The Experts below are selected from a list of 168 Experts worldwide ranked by ideXlab platform
Kenneth I Berger - One of the best experts on this subject based on the ideXlab platform.
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pulmonary function tests maximum inspiratory pressure maximum expiratory pressure Vital Capacity forced Vital Capacity predict ventilator use in late onset pompe disease
Neuromuscular Disorders, 2016Co-Authors: Erin M Johnson, Mark Roberts, Tahseen Mozaffar, Peter Young, Adrian Quartel, Kenneth I BergerAbstract:Abstract In patients with Late-Onset Pompe Disease (LOPD), progressive respiratory muscle involvement leads to reduced pulmonary function, with respiratory failure the most common cause of mortality. Early disease manifestations include sleep-disordered breathing, which can be treated with non-invasive ventilation; however, progressive diurnal deficits can require invasive ventilation. To determine if pulmonary function tests (PFTs) predict the thresholds for ventilation and wheelchair use, a systematic literature review identified cross-sectional clinical patient data (N = 174) that was classified into ventilation and wheelchair cohorts. PFTs included maximum inspiratory pressure (MIP), maximum expiratory pressure (MEP), forced Vital Capacity (FVC), and Vital Capacity (VC), with Vital capacities measured in the upright (-U) and supine (-S) positions. Receiver operating characteristic (ROC) curves were used to calculate cut-points (CP) and area under the curve (AUC). For all ventilation and mobility thresholds tested, ROC analyses demonstrated AUC values from 86–89% for MIP, 72–96% for MEP, and 74–96% for all Vital Capacity metrics. Thus, PFTs are useful in predicting the thresholds for nighttime ventilation, daytime ventilation, and wheelchair use, with MIP and VC-U having both high AUC values and consistency. The PFT mobility CPs were low (MIP CP = 0.9 kPa, MEP, CP = 2.6 kPa, VC-U CP = 19% predicted), suggesting an endurance component associated with wheelchair use.
Magnus Skold - One of the best experts on this subject based on the ideXlab platform.
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Vital Capacity and copd the swedish cardiopulmonary bioimage study scapis
International Journal of Chronic Obstructive Pulmonary Disease, 2016Co-Authors: Kjell Toren, Annacarin Olin, Anne Lindberg, Jenny Vikgren, Linus Schioler, John Brandberg, Ase A Johnsson, Gunnar Engstrom, Lennart H Persson, Magnus SkoldAbstract:Background: Spirometric diagnosis of chronic obstructive pulmonary disease (COPD) is based on the ratio of forced expiratory volume in 1 second (FEV1)/Vital Capacity (VC), either as a fixed value & ...
Erin M Johnson - One of the best experts on this subject based on the ideXlab platform.
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pulmonary function tests maximum inspiratory pressure maximum expiratory pressure Vital Capacity forced Vital Capacity predict ventilator use in late onset pompe disease
Neuromuscular Disorders, 2016Co-Authors: Erin M Johnson, Mark Roberts, Tahseen Mozaffar, Peter Young, Adrian Quartel, Kenneth I BergerAbstract:Abstract In patients with Late-Onset Pompe Disease (LOPD), progressive respiratory muscle involvement leads to reduced pulmonary function, with respiratory failure the most common cause of mortality. Early disease manifestations include sleep-disordered breathing, which can be treated with non-invasive ventilation; however, progressive diurnal deficits can require invasive ventilation. To determine if pulmonary function tests (PFTs) predict the thresholds for ventilation and wheelchair use, a systematic literature review identified cross-sectional clinical patient data (N = 174) that was classified into ventilation and wheelchair cohorts. PFTs included maximum inspiratory pressure (MIP), maximum expiratory pressure (MEP), forced Vital Capacity (FVC), and Vital Capacity (VC), with Vital capacities measured in the upright (-U) and supine (-S) positions. Receiver operating characteristic (ROC) curves were used to calculate cut-points (CP) and area under the curve (AUC). For all ventilation and mobility thresholds tested, ROC analyses demonstrated AUC values from 86–89% for MIP, 72–96% for MEP, and 74–96% for all Vital Capacity metrics. Thus, PFTs are useful in predicting the thresholds for nighttime ventilation, daytime ventilation, and wheelchair use, with MIP and VC-U having both high AUC values and consistency. The PFT mobility CPs were low (MIP CP = 0.9 kPa, MEP, CP = 2.6 kPa, VC-U CP = 19% predicted), suggesting an endurance component associated with wheelchair use.
Philip L Molyneaux - One of the best experts on this subject based on the ideXlab platform.
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modelling forced Vital Capacity in idiopathic pulmonary fibrosis optimising trial design
Advances in Therapy, 2019Co-Authors: Eva Santermans, P Ford, Michael Kreuter, Nadia Verbruggen, Paul Meyvisch, Wim Wuyts, Kevin K Brown, David J Lederer, Adam J Byrne, Philip L MolyneauxAbstract:Introduction Forced Vital Capacity is the only registrational endpoint in idiopathic pulmonary fibrosis clinical trials. As most new treatments will be administered on top of standard of care, estimating treatment response will become more challenging. We developed a simulation model to quantify variability associated with forced Vital Capacity decline.
Kjell Toren - One of the best experts on this subject based on the ideXlab platform.
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Vital Capacity and copd the swedish cardiopulmonary bioimage study scapis
International Journal of Chronic Obstructive Pulmonary Disease, 2016Co-Authors: Kjell Toren, Annacarin Olin, Anne Lindberg, Jenny Vikgren, Linus Schioler, John Brandberg, Ase A Johnsson, Gunnar Engstrom, Lennart H Persson, Magnus SkoldAbstract:Background: Spirometric diagnosis of chronic obstructive pulmonary disease (COPD) is based on the ratio of forced expiratory volume in 1 second (FEV1)/Vital Capacity (VC), either as a fixed value & ...
