The Experts below are selected from a list of 42 Experts worldwide ranked by ideXlab platform
Richard K. Winkelmann - One of the best experts on this subject based on the ideXlab platform.
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Weber-Christian Panniculitis: A review of 30 cases with this diagnosis
Journal of the American Academy of Dermatology, 1998Co-Authors: John W. White, Richard K. WinkelmannAbstract:Abstract Background: More than 60 years ago, Christian described a Panniculitis that was later termed Weber-Christian disease . Objective: The purpose of this study was to investigate whether this is a specific disease or a nonspecific disease that embraces several specific conditions. Methods: We studied 30 cases diagnosed as Weber-Christian Panniculitis and found it possible to make a more specific diagnosis. Results: In 12 patients, findings were compatible with erythema nodosum. Six patients had phlebitis or postphlebitic syndrome. Factitial Panniculitis was diagnosed in five patients, and trauma had a role in the conditions of another three patients. Cytophagic Panniculitis, lymphoma, and leukemia were recognized in one patient each. The lesion was lobular in almost all cases, and the presence of lipophagia was noted in 19 biopsy specimens. Granulomatous, neutrophilic, and lymphocytic pathologic changes were present in nine, eight, and eight tissue specimens, respectively. Conclusion: The recognition of distinct disease patterns of fat lesions as fat necrosis with pancreatic disease, α 1 -antitrypsin Panniculitis, lupus and connective tissue disease Panniculitis, involution lipoatrophy, lipomembranous Panniculitis, factitial Panniculitis syndromes, calcification Panniculitis, lipophagic lipoatrophy, and cytophagic Panniculitis has lessened the need for a less specific Panniculitis category. All these diseases have been reported in the literature as "Weber-Christian disease." Because separate and distinct forms of fat lesions have been described, we believe that the eponym should be abandoned and that more specific diagnoses should be made on the basis of pathogenesis or cause. (J Am Acad Dermatol 1998;39:56-62.)
He Lejian - One of the best experts on this subject based on the ideXlab platform.
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Weber-Christian Panniculitis in children : it is related to some specific diseases
Chinexe Journal of Pediatrics, 2001Co-Authors: He LejianAbstract:Objective More than half a century ago, Weber and Christian described a Panniculitis that was later termed Weber-Christian disease. Recently, it was recognized that a variety of distinctive disease entities are associated with Weber-Christian disease.The most researchers consider that the term "Weber-Christian disease" should be abandoned and more specific diagnoses should be made on the basis of pathogenesis or cause. The purpose of this study was to investigate whether Weber-Christian Panniculitis in children is a specific or nonspecific disease. Methods The authors studied 16 cases diagnosed as Weber-Christian Panniculitis at the rheumatologic clinic, Beijing Children′s Hospital from Jan 1993 to Feb 2000. The ratio of boy to girl was 7∶9. The mean age of onset was 5.1 years. The average course of the disease was 10.8 months. Based on clinical manifestations, routine pathological and immunohistochemical methods, results of laboratory examination and follow-up data, the arthors found that it was possible to make a more specific diagnosis. Result A variety of distinctive disease entities were recognized in the 16 children, including 7 subcutaneous Panniculitis-like T-cell lymphoma (SPTCL); systemic lupus erythematosis (SLE), systemic cryptococcosis, inflammatory bowel disease (IBD) and malignant histiocytosis in one patient each; tuberculosis and streptococcus infection were diagnosed in two children each. The cause was unclear in one case. Thirteen of 16 children were followed-up. Four cases, tuberculosis or streptococcus infection, were cured with antibiotics and antituberculosis agents. SLE and IBD were stable with regular treatment. One SPTCL case was unstable who were treated with irregular prednisone.Six cases died, including 3 with SPTCL, one with malignant histiocytosis and one with systemic cryptococcosis, one with unknown cause. Conclusion Weber-Christian Panniculitis seems not to be a specific disease.It is rather a nonspecific subcutaneous inflammation. A variety of distinctive diseases are associated with Weber-Christian disease. It is proposed that the term "Weber-Christian Panniculitis" should be abandoned and that more specific diagnosis should be made on the base of pathogenesis or causes.
John W. White - One of the best experts on this subject based on the ideXlab platform.
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Weber-Christian Panniculitis: A review of 30 cases with this diagnosis
Journal of the American Academy of Dermatology, 1998Co-Authors: John W. White, Richard K. WinkelmannAbstract:Abstract Background: More than 60 years ago, Christian described a Panniculitis that was later termed Weber-Christian disease . Objective: The purpose of this study was to investigate whether this is a specific disease or a nonspecific disease that embraces several specific conditions. Methods: We studied 30 cases diagnosed as Weber-Christian Panniculitis and found it possible to make a more specific diagnosis. Results: In 12 patients, findings were compatible with erythema nodosum. Six patients had phlebitis or postphlebitic syndrome. Factitial Panniculitis was diagnosed in five patients, and trauma had a role in the conditions of another three patients. Cytophagic Panniculitis, lymphoma, and leukemia were recognized in one patient each. The lesion was lobular in almost all cases, and the presence of lipophagia was noted in 19 biopsy specimens. Granulomatous, neutrophilic, and lymphocytic pathologic changes were present in nine, eight, and eight tissue specimens, respectively. Conclusion: The recognition of distinct disease patterns of fat lesions as fat necrosis with pancreatic disease, α 1 -antitrypsin Panniculitis, lupus and connective tissue disease Panniculitis, involution lipoatrophy, lipomembranous Panniculitis, factitial Panniculitis syndromes, calcification Panniculitis, lipophagic lipoatrophy, and cytophagic Panniculitis has lessened the need for a less specific Panniculitis category. All these diseases have been reported in the literature as "Weber-Christian disease." Because separate and distinct forms of fat lesions have been described, we believe that the eponym should be abandoned and that more specific diagnoses should be made on the basis of pathogenesis or cause. (J Am Acad Dermatol 1998;39:56-62.)
R. D. Gotteron - One of the best experts on this subject based on the ideXlab platform.
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Idiopathic retroperitoneal fibrosis with systemic manifestations.
The Journal of rheumatology, 1994Co-Authors: Bonnet C, Arnaud M, Philippe Bertin, Richard Trèves, R. D. GotteronAbstract:We describe a previously unreported association of idiopathic retroperitoneal fibrosis with mesenteric, pulmonary and perhaps periarticular fibrotic involvement, and Panniculitis resembling Weber-Christian Panniculitis. The onset of the disease was uncommon with arthritis. Then, several episodes of migratory Panniculitis appeared; biopsy showed septal Panniculitis without necrosis of adipose tissue. Considering the patient's anamnesis, it is tempting to speculate that these manifestations all originate from the same mechanism.
Robert W. Bradsher - One of the best experts on this subject based on the ideXlab platform.
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The endemic mimic: blastomycosis an illness often misdiagnosed.
Transactions of the American Clinical and Climatological Association, 2014Co-Authors: Robert W. BradsherAbstract:One of the endemic fungi, Blastomyces dermatitidis, can cause epidemics of infection with multiple persons involved in a point source outbreak but more commonly causes sporadic cases of infection within the areas of endemicity. Blastomycosis can present as an acute pneumonia which is often misdiagnosed as acute pneumococcal pneumonia or the infection may present as a chronic pneumonia along with weight loss, night sweats, hemoptysis, and a lung mass suggesting tuberculosis or carcinoma of the lung. Extrapulmonary infection with B. dermatitidis is protean with many different manifestations. Most commonly, skin or subcutaneous lesions are found with either a verrucous or warty appearance or in an ulcerative form. Cases have been misidentified as keratoacanthoma, pyoderma gangrenosum, carcinoma, or as Weber-Christian Panniculitis if there are nodular subcutaneous lesions. Essentially any site or organ can have lesions of disseminated blastomycosis. In our series, cases of laryngeal carcinoma, adrenal insufficiency, thyroid nodules, granulomatous hypercalcemia, abnormal mammograms thought to represent breast carcinoma, otitis media with cranial extension, immune thrombocytopenic purpura, and hemolytic anemia of unknown cause have been misdiagnosed and blastomycosis subsequently identified as the cause. This infection causes manifestations which mimic many other more commonly diagnosed conditions and must always be considered by clinicians practicing in the endemic region.