The Experts below are selected from a list of 8664 Experts worldwide ranked by ideXlab platform
Leonid Titov - One of the best experts on this subject based on the ideXlab platform.
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stampidine prevents mortality in an experimental mouse model of Viral Hemorrhagic Fever caused by lassa virus
BMC Infectious Diseases, 2004Co-Authors: Fatih M Uckun, Alexander S Petkevich, Alexei O Vassilev, Heather E Tibbles, Leonid TitovAbstract:Background The potential use of microorganisms as agents of biological warfare (BW) is a growing concern. Lassa virus, a member of the Arenavirus class of Hemorrhagic Fever (HF) viruses has emerged as a worldwide concern among public health officials. The purpose of the present study was to further elucidate the antiViral activity spectrum of stampidine, a novel nucleoside analog with potent anti-Viral activity against the immunodeficiency viruses HIV-1, HIV-2, and FIV, by examining its effects on survival of mice challenged with Lassa virus.
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Stampidine prevents mortality in an experimental mouse model of Viral Hemorrhagic Fever caused by lassa virus
BMC Infectious Diseases, 2004Co-Authors: Fatih M Uckun, Alexander S Petkevich, Alexei O Vassilev, Heather E Tibbles, Leonid TitovAbstract:Background The potential use of microorganisms as agents of biological warfare (BW) is a growing concern. Lassa virus, a member of the Arenavirus class of Hemorrhagic Fever (HF) viruses has emerged as a worldwide concern among public health officials. The purpose of the present study was to further elucidate the antiViral activity spectrum of stampidine, a novel nucleoside analog with potent anti-Viral activity against the immunodeficiency viruses HIV-1, HIV-2, and FIV, by examining its effects on survival of mice challenged with Lassa virus. Methods We examined the therapeutic effect of Stampidine in CBA mice inoculated with intracerebral injections of the Josiah strain of Lassa virus. Mice were treated either with vehicle or nontoxic doses of stampidine administered intraperitoneally 24 hours prior to, 1 hour prior to, and 24 hours, 48 hours, 72 hours, and 96 hours after virus inoculation. Results The probability of survival following the Lassa challenge was significantly improved for stampidine treated mice (Kaplan Meier, Chi-squared = 11.7, df = 2, Log-Rank p-value = 0.003). Conclusion Therefore, stampidine shows clinical potential as a new agent for treatment of Viral Hemorrhagic Fevers caused by Lassa virus.
Fatih M Uckun - One of the best experts on this subject based on the ideXlab platform.
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stampidine prevents mortality in an experimental mouse model of Viral Hemorrhagic Fever caused by lassa virus
BMC Infectious Diseases, 2004Co-Authors: Fatih M Uckun, Alexander S Petkevich, Alexei O Vassilev, Heather E Tibbles, Leonid TitovAbstract:Background The potential use of microorganisms as agents of biological warfare (BW) is a growing concern. Lassa virus, a member of the Arenavirus class of Hemorrhagic Fever (HF) viruses has emerged as a worldwide concern among public health officials. The purpose of the present study was to further elucidate the antiViral activity spectrum of stampidine, a novel nucleoside analog with potent anti-Viral activity against the immunodeficiency viruses HIV-1, HIV-2, and FIV, by examining its effects on survival of mice challenged with Lassa virus.
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Stampidine prevents mortality in an experimental mouse model of Viral Hemorrhagic Fever caused by lassa virus
BMC Infectious Diseases, 2004Co-Authors: Fatih M Uckun, Alexander S Petkevich, Alexei O Vassilev, Heather E Tibbles, Leonid TitovAbstract:Background The potential use of microorganisms as agents of biological warfare (BW) is a growing concern. Lassa virus, a member of the Arenavirus class of Hemorrhagic Fever (HF) viruses has emerged as a worldwide concern among public health officials. The purpose of the present study was to further elucidate the antiViral activity spectrum of stampidine, a novel nucleoside analog with potent anti-Viral activity against the immunodeficiency viruses HIV-1, HIV-2, and FIV, by examining its effects on survival of mice challenged with Lassa virus. Methods We examined the therapeutic effect of Stampidine in CBA mice inoculated with intracerebral injections of the Josiah strain of Lassa virus. Mice were treated either with vehicle or nontoxic doses of stampidine administered intraperitoneally 24 hours prior to, 1 hour prior to, and 24 hours, 48 hours, 72 hours, and 96 hours after virus inoculation. Results The probability of survival following the Lassa challenge was significantly improved for stampidine treated mice (Kaplan Meier, Chi-squared = 11.7, df = 2, Log-Rank p-value = 0.003). Conclusion Therefore, stampidine shows clinical potential as a new agent for treatment of Viral Hemorrhagic Fevers caused by Lassa virus.
Aridth Gibbons - One of the best experts on this subject based on the ideXlab platform.
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genomic analysis of filoviruses associated with four Viral Hemorrhagic Fever outbreaks in uganda and the democratic republic of the congo in 2012
Virology, 2013Co-Authors: César G. Albariño, Alex Tumusiime, Stephen Balinandi, Joseph Francis Wamala, Trevor Shoemaker, Jean Jacques Muyembe, Marina L. Khristova, S Campbell, Deborah Cannon, Aridth GibbonsAbstract:In 2012, an unprecedented number of four distinct, partially overlapping filovirus-associated Viral Hemorrhagic Fever outbreaks were detected in equatorial Africa. Analysis of complete virus genome sequences confirmed the reemergence of Sudan virus and Marburg virus in Uganda, and the first emergence of Bundibugyo virus in the Democratic Republic of the Congo.
Alexander S Petkevich - One of the best experts on this subject based on the ideXlab platform.
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stampidine prevents mortality in an experimental mouse model of Viral Hemorrhagic Fever caused by lassa virus
BMC Infectious Diseases, 2004Co-Authors: Fatih M Uckun, Alexander S Petkevich, Alexei O Vassilev, Heather E Tibbles, Leonid TitovAbstract:Background The potential use of microorganisms as agents of biological warfare (BW) is a growing concern. Lassa virus, a member of the Arenavirus class of Hemorrhagic Fever (HF) viruses has emerged as a worldwide concern among public health officials. The purpose of the present study was to further elucidate the antiViral activity spectrum of stampidine, a novel nucleoside analog with potent anti-Viral activity against the immunodeficiency viruses HIV-1, HIV-2, and FIV, by examining its effects on survival of mice challenged with Lassa virus.
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Stampidine prevents mortality in an experimental mouse model of Viral Hemorrhagic Fever caused by lassa virus
BMC Infectious Diseases, 2004Co-Authors: Fatih M Uckun, Alexander S Petkevich, Alexei O Vassilev, Heather E Tibbles, Leonid TitovAbstract:Background The potential use of microorganisms as agents of biological warfare (BW) is a growing concern. Lassa virus, a member of the Arenavirus class of Hemorrhagic Fever (HF) viruses has emerged as a worldwide concern among public health officials. The purpose of the present study was to further elucidate the antiViral activity spectrum of stampidine, a novel nucleoside analog with potent anti-Viral activity against the immunodeficiency viruses HIV-1, HIV-2, and FIV, by examining its effects on survival of mice challenged with Lassa virus. Methods We examined the therapeutic effect of Stampidine in CBA mice inoculated with intracerebral injections of the Josiah strain of Lassa virus. Mice were treated either with vehicle or nontoxic doses of stampidine administered intraperitoneally 24 hours prior to, 1 hour prior to, and 24 hours, 48 hours, 72 hours, and 96 hours after virus inoculation. Results The probability of survival following the Lassa challenge was significantly improved for stampidine treated mice (Kaplan Meier, Chi-squared = 11.7, df = 2, Log-Rank p-value = 0.003). Conclusion Therefore, stampidine shows clinical potential as a new agent for treatment of Viral Hemorrhagic Fevers caused by Lassa virus.
Alexei O Vassilev - One of the best experts on this subject based on the ideXlab platform.
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stampidine prevents mortality in an experimental mouse model of Viral Hemorrhagic Fever caused by lassa virus
BMC Infectious Diseases, 2004Co-Authors: Fatih M Uckun, Alexander S Petkevich, Alexei O Vassilev, Heather E Tibbles, Leonid TitovAbstract:Background The potential use of microorganisms as agents of biological warfare (BW) is a growing concern. Lassa virus, a member of the Arenavirus class of Hemorrhagic Fever (HF) viruses has emerged as a worldwide concern among public health officials. The purpose of the present study was to further elucidate the antiViral activity spectrum of stampidine, a novel nucleoside analog with potent anti-Viral activity against the immunodeficiency viruses HIV-1, HIV-2, and FIV, by examining its effects on survival of mice challenged with Lassa virus.
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Stampidine prevents mortality in an experimental mouse model of Viral Hemorrhagic Fever caused by lassa virus
BMC Infectious Diseases, 2004Co-Authors: Fatih M Uckun, Alexander S Petkevich, Alexei O Vassilev, Heather E Tibbles, Leonid TitovAbstract:Background The potential use of microorganisms as agents of biological warfare (BW) is a growing concern. Lassa virus, a member of the Arenavirus class of Hemorrhagic Fever (HF) viruses has emerged as a worldwide concern among public health officials. The purpose of the present study was to further elucidate the antiViral activity spectrum of stampidine, a novel nucleoside analog with potent anti-Viral activity against the immunodeficiency viruses HIV-1, HIV-2, and FIV, by examining its effects on survival of mice challenged with Lassa virus. Methods We examined the therapeutic effect of Stampidine in CBA mice inoculated with intracerebral injections of the Josiah strain of Lassa virus. Mice were treated either with vehicle or nontoxic doses of stampidine administered intraperitoneally 24 hours prior to, 1 hour prior to, and 24 hours, 48 hours, 72 hours, and 96 hours after virus inoculation. Results The probability of survival following the Lassa challenge was significantly improved for stampidine treated mice (Kaplan Meier, Chi-squared = 11.7, df = 2, Log-Rank p-value = 0.003). Conclusion Therefore, stampidine shows clinical potential as a new agent for treatment of Viral Hemorrhagic Fevers caused by Lassa virus.
