The Experts below are selected from a list of 142953 Experts worldwide ranked by ideXlab platform
A Haouz - One of the best experts on this subject based on the ideXlab platform.
-
Structural basis of potent Zika–dengue Virus Antibody cross-neutralization
Nature, 2016Co-Authors: Giovanna Barba-spaeth, Wanwisa Dejnirattisai, Alexander Rouvinski, Marie Christine Vaney, Iris Medits, Arvind Sharma, Anavaj Sakuntabhai, Etienne Simon-lorière, Van-mai Cao-lormeau, A HaouzAbstract:Zika Virus is a member of the FlaviVirus genus that had not been associated with severe disease in humans until the recent outbreaks, when it was linked to microcephaly in newborns in Brazil and to Guillain-Barré syndrome in adults in French Polynesia. Zika Virus is related to dengue Virus, and here we report that a subset of antibodies targeting a conformational epitope isolated from patients with dengue Virus also potently neutralize Zika Virus. The crystal structure of two of these antibodies in complex with the envelope protein of Zika Virus reveals the details of a conserved epitope, which is also the site of interaction of the envelope protein dimer with the precursor membrane (prM) protein during Virus maturation. Comparison of the Zika and dengue Virus immunocomplexes provides a lead for rational, epitope-focused design of a universal vaccine capable of eliciting potent cross-neutralizing antibodies to protect simultaneously against both Zika and dengue Virus infections.
-
structural basis of potent zika dengue Virus Antibody cross neutralization
Nature, 2016Co-Authors: Giovanna Barbaspaeth, Wanwisa Dejnirattisai, Alexander Rouvinski, Marie Christine Vaney, Iris Medits, Arvind Sharma, Etienne Simonloriere, Anavaj Sakuntabhai, Vanmai Caolormeau, A HaouzAbstract:Zika Virus is a member of the FlaviVirus genus that had not been associated with severe disease in humans until the recent outbreaks, when it was linked to microcephaly in newborns in Brazil and to Guillain-Barre syndrome in adults in French Polynesia. Zika Virus is related to dengue Virus, and here we report that a subset of antibodies targeting a conformational epitope isolated from patients with dengue Virus also potently neutralize Zika Virus. The crystal structure of two of these antibodies in complex with the envelope protein of Zika Virus reveals the details of a conserved epitope, which is also the site of interaction of the envelope protein dimer with the precursor membrane (prM) protein during Virus maturation. Comparison of the Zika and dengue Virus immunocomplexes provides a lead for rational, epitope-focused design of a universal vaccine capable of eliciting potent cross-neutralizing antibodies to protect simultaneously against both Zika and dengue Virus infections.
Anavaj Sakuntabhai - One of the best experts on this subject based on the ideXlab platform.
-
Structural basis of potent Zika–dengue Virus Antibody cross-neutralization
Nature, 2016Co-Authors: Giovanna Barba-spaeth, Wanwisa Dejnirattisai, Alexander Rouvinski, Marie Christine Vaney, Iris Medits, Arvind Sharma, Anavaj Sakuntabhai, Etienne Simon-lorière, Van-mai Cao-lormeau, A HaouzAbstract:Zika Virus is a member of the FlaviVirus genus that had not been associated with severe disease in humans until the recent outbreaks, when it was linked to microcephaly in newborns in Brazil and to Guillain-Barré syndrome in adults in French Polynesia. Zika Virus is related to dengue Virus, and here we report that a subset of antibodies targeting a conformational epitope isolated from patients with dengue Virus also potently neutralize Zika Virus. The crystal structure of two of these antibodies in complex with the envelope protein of Zika Virus reveals the details of a conserved epitope, which is also the site of interaction of the envelope protein dimer with the precursor membrane (prM) protein during Virus maturation. Comparison of the Zika and dengue Virus immunocomplexes provides a lead for rational, epitope-focused design of a universal vaccine capable of eliciting potent cross-neutralizing antibodies to protect simultaneously against both Zika and dengue Virus infections.
-
structural basis of potent zika dengue Virus Antibody cross neutralization
Nature, 2016Co-Authors: Giovanna Barbaspaeth, Wanwisa Dejnirattisai, Alexander Rouvinski, Marie Christine Vaney, Iris Medits, Arvind Sharma, Etienne Simonloriere, Anavaj Sakuntabhai, Vanmai Caolormeau, A HaouzAbstract:Zika Virus is a member of the FlaviVirus genus that had not been associated with severe disease in humans until the recent outbreaks, when it was linked to microcephaly in newborns in Brazil and to Guillain-Barre syndrome in adults in French Polynesia. Zika Virus is related to dengue Virus, and here we report that a subset of antibodies targeting a conformational epitope isolated from patients with dengue Virus also potently neutralize Zika Virus. The crystal structure of two of these antibodies in complex with the envelope protein of Zika Virus reveals the details of a conserved epitope, which is also the site of interaction of the envelope protein dimer with the precursor membrane (prM) protein during Virus maturation. Comparison of the Zika and dengue Virus immunocomplexes provides a lead for rational, epitope-focused design of a universal vaccine capable of eliciting potent cross-neutralizing antibodies to protect simultaneously against both Zika and dengue Virus infections.
Arvind Sharma - One of the best experts on this subject based on the ideXlab platform.
-
Structural basis of potent Zika–dengue Virus Antibody cross-neutralization
Nature, 2016Co-Authors: Giovanna Barba-spaeth, Wanwisa Dejnirattisai, Alexander Rouvinski, Marie Christine Vaney, Iris Medits, Arvind Sharma, Anavaj Sakuntabhai, Etienne Simon-lorière, Van-mai Cao-lormeau, A HaouzAbstract:Zika Virus is a member of the FlaviVirus genus that had not been associated with severe disease in humans until the recent outbreaks, when it was linked to microcephaly in newborns in Brazil and to Guillain-Barré syndrome in adults in French Polynesia. Zika Virus is related to dengue Virus, and here we report that a subset of antibodies targeting a conformational epitope isolated from patients with dengue Virus also potently neutralize Zika Virus. The crystal structure of two of these antibodies in complex with the envelope protein of Zika Virus reveals the details of a conserved epitope, which is also the site of interaction of the envelope protein dimer with the precursor membrane (prM) protein during Virus maturation. Comparison of the Zika and dengue Virus immunocomplexes provides a lead for rational, epitope-focused design of a universal vaccine capable of eliciting potent cross-neutralizing antibodies to protect simultaneously against both Zika and dengue Virus infections.
-
structural basis of potent zika dengue Virus Antibody cross neutralization
Nature, 2016Co-Authors: Giovanna Barbaspaeth, Wanwisa Dejnirattisai, Alexander Rouvinski, Marie Christine Vaney, Iris Medits, Arvind Sharma, Etienne Simonloriere, Anavaj Sakuntabhai, Vanmai Caolormeau, A HaouzAbstract:Zika Virus is a member of the FlaviVirus genus that had not been associated with severe disease in humans until the recent outbreaks, when it was linked to microcephaly in newborns in Brazil and to Guillain-Barre syndrome in adults in French Polynesia. Zika Virus is related to dengue Virus, and here we report that a subset of antibodies targeting a conformational epitope isolated from patients with dengue Virus also potently neutralize Zika Virus. The crystal structure of two of these antibodies in complex with the envelope protein of Zika Virus reveals the details of a conserved epitope, which is also the site of interaction of the envelope protein dimer with the precursor membrane (prM) protein during Virus maturation. Comparison of the Zika and dengue Virus immunocomplexes provides a lead for rational, epitope-focused design of a universal vaccine capable of eliciting potent cross-neutralizing antibodies to protect simultaneously against both Zika and dengue Virus infections.
Iris Medits - One of the best experts on this subject based on the ideXlab platform.
-
Structural basis of potent Zika–dengue Virus Antibody cross-neutralization
Nature, 2016Co-Authors: Giovanna Barba-spaeth, Wanwisa Dejnirattisai, Alexander Rouvinski, Marie Christine Vaney, Iris Medits, Arvind Sharma, Anavaj Sakuntabhai, Etienne Simon-lorière, Van-mai Cao-lormeau, A HaouzAbstract:Zika Virus is a member of the FlaviVirus genus that had not been associated with severe disease in humans until the recent outbreaks, when it was linked to microcephaly in newborns in Brazil and to Guillain-Barré syndrome in adults in French Polynesia. Zika Virus is related to dengue Virus, and here we report that a subset of antibodies targeting a conformational epitope isolated from patients with dengue Virus also potently neutralize Zika Virus. The crystal structure of two of these antibodies in complex with the envelope protein of Zika Virus reveals the details of a conserved epitope, which is also the site of interaction of the envelope protein dimer with the precursor membrane (prM) protein during Virus maturation. Comparison of the Zika and dengue Virus immunocomplexes provides a lead for rational, epitope-focused design of a universal vaccine capable of eliciting potent cross-neutralizing antibodies to protect simultaneously against both Zika and dengue Virus infections.
-
structural basis of potent zika dengue Virus Antibody cross neutralization
Nature, 2016Co-Authors: Giovanna Barbaspaeth, Wanwisa Dejnirattisai, Alexander Rouvinski, Marie Christine Vaney, Iris Medits, Arvind Sharma, Etienne Simonloriere, Anavaj Sakuntabhai, Vanmai Caolormeau, A HaouzAbstract:Zika Virus is a member of the FlaviVirus genus that had not been associated with severe disease in humans until the recent outbreaks, when it was linked to microcephaly in newborns in Brazil and to Guillain-Barre syndrome in adults in French Polynesia. Zika Virus is related to dengue Virus, and here we report that a subset of antibodies targeting a conformational epitope isolated from patients with dengue Virus also potently neutralize Zika Virus. The crystal structure of two of these antibodies in complex with the envelope protein of Zika Virus reveals the details of a conserved epitope, which is also the site of interaction of the envelope protein dimer with the precursor membrane (prM) protein during Virus maturation. Comparison of the Zika and dengue Virus immunocomplexes provides a lead for rational, epitope-focused design of a universal vaccine capable of eliciting potent cross-neutralizing antibodies to protect simultaneously against both Zika and dengue Virus infections.
Marie Christine Vaney - One of the best experts on this subject based on the ideXlab platform.
-
Structural basis of potent Zika–dengue Virus Antibody cross-neutralization
Nature, 2016Co-Authors: Giovanna Barba-spaeth, Wanwisa Dejnirattisai, Alexander Rouvinski, Marie Christine Vaney, Iris Medits, Arvind Sharma, Anavaj Sakuntabhai, Etienne Simon-lorière, Van-mai Cao-lormeau, A HaouzAbstract:Zika Virus is a member of the FlaviVirus genus that had not been associated with severe disease in humans until the recent outbreaks, when it was linked to microcephaly in newborns in Brazil and to Guillain-Barré syndrome in adults in French Polynesia. Zika Virus is related to dengue Virus, and here we report that a subset of antibodies targeting a conformational epitope isolated from patients with dengue Virus also potently neutralize Zika Virus. The crystal structure of two of these antibodies in complex with the envelope protein of Zika Virus reveals the details of a conserved epitope, which is also the site of interaction of the envelope protein dimer with the precursor membrane (prM) protein during Virus maturation. Comparison of the Zika and dengue Virus immunocomplexes provides a lead for rational, epitope-focused design of a universal vaccine capable of eliciting potent cross-neutralizing antibodies to protect simultaneously against both Zika and dengue Virus infections.
-
structural basis of potent zika dengue Virus Antibody cross neutralization
Nature, 2016Co-Authors: Giovanna Barbaspaeth, Wanwisa Dejnirattisai, Alexander Rouvinski, Marie Christine Vaney, Iris Medits, Arvind Sharma, Etienne Simonloriere, Anavaj Sakuntabhai, Vanmai Caolormeau, A HaouzAbstract:Zika Virus is a member of the FlaviVirus genus that had not been associated with severe disease in humans until the recent outbreaks, when it was linked to microcephaly in newborns in Brazil and to Guillain-Barre syndrome in adults in French Polynesia. Zika Virus is related to dengue Virus, and here we report that a subset of antibodies targeting a conformational epitope isolated from patients with dengue Virus also potently neutralize Zika Virus. The crystal structure of two of these antibodies in complex with the envelope protein of Zika Virus reveals the details of a conserved epitope, which is also the site of interaction of the envelope protein dimer with the precursor membrane (prM) protein during Virus maturation. Comparison of the Zika and dengue Virus immunocomplexes provides a lead for rational, epitope-focused design of a universal vaccine capable of eliciting potent cross-neutralizing antibodies to protect simultaneously against both Zika and dengue Virus infections.
