002
    Co-Authors: Ron Ofri
    Abstract:

    The aim of this review is to introduce the reader to the world of clinical Veterinary electroretinography. An important indication for ERG recordings in the dog is the early diagnosis of progressive retinal atrophy, an inherited form of photoreceptor degeneration, analogous to retinitis pigmentosa in humans. In most of the 20 canine breeds in which the disease has been studied electrophysiologically, changes in the ERG appear long before the appearance of clinical signs. This early diagnosis is a vital tool in efforts to eradicate the disease through preventive breeding. Pre-operative screening of canine cataract patients is another common indication for electroretinography in the dog. The ERG is also used to diagnose inherited and nutritional photoreceptor degenerations in the cat, and retinal disorders in a number of other animal species. The abundance of animal species (and breeds) seen by the Veterinary ophthalmologist lends additional importance to the problem of a harmonized ERG recording protocol. The European College of Veterinary Ophthalmologists has set up a special committee to formulate guidelines for such a protocol. International meetings and wetlabs are also being organized as part of an effort to improve the quality of electrophysiological diagnosis that Veterinary ophthalmologists provide their patients.

Bernhard M. Spiess - One of the best experts on this subject based on the ideXlab platform.

  • The use of lasers in Veterinary Ophthalmology: Recommendations based on literature
    Photonics & Lasers in Medicine, 2012
    Co-Authors: Bernhard M. Spiess
    Abstract:

    Lasers are routinely used in Veterinary Ophthalmology for the treatment of a number of ophthalmic conditions and diseases. In Veterinary Ophthalmology, gas lasers (CO 2 lasers) and semiconductor lasers (diode lasers) are used primarily, but the therapy of posterior capsular opacifi cation with the Nd:YAG laser has also been described. This paper presents and discusses the most common indications for the use of the diode and CO 2 lasers. Diode lasers are mainly used in the treatment of glaucoma, either by transscleral cyclophotocoagulation or by endoscopic cyclophotocoagulation. Other indications are various forms of retinal detachments, as well as pigmented neoplasms of the uvea. An emerging fi eld in Veterinary Ophthalmology using diode lasers is photodynamic therapy of periocular tumors. CO 2 lasers are used for pars plana vitrectomies and surgical excision of ocular tumors.

  • Equine recurrent uveitis: The European viewpoint
    Equine veterinary journal. Supplement, 2010
    Co-Authors: Bernhard M. Spiess
    Abstract:

    Equine recurrent uveitis (ERU) has always been and still is an important disease with a significant impact on the horse industry in Europe, with a prevalence of 8-10%. The need to understand and manage the disease has spurred the development of Veterinary Ophthalmology in general, although the aetiology of the disease remains the subject of intense discussion. It is most probably an autoimmune disease triggered, at least in Europe, in the majority of cases by Leptospira spp. The therapy of ERU has evolved over the centuries from various methods of bloodletting to rational medical therapy using mydriatics and steroidal and nonsteroidal anti-inflammatory drugs, to surgical therapies, such as vitrectomy or implantation of cyclosporin-releasing devices. In Europe, pars plana vitrectomy in horses testing positive for Leptospira spp. appears to be the most successful form of therapy at the present time.

  • Guidelines for clinical electroretinography in the dog
    Documenta Ophthalmologica, 2002
    Co-Authors: Kristina Narfström, Bernhard M. Spiess, Christine L. Percicot, Björn Ekesten, Serge G. Rosolen, Ron Ofri
    Abstract:

    These procedures described for the dog ERG were approved at the 1st European Conference on Veterinary Visual Electrophysiology in Vienna, Austria, May 30, 2000. Dr. Narfström was Chair of the Committee for a Harmonized ERG Protocol, appointed by the European College of Veterinary Ophthalmology (ECVO), and Dr. Ofri was secretary. The other coauthors are committee members. Guidelines for ERG procedures in other animal species for clinical and laboratory studies are planned for in the future and the present guidelines are planned to be revised on a biannual basis. A brief report of the recommended procedures is available in the Conference Proceedings book.

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