The Experts below are selected from a list of 732 Experts worldwide ranked by ideXlab platform
Mie, Mie Sein - One of the best experts on this subject based on the ideXlab platform.
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Acute and chronic rhinoSinusitis, pathophysiology and treatment
2015Co-Authors: Murtaza Mustafa, P. Patawari, Mie, Mie SeinAbstract:Acute Sinusitis (ARS) and chronic rhinoSinusitis (CRS) is a common condition worldwide.CRS is due to the infection and inflammation of paranasal sinuses. Frequent clinical manifestations of ARS include persistent symptoms with nasal discharge or cough or both, presentation with fever accompanies purulent nasal discharge, and worsening symptoms. Complications of CRS have five stages, preseptal cellulitis, orbital cellulitis, subperiosteal abscess, orbital abscess and cavernous sinus septic thrombosis. Most acute Sinusitis generally of Viral origin, e,g. rhinoviruses, corona viruses,and influenza viruses. Bacterial pathogen include Streptococcus pneumonia, Haemophilus influenza and Moraxella catarrhalis. Bacteria found in biofilms have their antibiotic resistant increased up to 1000 times when compared to bacteria free living of same species. Sinusitis also results from fungal invasion in patients with diabetes, immune deficiencies, and AIDSor transplant patients. Bacterial and Viral Sinusitis are difficult to distinguish. The diagnosis of acute Sinusitis should be on clinical presentation in most patients CT scan of sinuses is useful for patients with complications and in patients in whom sinus surgery is considered. MRI may have a role in the diagnosis of fungal rhinitis. The benefit of Functional Endoscopic Sinus Surgery (FESS) is its ability for a more targeted approach. Recently developed treatment by balloon sinuplasty is promising. A short-course of antibiotics is helpful in clinically diagnosed bacterial Sinusitis without complicating factors
Pentti Huovinenc For - One of the best experts on this subject based on the ideXlab platform.
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doi:10.1093/fampra/cml074 Family Practice Advance Access published on 20 January 2007 Implementing guidelines on acute maxillary Sinusitis in general practice—a randomized controlled trial
2015Co-Authors: Helena Varonena, Ulla-maija Rautakorpib, Solja Nybergc, Pekka O Honkanene, Timo Klaukkaf, Erkki Palvag, Risto Roineh, Hannu Sarkkineni, Pentti Huovinenc ForAbstract:lines on acute maxillary Sinusitis in general practice—a randomized controlled trial. Family Prac-tice 2007; 24: 201–206. Background. Management of acute maxillary Sinusitis (AMS) is not optimal; antibiotics are often prescribed for Viral Sinusitis, which leads to many problems including those with antimicro-bial resistance. Guidelines have been proposed as a means to change the professional practices. Objective. Our aim was to study whether a nationwide guidelines implementation programme has an effect on the management of AMS in primary care. Methods. A multi-centre randomized controlled trial was conducted in 30 health centres (HCs) covering a population of 819 777 people from 1998 to 2002. The participating HCs were random-ized to implement guidelines either according to a problem-based learning (PBL) or an academic detailing (AD) method facilitated by local GPs. Data were gathered during 1 week in November in all study years and also from external control HCs in 2002. The main outcome measure was com-pliance with the key points of AMS management in national Current Care guidelines. Results. Implementation of guidelines produced minor changes towards the recommended practices in the management of AMS. Use of the first-line drug amoxicillin increased slightl
Boyle, Sarah K - One of the best experts on this subject based on the ideXlab platform.
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Is Sinupret (BNO 1016- Herbal Combination) an Effective Treatment for the Symptoms of Acute and Chronic RhinoSinusitis Compared to Non-treatment in Male and Female Adults Ages 18-75?
2019Co-Authors: Boyle, Sarah KAbstract:Objective: The objective of this selective EBM review is to determine whether or not Sinupret (BNO 1016- herbal combination) is an effective treatment for the symptoms of acute and chronic rhinoSinusitis compared to non-treatment in male and female adults ages 18-75? Study Design: This is a systematic review of three randomized controlled trials (RCTs) regarding Sinupret treatment for sinonasal symptoms. All RCTs were published in the English language in peer-reviewed journals in 2011, 2015, and 2017. Data Sources: Three randomized controlled trials were found using PubMED and CINAHL databases. Outcomes Measured: Symptom relief of acute and chronic rhinoSinusitis was measured via major symptom score (MSS) of rhinorrhea, post-nasal drip, congestion, headache, and facial pressure by participants (measured by mean change from baseline). Assessment of responders vs. non-responders to treatment as designated by “cured/improved” vs. “unchanged/deteriorated.” Improvement of olfactory function per phenylethanol odor testing as well as odor discrimination and identification testing. Results: Jund et al.3 showed a greater decrease in acute Viral Sinusitis symptoms (MSS decrease) with Sinupret treatment than with placebo-treated group (p\u3c0.0001) as well as a NNT of 10. Palm et al.6 showed similar reduction in MSS in the use of Sinupret for chronic Sinusitis (p\u3c0.0015). Reden et al. 7 showed improvement in olfactory function in Sinusitis patients withdrawing from prednisolone with the use of Sinupret, but failed to show statistical significance (p=0.67). Conclusions: Two of the three studies reviewed studies revealed that Sinupret, herbal combination, can be used as an effective treatment in adults 18-75 years old for decreasing the symptoms of acute Viral and chronic Sinusitis at a faster rate than no treatment at all. Multiple studies suggested expanding the study population beyond German participants
Murtaza Mustafa - One of the best experts on this subject based on the ideXlab platform.
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Acute and chronic rhinoSinusitis, pathophysiology and treatment
2015Co-Authors: Murtaza Mustafa, P. Patawari, Mie, Mie SeinAbstract:Acute Sinusitis (ARS) and chronic rhinoSinusitis (CRS) is a common condition worldwide.CRS is due to the infection and inflammation of paranasal sinuses. Frequent clinical manifestations of ARS include persistent symptoms with nasal discharge or cough or both, presentation with fever accompanies purulent nasal discharge, and worsening symptoms. Complications of CRS have five stages, preseptal cellulitis, orbital cellulitis, subperiosteal abscess, orbital abscess and cavernous sinus septic thrombosis. Most acute Sinusitis generally of Viral origin, e,g. rhinoviruses, corona viruses,and influenza viruses. Bacterial pathogen include Streptococcus pneumonia, Haemophilus influenza and Moraxella catarrhalis. Bacteria found in biofilms have their antibiotic resistant increased up to 1000 times when compared to bacteria free living of same species. Sinusitis also results from fungal invasion in patients with diabetes, immune deficiencies, and AIDSor transplant patients. Bacterial and Viral Sinusitis are difficult to distinguish. The diagnosis of acute Sinusitis should be on clinical presentation in most patients CT scan of sinuses is useful for patients with complications and in patients in whom sinus surgery is considered. MRI may have a role in the diagnosis of fungal rhinitis. The benefit of Functional Endoscopic Sinus Surgery (FESS) is its ability for a more targeted approach. Recently developed treatment by balloon sinuplasty is promising. A short-course of antibiotics is helpful in clinically diagnosed bacterial Sinusitis without complicating factors
Helena Varonena - One of the best experts on this subject based on the ideXlab platform.
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doi:10.1093/fampra/cml074 Family Practice Advance Access published on 20 January 2007 Implementing guidelines on acute maxillary Sinusitis in general practice—a randomized controlled trial
2015Co-Authors: Helena Varonena, Ulla-maija Rautakorpib, Solja Nybergc, Pekka O Honkanene, Timo Klaukkaf, Erkki Palvag, Risto Roineh, Hannu Sarkkineni, Pentti Huovinenc ForAbstract:lines on acute maxillary Sinusitis in general practice—a randomized controlled trial. Family Prac-tice 2007; 24: 201–206. Background. Management of acute maxillary Sinusitis (AMS) is not optimal; antibiotics are often prescribed for Viral Sinusitis, which leads to many problems including those with antimicro-bial resistance. Guidelines have been proposed as a means to change the professional practices. Objective. Our aim was to study whether a nationwide guidelines implementation programme has an effect on the management of AMS in primary care. Methods. A multi-centre randomized controlled trial was conducted in 30 health centres (HCs) covering a population of 819 777 people from 1998 to 2002. The participating HCs were random-ized to implement guidelines either according to a problem-based learning (PBL) or an academic detailing (AD) method facilitated by local GPs. Data were gathered during 1 week in November in all study years and also from external control HCs in 2002. The main outcome measure was com-pliance with the key points of AMS management in national Current Care guidelines. Results. Implementation of guidelines produced minor changes towards the recommended practices in the management of AMS. Use of the first-line drug amoxicillin increased slightl