The Experts below are selected from a list of 57 Experts worldwide ranked by ideXlab platform
Karl B Kern - One of the best experts on this subject based on the ideXlab platform.
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amplitude spectral area and chest compression release velocity independently predict hospital discharge and good neurological outcome in ventricular fibrillation out of hospital cardiac arrest
Resuscitation, 2015Co-Authors: Julia H Indik, Zacherie Conover, Meghan Mcgovern, Annemarie Silver, Daniel W Spaite, Bentley J Bobrow, Karl B KernAbstract:Abstract Objective In out-of-hospital cardiac arrest (OHCA) with ventricular fibrillation (VF) the frequency-based Waveform Characteristic, amplitude-spectral area (AMSA) is associated with hospital discharge and good neurological outcome, yet AMSA is also known to increase in response to chest compressions (CC). In addition to rate and depth, well performed CC provides good chest recoil without leaning, reflected in the release velocity (RV). We hypothesized that AMSA is associated with hospital discharge and good neurological outcome independent of CC quality. Methods OHCA patients (age≥18), with initial rhythm of VF from an Utstein-Style database were analyzed. AMSA was measured prior to each shock, and averaged for each subject (AMSA-avg). Primary endpoint was hospital discharge and secondary endpoint was a good neurological outcome. Univariate and stepwise multivariable logistic regression, and receiver–operator–Characteristic (ROC) analyses were performed. Factors analyzed were age, sex, witnessed status, time from dispatch to monitor/defibrillator application, number of shocks, first shock AMSA (AMSA 1 ), AMSA-avg, averaged pre-shock pause, CC rate, depth, and RV. Results 140 subjects were analyzed. Hospital discharge was 31% and with good neurological outcome in 24% (77% of those discharged). AMSA-avg ( p p =0.002), and age ( p =0.029) were independently associated with hospital discharge, with a non-significant trend for witnessed status ( p =0.069), with AUC=0.846 for the multivariate model. For good neurological outcome, AMSA-avg ( p =0.001) and RV ( p =0.001) remained independently significant, with AUC=0.782. Conclusion In OHCA with an initial rhythm of VF, AMSA-avg and CC RV are both highly and independently associated with hospital discharge and good neurological outcome.
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association of amplitude spectral area of the ventricular fibrillation Waveform with survival of out of hospital ventricular fibrillation cardiac arrest
Journal of the American College of Cardiology, 2014Co-Authors: Julia H Indik, Zacherie Conover, Meghan Mcgovern, Annemarie Silver, Daniel W Spaite, Bentley J Bobrow, Karl B KernAbstract:Abstract Background Previous investigations of out-of-hospital cardiac arrest (OHCA) have shown that the Waveform Characteristic amplitude spectral area (AMSA) can predict successful defibrillation and return of spontaneous circulation (ROSC) but has not been studied previously for survival. Objectives To determine whether AMSA computed from the ventricular fibrillation (VF) Waveform is associated with pre-hospital ROSC, hospital admission, and hospital discharge. Methods Adults with witnessed OHCA and an initial rhythm of VF from an Utstein style database were studied. AMSA was measured prior to each shock and averaged for each subject (AMSA-avg). Factors such as age, sex, number of shocks, time from dispatch to monitor/defibrillator application, first shock AMSA, and AMSA-avg that could predict pre-hospital ROSC, hospital admission, and hospital discharge were analyzed by logistic regression. Results Eighty-nine subjects (mean age 62 ± 15 years) with a total of 286 shocks were analyzed. AMSA-avg was associated with pre-hospital ROSC (p = 0.003); a threshold of 20.9 mV-Hz had a 95% sensitivity and a 43.4% specificity. Additionally, AMSA-avg was associated with hospital admission (p Conclusions AMSA is highly associated with pre-hospital ROSC, survival to hospital admission, and hospital discharge in witnessed VF OHCA. Future studies are needed to determine whether AMSA computed during resuscitation can identify patients for whom continuing current resuscitation efforts would likely be futile.
Julia H Indik - One of the best experts on this subject based on the ideXlab platform.
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amplitude spectral area and chest compression release velocity independently predict hospital discharge and good neurological outcome in ventricular fibrillation out of hospital cardiac arrest
Resuscitation, 2015Co-Authors: Julia H Indik, Zacherie Conover, Meghan Mcgovern, Annemarie Silver, Daniel W Spaite, Bentley J Bobrow, Karl B KernAbstract:Abstract Objective In out-of-hospital cardiac arrest (OHCA) with ventricular fibrillation (VF) the frequency-based Waveform Characteristic, amplitude-spectral area (AMSA) is associated with hospital discharge and good neurological outcome, yet AMSA is also known to increase in response to chest compressions (CC). In addition to rate and depth, well performed CC provides good chest recoil without leaning, reflected in the release velocity (RV). We hypothesized that AMSA is associated with hospital discharge and good neurological outcome independent of CC quality. Methods OHCA patients (age≥18), with initial rhythm of VF from an Utstein-Style database were analyzed. AMSA was measured prior to each shock, and averaged for each subject (AMSA-avg). Primary endpoint was hospital discharge and secondary endpoint was a good neurological outcome. Univariate and stepwise multivariable logistic regression, and receiver–operator–Characteristic (ROC) analyses were performed. Factors analyzed were age, sex, witnessed status, time from dispatch to monitor/defibrillator application, number of shocks, first shock AMSA (AMSA 1 ), AMSA-avg, averaged pre-shock pause, CC rate, depth, and RV. Results 140 subjects were analyzed. Hospital discharge was 31% and with good neurological outcome in 24% (77% of those discharged). AMSA-avg ( p p =0.002), and age ( p =0.029) were independently associated with hospital discharge, with a non-significant trend for witnessed status ( p =0.069), with AUC=0.846 for the multivariate model. For good neurological outcome, AMSA-avg ( p =0.001) and RV ( p =0.001) remained independently significant, with AUC=0.782. Conclusion In OHCA with an initial rhythm of VF, AMSA-avg and CC RV are both highly and independently associated with hospital discharge and good neurological outcome.
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association of amplitude spectral area of the ventricular fibrillation Waveform with survival of out of hospital ventricular fibrillation cardiac arrest
Journal of the American College of Cardiology, 2014Co-Authors: Julia H Indik, Zacherie Conover, Meghan Mcgovern, Annemarie Silver, Daniel W Spaite, Bentley J Bobrow, Karl B KernAbstract:Abstract Background Previous investigations of out-of-hospital cardiac arrest (OHCA) have shown that the Waveform Characteristic amplitude spectral area (AMSA) can predict successful defibrillation and return of spontaneous circulation (ROSC) but has not been studied previously for survival. Objectives To determine whether AMSA computed from the ventricular fibrillation (VF) Waveform is associated with pre-hospital ROSC, hospital admission, and hospital discharge. Methods Adults with witnessed OHCA and an initial rhythm of VF from an Utstein style database were studied. AMSA was measured prior to each shock and averaged for each subject (AMSA-avg). Factors such as age, sex, number of shocks, time from dispatch to monitor/defibrillator application, first shock AMSA, and AMSA-avg that could predict pre-hospital ROSC, hospital admission, and hospital discharge were analyzed by logistic regression. Results Eighty-nine subjects (mean age 62 ± 15 years) with a total of 286 shocks were analyzed. AMSA-avg was associated with pre-hospital ROSC (p = 0.003); a threshold of 20.9 mV-Hz had a 95% sensitivity and a 43.4% specificity. Additionally, AMSA-avg was associated with hospital admission (p Conclusions AMSA is highly associated with pre-hospital ROSC, survival to hospital admission, and hospital discharge in witnessed VF OHCA. Future studies are needed to determine whether AMSA computed during resuscitation can identify patients for whom continuing current resuscitation efforts would likely be futile.
Bentley J Bobrow - One of the best experts on this subject based on the ideXlab platform.
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amplitude spectral area and chest compression release velocity independently predict hospital discharge and good neurological outcome in ventricular fibrillation out of hospital cardiac arrest
Resuscitation, 2015Co-Authors: Julia H Indik, Zacherie Conover, Meghan Mcgovern, Annemarie Silver, Daniel W Spaite, Bentley J Bobrow, Karl B KernAbstract:Abstract Objective In out-of-hospital cardiac arrest (OHCA) with ventricular fibrillation (VF) the frequency-based Waveform Characteristic, amplitude-spectral area (AMSA) is associated with hospital discharge and good neurological outcome, yet AMSA is also known to increase in response to chest compressions (CC). In addition to rate and depth, well performed CC provides good chest recoil without leaning, reflected in the release velocity (RV). We hypothesized that AMSA is associated with hospital discharge and good neurological outcome independent of CC quality. Methods OHCA patients (age≥18), with initial rhythm of VF from an Utstein-Style database were analyzed. AMSA was measured prior to each shock, and averaged for each subject (AMSA-avg). Primary endpoint was hospital discharge and secondary endpoint was a good neurological outcome. Univariate and stepwise multivariable logistic regression, and receiver–operator–Characteristic (ROC) analyses were performed. Factors analyzed were age, sex, witnessed status, time from dispatch to monitor/defibrillator application, number of shocks, first shock AMSA (AMSA 1 ), AMSA-avg, averaged pre-shock pause, CC rate, depth, and RV. Results 140 subjects were analyzed. Hospital discharge was 31% and with good neurological outcome in 24% (77% of those discharged). AMSA-avg ( p p =0.002), and age ( p =0.029) were independently associated with hospital discharge, with a non-significant trend for witnessed status ( p =0.069), with AUC=0.846 for the multivariate model. For good neurological outcome, AMSA-avg ( p =0.001) and RV ( p =0.001) remained independently significant, with AUC=0.782. Conclusion In OHCA with an initial rhythm of VF, AMSA-avg and CC RV are both highly and independently associated with hospital discharge and good neurological outcome.
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association of amplitude spectral area of the ventricular fibrillation Waveform with survival of out of hospital ventricular fibrillation cardiac arrest
Journal of the American College of Cardiology, 2014Co-Authors: Julia H Indik, Zacherie Conover, Meghan Mcgovern, Annemarie Silver, Daniel W Spaite, Bentley J Bobrow, Karl B KernAbstract:Abstract Background Previous investigations of out-of-hospital cardiac arrest (OHCA) have shown that the Waveform Characteristic amplitude spectral area (AMSA) can predict successful defibrillation and return of spontaneous circulation (ROSC) but has not been studied previously for survival. Objectives To determine whether AMSA computed from the ventricular fibrillation (VF) Waveform is associated with pre-hospital ROSC, hospital admission, and hospital discharge. Methods Adults with witnessed OHCA and an initial rhythm of VF from an Utstein style database were studied. AMSA was measured prior to each shock and averaged for each subject (AMSA-avg). Factors such as age, sex, number of shocks, time from dispatch to monitor/defibrillator application, first shock AMSA, and AMSA-avg that could predict pre-hospital ROSC, hospital admission, and hospital discharge were analyzed by logistic regression. Results Eighty-nine subjects (mean age 62 ± 15 years) with a total of 286 shocks were analyzed. AMSA-avg was associated with pre-hospital ROSC (p = 0.003); a threshold of 20.9 mV-Hz had a 95% sensitivity and a 43.4% specificity. Additionally, AMSA-avg was associated with hospital admission (p Conclusions AMSA is highly associated with pre-hospital ROSC, survival to hospital admission, and hospital discharge in witnessed VF OHCA. Future studies are needed to determine whether AMSA computed during resuscitation can identify patients for whom continuing current resuscitation efforts would likely be futile.
Daniel W Spaite - One of the best experts on this subject based on the ideXlab platform.
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amplitude spectral area and chest compression release velocity independently predict hospital discharge and good neurological outcome in ventricular fibrillation out of hospital cardiac arrest
Resuscitation, 2015Co-Authors: Julia H Indik, Zacherie Conover, Meghan Mcgovern, Annemarie Silver, Daniel W Spaite, Bentley J Bobrow, Karl B KernAbstract:Abstract Objective In out-of-hospital cardiac arrest (OHCA) with ventricular fibrillation (VF) the frequency-based Waveform Characteristic, amplitude-spectral area (AMSA) is associated with hospital discharge and good neurological outcome, yet AMSA is also known to increase in response to chest compressions (CC). In addition to rate and depth, well performed CC provides good chest recoil without leaning, reflected in the release velocity (RV). We hypothesized that AMSA is associated with hospital discharge and good neurological outcome independent of CC quality. Methods OHCA patients (age≥18), with initial rhythm of VF from an Utstein-Style database were analyzed. AMSA was measured prior to each shock, and averaged for each subject (AMSA-avg). Primary endpoint was hospital discharge and secondary endpoint was a good neurological outcome. Univariate and stepwise multivariable logistic regression, and receiver–operator–Characteristic (ROC) analyses were performed. Factors analyzed were age, sex, witnessed status, time from dispatch to monitor/defibrillator application, number of shocks, first shock AMSA (AMSA 1 ), AMSA-avg, averaged pre-shock pause, CC rate, depth, and RV. Results 140 subjects were analyzed. Hospital discharge was 31% and with good neurological outcome in 24% (77% of those discharged). AMSA-avg ( p p =0.002), and age ( p =0.029) were independently associated with hospital discharge, with a non-significant trend for witnessed status ( p =0.069), with AUC=0.846 for the multivariate model. For good neurological outcome, AMSA-avg ( p =0.001) and RV ( p =0.001) remained independently significant, with AUC=0.782. Conclusion In OHCA with an initial rhythm of VF, AMSA-avg and CC RV are both highly and independently associated with hospital discharge and good neurological outcome.
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association of amplitude spectral area of the ventricular fibrillation Waveform with survival of out of hospital ventricular fibrillation cardiac arrest
Journal of the American College of Cardiology, 2014Co-Authors: Julia H Indik, Zacherie Conover, Meghan Mcgovern, Annemarie Silver, Daniel W Spaite, Bentley J Bobrow, Karl B KernAbstract:Abstract Background Previous investigations of out-of-hospital cardiac arrest (OHCA) have shown that the Waveform Characteristic amplitude spectral area (AMSA) can predict successful defibrillation and return of spontaneous circulation (ROSC) but has not been studied previously for survival. Objectives To determine whether AMSA computed from the ventricular fibrillation (VF) Waveform is associated with pre-hospital ROSC, hospital admission, and hospital discharge. Methods Adults with witnessed OHCA and an initial rhythm of VF from an Utstein style database were studied. AMSA was measured prior to each shock and averaged for each subject (AMSA-avg). Factors such as age, sex, number of shocks, time from dispatch to monitor/defibrillator application, first shock AMSA, and AMSA-avg that could predict pre-hospital ROSC, hospital admission, and hospital discharge were analyzed by logistic regression. Results Eighty-nine subjects (mean age 62 ± 15 years) with a total of 286 shocks were analyzed. AMSA-avg was associated with pre-hospital ROSC (p = 0.003); a threshold of 20.9 mV-Hz had a 95% sensitivity and a 43.4% specificity. Additionally, AMSA-avg was associated with hospital admission (p Conclusions AMSA is highly associated with pre-hospital ROSC, survival to hospital admission, and hospital discharge in witnessed VF OHCA. Future studies are needed to determine whether AMSA computed during resuscitation can identify patients for whom continuing current resuscitation efforts would likely be futile.
Annemarie Silver - One of the best experts on this subject based on the ideXlab platform.
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amplitude spectral area and chest compression release velocity independently predict hospital discharge and good neurological outcome in ventricular fibrillation out of hospital cardiac arrest
Resuscitation, 2015Co-Authors: Julia H Indik, Zacherie Conover, Meghan Mcgovern, Annemarie Silver, Daniel W Spaite, Bentley J Bobrow, Karl B KernAbstract:Abstract Objective In out-of-hospital cardiac arrest (OHCA) with ventricular fibrillation (VF) the frequency-based Waveform Characteristic, amplitude-spectral area (AMSA) is associated with hospital discharge and good neurological outcome, yet AMSA is also known to increase in response to chest compressions (CC). In addition to rate and depth, well performed CC provides good chest recoil without leaning, reflected in the release velocity (RV). We hypothesized that AMSA is associated with hospital discharge and good neurological outcome independent of CC quality. Methods OHCA patients (age≥18), with initial rhythm of VF from an Utstein-Style database were analyzed. AMSA was measured prior to each shock, and averaged for each subject (AMSA-avg). Primary endpoint was hospital discharge and secondary endpoint was a good neurological outcome. Univariate and stepwise multivariable logistic regression, and receiver–operator–Characteristic (ROC) analyses were performed. Factors analyzed were age, sex, witnessed status, time from dispatch to monitor/defibrillator application, number of shocks, first shock AMSA (AMSA 1 ), AMSA-avg, averaged pre-shock pause, CC rate, depth, and RV. Results 140 subjects were analyzed. Hospital discharge was 31% and with good neurological outcome in 24% (77% of those discharged). AMSA-avg ( p p =0.002), and age ( p =0.029) were independently associated with hospital discharge, with a non-significant trend for witnessed status ( p =0.069), with AUC=0.846 for the multivariate model. For good neurological outcome, AMSA-avg ( p =0.001) and RV ( p =0.001) remained independently significant, with AUC=0.782. Conclusion In OHCA with an initial rhythm of VF, AMSA-avg and CC RV are both highly and independently associated with hospital discharge and good neurological outcome.
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association of amplitude spectral area of the ventricular fibrillation Waveform with survival of out of hospital ventricular fibrillation cardiac arrest
Journal of the American College of Cardiology, 2014Co-Authors: Julia H Indik, Zacherie Conover, Meghan Mcgovern, Annemarie Silver, Daniel W Spaite, Bentley J Bobrow, Karl B KernAbstract:Abstract Background Previous investigations of out-of-hospital cardiac arrest (OHCA) have shown that the Waveform Characteristic amplitude spectral area (AMSA) can predict successful defibrillation and return of spontaneous circulation (ROSC) but has not been studied previously for survival. Objectives To determine whether AMSA computed from the ventricular fibrillation (VF) Waveform is associated with pre-hospital ROSC, hospital admission, and hospital discharge. Methods Adults with witnessed OHCA and an initial rhythm of VF from an Utstein style database were studied. AMSA was measured prior to each shock and averaged for each subject (AMSA-avg). Factors such as age, sex, number of shocks, time from dispatch to monitor/defibrillator application, first shock AMSA, and AMSA-avg that could predict pre-hospital ROSC, hospital admission, and hospital discharge were analyzed by logistic regression. Results Eighty-nine subjects (mean age 62 ± 15 years) with a total of 286 shocks were analyzed. AMSA-avg was associated with pre-hospital ROSC (p = 0.003); a threshold of 20.9 mV-Hz had a 95% sensitivity and a 43.4% specificity. Additionally, AMSA-avg was associated with hospital admission (p Conclusions AMSA is highly associated with pre-hospital ROSC, survival to hospital admission, and hospital discharge in witnessed VF OHCA. Future studies are needed to determine whether AMSA computed during resuscitation can identify patients for whom continuing current resuscitation efforts would likely be futile.
