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Michael Malkoch - One of the best experts on this subject based on the ideXlab platform.

  • Advantages of Monodisperse and Chemically Robust “SpheriCal” Polyester Dendrimers as a “Universal” MS Calibrant
    Journal of The American Society for Mass Spectrometry, 2014
    Co-Authors: Scott M. Grayson, Brittany K. Myers, Jonas Bengtsson, Michael Malkoch
    Abstract:

    The utilization of dendrimer calibrants as an alternative to peptides and proteins for high Mass calibration is explored. These synthetic macromolecules exhibited a number of attractive advantages, including exceptional shelf-lives, broad compatibility with a wide range of matrices and solvents, and evenly spaced calibration Masses across the Mass range examined, 700–30,000 u. The exceptional purity of these dendrimers and the technical simplicity of this calibration platform validate their broad relevance for high molecular Weight Mass spectrometry. Figure ᅟ

  • Advantages of monodisperse and chemically robust "SpheriCal" polyester dendrimers as a "universal" MS calibrant.
    Journal of the American Society for Mass Spectrometry, 2013
    Co-Authors: Scott M. Grayson, Brittany K. Myers, Jonas Bengtsson, Michael Malkoch
    Abstract:

    The utilization of dendrimer calibrants as an alternative to peptides and proteins for high Mass calibration is explored. These synthetic macromolecules exhibited a number of attractive advantages, including exceptional shelf-lives, broad compatibility with a wide range of matrices and solvents, and evenly spaced calibration Masses across the Mass range examined, 700-30,000 u. The exceptional purity of these dendrimers and the technical simplicity of this calibration platform validate their broad relevance for high molecular Weight Mass spectrometry.

Scott M. Grayson - One of the best experts on this subject based on the ideXlab platform.

  • Advantages of Monodisperse and Chemically Robust “SpheriCal” Polyester Dendrimers as a “Universal” MS Calibrant
    Journal of The American Society for Mass Spectrometry, 2014
    Co-Authors: Scott M. Grayson, Brittany K. Myers, Jonas Bengtsson, Michael Malkoch
    Abstract:

    The utilization of dendrimer calibrants as an alternative to peptides and proteins for high Mass calibration is explored. These synthetic macromolecules exhibited a number of attractive advantages, including exceptional shelf-lives, broad compatibility with a wide range of matrices and solvents, and evenly spaced calibration Masses across the Mass range examined, 700–30,000 u. The exceptional purity of these dendrimers and the technical simplicity of this calibration platform validate their broad relevance for high molecular Weight Mass spectrometry. Figure ᅟ

  • Advantages of monodisperse and chemically robust "SpheriCal" polyester dendrimers as a "universal" MS calibrant.
    Journal of the American Society for Mass Spectrometry, 2013
    Co-Authors: Scott M. Grayson, Brittany K. Myers, Jonas Bengtsson, Michael Malkoch
    Abstract:

    The utilization of dendrimer calibrants as an alternative to peptides and proteins for high Mass calibration is explored. These synthetic macromolecules exhibited a number of attractive advantages, including exceptional shelf-lives, broad compatibility with a wide range of matrices and solvents, and evenly spaced calibration Masses across the Mass range examined, 700-30,000 u. The exceptional purity of these dendrimers and the technical simplicity of this calibration platform validate their broad relevance for high molecular Weight Mass spectrometry.

Brittany K. Myers - One of the best experts on this subject based on the ideXlab platform.

  • Advantages of Monodisperse and Chemically Robust “SpheriCal” Polyester Dendrimers as a “Universal” MS Calibrant
    Journal of The American Society for Mass Spectrometry, 2014
    Co-Authors: Scott M. Grayson, Brittany K. Myers, Jonas Bengtsson, Michael Malkoch
    Abstract:

    The utilization of dendrimer calibrants as an alternative to peptides and proteins for high Mass calibration is explored. These synthetic macromolecules exhibited a number of attractive advantages, including exceptional shelf-lives, broad compatibility with a wide range of matrices and solvents, and evenly spaced calibration Masses across the Mass range examined, 700–30,000 u. The exceptional purity of these dendrimers and the technical simplicity of this calibration platform validate their broad relevance for high molecular Weight Mass spectrometry. Figure ᅟ

  • Advantages of monodisperse and chemically robust "SpheriCal" polyester dendrimers as a "universal" MS calibrant.
    Journal of the American Society for Mass Spectrometry, 2013
    Co-Authors: Scott M. Grayson, Brittany K. Myers, Jonas Bengtsson, Michael Malkoch
    Abstract:

    The utilization of dendrimer calibrants as an alternative to peptides and proteins for high Mass calibration is explored. These synthetic macromolecules exhibited a number of attractive advantages, including exceptional shelf-lives, broad compatibility with a wide range of matrices and solvents, and evenly spaced calibration Masses across the Mass range examined, 700-30,000 u. The exceptional purity of these dendrimers and the technical simplicity of this calibration platform validate their broad relevance for high molecular Weight Mass spectrometry.

Jonas Bengtsson - One of the best experts on this subject based on the ideXlab platform.

  • Advantages of Monodisperse and Chemically Robust “SpheriCal” Polyester Dendrimers as a “Universal” MS Calibrant
    Journal of The American Society for Mass Spectrometry, 2014
    Co-Authors: Scott M. Grayson, Brittany K. Myers, Jonas Bengtsson, Michael Malkoch
    Abstract:

    The utilization of dendrimer calibrants as an alternative to peptides and proteins for high Mass calibration is explored. These synthetic macromolecules exhibited a number of attractive advantages, including exceptional shelf-lives, broad compatibility with a wide range of matrices and solvents, and evenly spaced calibration Masses across the Mass range examined, 700–30,000 u. The exceptional purity of these dendrimers and the technical simplicity of this calibration platform validate their broad relevance for high molecular Weight Mass spectrometry. Figure ᅟ

  • Advantages of monodisperse and chemically robust "SpheriCal" polyester dendrimers as a "universal" MS calibrant.
    Journal of the American Society for Mass Spectrometry, 2013
    Co-Authors: Scott M. Grayson, Brittany K. Myers, Jonas Bengtsson, Michael Malkoch
    Abstract:

    The utilization of dendrimer calibrants as an alternative to peptides and proteins for high Mass calibration is explored. These synthetic macromolecules exhibited a number of attractive advantages, including exceptional shelf-lives, broad compatibility with a wide range of matrices and solvents, and evenly spaced calibration Masses across the Mass range examined, 700-30,000 u. The exceptional purity of these dendrimers and the technical simplicity of this calibration platform validate their broad relevance for high molecular Weight Mass spectrometry.

Frank Mayer - One of the best experts on this subject based on the ideXlab platform.

  • Neuromuscular shoulder activity during exercises with different combinations of stable and unstable Weight Mass.
    2020
    Co-Authors: Omar Baritello, Mina Khajooei, Tilman Engel, Stephan Kopinski, Andrew Quarmby, Steffen Mueller, Frank Mayer
    Abstract:

    Abstract Background: Recent shoulder injury prevention programs have utilized resistance exercises combined with different forms of instability, with the goal of eliciting functional adaptations and thereby reducing the risk of injury. However, it is still unknown how an unstable Weight Mass (UWM) affects the muscular activity of the shoulder stabilizers. Aim of the study was to assess neuromuscular activity of dynamic shoulder stabilizers under four conditions of stable and UWM during three shoulder exercises. It was hypothesized that a combined condition of Weight with UWM would elicit greater activation due to the increased stabilization demand. Methods: Sixteen participants (7 m/9 f) were included in this cross-sectional study and prepared with an EMG-setup for the: Mm. upper/lower trapezius (U.TA/L.TA), lateral deltoid (DE), latissimus dorsi (LD), serratus anterior (SA) and pectoralis major (PE). A maximal voluntary isometric contraction test (MVIC; 5 sec.) was performed on an isokinetic dynamometer. Next, internal/external rotation (In/Ex), abduction/adduction (Ab/Ad) and diagonal flexion/extension (F/E) exercises (5 reps.) were performed with four custom-made-pipes representing different exercise conditions. First, the empty-pipe (P; 0.5 kg) and then, randomly ordered, water-filled-pipe (PW; 1 kg), Weight-pipe (PG; 4.5 kg) and Weight + water-filled-pipe (PWG; 4.5 kg), while EMG was recorded. Raw root-mean-square values (RMS) were normalized to MVIC (%MVIC). Differences between conditions for RMS%MVIC, scapular stabilizer (SR: U.TA/L.TA; U.TA/SA) and contraction (CR: concentric/eccentric) ratios were analyzed (paired t-test; p ≤ 0.05; Bonferroni adjusted α = 0.008). Results: PWG showed significantly greater muscle activity for all exercises and all muscles except for PE compared to P and PW. Condition PG elicited muscular activity comparable to PWG (p > 0.008) with significantly lower activation of L.TA and SA in the In/Ex rotation. The SR ratio was significantly higher in PWG compared to P and PW. No significant differences were found for the CR ratio in all exercises and for all muscles. Conclusion: Higher Weight generated greater muscle activation whereas an UWM raised the neuromuscular activity, increasing the stabilization demands. Especially in the In/Ex rotation, an UWM increased the RMS%MVIC and SR ratio. This might improve training effects in shoulder prevention and rehabilitation programs.Trial Registration: not applicable

  • Neuromuscular shoulder activity during exercises with different combinations of stable and unstable Weight Mass.
    2020
    Co-Authors: Omar Baritello, Mina Khajooei, Tilman Engel, Stephan Kopinski, Andrew Quarmby, Steffen Mueller, Frank Mayer
    Abstract:

    Abstract Background:Recent shoulder injury prevention programs have utilized resistance exercises combined with different forms of instability, with the goal of eliciting functional adaptations and thereby reducing the risk of injury. However, it is still unknown how an unstable Weight Mass affects the muscular activity of the shoulder stabilizers.Aim of the study was to analyze the neuromuscular activity of the dynamic shoulder stabilizers under four conditions of stable and unstable Weight Mass during three shoulder exercises. It was hypothesized that a combined condition of Weight with unstable Mass would elicit significantly greater activation due to the increased stabilization demand.MethodsSixteen participants (7 m/9 f) were included in this cross-sectional study and prepared with an EMG-setup for the: Mm. upper/lower trapezius (U.TA/L.TA), lateral deltoid (DE), latissimus dorsi (LD), serratus anterior (SA) and pectoralis major (PE). A maximal voluntary isometric contraction test (MVIC; 5 sec.) was performed on an isokinetic dynamometer. Next, internal/external rotation (In/Ex), abduction/adduction (Ab/Ad) and diagonal flexion/extension (F/E) exercises (5 reps.) were performed with four custom-made-pipes representing different training conditions. First, the empty-pipe (P; 0.5 kg) and then, randomly ordered, water-filled-pipe (PW; 1 kg), Weight-pipe (PG; 4.5 kg) and Weight + water-filled-pipe (PWG; 4.5 kg), while EMG was recorded. Raw root mean square values (RMS) were normalized to MVIC (%MVIC). Differences between conditions for RMS%MVIC, scapular stabilizer (SR: U.TA/L.TA; U.TA/SA) and contraction (CR: concentric/eccentric) ratios were analyzed (paired t-test; a = 0.05; Bonferroni adjusted a = 0.008) ResultsPWG showed significantly greater muscle activity for all exercises and all muscles except for PE compared to P and PW. Condition PG elicited muscular activity comparable to PWG (p > 0.008) with significantly lower activation of L.TA and SA in the In/Ex rotation. The SR ratio was significantly higher in PWG compared to P and PW. No significant differences were found for the CR ratio in all exercises and for all muscles.ConclusionHigher Weight generated greater muscle activation whereas an unstable Weight Mass behavior raised the neuromuscular activity, increasing the stabilization demands. Especially in the In/Ex rotation, an unstable Weight Mass increased the RMS%MVIC and SR ratio. This might improve training effects in shoulder prevention and rehabilitation programs.Trial Registration: not applicable

  • Neuromuscular shoulder activity during exercises with different combinations of stable and unstable Weight Mass
    2019
    Co-Authors: Omar Baritello, Mina Khajooei, Tilman Engel, Stephan Kopinski, Andrew Quarmby, Steffen Mueller, Frank Mayer
    Abstract:

    Abstract Background:Recent shoulder injury prevention programs have utilized resistance exercises combined with different forms of instability, with the goal of eliciting functional adaptations and thereby reducing the risk of injury. However, it is still unknown how an unstable Weight Mass (UWM) affects the muscular activity of the shoulder stabilizers. Aim of the study was to assess neuromuscular activity of dynamic shoulder stabilizers under four conditions of stable and UWM during three shoulder exercises. It was hypothesized that a combined condition of Weight with UWM would elicit greater activation due to the increased stabilization demand. Methods:Sixteen participants (7 m/9 f) were included in this cross-sectional study and prepared with an EMG-setup for the: Mm. upper/lower trapezius (U.TA/L.TA), lateral deltoid (DE), latissimus dorsi (LD), serratus anterior (SA) and pectoralis major (PE). A maximal voluntary isometric contraction test (MVIC; 5 sec.) was performed on an isokinetic dynamometer. Next, internal/external rotation (In/Ex), abduction/adduction (Ab/Ad) and diagonal flexion/extension (F/E) exercises (5 reps.) were performed with four custom-made-pipes representing different training conditions. First, the empty-pipe (P; 0.5 kg) and then, randomly ordered, water-filled-pipe (PW; 1 kg), Weight-pipe (PG; 4.5 kg) and Weight + water-filled-pipe (PWG; 4.5 kg), while EMG was recorded. Raw root mean square values (RMS) were normalized to MVIC (%MVIC). Differences between conditions for RMS%MVIC, scapular stabilizer (SR : U.TA/L.TA; U.TA/SA) and contraction (CR : concentric/eccentric) ratios were analyzed (paired t-test; a = 0.05; Bonferroni adjusted a = 0.008). Results:PWG showed significantly greater muscle activity for all exercises and all muscles except for PE compared to P and PW. Condition PG elicited muscular activity comparable to PWG (p> 0.008) with significantly lower activation of L.TA and SA in the In/Ex rotation. The SR ratio was significantly higher in PWG compared to P and PW. No significant differences were found for the CR ratio in all exercises and for all muscles. Conclusion:Higher Weight generated greater muscle activation whereas an UWM raised the neuromuscular activity, increasing the stabilization demands. Especially in the In/Ex rotation, an unstable Weight Mass increased the RMS%MVIC and SR ratio. This might improve training effects in shoulder prevention and rehabilitation programs.

  • Neuromuscular shoulder activity during exercises with different combinations of stable and unstable Weight Mass
    2019
    Co-Authors: Omar Baritello, Mina Khajooei, Tilman Engel, Stephan Kopinski, Andrew Quarmby, Steffen Mueller, Frank Mayer
    Abstract:

    Abstract Background Recent shoulder injury prevention programs have utilized resistance exercises combined with different forms of instability, with the goal of eliciting functional adaptations and thereby reducing the risk of injury. However, it is still unknown how an unstable Weight Mass affects the muscular activity of the shoulder stabilizers (ST). Aim of the study was to analyzed the neuromuscular activity of the dynamic ST under four combinations of stable and unstable Weight Mass during three shoulder exercises. It was hypothesized that a combined condition of Weight with unstable Mass would elicit significantly greater activation due to the increased stabilization demand. Methods Sixteen participants (7 m/9 f) were included in this cross-sectional study and prepared with an EMG-setup for the: Mm. upper/lower trapezius (U.TA/L.TA), lateral deltoid (DE), latissimus dorsi (LD), serratus anterior (SA) and pectoralis major (PE). A maximal voluntary isometric contraction test (MVIC; 5 sec.) was performed on an isokinetic dynamometer. Next, internal/external rotation (In/Ex), abduction/adduction (Ab/Ad) and diagonal flexion/extension (F/E) exercises (5 reps.) were performed with four custom-made-pipes representing different training conditions. First, the empty-pipe (P; 0.5 kg) and then, randomly ordered, water-filled-pipe (PW; 1 kg), Weight-pipe (PG; 4.5 kg) and Weight + water-filled-pipe (PWG; 4.5 kg), while EMG was recorded. Raw root mean square values (RMS) were normalized to MVIC (%MVIC). Differences between conditions for RMS%MVIC, scapular stabilizer (SR: U.TA/L.TA; U.TA/SA) and contraction (CR: concentric/eccentric) ratios were analyzed (paired t-test;Bonferroni adjusted α=0.008) Results PWG showed significantly greater activation for all exercises and all muscles except for PE compared to P and PW. Condition PG elicited muscular activity comparable to PWG (p>0.008) with significantly lower activation of L.TA and SA in the In/Ex rotation. The SR ratio was significantly higher in PWG compared to P and PW. No significant differences were found for the CR ratio in all exercises and for all muscles. Conclusion Higher Weight generated greater muscle activation whereas an unstable Weight Mass behavior raised the neuromuscular activity, increasing the stabilization demands. Especially in the In/Ex rotation, an unstable Weight Mass increased the RMS%MVIC and SR ratio. This might improve training effects in shoulder prevention and rehabilitation programs.