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S Yamawaki - One of the best experts on this subject based on the ideXlab platform.
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Effect of repeated treatment with lamotrigine on locomotor activity and on DOI-elicited Wet Dog Shakes in rats
Biogenic Amines, 2002Co-Authors: Hideaki Katagiri, A Kagaya, Toshiro Kozuru, Hiroaki Jitsuiki, Ki-ichiro Kawano, Shigeru Morinobu, S YamawakiAbstract:Lamotrigine is a new anticonvulsant, and it is also effective for bipolar disorder, especially for bipolar depression. In this study, we have investigated the effect of single or repeated treatment with lamotrigine on some behavioral response in rats to understand its action mechanisms on mood disorder. As for acute effect of lamotrigine, single treatment with lamotrigine (5, 10 and 20 mg/kg) did not change the intensity of 8-OH-DPAT-induced flat body posture, the frequency of DOI-elicited Wet Dog Shakes (WDSs), or spontaneous locomotor activity in rats. As for chronic effect of lamotrigine, rats were subcutaneously injected with dexamethasone (1 mg/kg) and/or lamotrigine (10 mg/kg) intraperitoneally for 14 days. One day after the last administration, spontaneous locomotor activity of the rats was measured, and subsequently DOIinduced WDSs were observed. Repeated treatment with lamotrigine (10 mg/kg) itself facilitated spontaneous locomotor activity. Repeated dexamethasone injection significantly enhanced DOIproduced WDSs, and the enhancement declined with repeated treatment with lamotrigine (10 mg/kg). These findings are similar to the effect of some antidepressants and mood stabilizers on these behaviors, and can explain some action mechanisms of lamotrigine on mood disorder.
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Effect of interferon-alpha on DOI-induced Wet-Dog Shakes in rats.
Journal of neural transmission (Vienna Austria : 1996), 1996Co-Authors: A Kugaya, A Kagaya, Y Uchitomi, N Yokota, S YamawakiAbstract:Acute (1 h) intraperitoneal (i.p.) treatment with interferon (IFN)-alpha-2a (300 IU/g) significantly inhibited Wet-Dog Shakes (WDS) induced by (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2 aminopropane (DOI; 0.5, 1.0 mg/kg), which is mediated by serotonin (5-hydroxytryptamine; 5-HT)2 receptor in rats. IFN-alpha did not affect spontaneous locomotion. The inhibition of DOI (0.5 mg/kg)-induced WDS by IFN-alpha was dose (90-300 IU/g)- and time (1-6 h)-dependent, and was prevented by 30 min pretreatment with naltrexone (NLTX; 1.0 mg/kg, i.p.), an opioid receptor antagonist. Acute (1 h) intracerebroventricular (i.c.v.) treatment with IFN-alpha (1,500 IU/rat) also inhibited DOI (0.5 mg/kg)-induced WDS, and the effect was blocked by NLTX (50 micrograms/rat, i.c.v.). These results suggest that IFN-alpha may modulate 5-HT2 receptor-mediated behavior through opioid receptors in the central nervous system.
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Effect of interferon-α on DOI-induced Wet-Dog Shakes in rats
Journal of Neural Transmission, 1996Co-Authors: A Kugaya, A Kagaya, Y Uchitomi, N Yokota, S YamawakiAbstract:Acute (1 h) intraperitoneal (i.p.) treatment with interferon (IFN)-alpha-2a (300 IU/g) significantly inhibited Wet-Dog Shakes (WDS) induced by (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2 aminopropane (DOI; 0.5, 1.0 mg/kg), which is mediated by serotonin (5-hydroxytryptamine; 5-HT)2 receptor in rats. IFN-alpha did not affect spontaneous locomotion. The inhibition of DOI (0.5 mg/kg)-induced WDS by IFN-alpha was dose (90-300 IU/g)- and time (1-6 h)-dependent, and was prevented by 30 min pretreatment with naltrexone (NLTX; 1.0 mg/kg, i.p.), an opioid receptor antagonist. Acute (1 h) intracerebroventricular (i.c.v.) treatment with IFN-alpha (1,500 IU/rat) also inhibited DOI (0.5 mg/kg)-induced WDS, and the effect was blocked by NLTX (50 micrograms/rat, i.c.v.). These results suggest that IFN-alpha may modulate 5-HT2 receptor-mediated behavior through opioid receptors in the central nervous system.
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Chronic forced swim stress of rats increases frontal cortical 5-HT2 receptors and the Wet-Dog Shakes they mediate, but not frontal cortical β-adrenoceptors
European journal of pharmacology, 1995Co-Authors: Katsuyuki Takao, Yoshihisa Kitamura, Tadashi Nagatani, Koh Kawasaki, Hiroshi Hayakawa, S YamawakiAbstract:Abstract We studied the effects of chronic forced swim stress on 5-HT 2 receptors and β-adrenoceptors in the rat frontal cortex. The number of 5-HT 2 receptors was increased immediately after the last chronic stress, but not after an acute stress. In vivo, the number of Wet-Dog Shakes induced by a 5-HT 2 receptor agonist, (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI), was increased 24 h after the last chronic stress. However, the concentrations of 5-HT and 5-hydroxyindole acetic acid (5-HIAA), measured by high pressure liquid chromatography (HPLC), were not altered by this stress. Binding sites for [ 3 H]CGP-12177, i.e., β-adrenoceptor sites, were unchanged after both the acute and the chronic stress. These results suggest that, in the rat, the chronic forced swim stress increases the number of frontal cortical 5-HT 2 receptors and the number of Wet-Dog Shakes mediated by these receptors, while the number of frontal cortical β-adrenoceptors is not increased by this treatment.
Yutaka Gomita - One of the best experts on this subject based on the ideXlab platform.
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effects of monoamine reuptake inhibitors on Wet Dog Shakes mediated by 5 ht2a receptors in acth treated rats
Pharmacology Biochemistry and Behavior, 2005Co-Authors: Yasuhiro Kawakami, Kouhei Kitagawa, Kazuhiko Shibata, Katsuya Suemaru, Hiroaki Araki, Yoshihisa Kitamura, Yutaka GomitaAbstract:We examined the influence of imipramine, a serotonin (5-HT) and noradrenaline (NA) reuptake inhibitor, desipramine, a NA reuptake inhibitor, bupropion, a dopamine reuptake inhibitor, fluvoxamine, a selective 5-HT reuptake inhibitor, and mazindol, a catecholamine reuptake inhibitor, on a 5-HT2A receptor-mediated behavior, (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI)-induced Wet-Dog Shakes, in naive and adrenocorticotropic hormone (ACTH)-treated rats. Chronic administration of imipramine, desipramine and mazindol suppressed the number of Wet-Dog Shakes in naive rats. Chronic ACTH (100 μg/rat, s.c.) treatment increased the number. Chronic administration of imipramine did not decrease the number of Wet-Dog Shakes in ACTH-treated rats. On the other hand, desipramine and mazindol inhibited the increase in Wet-Dog Shakes in ACTH-treated rats. Fluvoxamine and bupropion did not have any effect on the (±)-DOI-induced response in naive and ACTH-treated rats. NA reuptake inhibitors may improve the hyperfunction of 5-HT2A receptors induced by chronic ACTH treatment.
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Effects of imipramine and lithium on Wet-Dog Shakes mediated by the 5-HT2A receptor in ACTH-treated rats.
Pharmacology biochemistry and behavior, 2002Co-Authors: Yoshihisa Kitamura, Hiroaki Araki, Katsuya Suemaru, Yutaka GomitaAbstract:We examined the influence of imipramine and lithium on Wet-Dog Shakes induced by the (+/-)-DOI, 5-HT2A receptor agonist in adrenocorticotropic hormone (ACTH)-treated rats. The administration of imipramine for 14 days decreased the (+/-)-DOI-induced Wet-Dog Shakes response; chronic administration of lithium for 14 days, however, had no effect. Chronic ACTH (100 microg/rat sc) treatment increased the Wet-Dog shake response induced by (+/-)-DOI. This effect of ACTH for 14 days, increasing the (+/-)-DOI-induced Wet-Dog Shakes, was not inhibited by a 14-day administration of imipramine. Chronic coadministration of imipramine and lithium, lasting 14 days, decreased the Wet-Dog Shakes response induced by (+/-)-DOI in rats treated with ACTH for 14 days. These findings indicate that lithium inhibits the hyperfunction of the 5-HT2A receptor in rats treated with ACTH when coadministered with imipramine.
Yoshihisa Kitamura - One of the best experts on this subject based on the ideXlab platform.
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effects of monoamine reuptake inhibitors on Wet Dog Shakes mediated by 5 ht2a receptors in acth treated rats
Pharmacology Biochemistry and Behavior, 2005Co-Authors: Yasuhiro Kawakami, Kouhei Kitagawa, Kazuhiko Shibata, Katsuya Suemaru, Hiroaki Araki, Yoshihisa Kitamura, Yutaka GomitaAbstract:We examined the influence of imipramine, a serotonin (5-HT) and noradrenaline (NA) reuptake inhibitor, desipramine, a NA reuptake inhibitor, bupropion, a dopamine reuptake inhibitor, fluvoxamine, a selective 5-HT reuptake inhibitor, and mazindol, a catecholamine reuptake inhibitor, on a 5-HT2A receptor-mediated behavior, (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI)-induced Wet-Dog Shakes, in naive and adrenocorticotropic hormone (ACTH)-treated rats. Chronic administration of imipramine, desipramine and mazindol suppressed the number of Wet-Dog Shakes in naive rats. Chronic ACTH (100 μg/rat, s.c.) treatment increased the number. Chronic administration of imipramine did not decrease the number of Wet-Dog Shakes in ACTH-treated rats. On the other hand, desipramine and mazindol inhibited the increase in Wet-Dog Shakes in ACTH-treated rats. Fluvoxamine and bupropion did not have any effect on the (±)-DOI-induced response in naive and ACTH-treated rats. NA reuptake inhibitors may improve the hyperfunction of 5-HT2A receptors induced by chronic ACTH treatment.
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Effects of imipramine and lithium on Wet-Dog Shakes mediated by the 5-HT2A receptor in ACTH-treated rats.
Pharmacology biochemistry and behavior, 2002Co-Authors: Yoshihisa Kitamura, Hiroaki Araki, Katsuya Suemaru, Yutaka GomitaAbstract:We examined the influence of imipramine and lithium on Wet-Dog Shakes induced by the (+/-)-DOI, 5-HT2A receptor agonist in adrenocorticotropic hormone (ACTH)-treated rats. The administration of imipramine for 14 days decreased the (+/-)-DOI-induced Wet-Dog Shakes response; chronic administration of lithium for 14 days, however, had no effect. Chronic ACTH (100 microg/rat sc) treatment increased the Wet-Dog shake response induced by (+/-)-DOI. This effect of ACTH for 14 days, increasing the (+/-)-DOI-induced Wet-Dog Shakes, was not inhibited by a 14-day administration of imipramine. Chronic coadministration of imipramine and lithium, lasting 14 days, decreased the Wet-Dog Shakes response induced by (+/-)-DOI in rats treated with ACTH for 14 days. These findings indicate that lithium inhibits the hyperfunction of the 5-HT2A receptor in rats treated with ACTH when coadministered with imipramine.
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Chronic forced swim stress of rats increases frontal cortical 5-HT2 receptors and the Wet-Dog Shakes they mediate, but not frontal cortical β-adrenoceptors
European journal of pharmacology, 1995Co-Authors: Katsuyuki Takao, Yoshihisa Kitamura, Tadashi Nagatani, Koh Kawasaki, Hiroshi Hayakawa, S YamawakiAbstract:Abstract We studied the effects of chronic forced swim stress on 5-HT 2 receptors and β-adrenoceptors in the rat frontal cortex. The number of 5-HT 2 receptors was increased immediately after the last chronic stress, but not after an acute stress. In vivo, the number of Wet-Dog Shakes induced by a 5-HT 2 receptor agonist, (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI), was increased 24 h after the last chronic stress. However, the concentrations of 5-HT and 5-hydroxyindole acetic acid (5-HIAA), measured by high pressure liquid chromatography (HPLC), were not altered by this stress. Binding sites for [ 3 H]CGP-12177, i.e., β-adrenoceptor sites, were unchanged after both the acute and the chronic stress. These results suggest that, in the rat, the chronic forced swim stress increases the number of frontal cortical 5-HT 2 receptors and the number of Wet-Dog Shakes mediated by these receptors, while the number of frontal cortical β-adrenoceptors is not increased by this treatment.
Agu Pert - One of the best experts on this subject based on the ideXlab platform.
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Role of central dopaminergic and 5-hydroxytryptaminergic projections in the behavioral responses elicited by thyrotropin-releasing hormone in rats.
Psychopharmacology, 1997Co-Authors: D. Funk, Robert M. Post, Agu PertAbstract:The systemic administration of thyrotropin-releasing hormone (TRH) to rats elicits locomotor activation, Wet Dog Shakes, jaw movements, paw licking and tail rattle. Central dopamine (DA) and 5-hydroxytryptamine (5-HT) systems and peripheral vagal afferents have been implicated in these responses. To define this circuitry further, the effects of lesions of these pathways on the behavioral responses elicited by intraperitoneal (IP) injections of TRH were assessed in rats. Lesions of the DAergic innervation of the nucleus accumbens did not affect the locomotor activation, Wet Dog Shakes, paw licking, jaw movements or tail rattle elicited by TRH. This is consistent with our in vivo microdialysis finding that TRH did not affect the release of DA in the nucleus accumbens at a dose that strongly increased locomotor activity. Depletion of spinal 5-HT significantly decreased the Wet Dog Shakes induced by TRH, while depletion of forebrain 5-HT had no effect on any behavior. Bilateral vagotomy did not affect the locomotor response to TRH or any of the other behaviors measured. Taken together, these results suggest that the DAergic mesolimbic, the 5-HTergic projections to the forebrain and vagal afferent systems are not mediators of the behavioral responses to systemic TRH. In contrast, the raphe-spinal 5-HTergic projection system may serve to modulate the Wet Dog Shakes elicited by this peptide.
Ricardo Tapia - One of the best experts on this subject based on the ideXlab platform.
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NMDA receptor antagonists protect against seizures and Wet-Dog Shakes induced by 4-aminopyridine.
European journal of pharmacology, 1992Co-Authors: Jorge Fragoso-veloz, Ricardo TapiaAbstract:The effect of N-methyl-D-aspartate (NMDA) and non-NMDA receptor antagonists on the generalized tonic-clonic convulsions and Wet-Dog Shakes induced by the intraperitoneal (i.p.) or the intrahippocampal (i.h., stereotaxic microinjection into the CA1 region) administration of 4-aminopyridine (4-AP) was studied in rats. Pretreatment with NMDA competitive and non-competitive antagonists resulted in potent protection against the motor effects of both the i.p. and the i.h. administration of 4-AP. MK-801 (0.25 mg/kg i.p.) and 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP, 0.8 nmol intracerebroventricular, i.c.v.) showed the most powerful anticonvulsive effect, since they prevented the occurrence of generalized tonic convulsions and the death of the animals in convulsions after i.p. 4-AP. The i.c.v. injection (10 nmol) of the NMDA competitive antagonists 2-amino-5-phosphonopentanoate (AP-5) and 2-amino-5-phosphonoheptanoate (AP-7) also showed a clear though less potent protective effect. Similarly, the frequency of Wet-Dog Shakes induced by i.h. 4-AP was markedly decreased by pretreating the animals with i.p. MK-801 or with i.c.v. CPP or AP-7. However, the co-injection of CPP with 4-AP failed to protect against the occurrence of Wet-Dog Shakes. The i.c.v. pretreatment with the unselective antagonist, kynurenate (up to 68 nmol) or with the non-NMDA receptor antagonist, 6-cyano-7-nitroquinoxaline-2,3-dione (0.5 nmol), did not significantly modify the effects of 4-AP when administered either i.p. or i.h. We conclude that NMDA receptors are involved in the mechanism of the convulsive activity induced by 4-AP, probably because this drug induces the release of glutamate.
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Convulsions and Wet-Dog Shakes produced by systemic or intrahippocampal administration of ruthenium red in the rat.
Experimental brain research, 1991Co-Authors: G. García-ugalde, Ricardo TapiaAbstract:In this work we have studied in the rat the behavioral effects of the intraperitoneal (i.p.) and intrahippocampal (i.h.) administration of ruthenium red (RuR), an inorganic dye which has been shown to inhibit neurotransmitter release in synaptosomes. The i.p. injection induced initially flaccid paralysis and subsequently generalized tonic-clonic convulsions. It contrast, unilateral RuR microinjection into the CA1 area of the hippocampus produced complex seizure behavior and Wet-Dog Shakes (WDS). The i.p. administration of the serotonin receptor antagonist ketanserin markedly inhibited the WDS induced by i.h. RuR. In contrast, the i.h. injection of ketanserin and of the γ-aminobutyric acid (GABA) agonists 4,5,6,7-tetrahydroisoxazol[5,4-c]pyridin-3-ol (THIP) and baclofen together with RuR did not affect the frequency of WDS nor the seizure behavior. However, the i.h. injection of the GABA uptake blocker nipecotic acid, simultaneously with RuR, increased the frequency of WDS. The release of [3H]GABA, measured in synaptosomes of different cerebral structures of the rats injected i.p. with RuR, and in slices of the CA1 area after i.h. injection of the dye, was not affected. Histological observations of the injected area showed a specific and intense staining of the somas of the CA1 pyramidal neurons. It is concluded that the convulsant action induced by i.h. RuR microinjection is probably the result of an increased excitability of these CA1 neurons, which is independent of any action on GABA release.
