The Experts below are selected from a list of 69 Experts worldwide ranked by ideXlab platform

Helmut G Rennke - One of the best experts on this subject based on the ideXlab platform.

  • International Journal of Surgical Pathology 14(1):57-63, 2006 Granulomatous Interstitial Nephritis: A Clinicopathologic Study of 46 Cases from a Single Institution
    2016
    Co-Authors: Helmut G Rennke
    Abstract:

    Acute interstitial nephritis is commonly seen in kidney biopsies of patients with acute renal failure; however, granulomatous interstitial nephritis (GIN) is rare. We identified 46 cases of GIN in a 17-year period in this institution and we investigated their most probable etiologies. Complete clinical information was available in 38 patients. Seven-teen of 38 patients (44.7%) were classified as drug-induced. Renal sarcoidosis was re-sponsible for 28.9 % of cases, and the remaining 15.9 % of cases included Wegeners Granulomatosis, foreign body giant cell reaction, GIN secondary to intravesical bacillus Calmette-Guerin therapy for bladder cancer, and xanthogranulomatous pyelonephri-tis. Clinical investigation failed to reveal possible etiology in 4 patients (10.5%), classi-fied as idiopathic. We concluded that three quarters of our cases were either drug-in-duced or due to sarcoidosis; only a small proportion of our cases occurred secondary to any other cause or to unknown factors. Int J Surg Pathol 14(1):57-63, 2006 Key words: granulomatous interstitial nephritis, renal granulomas, drug-induced interstitial nephritis, renal sarcoidosis, Wegener's Granulomatosis. While acute interstitial nephritis is commonl

  • granulomatous interstitial nephritis a clinicopathologic study of 46 cases from a single institution
    2006
    Co-Authors: Vanesa Bijol, Gonzalo P Mendez, Vania Nose, Helmut G Rennke
    Abstract:

    Acute interstitial nephritis is commonly seen in kidney biopsies of patients with acute renal failure; however, granulomatous interstitial nephritis (GIN) is rare. We identified 46 cases of GIN in a 17-year period in this institution and we investigated their most probable etiologies. Complete clinical information was available in 38 patients. Seventeen of 38 patients (44.7%) were classified as drug-induced. Renal sarcoidosis was responsible for 28.9% of cases, and the remaining 15.9% of cases included Wegeners Granulomatosis, foreign body giant cell reaction, GIN secondary to intravesical bacillus Calmette-Guerin therapy for bladder cancer, and xanthogranulomatous pyelonephritis. Clinical investigation failed to reveal possible etiology in 4 patients (10.5%), classified as idiopathic. We concluded that three quarters of our cases were either drug-induced or due to sarcoidosis; only a small proportion of our cases occurred secondary to any other cause or to unknown factors.

Rajesh Kumar - One of the best experts on this subject based on the ideXlab platform.

  • a rare case of Wegeners Granulomatosis with allergic bronchopulmonary aspergillosis in a child
    2016
    Co-Authors: Vikas Gupta, Ashok Gupta, P C Mathur, Manish Sharma, Manisha Garg, Rajesh Kumar
    Abstract:

    Wegener’s Granulomatosis is an uncommon autoimmue disease with multi-system involvement, characterized by necrotizing granulomatous inflammation of the upper and lower respiratory tracts and general focal necrotizing vasculitis (Commonly known as Wegener’s triad). The lungs are involved in 72 percents of patients and the clinical and radiographic findings indicate bilateral pulmonary nodules of varying size and definition, cavitated in half of the patients, accompanied by the nodular lesion with rare involvement of the pleura. We present a case in 4 year old male child presenting with symptoms of recurrent airway disease and chronic sinusitis with detection of lung lesions on further investigations and pathological confirmation by antineutrophil cytoplasmic antibody positivity and based on radiological and clinical suspicion.

Jyoti Dabholkar - One of the best experts on this subject based on the ideXlab platform.

  • ENT manifestations of Wegeners Granulomatosis.
    2013
    Co-Authors: Arpit Sharma, Shraddha Deshmukh, Jyoti Dabholkar
    Abstract:

    Wegeners Granulomatosis is a necrotizing granulomatous vasculitis with multisystemic involvement. We present two cases of Wegener's presenting with otological manifestations as the first symptom. These symptoms are subtle and diagnosis may be easily overlooked. Hence a high index of suspicion is required. Early diagnosis and treatment goes a long way in improving the outcomes and in preventing further complications.

  • ENT manifestations of Wegeners Granulomatosis Otologiczne objawy ziarniniaka Wegenera
    2013
    Co-Authors: Arpit Sharma, Shraddha Deshmukh, Jyoti Dabholkar
    Abstract:

    Wegeners Granulomatosis is a necrotizing granulomatous vasculitis with multisystemic involvement. We present two cases of Wegener's presenting with otological manifesta- tions as the first symptom. These symptoms are subtle and diagnosis may be easily overlooked. Hence a high index of suspicion is required. Early diagnosis and treatment goes a long way in improving the outcomes and in preventing further complications.

Vikas Gupta - One of the best experts on this subject based on the ideXlab platform.

  • a rare case of Wegeners Granulomatosis with allergic bronchopulmonary aspergillosis in a child
    2016
    Co-Authors: Vikas Gupta, Ashok Gupta, P C Mathur, Manish Sharma, Manisha Garg, Rajesh Kumar
    Abstract:

    Wegener’s Granulomatosis is an uncommon autoimmue disease with multi-system involvement, characterized by necrotizing granulomatous inflammation of the upper and lower respiratory tracts and general focal necrotizing vasculitis (Commonly known as Wegener’s triad). The lungs are involved in 72 percents of patients and the clinical and radiographic findings indicate bilateral pulmonary nodules of varying size and definition, cavitated in half of the patients, accompanied by the nodular lesion with rare involvement of the pleura. We present a case in 4 year old male child presenting with symptoms of recurrent airway disease and chronic sinusitis with detection of lung lesions on further investigations and pathological confirmation by antineutrophil cytoplasmic antibody positivity and based on radiological and clinical suspicion.

Guimaraes Penido - One of the best experts on this subject based on the ideXlab platform.

  • granulomatose de wegener apresentacao clinica e tratamento Wegeners Granulomatosis clinical features and management
    2006
    Co-Authors: Claudia Ribeiro, Milton Soares, Campos Neto, Gustavo Mario, C R M Silva, Adriana Albarez, Maria Goretti Moreira, Guimaraes Penido
    Abstract:

    Wegener Granulomatosis (WG) is a rare disorder characterized by vasculitis of small arteries, arterioles and capillaries, necrotizing granulomatous lesions of both upper and lower respiratory tract and glomerulonephritis. The entity carries high morbidity and mortality rates; renal involvement aggravates its prognosis. A case of this relatively rare disease is reported aiming to review the literature regarding the therapeutic alterna tives and discuss our treatment choice and the drug-associated complications emphasizing the clinical picture of the patient. A 69 year old man with chronic sinusitis, epistaxis, nasal ulcerations, purpura, hematuria, and advanced renal insufficiency for one month, showed high c-ANCA level (positive until 1/640) and focal segmental glomerulonephritis with crescent formation and necrosis on renal histology. The patient was aggressively treated with methylprednisolone followed by oral corticosteroids. Despite 15 day therapy he died from septic shock. The patient’s clinical presentation agreed with the one foun d in previous studies, but the treatment chosen was different from the most frequent recommendation: cyclophosphamide and corticosteroids. Based on the course of the patient, a questions remains unanswered: would it be immunosuppressive therapy with cyclophosphamide the best choice in face of a severe infectious disease? (J Bras Nefrol 2006;28(2):114-117)