The Experts below are selected from a list of 26403 Experts worldwide ranked by ideXlab platform
Sima Tokajian - One of the best experts on this subject based on the ideXlab platform.
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genomic mapping of st85 blandm 1 and blaoxa 94 producing acinetobacter baumannii isolates from syrian civil War Victims
International Journal of Infectious Diseases, 2018Co-Authors: Tamara Salloum, Elie Tannous, Sahar Alousi, Harout Arabaghian, Rayane Rafei, Monzer Hamze, Sima TokajianAbstract:Abstract Objectives The rapid emergence of carbapenem-resistant Acinetobacter baumannii is a global health concern. A comparative genomic analysis was performed on two ST85 A. baumannii strains harboring blaNDM-1 and blaOXA-94 collected in Lebanon from Syrian Civil War Victims. Methods Genome sequencing data of ACMH-6200 and ACMH-6201 were used for in silico extraction of multilocus sequence types (MLST), resistance genes, and virulence factors. Plasmids were genetically mapped in silico and using PCR-based replicon typing (PBRT). The genetic environment of blaNDM-1 and blaOXA-94 was determined, and whole-genome single nucleotide polymorphism (wgSNP) analysis in comparison with 41 publicly available A. baumannii genomes was performed. Results Tn125 carrying blaNDM-1 was truncated by the insertion of ISAba14 downstream of dct, generating ΔTn125. blaOXA-94 was upstream of ISAba13 and ISAba17. Resistance to ceftazidime could be attributed to AmpC cephalosporinase encoded by blaADC-25, and to blaNDM-1 on plasmids. GyrA (S83L) and ParC (S80L) substitutions conferred resistance to fluoroquinolones. wgSNP analysis separated the isolates based on their sequence types. Conclusions The role of refugees in the transmission of antimicrobial resistance in developing countries is understudied. As such, this study sheds light on the correlation between population mobility and the importation of drug-resistant pathogens. It also highlights the manifold mechanisms underlying antibiotic resistance in A. baumannii.
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Genomic mapping of ST85 blaNDM-1 and blaOXA-94 producing Acinetobacter baumannii isolates from Syrian Civil War Victims
'Elsevier BV', 2018Co-Authors: Tamara Salloum, Elie Tannous, Sahar Alousi, Harout Arabaghian, Rayane Rafei, Monzer Hamze, Sima TokajianAbstract:Objectives: The rapid emergence of carbapenem-resistant Acinetobacter baumannii is a global health concern. A comparative genomic analysis was performed on two ST85 A. baumannii strains harboring blaNDM-1 and blaOXA-94 collected in Lebanon from Syrian Civil War Victims. Methods: Genome sequencing data of ACMH-6200 and ACMH-6201 were used for in silico extraction of multilocus sequence types (MLST), resistance genes, and virulence factors. Plasmids were genetically mapped in silico and using PCR-based replicon typing (PBRT). The genetic environment of blaNDM-1 and blaOXA-94 was determined, and whole-genome single nucleotide polymorphism (wgSNP) analysis in comparison with 41 publicly available A. baumannii genomes was performed. Results: Tn125 carrying blaNDM-1 was truncated by the insertion of ISAba14 downstream of dct, generating ΔTn125. blaOXA-94 was upstream of ISAba13 and ISAba17. Resistance to ceftazidime could be attributed to AmpC cephalosporinase encoded by blaADC-25, and to blaNDM-1 on plasmids. GyrA (S83L) and ParC (S80L) substitutions conferred resistance to fluoroquinolones. wgSNP analysis separated the isolates based on their sequence types. Conclusions: The role of refugees in the transmission of antimicrobial resistance in developing countries is understudied. As such, this study sheds light on the correlation between population mobility and the importation of drug-resistant pathogens. It also highlights the manifold mechanisms underlying antibiotic resistance in A. baumannii. Keywords: Acinetobacter baumannii, blaNDM-1, blaOXA-94, Plasmids, wgSNP
Ali Akbar Vosoghi - One of the best experts on this subject based on the ideXlab platform.
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An epidemiologic study to screen for chronic myelocytic leukemia in War Victims exposed to mustard gas.
Environmental Health Perspectives, 2002Co-Authors: Mostafa Ghanei, Ali Akbar VosoghiAbstract:Chemical agents such as mustard gas (or sulfur mustard), which has alkylating characteristics, were used against Iranian combatants in the Iraq-Iran War. Previous studies have not shown a strong link between these chemical agents and the development of chronic myelocytic leukemia (CML). The purpose of this study was to evaluate the increased risk of CML development in Iranian soldiers exposed to mustard gas during the War. Based on a descriptive study of 2,500 cases with documented exposure to various chemical Warfare agents, 665 patients had documented exposure to mustard gas. We screened the latter using the leukocyte alkaline phosphatase (LAP) test and performed further cytochemical studies on cases with positive results. From among the 665 cases with documented exposure to mustard gas, 9 cases had LAP scores < 20; 2 of these 9 cases had CML and a score of zero (0.3%). We detected cytogenetic abnormalities in 7 patients with low LAP scores and atypical lymphocytes of 5-11% in 40 patients. The risk ratio of CML developing in Victims exposed to mustard gas (cutaneous or respiratory) may be higher in comparison with the normal population, although confounding factors (e.g., the possibility of exposure to combined chemical agents, excluding patients who did not manifest blisters) limited our results. Because the increased development of CML in young patients with a documented history of exposure to mustard gas cannot be disregarded, further studies are needed.
Ali Akbar Moghadamnia - One of the best experts on this subject based on the ideXlab platform.
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long term effects of chemical weapons on respiratory tract in iraq iran War Victims living in babol north of iran
Ecotoxicology and Environmental Safety, 2002Co-Authors: Kh Bijani, Ali Akbar MoghadamniaAbstract:In the Iraq-Iran War (1981-1989), extensive use of chemical weapons such as mustard gas caused high mortality, morbidity, injuries, and chronic side effects in vital organs, especially the respiratory tract. This study was performed to evaluate the long-term effects on respiratory tract of Victims. Two hundred and twenty Victims were referred from the Mostazafan and Janbazan Foundation of Babol from 1994 to 1998. Complete histories, physical examinations, chest X-rays, and PFTs were performed. Nearly all the Victims complained of cough, dyspnea, and suffocation. Hemoptysis was found in 6 Victims. In 4 patients, respiratory distress with use of accessory muscles was observed. Two-thirds of the subjects had wheezing and coarse rale. For the other third, physical examination revealed no abnormal finding. Radiographic findings were mostly normal. Spirometry revealed an obstructive pattern in all patients and PFT revealed mostly normal and restrictive patterns. The shortlist time from exposure to study was 7 years and the longest was 13 years. Most patients reported mustard gas exposure and a few of them did not know what type of gas exposure they had. The clinical evaluations, radiography, and PFTs revealed that the most prevalent effects of chemical weapons on respiratory tract were chronic obstructive lung disease, presenting as many types of obstructive involvement.
Tamara Salloum - One of the best experts on this subject based on the ideXlab platform.
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genomic mapping of st85 blandm 1 and blaoxa 94 producing acinetobacter baumannii isolates from syrian civil War Victims
International Journal of Infectious Diseases, 2018Co-Authors: Tamara Salloum, Elie Tannous, Sahar Alousi, Harout Arabaghian, Rayane Rafei, Monzer Hamze, Sima TokajianAbstract:Abstract Objectives The rapid emergence of carbapenem-resistant Acinetobacter baumannii is a global health concern. A comparative genomic analysis was performed on two ST85 A. baumannii strains harboring blaNDM-1 and blaOXA-94 collected in Lebanon from Syrian Civil War Victims. Methods Genome sequencing data of ACMH-6200 and ACMH-6201 were used for in silico extraction of multilocus sequence types (MLST), resistance genes, and virulence factors. Plasmids were genetically mapped in silico and using PCR-based replicon typing (PBRT). The genetic environment of blaNDM-1 and blaOXA-94 was determined, and whole-genome single nucleotide polymorphism (wgSNP) analysis in comparison with 41 publicly available A. baumannii genomes was performed. Results Tn125 carrying blaNDM-1 was truncated by the insertion of ISAba14 downstream of dct, generating ΔTn125. blaOXA-94 was upstream of ISAba13 and ISAba17. Resistance to ceftazidime could be attributed to AmpC cephalosporinase encoded by blaADC-25, and to blaNDM-1 on plasmids. GyrA (S83L) and ParC (S80L) substitutions conferred resistance to fluoroquinolones. wgSNP analysis separated the isolates based on their sequence types. Conclusions The role of refugees in the transmission of antimicrobial resistance in developing countries is understudied. As such, this study sheds light on the correlation between population mobility and the importation of drug-resistant pathogens. It also highlights the manifold mechanisms underlying antibiotic resistance in A. baumannii.
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Genomic mapping of ST85 blaNDM-1 and blaOXA-94 producing Acinetobacter baumannii isolates from Syrian Civil War Victims
'Elsevier BV', 2018Co-Authors: Tamara Salloum, Elie Tannous, Sahar Alousi, Harout Arabaghian, Rayane Rafei, Monzer Hamze, Sima TokajianAbstract:Objectives: The rapid emergence of carbapenem-resistant Acinetobacter baumannii is a global health concern. A comparative genomic analysis was performed on two ST85 A. baumannii strains harboring blaNDM-1 and blaOXA-94 collected in Lebanon from Syrian Civil War Victims. Methods: Genome sequencing data of ACMH-6200 and ACMH-6201 were used for in silico extraction of multilocus sequence types (MLST), resistance genes, and virulence factors. Plasmids were genetically mapped in silico and using PCR-based replicon typing (PBRT). The genetic environment of blaNDM-1 and blaOXA-94 was determined, and whole-genome single nucleotide polymorphism (wgSNP) analysis in comparison with 41 publicly available A. baumannii genomes was performed. Results: Tn125 carrying blaNDM-1 was truncated by the insertion of ISAba14 downstream of dct, generating ΔTn125. blaOXA-94 was upstream of ISAba13 and ISAba17. Resistance to ceftazidime could be attributed to AmpC cephalosporinase encoded by blaADC-25, and to blaNDM-1 on plasmids. GyrA (S83L) and ParC (S80L) substitutions conferred resistance to fluoroquinolones. wgSNP analysis separated the isolates based on their sequence types. Conclusions: The role of refugees in the transmission of antimicrobial resistance in developing countries is understudied. As such, this study sheds light on the correlation between population mobility and the importation of drug-resistant pathogens. It also highlights the manifold mechanisms underlying antibiotic resistance in A. baumannii. Keywords: Acinetobacter baumannii, blaNDM-1, blaOXA-94, Plasmids, wgSNP
Rayane Rafei - One of the best experts on this subject based on the ideXlab platform.
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genomic mapping of st85 blandm 1 and blaoxa 94 producing acinetobacter baumannii isolates from syrian civil War Victims
International Journal of Infectious Diseases, 2018Co-Authors: Tamara Salloum, Elie Tannous, Sahar Alousi, Harout Arabaghian, Rayane Rafei, Monzer Hamze, Sima TokajianAbstract:Abstract Objectives The rapid emergence of carbapenem-resistant Acinetobacter baumannii is a global health concern. A comparative genomic analysis was performed on two ST85 A. baumannii strains harboring blaNDM-1 and blaOXA-94 collected in Lebanon from Syrian Civil War Victims. Methods Genome sequencing data of ACMH-6200 and ACMH-6201 were used for in silico extraction of multilocus sequence types (MLST), resistance genes, and virulence factors. Plasmids were genetically mapped in silico and using PCR-based replicon typing (PBRT). The genetic environment of blaNDM-1 and blaOXA-94 was determined, and whole-genome single nucleotide polymorphism (wgSNP) analysis in comparison with 41 publicly available A. baumannii genomes was performed. Results Tn125 carrying blaNDM-1 was truncated by the insertion of ISAba14 downstream of dct, generating ΔTn125. blaOXA-94 was upstream of ISAba13 and ISAba17. Resistance to ceftazidime could be attributed to AmpC cephalosporinase encoded by blaADC-25, and to blaNDM-1 on plasmids. GyrA (S83L) and ParC (S80L) substitutions conferred resistance to fluoroquinolones. wgSNP analysis separated the isolates based on their sequence types. Conclusions The role of refugees in the transmission of antimicrobial resistance in developing countries is understudied. As such, this study sheds light on the correlation between population mobility and the importation of drug-resistant pathogens. It also highlights the manifold mechanisms underlying antibiotic resistance in A. baumannii.
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Genomic mapping of ST85 blaNDM-1 and blaOXA-94 producing Acinetobacter baumannii isolates from Syrian Civil War Victims
'Elsevier BV', 2018Co-Authors: Tamara Salloum, Elie Tannous, Sahar Alousi, Harout Arabaghian, Rayane Rafei, Monzer Hamze, Sima TokajianAbstract:Objectives: The rapid emergence of carbapenem-resistant Acinetobacter baumannii is a global health concern. A comparative genomic analysis was performed on two ST85 A. baumannii strains harboring blaNDM-1 and blaOXA-94 collected in Lebanon from Syrian Civil War Victims. Methods: Genome sequencing data of ACMH-6200 and ACMH-6201 were used for in silico extraction of multilocus sequence types (MLST), resistance genes, and virulence factors. Plasmids were genetically mapped in silico and using PCR-based replicon typing (PBRT). The genetic environment of blaNDM-1 and blaOXA-94 was determined, and whole-genome single nucleotide polymorphism (wgSNP) analysis in comparison with 41 publicly available A. baumannii genomes was performed. Results: Tn125 carrying blaNDM-1 was truncated by the insertion of ISAba14 downstream of dct, generating ΔTn125. blaOXA-94 was upstream of ISAba13 and ISAba17. Resistance to ceftazidime could be attributed to AmpC cephalosporinase encoded by blaADC-25, and to blaNDM-1 on plasmids. GyrA (S83L) and ParC (S80L) substitutions conferred resistance to fluoroquinolones. wgSNP analysis separated the isolates based on their sequence types. Conclusions: The role of refugees in the transmission of antimicrobial resistance in developing countries is understudied. As such, this study sheds light on the correlation between population mobility and the importation of drug-resistant pathogens. It also highlights the manifold mechanisms underlying antibiotic resistance in A. baumannii. Keywords: Acinetobacter baumannii, blaNDM-1, blaOXA-94, Plasmids, wgSNP
