The Experts below are selected from a list of 54 Experts worldwide ranked by ideXlab platform
Qazi Najam Us Saqib - One of the best experts on this subject based on the ideXlab platform.
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antihaemorrhagic potentials of fagonia cretica against naja naja karachiensis black pakistan cobra venom
Natural Product Research, 2011Co-Authors: Muhammad Tahir Razi, Muhammad Hassham Hassan Bin Asad, Taous Khan, Muhammad Zabta Chaudhary, Muhammad Tayyab Ansari, Muhammad Anwar Arshad, Qazi Najam Us SaqibAbstract:Plants have been extensively used as a remedy for the treatment of snake bites. The aim of this study was to determine the antivenom potentials of methanolic extract from the aerial parts (leaves and twigs) of Fagonia cretica L. on a haemorrhage induced by venom from Naja naja karachiensis. The haemorrhagic response of venom was dose dependent from 0.1 to 4.0 µg per 1.5 µL phosphate buffer saline (PBS) on Vitelline Veins of fertilised hens’ eggs in their shells. The extract effectively eliminated and neutralised, in a dose-dependent manner, the haemorrhagic activity of snake venom. The minimum effective neutralising dose of F. cretica extract was found to be 15 µg per 1.5 µL PBS. The extract possesses potentials as haemorrhagic inhibitor against snake venom compared to the standard antiserum and various plants reported in the literature. This study also provides a scientific base for the use of F. cretica in traditional medicine for the treatment of snake bite.
Muhammad Tahir Razi - One of the best experts on this subject based on the ideXlab platform.
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antihaemorrhagic potential of citrullus colocynthis schrad cucurbitaceae against naja naja karachiensis black pakistan cobra venom
Journal of Medicinal Plants Research, 2012Co-Authors: Mhhb Asad, Muhammad Tahir Razi, G Murtaza, Saira Azhar, Shahid A Khan, Qnu Saqib, Irshad HussainAbstract:Snake bites have been widely treated using plant remedies in rural areas of Pakistan.Citrullus colocynthis Schrad (Cucurbitaceae) is one of the plants used for the treatment of snake bite. This project evaluated the antivenom potential of the methanol extract from the fruit, pulp, seeds, and stems of C. colocynthis on a haemorrhage provoked by Naja naja karachiensis venom. A whole dried plant including fruit and stems of C. colocynthis was chopped and macerated to prepare methanol extract for anti-haemorrhagic testing. The reference haemorrhagic dose (RHD) and minimum effective neutralizing dose (MEND) values were determined for study extract. A dose dependent haemorrhagic response of venom was observed in a range of 0.1 to 4.0 μg/1.5 μL phosphate buffer saline (PBS) on the Vitelline Veins of fertilized chicken eggs (in their shells). The neutralizing response of C. colocynthis methanol extract against snake venom was valuable against venom haemorrhage and dose-dependent with a minimum effective neutralizing dose of 11 μg/1.5 μL of PBS. Methanol extract of C. colocynthis has antihaemorrhagic potential against Naja naja karachiensis venom. The present finding suggests that the methanol extract of C. colocynthis can be used to treat snake bites. Key Words: Antiserum fertilized chicken eggs, maceration, reference haemorrhagic dose (RHD), minimum effective neutralizing dose (MEND).
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antihaemorrhagic potentials of fagonia cretica against naja naja karachiensis black pakistan cobra venom
Natural Product Research, 2011Co-Authors: Muhammad Tahir Razi, Muhammad Hassham Hassan Bin Asad, Taous Khan, Muhammad Zabta Chaudhary, Muhammad Tayyab Ansari, Muhammad Anwar Arshad, Qazi Najam Us SaqibAbstract:Plants have been extensively used as a remedy for the treatment of snake bites. The aim of this study was to determine the antivenom potentials of methanolic extract from the aerial parts (leaves and twigs) of Fagonia cretica L. on a haemorrhage induced by venom from Naja naja karachiensis. The haemorrhagic response of venom was dose dependent from 0.1 to 4.0 µg per 1.5 µL phosphate buffer saline (PBS) on Vitelline Veins of fertilised hens’ eggs in their shells. The extract effectively eliminated and neutralised, in a dose-dependent manner, the haemorrhagic activity of snake venom. The minimum effective neutralising dose of F. cretica extract was found to be 15 µg per 1.5 µL PBS. The extract possesses potentials as haemorrhagic inhibitor against snake venom compared to the standard antiserum and various plants reported in the literature. This study also provides a scientific base for the use of F. cretica in traditional medicine for the treatment of snake bite.
Muhammad Zabta Chaudhary - One of the best experts on this subject based on the ideXlab platform.
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antihaemorrhagic potentials of fagonia cretica against naja naja karachiensis black pakistan cobra venom
Natural Product Research, 2011Co-Authors: Muhammad Tahir Razi, Muhammad Hassham Hassan Bin Asad, Taous Khan, Muhammad Zabta Chaudhary, Muhammad Tayyab Ansari, Muhammad Anwar Arshad, Qazi Najam Us SaqibAbstract:Plants have been extensively used as a remedy for the treatment of snake bites. The aim of this study was to determine the antivenom potentials of methanolic extract from the aerial parts (leaves and twigs) of Fagonia cretica L. on a haemorrhage induced by venom from Naja naja karachiensis. The haemorrhagic response of venom was dose dependent from 0.1 to 4.0 µg per 1.5 µL phosphate buffer saline (PBS) on Vitelline Veins of fertilised hens’ eggs in their shells. The extract effectively eliminated and neutralised, in a dose-dependent manner, the haemorrhagic activity of snake venom. The minimum effective neutralising dose of F. cretica extract was found to be 15 µg per 1.5 µL PBS. The extract possesses potentials as haemorrhagic inhibitor against snake venom compared to the standard antiserum and various plants reported in the literature. This study also provides a scientific base for the use of F. cretica in traditional medicine for the treatment of snake bite.
Muhammad Anwar Arshad - One of the best experts on this subject based on the ideXlab platform.
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antihaemorrhagic potentials of fagonia cretica against naja naja karachiensis black pakistan cobra venom
Natural Product Research, 2011Co-Authors: Muhammad Tahir Razi, Muhammad Hassham Hassan Bin Asad, Taous Khan, Muhammad Zabta Chaudhary, Muhammad Tayyab Ansari, Muhammad Anwar Arshad, Qazi Najam Us SaqibAbstract:Plants have been extensively used as a remedy for the treatment of snake bites. The aim of this study was to determine the antivenom potentials of methanolic extract from the aerial parts (leaves and twigs) of Fagonia cretica L. on a haemorrhage induced by venom from Naja naja karachiensis. The haemorrhagic response of venom was dose dependent from 0.1 to 4.0 µg per 1.5 µL phosphate buffer saline (PBS) on Vitelline Veins of fertilised hens’ eggs in their shells. The extract effectively eliminated and neutralised, in a dose-dependent manner, the haemorrhagic activity of snake venom. The minimum effective neutralising dose of F. cretica extract was found to be 15 µg per 1.5 µL PBS. The extract possesses potentials as haemorrhagic inhibitor against snake venom compared to the standard antiserum and various plants reported in the literature. This study also provides a scientific base for the use of F. cretica in traditional medicine for the treatment of snake bite.
Muhammad Tayyab Ansari - One of the best experts on this subject based on the ideXlab platform.
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antihaemorrhagic potentials of fagonia cretica against naja naja karachiensis black pakistan cobra venom
Natural Product Research, 2011Co-Authors: Muhammad Tahir Razi, Muhammad Hassham Hassan Bin Asad, Taous Khan, Muhammad Zabta Chaudhary, Muhammad Tayyab Ansari, Muhammad Anwar Arshad, Qazi Najam Us SaqibAbstract:Plants have been extensively used as a remedy for the treatment of snake bites. The aim of this study was to determine the antivenom potentials of methanolic extract from the aerial parts (leaves and twigs) of Fagonia cretica L. on a haemorrhage induced by venom from Naja naja karachiensis. The haemorrhagic response of venom was dose dependent from 0.1 to 4.0 µg per 1.5 µL phosphate buffer saline (PBS) on Vitelline Veins of fertilised hens’ eggs in their shells. The extract effectively eliminated and neutralised, in a dose-dependent manner, the haemorrhagic activity of snake venom. The minimum effective neutralising dose of F. cretica extract was found to be 15 µg per 1.5 µL PBS. The extract possesses potentials as haemorrhagic inhibitor against snake venom compared to the standard antiserum and various plants reported in the literature. This study also provides a scientific base for the use of F. cretica in traditional medicine for the treatment of snake bite.
