The Experts below are selected from a list of 1098 Experts worldwide ranked by ideXlab platform
Abraham Thomas - One of the best experts on this subject based on the ideXlab platform.
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one pot synthesis of highly substituted nicotinic acid derivatives based on a formylation strategy of enamino keto esters
Journal of Organic Chemistry, 2016Co-Authors: Sukeerthi Kumar, Rajendra P. Chikhale, Keya Karanjai, Aarti A Sawant, Abraham ThomasAbstract:A facile one-pot synthesis of 4-chloro or 4-bromonicotinic acid esters with optional 2- and 2,5-disubstitution on the pyridine ring has been developed from easily accessible enamino keto esters by a formylation followed by in situ intramolecular cyclization strategy under optimized Vilsmeier Reaction conditions. The effect of the substituents on the β-carbon and the nature of the keto functionality were explored in detail to understand the mechanism of pyridine ring formation under the described conditions.
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One-Pot Synthesis of Highly Substituted Nicotinic Acid Derivatives Based on a Formylation Strategy of Enamino Keto Esters
2016Co-Authors: Sukeerthi Kumar, Aarti A. Sawant, Rajendra P. Chikhale, Keya Karanjai, Abraham ThomasAbstract:A facile one-pot synthesis of 4-chloro or 4-bromonicotinic acid esters with optional 2- and 2,5-disubstitution on the pyridine ring has been developed from easily accessible enamino keto esters by a formylation followed by in situ intramolecular cyclization strategy under optimized Vilsmeier Reaction conditions. The effect of the substituents on the β-carbon and the nature of the keto functionality were explored in detail to understand the mechanism of pyridine ring formation under the described conditions
Roberto Paolesse - One of the best experts on this subject based on the ideXlab platform.
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a leopard cannot change its spots unexpected products from the Vilsmeier Reaction on 5 10 15 tritolylcorrole
Molecules, 2020Co-Authors: Fabrizio Caroleo, Sara Nardis, Greta Petrella, Lorena Di Zazzo, Beatrice Berionni Berna, Daniel Oscar Cicero, Roberto PaolesseAbstract:The Reaction of 5,10,15-tritolylcorrole with 3-dimethylaminoacrolein (3-DMA) and POCl3 gives a further example of the rebel reactivity of this contracted macrocycle. While no evidence was obtained for the formation of the expected β-acrolein corrole, the inner core substituted N21,N22-3-formylpropylcorrole and the 10-acrolein isocorrole were the Reaction products. By increasing the temperature or the amount of the Vilsmeier reagent, the 10-isocorrole became the unique Reaction product. The formation of the isocorrole by electrophilic attack of the Vilsmeier reagent to the 10-position of the corrole is unprecedented in the porphyrinoids field and it could pave the way for a novel route to the preparation of stable isocorroles.
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Moving corrole towards a red-record: synthesis of β-acrolein Ga and Cu corroles using the Vilsmeier Reaction
New Journal of Chemistry, 2018Co-Authors: Andrea Savoldelli, Sara Nardis, Damiano Genovese, Luca Prodi, Frank R. Fronczek, Kevin M Smith, Roberto PaolesseAbstract:Copper and gallium β-acrolein corroles have been obtained by Reaction of corrole complexes with 3-(dimethylamino)-acrolein/phosphoryl chloride (3-DMA/POCl3) under Vilsmeier conditions. In the case of the Ga complex, up to four acroleyl substituents have been introduced at the β-peripheral positions of the corrole macrocycle. The introduction of the acroleyl moiety on the corrole scaffold strongly influences the photophysical behaviour of the Ga corroles.
Sukeerthi Kumar - One of the best experts on this subject based on the ideXlab platform.
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one pot synthesis of highly substituted nicotinic acid derivatives based on a formylation strategy of enamino keto esters
Journal of Organic Chemistry, 2016Co-Authors: Sukeerthi Kumar, Rajendra P. Chikhale, Keya Karanjai, Aarti A Sawant, Abraham ThomasAbstract:A facile one-pot synthesis of 4-chloro or 4-bromonicotinic acid esters with optional 2- and 2,5-disubstitution on the pyridine ring has been developed from easily accessible enamino keto esters by a formylation followed by in situ intramolecular cyclization strategy under optimized Vilsmeier Reaction conditions. The effect of the substituents on the β-carbon and the nature of the keto functionality were explored in detail to understand the mechanism of pyridine ring formation under the described conditions.
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One-Pot Synthesis of Highly Substituted Nicotinic Acid Derivatives Based on a Formylation Strategy of Enamino Keto Esters
2016Co-Authors: Sukeerthi Kumar, Aarti A. Sawant, Rajendra P. Chikhale, Keya Karanjai, Abraham ThomasAbstract:A facile one-pot synthesis of 4-chloro or 4-bromonicotinic acid esters with optional 2- and 2,5-disubstitution on the pyridine ring has been developed from easily accessible enamino keto esters by a formylation followed by in situ intramolecular cyclization strategy under optimized Vilsmeier Reaction conditions. The effect of the substituents on the β-carbon and the nature of the keto functionality were explored in detail to understand the mechanism of pyridine ring formation under the described conditions
Rajendra P. Chikhale - One of the best experts on this subject based on the ideXlab platform.
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one pot synthesis of highly substituted nicotinic acid derivatives based on a formylation strategy of enamino keto esters
Journal of Organic Chemistry, 2016Co-Authors: Sukeerthi Kumar, Rajendra P. Chikhale, Keya Karanjai, Aarti A Sawant, Abraham ThomasAbstract:A facile one-pot synthesis of 4-chloro or 4-bromonicotinic acid esters with optional 2- and 2,5-disubstitution on the pyridine ring has been developed from easily accessible enamino keto esters by a formylation followed by in situ intramolecular cyclization strategy under optimized Vilsmeier Reaction conditions. The effect of the substituents on the β-carbon and the nature of the keto functionality were explored in detail to understand the mechanism of pyridine ring formation under the described conditions.
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One-Pot Synthesis of Highly Substituted Nicotinic Acid Derivatives Based on a Formylation Strategy of Enamino Keto Esters
2016Co-Authors: Sukeerthi Kumar, Aarti A. Sawant, Rajendra P. Chikhale, Keya Karanjai, Abraham ThomasAbstract:A facile one-pot synthesis of 4-chloro or 4-bromonicotinic acid esters with optional 2- and 2,5-disubstitution on the pyridine ring has been developed from easily accessible enamino keto esters by a formylation followed by in situ intramolecular cyclization strategy under optimized Vilsmeier Reaction conditions. The effect of the substituents on the β-carbon and the nature of the keto functionality were explored in detail to understand the mechanism of pyridine ring formation under the described conditions
Keya Karanjai - One of the best experts on this subject based on the ideXlab platform.
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one pot synthesis of highly substituted nicotinic acid derivatives based on a formylation strategy of enamino keto esters
Journal of Organic Chemistry, 2016Co-Authors: Sukeerthi Kumar, Rajendra P. Chikhale, Keya Karanjai, Aarti A Sawant, Abraham ThomasAbstract:A facile one-pot synthesis of 4-chloro or 4-bromonicotinic acid esters with optional 2- and 2,5-disubstitution on the pyridine ring has been developed from easily accessible enamino keto esters by a formylation followed by in situ intramolecular cyclization strategy under optimized Vilsmeier Reaction conditions. The effect of the substituents on the β-carbon and the nature of the keto functionality were explored in detail to understand the mechanism of pyridine ring formation under the described conditions.
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One-Pot Synthesis of Highly Substituted Nicotinic Acid Derivatives Based on a Formylation Strategy of Enamino Keto Esters
2016Co-Authors: Sukeerthi Kumar, Aarti A. Sawant, Rajendra P. Chikhale, Keya Karanjai, Abraham ThomasAbstract:A facile one-pot synthesis of 4-chloro or 4-bromonicotinic acid esters with optional 2- and 2,5-disubstitution on the pyridine ring has been developed from easily accessible enamino keto esters by a formylation followed by in situ intramolecular cyclization strategy under optimized Vilsmeier Reaction conditions. The effect of the substituents on the β-carbon and the nature of the keto functionality were explored in detail to understand the mechanism of pyridine ring formation under the described conditions
