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Armin Curt - One of the best experts on this subject based on the ideXlab platform.

  • assessment of Walking Speed and distance in subjects with an incomplete spinal cord injury
    Neurorehabilitation and Neural Repair, 2007
    Co-Authors: Hubertus J A Van Hedel, V Dietz, Armin Curt
    Abstract:

    Background. The 10-meter walk test and 6-minute walk test are increasingly used to evaluate the recovery of Walking in patients with incomplete spinal cord injury. So far, there is no evidence whether the application of different Walking distances provides complementary information about ambulatory capacity in patients with incomplete spinal cord injury. Studies about testing preferred and maximum Speeds in subjects with incomplete spinal cord injury are lacking. Objective. To determine whether the combined testing of short and long distances as well as preferred and maximum Speeds provides additional information about Walking capacity in subjects with incomplete spinal cord injury. Methods. Depending on the objective, the subjects with incomplete spinal cord injury and age-matched control subjects had to perform the 10meter walk test or 6-minute walk test at preferred and/or maximum Walking Speed. Results. During recovery, the preferred Walking Speed increased but did not differ when assessed during short or long distances in 51 subjects with incomplete spinal cord injury at 1, 3, and 6 months after injury (mean and SD, 6-minute walk test: 0.37 ± 0.52, 0.87 ± 0.56, and 1.14 ± 0.52 ms –1 ; 10-meter walk test: 0.40 ± 0.53, 0.88 ± 0.51, and 1.12 ± 0.51 ms –1 , respectively). In 18 subjects with incomplete spinal cord injury, both preferred and maximum Walking Speeds assessed with the 10-meter walk test predicted the Walking Speeds of the 6-minute walk test well. Subjects with incomplete spinal cord injury prefer to walk closer to their maximum Walking Speed (74% ± 10%) compared to control subjects (59% ± 8%). Conclusions. The velocity used for the 6minute Walking distance and the 10-meter Walking Speed provides comparable information in patients with incomplete spinal cord injury who can perform both tests. However, tests of the preferred and maximum Walking Speed add information about Walking capacity. Due to the easier applicability of the 10-meter walk test in the clinical setting, the authors suggest performing this test at the preferred and maximum Speeds for the assessment of Walking capacity by 1 month after incomplete spinal cord injury.

Joanne M Jordan - One of the best experts on this subject based on the ideXlab platform.

  • associations between slower Walking Speed and t1ρ magnetic resonance imaging of femoral cartilage following anterior cruciate ligament reconstruction
    Arthritis Care and Research, 2018
    Co-Authors: Steven J Pfeiffer, Troy J Blackburn, Matthew S Harkey, Darin A Padua, Jeffrey T Spang, Joanne M Jordan, Laura E Stanley, Stephen W Marshall, Randy Schmitz, Daniel Nissman
    Abstract:

    Objective To determine whether Walking Speed, collected at 6 and 12 months following anterior cruciate ligament reconstruction (ACLR), is associated with inter-extremity differences in proteoglycan density, measured via T1ρ magnetic resonance imaging, in tibiofemoral articular cartilage 12 months following ACLR. Methods Twenty-one individuals with a unilateral patellar-tendon autograft ACLR (10 women and 11 men, mean ± SD age 23.9 ± 2.7 years, mean ± SD body mass index 23.9 ± 2.7 kg/m2 ) were recruited for participation in this study. Walking Speed was collected using 3-dimensional motion capture at 6 and 12 months following ACLR. The articular cartilage of the medial femoral condyle (MFC) and lateral femoral condyle and medial and lateral tibial condyles was manually segmented and subsectioned into 3 regions of interest (anterior, central, and posterior) based on the location of the meniscus in the sagittal plane. Inter-extremity mean T1ρ relaxation time ratios (T1ρ ACLR extremity / T1ρ contralateral extremity) were calculated and used for analysis. Pearson product-moment correlations were used to determine associations between Walking Speed and inter-extremity differences in T1ρ relaxation time ratios. Results Slower Walking Speed 6 months post-ACLR was significantly associated with higher T1ρ relaxation time ratios in the MFC of the ACLR extremity 12 months following ACLR (posterior MFC, r = -0.51, P = 0.02; central MFC, r = -0.47, P = 0.04). Similarly, slower Walking Speed at 12 months post-ACLR was significantly associated with higher T1ρ relaxation time ratios in the posterior MFC ACLR extremity (r = -0.47, P = 0.04) 12 months following ACLR. Conclusion Slower Walking Speed at 6 and 12 months following ACLR may be associated with early proteoglycan density changes in medial femoral compartment cartilage health in the first 12 months following ACLR.

  • Walking Speed as a potential indicator of cartilage breakdown following anterior cruciate ligament reconstruction
    Arthritis Care and Research, 2016
    Co-Authors: Brian Pietrosimone, Troy J Blackburn, Matthew S Harkey, Brittney A Luc, Anthony C Hackney, Darin A Padua, Jeffrey B Driban, Jeffrey T Spang, Joanne M Jordan
    Abstract:

    Objective To determine whether or not self-selected Walking Speed associates with serum biomarkers of cartilage (collagen and proteoglycan) breakdown in anterior cruciate ligament reconstructed (ACLR) individuals. Methods Twenty individuals with a history of a primary unilateral ACLR participated in this cross-sectional study. Resting blood was collected from each participant prior to completing 5 Walking gait trials at a self-selected comfortable Speed. Walking Speed was evaluated in a 3-dimensional motion capture laboratory and determined from the velocity of the pelvic center of mass. Sera were assessed for collagen type II cleavage product (C2C) and proteoglycan (aggrecan) concentrations using commercially available specific enzyme-linked immunosorbent assays. Pearson's product-moment (r) and Spearman's (ρ) correlations were used to evaluate associations between Walking Speed and biomarkers of cartilage breakdown metabolism. Partial correlations were used to determine whether covariates influenced associations between Walking Speed and biomarkers of cartilage breakdown. Results ACLR individuals with a slower Walking Speed demonstrated higher concentrations of serum C2C (r = −0.52, P = 0.02), while there was no significant association between Walking Speed and aggrecan concentrations (ρ = −0.29, P = 0.31). After accounting for the variance associated with stance phase duration, ACLR individuals with a slower Walking Speed still demonstrated greater serum C2C concentrations (partial r = −0.53, P = 0.02). Conclusion ACLR individuals who habitually walk slower may experience a greater degree of collagen breakdown, suggesting that Walking Speed may be a future useful clinical indicator for identifying individuals with higher levels of cartilage breakdown and preradiographic osteoarthritic joint changes.

Hubertus J A Van Hedel - One of the best experts on this subject based on the ideXlab platform.

  • assessment of Walking Speed and distance in subjects with an incomplete spinal cord injury
    Neurorehabilitation and Neural Repair, 2007
    Co-Authors: Hubertus J A Van Hedel, V Dietz, Armin Curt
    Abstract:

    Background. The 10-meter walk test and 6-minute walk test are increasingly used to evaluate the recovery of Walking in patients with incomplete spinal cord injury. So far, there is no evidence whether the application of different Walking distances provides complementary information about ambulatory capacity in patients with incomplete spinal cord injury. Studies about testing preferred and maximum Speeds in subjects with incomplete spinal cord injury are lacking. Objective. To determine whether the combined testing of short and long distances as well as preferred and maximum Speeds provides additional information about Walking capacity in subjects with incomplete spinal cord injury. Methods. Depending on the objective, the subjects with incomplete spinal cord injury and age-matched control subjects had to perform the 10meter walk test or 6-minute walk test at preferred and/or maximum Walking Speed. Results. During recovery, the preferred Walking Speed increased but did not differ when assessed during short or long distances in 51 subjects with incomplete spinal cord injury at 1, 3, and 6 months after injury (mean and SD, 6-minute walk test: 0.37 ± 0.52, 0.87 ± 0.56, and 1.14 ± 0.52 ms –1 ; 10-meter walk test: 0.40 ± 0.53, 0.88 ± 0.51, and 1.12 ± 0.51 ms –1 , respectively). In 18 subjects with incomplete spinal cord injury, both preferred and maximum Walking Speeds assessed with the 10-meter walk test predicted the Walking Speeds of the 6-minute walk test well. Subjects with incomplete spinal cord injury prefer to walk closer to their maximum Walking Speed (74% ± 10%) compared to control subjects (59% ± 8%). Conclusions. The velocity used for the 6minute Walking distance and the 10-meter Walking Speed provides comparable information in patients with incomplete spinal cord injury who can perform both tests. However, tests of the preferred and maximum Walking Speed add information about Walking capacity. Due to the easier applicability of the 10-meter walk test in the clinical setting, the authors suggest performing this test at the preferred and maximum Speeds for the assessment of Walking capacity by 1 month after incomplete spinal cord injury.

Darin A Padua - One of the best experts on this subject based on the ideXlab platform.

  • associations between slower Walking Speed and t1ρ magnetic resonance imaging of femoral cartilage following anterior cruciate ligament reconstruction
    Arthritis Care and Research, 2018
    Co-Authors: Steven J Pfeiffer, Troy J Blackburn, Matthew S Harkey, Darin A Padua, Jeffrey T Spang, Joanne M Jordan, Laura E Stanley, Stephen W Marshall, Randy Schmitz, Daniel Nissman
    Abstract:

    Objective To determine whether Walking Speed, collected at 6 and 12 months following anterior cruciate ligament reconstruction (ACLR), is associated with inter-extremity differences in proteoglycan density, measured via T1ρ magnetic resonance imaging, in tibiofemoral articular cartilage 12 months following ACLR. Methods Twenty-one individuals with a unilateral patellar-tendon autograft ACLR (10 women and 11 men, mean ± SD age 23.9 ± 2.7 years, mean ± SD body mass index 23.9 ± 2.7 kg/m2 ) were recruited for participation in this study. Walking Speed was collected using 3-dimensional motion capture at 6 and 12 months following ACLR. The articular cartilage of the medial femoral condyle (MFC) and lateral femoral condyle and medial and lateral tibial condyles was manually segmented and subsectioned into 3 regions of interest (anterior, central, and posterior) based on the location of the meniscus in the sagittal plane. Inter-extremity mean T1ρ relaxation time ratios (T1ρ ACLR extremity / T1ρ contralateral extremity) were calculated and used for analysis. Pearson product-moment correlations were used to determine associations between Walking Speed and inter-extremity differences in T1ρ relaxation time ratios. Results Slower Walking Speed 6 months post-ACLR was significantly associated with higher T1ρ relaxation time ratios in the MFC of the ACLR extremity 12 months following ACLR (posterior MFC, r = -0.51, P = 0.02; central MFC, r = -0.47, P = 0.04). Similarly, slower Walking Speed at 12 months post-ACLR was significantly associated with higher T1ρ relaxation time ratios in the posterior MFC ACLR extremity (r = -0.47, P = 0.04) 12 months following ACLR. Conclusion Slower Walking Speed at 6 and 12 months following ACLR may be associated with early proteoglycan density changes in medial femoral compartment cartilage health in the first 12 months following ACLR.

  • Walking Speed as a potential indicator of cartilage breakdown following anterior cruciate ligament reconstruction
    Arthritis Care and Research, 2016
    Co-Authors: Brian Pietrosimone, Troy J Blackburn, Matthew S Harkey, Brittney A Luc, Anthony C Hackney, Darin A Padua, Jeffrey B Driban, Jeffrey T Spang, Joanne M Jordan
    Abstract:

    Objective To determine whether or not self-selected Walking Speed associates with serum biomarkers of cartilage (collagen and proteoglycan) breakdown in anterior cruciate ligament reconstructed (ACLR) individuals. Methods Twenty individuals with a history of a primary unilateral ACLR participated in this cross-sectional study. Resting blood was collected from each participant prior to completing 5 Walking gait trials at a self-selected comfortable Speed. Walking Speed was evaluated in a 3-dimensional motion capture laboratory and determined from the velocity of the pelvic center of mass. Sera were assessed for collagen type II cleavage product (C2C) and proteoglycan (aggrecan) concentrations using commercially available specific enzyme-linked immunosorbent assays. Pearson's product-moment (r) and Spearman's (ρ) correlations were used to evaluate associations between Walking Speed and biomarkers of cartilage breakdown metabolism. Partial correlations were used to determine whether covariates influenced associations between Walking Speed and biomarkers of cartilage breakdown. Results ACLR individuals with a slower Walking Speed demonstrated higher concentrations of serum C2C (r = −0.52, P = 0.02), while there was no significant association between Walking Speed and aggrecan concentrations (ρ = −0.29, P = 0.31). After accounting for the variance associated with stance phase duration, ACLR individuals with a slower Walking Speed still demonstrated greater serum C2C concentrations (partial r = −0.53, P = 0.02). Conclusion ACLR individuals who habitually walk slower may experience a greater degree of collagen breakdown, suggesting that Walking Speed may be a future useful clinical indicator for identifying individuals with higher levels of cartilage breakdown and preradiographic osteoarthritic joint changes.

Troy J Blackburn - One of the best experts on this subject based on the ideXlab platform.

  • associations between slower Walking Speed and t1ρ magnetic resonance imaging of femoral cartilage following anterior cruciate ligament reconstruction
    Arthritis Care and Research, 2018
    Co-Authors: Steven J Pfeiffer, Troy J Blackburn, Matthew S Harkey, Darin A Padua, Jeffrey T Spang, Joanne M Jordan, Laura E Stanley, Stephen W Marshall, Randy Schmitz, Daniel Nissman
    Abstract:

    Objective To determine whether Walking Speed, collected at 6 and 12 months following anterior cruciate ligament reconstruction (ACLR), is associated with inter-extremity differences in proteoglycan density, measured via T1ρ magnetic resonance imaging, in tibiofemoral articular cartilage 12 months following ACLR. Methods Twenty-one individuals with a unilateral patellar-tendon autograft ACLR (10 women and 11 men, mean ± SD age 23.9 ± 2.7 years, mean ± SD body mass index 23.9 ± 2.7 kg/m2 ) were recruited for participation in this study. Walking Speed was collected using 3-dimensional motion capture at 6 and 12 months following ACLR. The articular cartilage of the medial femoral condyle (MFC) and lateral femoral condyle and medial and lateral tibial condyles was manually segmented and subsectioned into 3 regions of interest (anterior, central, and posterior) based on the location of the meniscus in the sagittal plane. Inter-extremity mean T1ρ relaxation time ratios (T1ρ ACLR extremity / T1ρ contralateral extremity) were calculated and used for analysis. Pearson product-moment correlations were used to determine associations between Walking Speed and inter-extremity differences in T1ρ relaxation time ratios. Results Slower Walking Speed 6 months post-ACLR was significantly associated with higher T1ρ relaxation time ratios in the MFC of the ACLR extremity 12 months following ACLR (posterior MFC, r = -0.51, P = 0.02; central MFC, r = -0.47, P = 0.04). Similarly, slower Walking Speed at 12 months post-ACLR was significantly associated with higher T1ρ relaxation time ratios in the posterior MFC ACLR extremity (r = -0.47, P = 0.04) 12 months following ACLR. Conclusion Slower Walking Speed at 6 and 12 months following ACLR may be associated with early proteoglycan density changes in medial femoral compartment cartilage health in the first 12 months following ACLR.

  • Walking Speed as a potential indicator of cartilage breakdown following anterior cruciate ligament reconstruction
    Arthritis Care and Research, 2016
    Co-Authors: Brian Pietrosimone, Troy J Blackburn, Matthew S Harkey, Brittney A Luc, Anthony C Hackney, Darin A Padua, Jeffrey B Driban, Jeffrey T Spang, Joanne M Jordan
    Abstract:

    Objective To determine whether or not self-selected Walking Speed associates with serum biomarkers of cartilage (collagen and proteoglycan) breakdown in anterior cruciate ligament reconstructed (ACLR) individuals. Methods Twenty individuals with a history of a primary unilateral ACLR participated in this cross-sectional study. Resting blood was collected from each participant prior to completing 5 Walking gait trials at a self-selected comfortable Speed. Walking Speed was evaluated in a 3-dimensional motion capture laboratory and determined from the velocity of the pelvic center of mass. Sera were assessed for collagen type II cleavage product (C2C) and proteoglycan (aggrecan) concentrations using commercially available specific enzyme-linked immunosorbent assays. Pearson's product-moment (r) and Spearman's (ρ) correlations were used to evaluate associations between Walking Speed and biomarkers of cartilage breakdown metabolism. Partial correlations were used to determine whether covariates influenced associations between Walking Speed and biomarkers of cartilage breakdown. Results ACLR individuals with a slower Walking Speed demonstrated higher concentrations of serum C2C (r = −0.52, P = 0.02), while there was no significant association between Walking Speed and aggrecan concentrations (ρ = −0.29, P = 0.31). After accounting for the variance associated with stance phase duration, ACLR individuals with a slower Walking Speed still demonstrated greater serum C2C concentrations (partial r = −0.53, P = 0.02). Conclusion ACLR individuals who habitually walk slower may experience a greater degree of collagen breakdown, suggesting that Walking Speed may be a future useful clinical indicator for identifying individuals with higher levels of cartilage breakdown and preradiographic osteoarthritic joint changes.