The Experts below are selected from a list of 18 Experts worldwide ranked by ideXlab platform
Jorn Herrstedt - One of the best experts on this subject based on the ideXlab platform.
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fosaprepitant for the prevention of chemotherapy induced nausea and Vomiting
Expert Review of Anticancer Therapy, 2012Co-Authors: Christina H Ruhlmann, Jorn HerrstedtAbstract:For patients receiving cancer chemotherapy, the ongoing development of antiemetic treatment is of significant importance. Patients consider nausea and Vomiting among the most distressing symptoms of chemotherapy, and as new antiemetics have been very successful in prevention of Vomiting, Agents effective against nausea have become one of the major unmet needs. The neurokinin (NK)1 receptor antagonist aprepitant potentiates the antiemetic efficacy of the combination of a serotonin receptor antagonist and a corticosteroid. Fosaprepitant (intravenous prodrug of aprepitant) given as a single intravenous dose of 150 mg can replace the aprepitant 3-day oral regimen. This article focuses on the development and clinical application of fosaprepitant.
Christina H Ruhlmann - One of the best experts on this subject based on the ideXlab platform.
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fosaprepitant for the prevention of chemotherapy induced nausea and Vomiting
Expert Review of Anticancer Therapy, 2012Co-Authors: Christina H Ruhlmann, Jorn HerrstedtAbstract:For patients receiving cancer chemotherapy, the ongoing development of antiemetic treatment is of significant importance. Patients consider nausea and Vomiting among the most distressing symptoms of chemotherapy, and as new antiemetics have been very successful in prevention of Vomiting, Agents effective against nausea have become one of the major unmet needs. The neurokinin (NK)1 receptor antagonist aprepitant potentiates the antiemetic efficacy of the combination of a serotonin receptor antagonist and a corticosteroid. Fosaprepitant (intravenous prodrug of aprepitant) given as a single intravenous dose of 150 mg can replace the aprepitant 3-day oral regimen. This article focuses on the development and clinical application of fosaprepitant.
Takafumi Satoh - One of the best experts on this subject based on the ideXlab platform.
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correction to sensitive and comprehensive detection of chemical warfare Agents in air by atmospheric pressure chemical ionization ion trap tandem mass spectrometry with counterflow introduction
Analytical Chemistry, 2014Co-Authors: Yasuo Seto, Hiroshi Sekiguchi, Hisashi Maruko, Shigeharu Yamashiro, Yasuhiro Sano, Yasuo Takayama, Ryoji Sekioka, Shintaro Yamaguchi, Shintaro Kishi, Takafumi SatohAbstract:A highly sensitive and specific real-time field-deployable detection technology, based on counterflow air introduction atmospheric pressure chemical ionization, has been developed for a wide range of chemical warfare Agents (CWAs) comprising gaseous (two blood Agents, three choking Agents), volatile (six nerve gases and one precursor agent, five blister Agents), and nonvolatile (three lachrymators, three Vomiting Agents) Agents in air. The approach can afford effective chemical ionization, in both positive and negative ion modes, for ion trap multiple-stage mass spectrometry (MSn). The volatile and nonvolatile CWAs tested provided characteristic ions, which were fragmented into MS3 product ions in positive and negative ion modes. Portions of the fragment ions were assigned by laboratory hybrid mass spectrometry (MS) composed of linear ion trap and high-resolution mass spectrometers. Gaseous Agents were detected by MS or MS2 in negative ion mode. The limits of detection for a 1 s measurement were typically...
Yasuo Seto - One of the best experts on this subject based on the ideXlab platform.
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correction to sensitive and comprehensive detection of chemical warfare Agents in air by atmospheric pressure chemical ionization ion trap tandem mass spectrometry with counterflow introduction
Analytical Chemistry, 2014Co-Authors: Yasuo Seto, Hiroshi Sekiguchi, Hisashi Maruko, Shigeharu Yamashiro, Yasuhiro Sano, Yasuo Takayama, Ryoji Sekioka, Shintaro Yamaguchi, Shintaro Kishi, Takafumi SatohAbstract:A highly sensitive and specific real-time field-deployable detection technology, based on counterflow air introduction atmospheric pressure chemical ionization, has been developed for a wide range of chemical warfare Agents (CWAs) comprising gaseous (two blood Agents, three choking Agents), volatile (six nerve gases and one precursor agent, five blister Agents), and nonvolatile (three lachrymators, three Vomiting Agents) Agents in air. The approach can afford effective chemical ionization, in both positive and negative ion modes, for ion trap multiple-stage mass spectrometry (MSn). The volatile and nonvolatile CWAs tested provided characteristic ions, which were fragmented into MS3 product ions in positive and negative ion modes. Portions of the fragment ions were assigned by laboratory hybrid mass spectrometry (MS) composed of linear ion trap and high-resolution mass spectrometers. Gaseous Agents were detected by MS or MS2 in negative ion mode. The limits of detection for a 1 s measurement were typically...
Zhang Ling - One of the best experts on this subject based on the ideXlab platform.
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comparison effect of ondansetron with one of droperidol on preventive nausea and Vomiting in patients of postoperative analgesia
Anhui Medical and Pharmaceutical Journal, 2004Co-Authors: Zhang LingAbstract:AIM To compare effect of ondansetron with one of droperidol on preventive nausea and Vomiting in patients of postopeative analgesia. METHODS Ninety patinets were selected this experiment, ASA Ⅰ～Ⅱ, male 15, female 75. Ninety patients were randomly divided into three group,Ⅰ group, control (without anti Vomiting Agents), Ⅱ group, with droperidol 5 mg, Ⅲ group, with ondansetron 8 mg. Ninety patients were administered the controlled epidural analgesia (PCEA) with morphine at end of operation. The analgesic effect, hemodynamics and the side effects such as nausea and Vomiting were observed for 48 h after operation. SBP,DBP,HR,SPO 2 were recorded simultaneously at end of operation, 12, 24, 48 h after operation. RESULTS The SBP,DBP,HR,SPO 2 were not significant difference at end of operation, 12 h, 24 h, 48 h after operation. The analgesic effect of ninety patients were very good, and there were not significant difference between three groups ( P 0 05). The rate of postoperative nausea and Vomiting in the Ⅲ group was significantly lower than one of postoperative nausea and Vomiting in the Ⅰ group Ⅱ group ( P 0 01). CONCLUSION These data indicate that the ondansetron can effectively prevent the postoperative nausea and Vomiting induced by PCEA.
