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Hidenobu Tanihara - One of the best experts on this subject based on the ideXlab platform.
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Transthyretin-related Vitreous amyloidosis in different endemic areas.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, 2010Co-Authors: Takahiro Kawaji, Yukio Ando, Eiko Ando, Ola Sandgren, Ole B. Suhr, Hidenobu TaniharaAbstract:Background: to investigate the Vitreous Opacity in patients with familial amyloidotic polyneuropathy (FAP) in two major endemic areas, Japan and Sweden. Methods: we obtained clinical data for 90 pa ...
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A case of Vitreous amyloidosis without systemic symptoms in familial amyloidotic polyneuropathy.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, 2004Co-Authors: Takahiro Kawaji, Yukio Ando, Eiko Ando, Akira Hirata, Masaaki Nakamura, Hidenobu TaniharaAbstract:We describe a case of Vitreous amyloidosis without systemic symptoms in familial amyloidotic polyneuropathy (FAP) associated with Val30Met transthyretin mutation. A healthy 74-year-old woman noticed left blurred vision and floaters in 1992. Severe Vitreous opacities were identified in the left eye. The patient displayed no systemic symptoms, and Congo red staining of the biopsy samples of the stomach and duodenum revealed no amyloid deposition. A diagnosis of FAP was confirmed following genetic investigation. Vitrectomy and cataract surgery was performed with intraocular lens implantation in April 1998. Histopathological examination of the Vitreous material revealed amyloid fibrils. Intraocular pressure (IOP) gradually elevated and cupping of the optic disc enlarged. Trabeculectomy was performed in February 2000, but postoperative IOP was again elevated and a needling procedure was performed in March 2000. No postoperative recurrence of Vitreous Opacity has been reported and IOP has remained well controll...
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Intraocular infiltration of adult T-cell leukemia.
American journal of ophthalmology, 2002Co-Authors: Akira Hirata, Tomonari Miyazaki, Hidenobu TaniharaAbstract:Abstract PURPOSE: To report a case of adult T-cell leukemia (ATL) with unilateral dense Vitreous opacities that benefited from vitrectomy. DESIGN: Interventional case report. METHODS: Diagnostic vitrectomy was performed on a 59-year-old man with ATL who had Vitreous Opacity in the right eye. RESULTS: White infiltration of the retina was noted after vitrectomy. Cytologic examination of the Vitreous specimen obtained during surgery revealed infiltration of ATL cells into the Vitreous and retina. After vitrectomy and additional chemotherapy, visual acuity improved in the right eye from 20/100 to 25/20. CONCLUSION: Infiltration of the Vitreous and retina by ATL is rare. Diagnostic vitrectomy is effective for treatment and visual improvement.
Susumu Ishida - One of the best experts on this subject based on the ideXlab platform.
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Multiple evanescent white dot syndrome and panuveitis: a case report.
Journal of ophthalmic inflammation and infection, 2020Co-Authors: Kazuomi Mizuuchi, Wataru Saito, Kenichi Namba, Susumu IshidaAbstract:AIM To report a patient with multiple evanescent white dot syndrome (MEWDS) complicated by iridocyclitis and vitritis. CASE DESCRIPTION A 70-year-old woman developed multiple subretinal white dots, iritis, and diffuse Vitreous Opacity. Angiographic and macular morphological features were consistent with those of MEWDS. Inflammatory findings including the white dots improved following only topical dexamethasone within 1 month after the initial visit. Best-corrected visual acuity recovered to 1.0 with restored photoreceptor structure. CONCLUSION The presence of iridocyclitis and vitritis, atypical to MEWDS, indicates the concurrent development of panuveitis associated with MEWDS. These results suggest that MEWDS is a clinical entity of uveitis.
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A case of tuberculous endophthalmitis successfully treated with vitrectomy followed by antituberculous agents
Journal of Ophthalmic Inflammation and Infection, 2015Co-Authors: Keitaro Hase, Shigeaki Ohno, Kenichi Namba, Wataru Saito, Susumu IshidaAbstract:Background Tuberculous endophthalmitis is very rare with only 18 reports published worldwide and only a few cases in Japan. We report a case of tuberculous endophthalmitis successfully treated with vitrectomy followed by antituberculous agents. Findings An 81-year-old man was referred to us due to the exacerbation of Vitreous Opacity on his left eye(OS) after he had received the corticosteroid therapy. His best corrected visual acuity was light perception OS, and he had severe intraocular inflammation with fibrin formation in the anterior chamber and dense Vitreous Opacity. A chest CT showed miliary nodules indicating miliary tuberculosis, and pars plana vitrectomy was performed. Intraoperative observation showed that the Vitreous cavity was filled by fibrin, and large elevated subretinal yellow-white lesions were present at the mid-periphery. The patient immediately received triple antituberculous agents orally, and Mycobacterium tuberculosis was detected in Vitreous fluids. The intraocular inflammation gradually decreased, and the subretinal mass regressed within 2 weeks. Conclusions We encountered a case of tuberculous endophthalmitis successfully treated with vitrectomy followed by antituberculous agents. If endophthalmitis is suspected in a patient with systemic tuberculosis infection, prompt vitrectomy along with the administration of antituberculous agents may be necessary.
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Clinical features of human T lymphotropic virus type 1-associated uveitis in Hokkaido, Japan
Japanese Journal of Ophthalmology, 2013Co-Authors: Satoru Kase, Shigeaki Ohno, Kenichi Namba, Nobuyoshi Kitaichi, Daiju Iwata, Susumu IshidaAbstract:Purpose To clarify the clinical features of human lymphotropic virus type 1 (HTLV-1)-associated uveitis (HAU) in patients of Hokkaido University Hospital, Hokkaido, northern Japan. Methods We reviewed the records of a consecutive series of 21 patients with HAU who were followed up for more than 12 months at Hokkaido University Hospital. Results Of the 21 patients enrolled in this study, 19 as well as their parents (90.5 %) were born in Hokkaido. One patient was a member of the Ainu ethnic group. Unilateral involvement was found in 16 cases (76 %). In the ophthalmological examinations, Vitreous Opacity was most frequently followed by keratic precipitate, iris/gonio nodules, and posterior synechiae, while hypopyon, retinal vasculitis, and neovascularization were rarely observed. Intraocular inflammation was controlled by topical treatment, while systemic corticosteroids were required in less than one-fourth of patients. Visual acuity improved in 15 patients, remained unchanged in four patients, and deteriorated in two patients. HAU was observed in two patients with adult T-cell leukemia/lymphoma (ATLL). Three out of the four patients (75 %) for whom HLA typing was available had HLA-A26. Conclusions A number of clinical features were unique to Hokkaido, namely, predominant unilateral involvement, as well as two HAU patients with ATLL. The phylogenetic difference of HTLV-1 and HLA typing may correlate with different clinical manifestations in HAU.
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Diffuse infiltrating retinoblastoma invading subarachnoid space.
Clinical ophthalmology (Auckland N.Z.), 2011Co-Authors: Satoru Kase, Shigeaki Ohno, Kazuhiko Yoshida, Shigenobu Suzuki, Koh-ichi Ohshima, Susumu IshidaAbstract:We report herein an unusual case of diffuse infiltrating retinoblastoma involving the brain, which caused a patient’s death 27 months after enucleation. An eight-year-old boy complained of blurred vision in his right eye (OD) in October 2006. Funduscopic examination showed optic disc swelling, dense whitish Vitreous Opacity, and an orange-colored subretinal elevated lesion adjacent to the optic disc. Fluorescein angiography revealed hyperfluorescence in the peripapillary region at an early-phase OD. Because the size of the subretinal lesion and Vitreous Opacity gradually increased, he was referred to us. His visual acuity was 20/1000 OD on June 20, 2007. Slit-lamp biomicroscopy showed a dense anterior Vitreous Opacity. Ophthalmoscopically, the subretinal orange-colored area spread out until reaching the mid peripheral region. A B-mode sonogram and computed tomography showed a thick homogeneous lesion without calcification. Gadolinium-enhanced magnetic resonance imaging showed a markedly enhanced appearance of the underlying posterior retina. Enucleation of the right eye was performed nine months after the initial presentation. Histopathology demonstrated retinal detachment and a huge choroidal mass invading the optic nerve head. The tumor was consistent with diffuse infiltrating retinoblastoma. The patient died due to brain involvement 27 months after enucleation. Ophthalmologists should be aware that diffuse infiltrating retinoblastoma may show an unfavorable course if its diagnosis is delayed.
William J. Wirostko - One of the best experts on this subject based on the ideXlab platform.
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Vitrectomy for large Vitreous Opacity in retinitis pigmentosa.
American journal of ophthalmology, 2001Co-Authors: Pauline H Hong, Dennis P. Han, Janice M. Burke, William J. WirostkoAbstract:To describe a patient with bilateral retinitis pigmentosa and visually disabling Vitreous opacities, who benefited from vitrectomy in both eyes. A 37-year-old man with retinitis pigmentosa and severely constricted visual fields developed a large, dense, Vitreous floater and visual obscuration in the right eye. Subsequently, diffuse Vitreous opacification and visual obscuration developed in the left eye. Bilateral pars plana vitrectomy relieved the patient's visual obscurations. Electron micrographs of the excised Vitreous Opacity from the left eye showed collagen fibrils and cellular debris. Visually significant Vitreous opacities may develop as a complication of retinitis pigmentosa. The visual impact of such opacities may be magnified by its superimposition on limited visual fields. Vitrectomy may be of benefit in such cases.
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Vitrectomy for large Vitreous Opacity in retinitis pigmentosa.
American journal of ophthalmology, 2001Co-Authors: Pauline H Hong, Dennis P. Han, Janice M. Burke, William J. WirostkoAbstract:Abstract PURPOSE: To describe a patient with bilateral retinitis pigmentosa and visually disabling Vitreous opacities, who benefited from vitrectomy in both eyes. METHODS: A 37-year-old man with retinitis pigmentosa and severely constricted visual fields developed a large, dense, Vitreous floater and visual obscuration in the right eye. Subsequently, diffuse Vitreous opacification and visual obscuration developed in the left eye. RESULTS: Bilateral pars plana vitrectomy relieved the patient's visual obscurations. Electron micrographs of the excised Vitreous Opacity from the left eye showed collagen fibrils and cellular debris. CONCLUSION: Visually significant Vitreous opacities may develop as a complication of retinitis pigmentosa. The visual impact of such opacities may be magnified by its superimposition on limited visual fields. Vitrectomy may be of benefit in such cases.
Robert Ritch - One of the best experts on this subject based on the ideXlab platform.
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Vitreous opacities affect scanning laser polarimetry measurements.
American journal of ophthalmology, 2001Co-Authors: Mauricio E Pons, Robert F. Rothman, Rabia Gurses Ozden, Jeffrey M. Liebmann, Robert RitchAbstract:Abstract PURPOSE: To assess the effect of Vitreous opacities on retinal nerve fiber layer retardation measurements obtained during scanning laser polarimetry. METHODS: Scanning laser polarimetry was performed in two eyes of two patients with Vitreous opacities. RESULTS: The presence of a Vitreous Opacity within the measurement ellipse during scanning caused a marked, localized increase in polarization in the area of the Opacity. This falsely increased the value obtained for the mean retinal nerve fiber layer thickness. Retinal nerve fiber layer thickness values were reduced when the Opacity was not incorporated into the measurement ellipse. CONCLUSION: Artifact introduced by the presence of Vitreous opacities can affect scanning laser polarimetry measurement reliability.
Takahiro Kawaji - One of the best experts on this subject based on the ideXlab platform.
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Transthyretin-related Vitreous amyloidosis in different endemic areas.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, 2010Co-Authors: Takahiro Kawaji, Yukio Ando, Eiko Ando, Ola Sandgren, Ole B. Suhr, Hidenobu TaniharaAbstract:Background: to investigate the Vitreous Opacity in patients with familial amyloidotic polyneuropathy (FAP) in two major endemic areas, Japan and Sweden. Methods: we obtained clinical data for 90 pa ...
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A case of Vitreous amyloidosis without systemic symptoms in familial amyloidotic polyneuropathy.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, 2004Co-Authors: Takahiro Kawaji, Yukio Ando, Eiko Ando, Akira Hirata, Masaaki Nakamura, Hidenobu TaniharaAbstract:We describe a case of Vitreous amyloidosis without systemic symptoms in familial amyloidotic polyneuropathy (FAP) associated with Val30Met transthyretin mutation. A healthy 74-year-old woman noticed left blurred vision and floaters in 1992. Severe Vitreous opacities were identified in the left eye. The patient displayed no systemic symptoms, and Congo red staining of the biopsy samples of the stomach and duodenum revealed no amyloid deposition. A diagnosis of FAP was confirmed following genetic investigation. Vitrectomy and cataract surgery was performed with intraocular lens implantation in April 1998. Histopathological examination of the Vitreous material revealed amyloid fibrils. Intraocular pressure (IOP) gradually elevated and cupping of the optic disc enlarged. Trabeculectomy was performed in February 2000, but postoperative IOP was again elevated and a needling procedure was performed in March 2000. No postoperative recurrence of Vitreous Opacity has been reported and IOP has remained well controll...
