The Experts below are selected from a list of 1293 Experts worldwide ranked by ideXlab platform
John B. Bodensteiner - One of the best experts on this subject based on the ideXlab platform.
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Acute and Delayed Cerebral Infarction After Wasp Sting Anaphylaxis
Clinical neuropharmacology, 1994Co-Authors: Jack E. Riggs, Leena Ketonen, James P. Wymer, Richard L. Barbano, Leena K. Valanne, John B. BodensteinerAbstract:A 52-year-old man developed a severe anaphylactic reaction after a Wasp Sting. Slurred speech and left hemiparesis were noted a few hours later. Three-and-one-half weeks later, he became acutely obtunded and quadriparetic. Angiographic studies demonstrated complete and near-complete occlusions of the right and left internal carotid arteries, respectively. A mechanism is suggested for delayed ischemic stroke after Wasp Sting anaphylaxis that involves cerebrovascular sympathetic innervation.
Tie Chen - One of the best experts on this subject based on the ideXlab platform.
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Clinical Features of Severe Wasp Sting Patients with Dominantly Toxic Reaction: Analysis of 1091 Cases
2016Co-Authors: Cuihong Xie, Fengfei Ding, Minjie Xie, Jihua Yao, Dengji Pan, Qian Sun, Chenchen Liu, Tie ChenAbstract:Background: Massive Wasp Stings have been greatly underestimated and have not been systematically studied. The aim of this study was to identify the clinical features and treatment strategies of severe Wasp Stings. Methods and Findings: A multicenter retrospective study was undertaken in 35 hospitals and medical centers including 12 tertiary care hospitals and 23 secondary care hospitals in the Hubei Province, China. The detailed clinical data of 1091 hospitalized Wasp Sting patients were investigated. Over three-fourths (76.9%) of the cases had 10 or more Stings and the in-hospital mortality of patients was 5.1%. Forty-eight patients died of organ injury following toxic reactions to the Stings, whereas six died from anaphylactic shock. The in-hospital mortality in patients with.10 Stings was higher than that of #10 Stings (5.2 % vs. 1.0%, p = 0.02). Acute kidney injury (AKI) was seen in 21.0 % patients and most patients required blood purification therapy. Rhabdomyolysis was seen in 24.1 % patients, hemolysis in 19.2 % patients, liver injury in 30.1 % patients, and coagulopathy in 22.5 % patients. Regression analysis revealed that high creatinine level, shock, oliguria, and anemia were risk factors for death. Blood purification therapy was beneficial for patients with $20 Stings and delayed hospital admission of patients ($4 hours after Sting). Conclusions: In China, most patients with multiple Wasp Stings presented with toxic reactions and multiple organ dysfunction caused by the venom rather than an anaphylactic reaction. AKI is the prominent clinical manifestation of was
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Clinical Features of Severe Wasp Sting Patients with Dominantly Toxic Reaction: Analysis of 1091 Cases
PloS one, 2013Co-Authors: Cuihong Xie, Fengfei Ding, Minjie Xie, Jihua Yao, Dengji Pan, Qian Sun, Chenchen Liu, Tie ChenAbstract:Background Massive Wasp Stings have been greatly underestimated and have not been systematically studied. The aim of this study was to identify the clinical features and treatment strategies of severe Wasp Stings. Methods and Findings A multicenter retrospective study was undertaken in 35 hospitals and medical centers including 12 tertiary care hospitals and 23 secondary care hospitals in the Hubei Province, China. The detailed clinical data of 1091 hospitalized Wasp Sting patients were investigated. Over three-fourths (76.9%) of the cases had 10 or more Stings and the in-hospital mortality of patients was 5.1%. Forty-eight patients died of organ injury following toxic reactions to the Stings, whereas six died from anaphylactic shock. The in-hospital mortality in patients with >10 Stings was higher than that of ≤10 Stings (5.2% vs. 1.0%, p = 0.02). Acute kidney injury (AKI) was seen in 21.0% patients and most patients required blood purification therapy. Rhabdomyolysis was seen in 24.1% patients, hemolysis in 19.2% patients, liver injury in 30.1% patients, and coagulopathy in 22.5% patients. Regression analysis revealed that high creatinine level, shock, oliguria, and anemia were risk factors for death. Blood purification therapy was beneficial for patients with ≥20 Stings and delayed hospital admission of patients (≥4 hours after Sting). Conclusions In China, most patients with multiple Wasp Stings presented with toxic reactions and multiple organ dysfunction caused by the venom rather than an anaphylactic reaction. AKI is the prominent clinical manifestation of Wasp Stings with toxic reaction. High creatinine levels, shock, oliguria, and anemia were risk factors for death.
Min Xiao - One of the best experts on this subject based on the ideXlab platform.
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Serum metabolomics analysis in Wasp Sting patients
BioMed research international, 2018Co-Authors: Xianyi Yang, Lin Chai, Chunyan Liu, Mei Liu, Limei Han, Hui Guo, Yuwen Sun, Xiaomin Rao, Min XiaoAbstract:To analyze the dynamic changes of serum metabolomics in Wasp Sting victims, we collected serum from 10 healthy volunteers and 10 patients who had been stung 3 hours, 24 hours, and 72 hours before sample collection. We analyzed the metabolomics by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) techniques and then performed enrichment analysis. A total of 838 metabolites were identified. Serum metabolomics analysis using MetaboAnalyst revealed 289 metabolites that were significantly different among patients in the 3-hour group versus healthy controls (P
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serum metabolomics analysis in Wasp Sting patients
BioMed Research International, 2018Co-Authors: Xianyi Yang, Lin Chai, Min Xiao, Chunyan Liu, Mei Liu, Limei Han, Hui Guo, Yuwen Sun, Xiaomin Rao, Zhicheng FangAbstract:To analyze the dynamic changes of serum metabolomics in Wasp Sting victims, we collected serum from 10 healthy volunteers and 10 patients who had been stung 3 hours, 24 hours, and 72 hours before sample collection. We analyzed the metabolomics by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) techniques and then performed enrichment analysis. A total of 838 metabolites were identified. Serum metabolomics analysis using MetaboAnalyst revealed 289 metabolites that were significantly different among patients in the 3-hour group versus healthy controls (P<0.001). Pathway analysis of those metabolites indicated that those metabolic sets were associated with sphingolipid metabolism. Based on the differences among the control, 3-hour, 24-hour, and 72-hour groups, we classified serum metabolites into different categories. The first and second categories included 297 and 280 metabolites that were significantly different in terms of concentration among healthy controls versus the participants whose sera were analyzed 3 hours, 24 hours, and 72 hours after Wasp Stings. Pathway analysis of those metabolites indicated that those metabolic sets were associated with thiamine metabolism. The third category included 269 significant metabolites. The fourth category included 28 significant metabolites. Pathway analysis of the metabolites in third and fourth categories indicated that those metabolic sets were associated with phenylalanine, tyrosine, and tryptophan biosynthesis. The fifth category included 31 metabolites, which were not significantly different between the control and 3-hour groups but were higher in concentration in the 24-hour and 72-hour groups. Pathway analysis of the fifth category of significant metabolites identified linoleic acid metabolism. In conclusion, multiple metabolic pathways are associated with Wasp Stings, and these might provide a basis for exploring mechanisms of Wasp Sting injury and potential targets for therapy.
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Biopanning of allergens from Wasp Sting patients
Bioscience Reports, 2018Co-Authors: Lin Chai, Xianyi Yang, Xiaoyan Li, Changsheng Li, Min XiaoAbstract:Objective: Wasp venom is a potentially important natural drug, but it can cause hypersensitivity reactions. The purpose of the present study was to systematically study the epitopes of Wasp venom. Methods: Using a random 12-peptide phage library, we performed antibody-binding epitope panning on ten serum samples from Wasp Sting victims at 3 h and 4 days after the Sting. The panning epitopes were identified by high-throughput sequencing and matched with Wasp venom proteins by BLAST. The panned antibody-binding epitopes were verified by ELISA. Results: A total of 35 specific potential Wasp venom epitopes in 4 days were identified. Amongst them, twelve peptide epitopes were matched with nine Wasp venom proteins, namely, vitellogenin precursor, hexamerin 70b precursor, venom carboxylesterase-6 precursor, MRJP5, major royal jelly protein 8 precursor, venom acid phosphatase Acph-1 precursor, phospholipase A2, venom serine protease 34 precursor, and major royal jelly protein 9 precursor. The changes in serum IgM antibodies induced by Wasp venom were confirmed by ELISA based on the 12 peptide epitopes. Conclusion: The nine Wasp venom proteins are potential allergens, which should be excluded or modified in the potential biomedical applications of Wasp venom.
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Expert consensus statement on standardized diagnosis and treatment of Wasp Sting in China
Zhonghua wei zhong bing ji jiu yi xue, 2018Co-Authors: Xianyi Yang, Min XiaoAbstract:To improve the diagnosis and treatment of Wasp Sting, summarize the experience, the experts from Chinese Society of Toxicology Poisoning and Treatment of Specialized Committee, Hubei Emergency Medicine Committee of Chinese Medical Association and Hubei Provincial Poisoning and Occupational Disease Union made the Expert consensus statement on standardized diagnosis and treatment of Wasp Stings in China on the development of domestic and oversea in this field. The consensus statement emphasized the idea of staged treatment, different treatments at different stages, and strived to achieve bundling and individuation. To achieve the four pairs of different concept as earlier as possible, the "two early" (early assessment and early treatment), the "two anti" (anti-anaphylaxis and anti-shock), namely the "two hormone" (adrenaline and glucocorticoid) and the "two hua" (hydration and alkalization), we could avoid or reduce subsequent organ failures, significantly shorten the course and improve prognosis of Wasp Sting victims. Key words: Wasp Sting; Diagnosis; Treatment; Expert consensus
Jack E. Riggs - One of the best experts on this subject based on the ideXlab platform.
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Acute and Delayed Cerebral Infarction After Wasp Sting Anaphylaxis
Clinical neuropharmacology, 1994Co-Authors: Jack E. Riggs, Leena Ketonen, James P. Wymer, Richard L. Barbano, Leena K. Valanne, John B. BodensteinerAbstract:A 52-year-old man developed a severe anaphylactic reaction after a Wasp Sting. Slurred speech and left hemiparesis were noted a few hours later. Three-and-one-half weeks later, he became acutely obtunded and quadriparetic. Angiographic studies demonstrated complete and near-complete occlusions of the right and left internal carotid arteries, respectively. A mechanism is suggested for delayed ischemic stroke after Wasp Sting anaphylaxis that involves cerebrovascular sympathetic innervation.
Etienne Aliot - One of the best experts on this subject based on the ideXlab platform.
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myocardial infarction in a 45 year old man following an anaphylactic reaction to a Wasp Sting
International Journal of Cardiology, 2011Co-Authors: Mathieu Valla, Frederic Moulin, Michael Angioi, Laurent Groben, Nicolas Sadoul, Etienne AliotAbstract:Abstract We present the case of a 45-year-old man with clinical features of acute coronary syndrome with persistent ST segment elevation following an anaphylactic reaction to a Wasp Sting treated with adrenaline. A thrombolysis is performed with no effect on clinical signs, leading to an emergency cardiac catheterization which reveals a non-occlusive thrombosis of the right coronary artery. The pathophysiology and clinical implications of this association are discussed.