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A. Mencacci - One of the best experts on this subject based on the ideXlab platform.
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The role of ozonized oil and a combination of tobramycin/dexamethasone eye drops in the treatment of Viral Conjunctivitis: a randomized clinical trial
International Ophthalmology, 2020Co-Authors: C. Cagini, M. Mariniello, M. Messina, A. Muzi, C. Balducci, A. Moretti, L. Levorato, A. MencacciAbstract:Purpose To determine whether topical tobramycin 0.3%/dexamethasone 0.1% plus ozonized oil eye drops reduces clinical signs and infectious Viral titers of presumed Viral Conjunctivitis more than tobramycin/dexamethasone eye drops alone. Methods Prospective, single-blind, randomized, parallel-groups trial. Eighty patients with a clinical diagnosis of presumed Viral Conjunctivitis were randomizedly divided into two treatment groups: a study group and a control group, 40 for each group. Patients in the study group received topical tobramycin 0.3%/dexamethasone 0.1% eye drops, plus ozonized oil eye drops, both four times daily; patients in the control group received only topical tobramycin 0.3%/dexamethasone eye drops four times daily. The treatment was for seven days in both groups. Swabs were taken from the conjunctival fornix for adenovirus PCR analysis on the day of recruitment and at seven days follow-up. Clinical signs were also recorded on the day of recruitment and at follow-up examination: the main outcomes were conjunctival injection and conjunctival chemosis, graded on a 4-point clinical scale, presence or absence of superficial punctate keratitis and subepithelial corneal infiltrates. Results No statistically significant difference was reached in adenoViral infection negativization between the two groups, although the study group showed a higher number of PCR negative results at seven days follow-up. PCR real time detected adenoViral infection in 17 of 24 patients on the day of recruitment and it was positive in 4 patients on the seventh day (Viral positivity reduction of 76%). In the control group PCR was positive for adenovirus in 18 of 24 patients on the day of recruitment and in 7 patients at seven days follow-up (reduction of 61%). There was statistically significant difference on conjunctival clinical signs between the study and control groups. Significant difference was also found on superficial punctate keratitis resolution between the study and the control group. In the former superficial punctate keratitis was detected in 14 eyes on the first day and in 5 eyes after seven days while in the latter superficial punctate keratitis was found in 124 eyes on the first day and in 6 eyes on the seventh day. No difference was found in subepithelial corneal infiltrates appearance between the two groups. Conclusions The use of ozonized-oil containing eye drops in combination with topical tobramycin 0.3%/dexamethasone 0.1% eye drops four times daily seems to reduce the signs of Conjunctivitis, and the duration of Viral infection, although it does not affect the subepithelial corneal infiltrates appearance.
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the role of ozonized oil and a combination of tobramycin dexamethasone eye drops in the treatment of Viral Conjunctivitis a randomized clinical trial
International Ophthalmology, 2020Co-Authors: C. Cagini, M. Mariniello, M. Messina, A. Muzi, C. Balducci, A. Moretti, L. Levorato, A. MencacciAbstract:Purpose To determine whether topical tobramycin 0.3%/dexamethasone 0.1% plus ozonized oil eye drops reduces clinical signs and infectious Viral titers of presumed Viral Conjunctivitis more than tobramycin/dexamethasone eye drops alone. Methods Prospective, single-blind, randomized, parallel-groups trial. Eighty patients with a clinical diagnosis of presumed Viral Conjunctivitis were randomizedly divided into two treatment groups: a study group and a control group, 40 for each group. Patients in the study group received topical tobramycin 0.3%/dexamethasone 0.1% eye drops, plus ozonized oil eye drops, both four times daily; patients in the control group received only topical tobramycin 0.3%/dexamethasone eye drops four times daily. The treatment was for seven days in both groups. Swabs were taken from the conjunctival fornix for adenovirus PCR analysis on the day of recruitment and at seven days follow-up. Clinical signs were also recorded on the day of recruitment and at follow-up examination: the main outcomes were conjunctival injection and conjunctival chemosis, graded on a 4-point clinical scale, presence or absence of superficial punctate keratitis and subepithelial corneal infiltrates. Results No statistically significant difference was reached in adenoViral infection negativization between the two groups, although the study group showed a higher number of PCR negative results at seven days follow-up. PCR real time detected adenoViral infection in 17 of 24 patients on the day of recruitment and it was positive in 4 patients on the seventh day (Viral positivity reduction of 76%). In the control group PCR was positive for adenovirus in 18 of 24 patients on the day of recruitment and in 7 patients at seven days follow-up (reduction of 61%). There was statistically significant difference on conjunctival clinical signs between the study and control groups. Significant difference was also found on superficial punctate keratitis resolution between the study and the control group. In the former superficial punctate keratitis was detected in 14 eyes on the first day and in 5 eyes after seven days while in the latter superficial punctate keratitis was found in 124 eyes on the first day and in 6 eyes on the seventh day. No difference was found in subepithelial corneal infiltrates appearance between the two groups. Conclusions The use of ozonized-oil containing eye drops in combination with topical tobramycin 0.3%/dexamethasone 0.1% eye drops four times daily seems to reduce the signs of Conjunctivitis, and the duration of Viral infection, although it does not affect the subepithelial corneal infiltrates appearance.
Shigeaki Ohno - One of the best experts on this subject based on the ideXlab platform.
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Ten years’ surveillance of Viral Conjunctivitis in Sapporo, Japan
Graefe's Archive for Clinical and Experimental Ophthalmology, 1999Co-Authors: W. Saitoh-inagawa, Eiichi Uchio, Koki Aoki, Norihiko Itoh, Shigeaki OhnoAbstract:· Background: We set out to establish the epidemiology of Viral conjunctivities over a 10-year period in Sapporo, northern Japan. · Methods: A total of 965 patients with clinically suspected Viral Conjunctivitis during the 10-year period from 1985 to 1994 in Sapporo were evaluated. · Results: Among the 965 patients, cumulative frequency of adenovirus (Ad) was 721 (75%). The dominant serotype of Ad changed with time; each serotype peaked at 3- to 5-year intervals. AdenoViral Conjunctivitis occurred most often in July and August each year. Ad3 and Ad4 were predominantly identified in patients 30–39 years old. No enterovirus 70 has been detected. Herpes simplex virus (HSV) and Chlamydia trachomatis had no significant peak. HSV was isolated throughout the year, and C. trachomatis had two peaks of detection: in March and from July to September. HSV and C. trachomatis were predominantly detected in patients 20–29 years old. · Conclusion: In this study, the main etiological agent of Viral Conjunctivitis in Sapporo, Japan, was Ad; however, attention should be paid to non-adenoViral agents, such as HSV and C. trachomatis , as possible causes of acute Conjunctivitis.
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Ten years' surveillance of Viral Conjunctivitis in Sapporo, Japan.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 1999Co-Authors: W. Saitoh-inagawa, Eiichi Uchio, Koki Aoki, Norihiko Itoh, Shigeaki OhnoAbstract:We set out to establish the epidemiology of Viral Conjunctivitis over a 10-year period in Sapporo, northern Japan. A total of 965 patients with clinically suspected Viral Conjunctivitis during the 10-year period from 1985 to 1994 in Sapporo were evaluated. Among the 965 patients, cumulative frequency of adenovirus (Ad) was 721 (75%). The dominant serotype of Ad changed with time; each serotype peaked at 3- to 5-year intervals. AdenoViral Conjunctivitis occurred most often in July and August each year. Ad3 and Ad4 were predominantly identified in patients 30-39 years old. No enterovirus 70 has been detected. Herpes simplex virus (HSV) and Chlamydia trachomatis had no significant peak. HSV was isolated throughout the year, and C. trachomatis had two peaks of detection: in March and from July to September. HSV and C. trachomatis were predominantly detected in patients 20-29 years old. In this study, the main etiological agent of Viral Conjunctivitis in Sapporo, Japan, was Ad; however, attention should be paid to non-adenoViral agents, such as HSV and C. trachomatis, as possible causes of acute Conjunctivitis.
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Genome analysis of adenovirus type 4 strains isolated from acute Conjunctivitis in Japan
Japanese journal of ophthalmology, 1997Co-Authors: Liping Tsuzuki-wang, Koki Aoki, Kazumi Isobe, Shia Shiao, Kazunori Toba, Nobuyoshi Kobayashi, Yuzo Noguchi, Shigeaki OhnoAbstract:Strains of adenovirus type 4 (Ad4) isolated from patients with acute Conjunctivitis were studied by DNA restriction analysis. The strains were isolated between July and December 1990 in Japan. All 63 isolates of Ad4 were identified as the genome type Ad4a. This study showed that the same Ad4 genome type, Ad4a, caused acute Viral Conjunctivitis, even in different areas of Japan.
C. Cagini - One of the best experts on this subject based on the ideXlab platform.
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The role of ozonized oil and a combination of tobramycin/dexamethasone eye drops in the treatment of Viral Conjunctivitis: a randomized clinical trial
International Ophthalmology, 2020Co-Authors: C. Cagini, M. Mariniello, M. Messina, A. Muzi, C. Balducci, A. Moretti, L. Levorato, A. MencacciAbstract:Purpose To determine whether topical tobramycin 0.3%/dexamethasone 0.1% plus ozonized oil eye drops reduces clinical signs and infectious Viral titers of presumed Viral Conjunctivitis more than tobramycin/dexamethasone eye drops alone. Methods Prospective, single-blind, randomized, parallel-groups trial. Eighty patients with a clinical diagnosis of presumed Viral Conjunctivitis were randomizedly divided into two treatment groups: a study group and a control group, 40 for each group. Patients in the study group received topical tobramycin 0.3%/dexamethasone 0.1% eye drops, plus ozonized oil eye drops, both four times daily; patients in the control group received only topical tobramycin 0.3%/dexamethasone eye drops four times daily. The treatment was for seven days in both groups. Swabs were taken from the conjunctival fornix for adenovirus PCR analysis on the day of recruitment and at seven days follow-up. Clinical signs were also recorded on the day of recruitment and at follow-up examination: the main outcomes were conjunctival injection and conjunctival chemosis, graded on a 4-point clinical scale, presence or absence of superficial punctate keratitis and subepithelial corneal infiltrates. Results No statistically significant difference was reached in adenoViral infection negativization between the two groups, although the study group showed a higher number of PCR negative results at seven days follow-up. PCR real time detected adenoViral infection in 17 of 24 patients on the day of recruitment and it was positive in 4 patients on the seventh day (Viral positivity reduction of 76%). In the control group PCR was positive for adenovirus in 18 of 24 patients on the day of recruitment and in 7 patients at seven days follow-up (reduction of 61%). There was statistically significant difference on conjunctival clinical signs between the study and control groups. Significant difference was also found on superficial punctate keratitis resolution between the study and the control group. In the former superficial punctate keratitis was detected in 14 eyes on the first day and in 5 eyes after seven days while in the latter superficial punctate keratitis was found in 124 eyes on the first day and in 6 eyes on the seventh day. No difference was found in subepithelial corneal infiltrates appearance between the two groups. Conclusions The use of ozonized-oil containing eye drops in combination with topical tobramycin 0.3%/dexamethasone 0.1% eye drops four times daily seems to reduce the signs of Conjunctivitis, and the duration of Viral infection, although it does not affect the subepithelial corneal infiltrates appearance.
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the role of ozonized oil and a combination of tobramycin dexamethasone eye drops in the treatment of Viral Conjunctivitis a randomized clinical trial
International Ophthalmology, 2020Co-Authors: C. Cagini, M. Mariniello, M. Messina, A. Muzi, C. Balducci, A. Moretti, L. Levorato, A. MencacciAbstract:Purpose To determine whether topical tobramycin 0.3%/dexamethasone 0.1% plus ozonized oil eye drops reduces clinical signs and infectious Viral titers of presumed Viral Conjunctivitis more than tobramycin/dexamethasone eye drops alone. Methods Prospective, single-blind, randomized, parallel-groups trial. Eighty patients with a clinical diagnosis of presumed Viral Conjunctivitis were randomizedly divided into two treatment groups: a study group and a control group, 40 for each group. Patients in the study group received topical tobramycin 0.3%/dexamethasone 0.1% eye drops, plus ozonized oil eye drops, both four times daily; patients in the control group received only topical tobramycin 0.3%/dexamethasone eye drops four times daily. The treatment was for seven days in both groups. Swabs were taken from the conjunctival fornix for adenovirus PCR analysis on the day of recruitment and at seven days follow-up. Clinical signs were also recorded on the day of recruitment and at follow-up examination: the main outcomes were conjunctival injection and conjunctival chemosis, graded on a 4-point clinical scale, presence or absence of superficial punctate keratitis and subepithelial corneal infiltrates. Results No statistically significant difference was reached in adenoViral infection negativization between the two groups, although the study group showed a higher number of PCR negative results at seven days follow-up. PCR real time detected adenoViral infection in 17 of 24 patients on the day of recruitment and it was positive in 4 patients on the seventh day (Viral positivity reduction of 76%). In the control group PCR was positive for adenovirus in 18 of 24 patients on the day of recruitment and in 7 patients at seven days follow-up (reduction of 61%). There was statistically significant difference on conjunctival clinical signs between the study and control groups. Significant difference was also found on superficial punctate keratitis resolution between the study and the control group. In the former superficial punctate keratitis was detected in 14 eyes on the first day and in 5 eyes after seven days while in the latter superficial punctate keratitis was found in 124 eyes on the first day and in 6 eyes on the seventh day. No difference was found in subepithelial corneal infiltrates appearance between the two groups. Conclusions The use of ozonized-oil containing eye drops in combination with topical tobramycin 0.3%/dexamethasone 0.1% eye drops four times daily seems to reduce the signs of Conjunctivitis, and the duration of Viral infection, although it does not affect the subepithelial corneal infiltrates appearance.
Minmuh Sheu - One of the best experts on this subject based on the ideXlab platform.
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human adenovirus type 8 epidemic keratoConjunctivitis with large corneal epithelial full layer detachment an endemic outbreak with uncommon manifestations
Clinical Ophthalmology, 2015Co-Authors: Yuehchang Lee, Nancy Chen, Itsong Huang, Huihua Yang, Chinte Huang, Likuang Chen, Minmuh SheuAbstract:Epidemic Viral Conjunctivitis is a highly contagious disease that is encountered year-round. The causative agents are mainly adenoviruses and enteroviruses. It occurs most commonly upon infection with subgroup D adenoviruses of types 8, 19, or 37. For common corneal involvement of human adenovirus type 8 epidemic keratoConjunctivitis, full-layer epithelial detachment is rarely seen. Herein, we report three cases of epidemic keratoConjunctivitis during an outbreak which manifested as large corneal epithelial full-layer detachment within a few days. The lesions healed without severe sequelae under proper treatment. The unique manifestation of this outbreak may indicate the evolution of human adenovirus type 8.
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The change of etiological agents and clinical signs of epidemic Viral Conjunctivitis over an 18-year period in southern Taiwan
Graefe's Archive for Clinical and Experimental Ophthalmology, 2003Co-Authors: Cheng-hsien Chang, Minmuh Sheu, Kuei-hsiang Lin, Wen-loong Huang, Huei-zu Wang, Chen-wu ChenAbstract:Background Epidemic Viral Conjunctivitis is a highly contagious eye disease that occurs worldwide and is caused mainly by adenoviruses and enteroviruses. An 18-year analysis of the changes of pathogens and clinical signs in a subtropical and densely populated island presents certain special features. Methods We retrospectively analyzed the clinical information and laboratory records of the Conjunctivitis patients with positive conjunctival swabs from 1980 to 1997. Results The positive rate of laboratory diagnosis of epidemic Conjunctivitis was 50.0% (1,233/2,467). From 1980 to 1994, the predominant causative agent of adenoViral keratoConjunctivitis was adenovirus type 8 (Ad8), with six genotypes being evolved. Three of the new Ad8 genotypes each caused a new epidemic. After 1995 the predominant adenoViral pathogens shifted to Ad37 and Ad19, and no more Ad8 was isolated. Enterovirus type 70 (EV70) was isolated from four outbreaks of acute hemorrhagic Conjunctivitis (AHC) from 1980 to 1984, but rarely in later years. Coxsackievirus A type 24 variant (CA24v), which first appeared in 1985, appeared later as the causes of four major epidemics of AHC from 1985 to 1994. The overall clinical symptoms of Viral Conjunctivitis were more severe in the 1990s than in the 1980s. Conclusion In southern Taiwan, outbreaks of adenoViral keratoConjunctivitis caused by new genomic variants could be associated with the long-term endemic co-circulation of Ad8, Ad19, and Ad37, while epidemics of CA24v AHC were caused mainly by introduction of new Viral strains from neighboring countries. The aggravation of host symptoms in the 1990s needs further investigation and close follow-up.
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The change of etiological agents and clinical signs of epidemic Viral Conjunctivitis over an 18-year period in southern Taiwan.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2003Co-Authors: Cheng-hsien Chang, Minmuh Sheu, Kuei-hsiang Lin, Wen-loong Huang, Huei-zu Wang, Chen-wu ChenAbstract:Background Epidemic Viral Conjunctivitis is a highly contagious eye disease that occurs worldwide and is caused mainly by adenoviruses and enteroviruses. An 18-year analysis of the changes of pathogens and clinical signs in a subtropical and densely populated island presents certain special features.
Chen-wu Chen - One of the best experts on this subject based on the ideXlab platform.
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The change of etiological agents and clinical signs of epidemic Viral Conjunctivitis over an 18-year period in southern Taiwan
Graefe's Archive for Clinical and Experimental Ophthalmology, 2003Co-Authors: Cheng-hsien Chang, Minmuh Sheu, Kuei-hsiang Lin, Wen-loong Huang, Huei-zu Wang, Chen-wu ChenAbstract:Background Epidemic Viral Conjunctivitis is a highly contagious eye disease that occurs worldwide and is caused mainly by adenoviruses and enteroviruses. An 18-year analysis of the changes of pathogens and clinical signs in a subtropical and densely populated island presents certain special features. Methods We retrospectively analyzed the clinical information and laboratory records of the Conjunctivitis patients with positive conjunctival swabs from 1980 to 1997. Results The positive rate of laboratory diagnosis of epidemic Conjunctivitis was 50.0% (1,233/2,467). From 1980 to 1994, the predominant causative agent of adenoViral keratoConjunctivitis was adenovirus type 8 (Ad8), with six genotypes being evolved. Three of the new Ad8 genotypes each caused a new epidemic. After 1995 the predominant adenoViral pathogens shifted to Ad37 and Ad19, and no more Ad8 was isolated. Enterovirus type 70 (EV70) was isolated from four outbreaks of acute hemorrhagic Conjunctivitis (AHC) from 1980 to 1984, but rarely in later years. Coxsackievirus A type 24 variant (CA24v), which first appeared in 1985, appeared later as the causes of four major epidemics of AHC from 1985 to 1994. The overall clinical symptoms of Viral Conjunctivitis were more severe in the 1990s than in the 1980s. Conclusion In southern Taiwan, outbreaks of adenoViral keratoConjunctivitis caused by new genomic variants could be associated with the long-term endemic co-circulation of Ad8, Ad19, and Ad37, while epidemics of CA24v AHC were caused mainly by introduction of new Viral strains from neighboring countries. The aggravation of host symptoms in the 1990s needs further investigation and close follow-up.
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The change of etiological agents and clinical signs of epidemic Viral Conjunctivitis over an 18-year period in southern Taiwan.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2003Co-Authors: Cheng-hsien Chang, Minmuh Sheu, Kuei-hsiang Lin, Wen-loong Huang, Huei-zu Wang, Chen-wu ChenAbstract:Background Epidemic Viral Conjunctivitis is a highly contagious eye disease that occurs worldwide and is caused mainly by adenoviruses and enteroviruses. An 18-year analysis of the changes of pathogens and clinical signs in a subtropical and densely populated island presents certain special features.
