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Elna-marie Larsson - One of the best experts on this subject based on the ideXlab platform.
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Visual rating versus Volumetry of regional brain atrophy and longitudinal changes over a 5-year period in an elderly population
Brain and behavior, 2020Co-Authors: Vilma Velickaite, Daniel Ferreira, Lars Lind, Håkan Ahlström, Lena Kilander, Erik Westman, Elna-marie LarssonAbstract:INTRODUCTION The purpose of our study was to compare visual rating and Volumetry of brain atrophy in an elderly population over a 5-year period and compare findings with cognitive test results. MATERIALS AND METHODS Two hundred and one subjects were examined with magnetic resonance imaging (MRI) of the brain. Visual rating and Volumetry were performed in all subjects at ages 75 and 80. Cognitive function at both time points was assessed with the Mini-Mental State Examination (MMSE) and Trail Making Tests A and B (TMT-A and TMT-B). Changes in visual rating and Volumetry were compared with changes in cognitive test. RESULTS A correlation was found between visual rating of medial temporal lobe atrophy (MTA) and hippocampal Volumetry at both time points (rs = -.42 and rs = -.49, p
Daniel Azoulay - One of the best experts on this subject based on the ideXlab platform.
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Spleen Volumetry and liver transient elastography: Predictors of persistent posthepatectomy decompensation in patients with hepatocellular carcinoma.
Surgery, 2020Co-Authors: Ramiro Fernández-placencia, Nicolas Golse, Luis Cano, Marc-antoine Allard, Gabriella Pittau, Oriana Ciacio, Antonio Sa Cunha, Denis Castaing, Chady Salloum, Daniel AzoulayAbstract:Abstract Background Posthepatectomy decompensation remains a frequent and poor outcome after hepatectomy, but its prediction is still inaccurate. Liver stiffness measurement can predict posthepatectomy decompensation, but there is a so-called “gray zone” that requires another predictor. Because splenomegaly is an objective sign of portal hypertension, we hypothesized that spleen Volumetry could improve the identification of patients at risk. Methods Patients with hepatocellular carcinoma who underwent hepatectomy in our tertiary center between August 2014 and December 2017 were reviewed. The primary endpoint was to determine if the spleen Volumetry and liver stiffness measurement were independent predictors of posthepatectomy decompensation, and secondarily, to determine if they were synergistic through a theoretic predictive model. Results One hundred and seven patients were included. The median follow-up time was 3 months (3–5). Postoperative 90-day mortality was 4.7%. By multivariate analysis, liver stiffness measurement and spleen Volumetry predicted posthepatectomy decompensation. The liver stiffness measurement had a cutoff point of 11.6 kPa (area under receiver operating curve = 0.71 confidence interval 95% 0.71–0.88, sensitivity: 89%, specificity: 47%). The spleen Volumetry cutoff point was 381.1 cm3 (area under receiver operating curve = 0.78, 95% confidence interval 0.77–0.93, sensitivity: 55%, specificity: 91%). The spleen Volumetry improved prediction of posthepatectomy decompensation, because use of the spleen Volumetry increased sensitivity (from 62% to 97%) and the negative predictive value (from 96% to 100%) along with a negligible decrease in specificity (from 96.7 to 93.4) and positive predictive value (from 64% to 59%) (P = .003). Conclusion Spleen Volumetry (>380 cm3) and liver stiffness measurement (>12 kPa) are non-invasive, independent, and synergistic tools that appear to be able to predict posthepatectomy decompensation. The importance of this finding is that these measurements may help to anticipate posthepatectomy decompensation and may possibly be used to direct alternative treatments to resection.
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Spleen Volumetry and liver transient elastography: Predictors of persistent posthepatectomy decompensation in patients with hepatocellular carcinoma
Surgery, 2020Co-Authors: Ramiro Fernández-placencia, Nicolas Golse, Marc-antoine Allard, Gabriella Pittau, Oriana Ciacio, Antonio Sa Cunha, Denis Castaing, Chady Salloum, L.c. Garcia Cano, Daniel AzoulayAbstract:Background Posthepatectomy decompensation remains a frequent and poor outcome after hepatectomy, but its prediction is still inaccurate. Liver stiffness measurement can predict posthepatectomy decompensation, but there is a so-called “gray zone” that requires another predictor. Because splenomegaly is an objective sign of portal hypertension, we hypothesized that spleen Volumetry could improve the identification of patients at risk. Methods Patients with hepatocellular carcinoma who underwent hepatectomy in our tertiary center between August 2014 and December 2017 were reviewed. The primary endpoint was to determine if the spleen Volumetry and liver stiffness measurement were independent predictors of posthepatectomy decompensation, and secondarily, to determine if they were synergistic through a theoretic predictive model. Results One hundred and seven patients were included. The median follow-up time was 3 months (3–5). Postoperative 90-day mortality was 4.7%. By multivariate analysis, liver stiffness measurement and spleen Volumetry predicted posthepatectomy decompensation. The liver stiffness measurement had a cutoff point of 11.6 kPa (area under receiver operating curve = 0.71 confidence interval 95% 0.71–0.88, sensitivity 89%, specificity 47%). The spleen Volumetry cutoff point was 381.1 cm3 (area under receiver operating curve = 0.78, 95% confidence interval 0.77–0.93, sensitivity 55%, specificity 91%). The spleen Volumetry improved prediction of posthepatectomy decompensation, because use of the spleen Volumetry increased sensitivity (from 62% to 97%) and the negative predictive value (from 96% to 100%) along with a negligible decrease in specificity (from 96.7 to 93.4) and positive predictive value (from 64% to 59%) (P = .003). Conclusion Spleen Volumetry (andgt;380 cm3) and liver stiffness measurement (andgt;12 kPa) are non-invasive, independent, and synergistic tools that appear to be able to predict posthepatectomy decompensation. The importance of this finding is that these measurements may help to anticipate posthepatectomy decompensation and may possibly be used to direct alternative treatments to resection. © 2020 Elsevier Inc.
David A. Gansler - One of the best experts on this subject based on the ideXlab platform.
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A Comparison of Voxel-Based Morphometry and Volumetry Methods in the Context of the Neural Basis of Aggression
Brain Imaging and Behavior, 2009Co-Authors: Britt C. Emerton, Matthew Jerram, Thilo Deckersbach, Darin D. Dougherty, Carl Fulwiler, David A. GanslerAbstract:The assumption that voxel-based morphometry (VBM) offers an automated substitution for manually-traced Volumetry was subjected to empirical evaluation. Data available from a previous Volumetry study (Gansler et al. Psychiatry Research: Neuroimaging 171:145–154, 2009 ) provided the basis for the current study, which assessed for convergence between the methods. Optimized modulated VBM was used to preprocess images ( N = 40). Gray matter volume and self-reported aggression associations were tested. Results indicate convergence, as both methods revealed significant negative associations of the left orbitofrontal cortex (OFC) and aggression. VBM detected an additional positive left OFC result not revealed with Volumetry, suggesting that VBM may allow greater within-region localization than Volumetry. However, the methods differentially deal with error rates and power demands and as such are better conceptualized as complementary than interchangeable.
Lawrence N. Masullo - One of the best experts on this subject based on the ideXlab platform.
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Reliability of water Volumetry and the figure of eight method on subjects with ankle joint swelling.
The Journal of orthopaedic and sports physical therapy, 1999Co-Authors: Evan J. Petersen, Shannon M. Irish, Christian L. Lyons, Sarah F. Miklaski, Jean M. Bryan, Nancy E. Henderson, Lawrence N. MasulloAbstract:Study Design Single-group repeated measures with 2 raters. Objectives To determine the interrater and intrarater reliability of water Volumetry and the figure of eight method on subjects with ankle joint swelling. Background Measurements of ankle swelling are commonly performed to determine the nature and stage of injury and to monitor progress made during rehabilitation. Water Volumetry and the figure of eight method are 2 techniques used to measure ankle swelling. Methods and Measures Twenty-nine subjects with ankle swelling were measured by 2 raters with the hypothesis that both measurement techniques would be reliable. Each rater performed 3 measurements of the swollen ankle using both measurement techniques during a single test session. The order of the rater and of the measurement technique was randomized, and the raters were blinded to each other's measurements. Results We found high interrater reliability for both the water Volumetry (ICC [intraclass correlation coefficient] = 0.99) and figure of ...
Philip Scheltens - One of the best experts on this subject based on the ideXlab platform.
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visual rating and Volumetry of the medial temporal lobe on magnetic resonance imaging in dementia a comparative study
Journal of Neurology Neurosurgery and Psychiatry, 2000Co-Authors: Lars-olof Wahlund, Per Julin, Svenerik Johansson, Philip ScheltensAbstract:OBJECTIVES It has been shown that atrophy of medial temporal lobe structures such as the hippocampus and entorhinal cortex shown on MRI may distinguish patients with Alzheimer9s disease from healthy controls. However, the diagnostic value of visual inspection and Volumetry of medial temporal lobe atrophy (MTA) on MRI in a clinical setting is insufficiently known. METHODS Medial temporal lobe atrophy in 143 patients was visually rated from hard copies, using a 0–4 rating scale and a comparison was made with the volumes (cm 3 ) of the medial temporal lobe as estimated with Volumetry, using a stereological method. All patients were recruited in an unselected way in a clinical setting in the centre for memory impairments at the Huddinge University Hospital. Patients with Alzheimer9s disease (n=41), patients with other dementias (vascular dementia, frontotemporal dementia, and unspecified dementia; n=36) as well as non-demented subjects (n=66) were included. Medial temporal atrophy and Volumetry were evaluated as a diagnostic tool by performing logistic regression analysis including age, sex, and mini mental state examination (MMSE) score and calculating the sensitivity and specificity and percentage correct classification. RESULTS Visual and volumetric analysis yielded statistically significant differences between patients with Alzheimer9s disease and non-demented subjects, as well as between those with other dementias and non-demented subjects. Combining MMSE scores and visually rated MTA ratings yielded a sensitivity of 95% for Alzheimer9s disease, 85% for other dementias. Non-demented subjects were identified with a specificity of 96%. Volumetry did not have an added value over the MMSE score alone. CONCLUSIONS Visual rating of MTA is a clinically useful method for differentiating Alzheimer9s disease from controls and is both quicker and more accurate than Volumetry.
