The Experts below are selected from a list of 1953 Experts worldwide ranked by ideXlab platform
Denis Houzelstein - One of the best experts on this subject based on the ideXlab platform.
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the ring finger protein 213 gene rnf213 contributes to rift valley fever resistance in mice
Mammalian Genome, 2021Co-Authors: Denis Houzelstein, Dominique Simonchazottes, Leandro Batista, Satoko Tokuda, Francina Langa Vives, Marie FlamandAbstract:Rift Valley fever (RVF) is an emerging Viral Zoonosis that primarily affects ruminants and humans. We have previously shown that wild-derived MBT/Pas mice are highly susceptible to RVF virus and that part of this phenotype is controlled by a locus located on distal Chromosome 11. Using congenic strains, we narrowed down the critical interval to a 530 kb region containing five protein-coding genes among which Rnf213 emerged as a potential candidate. We generated Rnf213-deficient mice by CRISPR/CAS9 on the C57BL/6 J background and showed that they were significantly more susceptible to RVF than control mice, with an average survival time post-infection reduced from 7 to 4 days. The human RNF213 gene had been associated with the cerebrovascular Moyamoya disease (MMD or MYMY) but the inactivation of this gene in the mouse resulted only in mild anomalies of the neovascularization. This study provides the first evidence that the Rnf213 gene may also impact the resistance to infectious diseases such as RVF.
Marie Flamand - One of the best experts on this subject based on the ideXlab platform.
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the ring finger protein 213 gene rnf213 contributes to rift valley fever resistance in mice
Mammalian Genome, 2021Co-Authors: Denis Houzelstein, Dominique Simonchazottes, Leandro Batista, Satoko Tokuda, Francina Langa Vives, Marie FlamandAbstract:Rift Valley fever (RVF) is an emerging Viral Zoonosis that primarily affects ruminants and humans. We have previously shown that wild-derived MBT/Pas mice are highly susceptible to RVF virus and that part of this phenotype is controlled by a locus located on distal Chromosome 11. Using congenic strains, we narrowed down the critical interval to a 530 kb region containing five protein-coding genes among which Rnf213 emerged as a potential candidate. We generated Rnf213-deficient mice by CRISPR/CAS9 on the C57BL/6 J background and showed that they were significantly more susceptible to RVF than control mice, with an average survival time post-infection reduced from 7 to 4 days. The human RNF213 gene had been associated with the cerebrovascular Moyamoya disease (MMD or MYMY) but the inactivation of this gene in the mouse resulted only in mild anomalies of the neovascularization. This study provides the first evidence that the Rnf213 gene may also impact the resistance to infectious diseases such as RVF.
Dominique Simonchazottes - One of the best experts on this subject based on the ideXlab platform.
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the ring finger protein 213 gene rnf213 contributes to rift valley fever resistance in mice
Mammalian Genome, 2021Co-Authors: Denis Houzelstein, Dominique Simonchazottes, Leandro Batista, Satoko Tokuda, Francina Langa Vives, Marie FlamandAbstract:Rift Valley fever (RVF) is an emerging Viral Zoonosis that primarily affects ruminants and humans. We have previously shown that wild-derived MBT/Pas mice are highly susceptible to RVF virus and that part of this phenotype is controlled by a locus located on distal Chromosome 11. Using congenic strains, we narrowed down the critical interval to a 530 kb region containing five protein-coding genes among which Rnf213 emerged as a potential candidate. We generated Rnf213-deficient mice by CRISPR/CAS9 on the C57BL/6 J background and showed that they were significantly more susceptible to RVF than control mice, with an average survival time post-infection reduced from 7 to 4 days. The human RNF213 gene had been associated with the cerebrovascular Moyamoya disease (MMD or MYMY) but the inactivation of this gene in the mouse resulted only in mild anomalies of the neovascularization. This study provides the first evidence that the Rnf213 gene may also impact the resistance to infectious diseases such as RVF.
Leandro Batista - One of the best experts on this subject based on the ideXlab platform.
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the ring finger protein 213 gene rnf213 contributes to rift valley fever resistance in mice
Mammalian Genome, 2021Co-Authors: Denis Houzelstein, Dominique Simonchazottes, Leandro Batista, Satoko Tokuda, Francina Langa Vives, Marie FlamandAbstract:Rift Valley fever (RVF) is an emerging Viral Zoonosis that primarily affects ruminants and humans. We have previously shown that wild-derived MBT/Pas mice are highly susceptible to RVF virus and that part of this phenotype is controlled by a locus located on distal Chromosome 11. Using congenic strains, we narrowed down the critical interval to a 530 kb region containing five protein-coding genes among which Rnf213 emerged as a potential candidate. We generated Rnf213-deficient mice by CRISPR/CAS9 on the C57BL/6 J background and showed that they were significantly more susceptible to RVF than control mice, with an average survival time post-infection reduced from 7 to 4 days. The human RNF213 gene had been associated with the cerebrovascular Moyamoya disease (MMD or MYMY) but the inactivation of this gene in the mouse resulted only in mild anomalies of the neovascularization. This study provides the first evidence that the Rnf213 gene may also impact the resistance to infectious diseases such as RVF.
Satoko Tokuda - One of the best experts on this subject based on the ideXlab platform.
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the ring finger protein 213 gene rnf213 contributes to rift valley fever resistance in mice
Mammalian Genome, 2021Co-Authors: Denis Houzelstein, Dominique Simonchazottes, Leandro Batista, Satoko Tokuda, Francina Langa Vives, Marie FlamandAbstract:Rift Valley fever (RVF) is an emerging Viral Zoonosis that primarily affects ruminants and humans. We have previously shown that wild-derived MBT/Pas mice are highly susceptible to RVF virus and that part of this phenotype is controlled by a locus located on distal Chromosome 11. Using congenic strains, we narrowed down the critical interval to a 530 kb region containing five protein-coding genes among which Rnf213 emerged as a potential candidate. We generated Rnf213-deficient mice by CRISPR/CAS9 on the C57BL/6 J background and showed that they were significantly more susceptible to RVF than control mice, with an average survival time post-infection reduced from 7 to 4 days. The human RNF213 gene had been associated with the cerebrovascular Moyamoya disease (MMD or MYMY) but the inactivation of this gene in the mouse resulted only in mild anomalies of the neovascularization. This study provides the first evidence that the Rnf213 gene may also impact the resistance to infectious diseases such as RVF.
