The Experts below are selected from a list of 45 Experts worldwide ranked by ideXlab platform
Nicolai Cramer - One of the best experts on this subject based on the ideXlab platform.
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alkynyl triazenes as fluoroalkyne surrogates regioselective access to 4 fluoro 2 pyridones by a rh iii catalyzed c h activation lossen rearrangement Wallach Reaction
ACS Catalysis, 2020Co-Authors: Jinfay Tan, Carl Thomas Bormann, Kay Severin, Nicolai CramerAbstract:Fluorinated pyridones are an important scaffold displaying relevant biological activities. Efficient assembly strategies of pyridones are transition metal-catalyzed C–H annulations with alkynes. Th...
Jinfay Tan - One of the best experts on this subject based on the ideXlab platform.
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alkynyl triazenes as fluoroalkyne surrogates regioselective access to 4 fluoro 2 pyridones by a rh iii catalyzed c h activation lossen rearrangement Wallach Reaction
ACS Catalysis, 2020Co-Authors: Jinfay Tan, Carl Thomas Bormann, Kay Severin, Nicolai CramerAbstract:Fluorinated pyridones are an important scaffold displaying relevant biological activities. Efficient assembly strategies of pyridones are transition metal-catalyzed C–H annulations with alkynes. Th...
Carl Thomas Bormann - One of the best experts on this subject based on the ideXlab platform.
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alkynyl triazenes as fluoroalkyne surrogates regioselective access to 4 fluoro 2 pyridones by a rh iii catalyzed c h activation lossen rearrangement Wallach Reaction
ACS Catalysis, 2020Co-Authors: Jinfay Tan, Carl Thomas Bormann, Kay Severin, Nicolai CramerAbstract:Fluorinated pyridones are an important scaffold displaying relevant biological activities. Efficient assembly strategies of pyridones are transition metal-catalyzed C–H annulations with alkynes. Th...
Kay Severin - One of the best experts on this subject based on the ideXlab platform.
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alkynyl triazenes as fluoroalkyne surrogates regioselective access to 4 fluoro 2 pyridones by a rh iii catalyzed c h activation lossen rearrangement Wallach Reaction
ACS Catalysis, 2020Co-Authors: Jinfay Tan, Carl Thomas Bormann, Kay Severin, Nicolai CramerAbstract:Fluorinated pyridones are an important scaffold displaying relevant biological activities. Efficient assembly strategies of pyridones are transition metal-catalyzed C–H annulations with alkynes. Th...
Cramer Nicolai - One of the best experts on this subject based on the ideXlab platform.
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Alkynyl Triazenes as Fluoroalkyne Surrogates: Regioselective Access to 4-Fluoro-2-pyridones by a Rh(III)-Catalyzed C–H Activation–Lossen Rearrangement–Wallach Reaction
'American Chemical Society (ACS)', 2020Co-Authors: Tan Jin-fay, Bormann, Carl Thomas, Severin Kay, Cramer NicolaiAbstract:Fluorinated pyridones are an important scaffold displaying relevant biological activities. Efficient assembly strategies of pyridones are transition metal-catalyzed C–H annulations with alkynes. The inaccessibility and extreme lability of fluoro alkynes render any direct utilization in catalysis futile. We report a highly regioselective synthesis of 4-fluoro-2-pyridones using 1-alkynyl triazenes as a convenient fluoroalkyne surrogates. The protocol comprises an alkenyl C–H annulation with 1-alkynyl triazenes followed by a treatment with HF·pyridine smoothly delivering a broad range of 4-fluoro-2-pyridones in a one-pot fashion in 90 min at 23–60 °C. Notably, a rare Lossen rearrangement occurs during the C–H functionalization part of the transformation, allowing selective access to the less-available 4-fluoro-2-pyridone framework. Furthermore, the triazenyl intermediate was elaborated into additional fluorine-containing substituents like fluorinated alkoxy and trifluoromethyl groups
