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Adnan Custovic - One of the best experts on this subject based on the ideXlab platform.

  • developmental profiles of eczema Wheeze and rhinitis two population based birth cohort studies
    PLOS Medicine, 2014
    Co-Authors: Danielle Belgrave, John Guiver, John A Henderson, Christopher M. Bishop, Angela Simpson, Raquel Granell, Iain Buchan, Adnan Custovic
    Abstract:

    BACKGROUND: The term "atopic march" has been used to imply a natural progression of a cascade of symptoms from eczema to asthma and rhinitis through childhood. We hypothesize that this expression does not adequately describe the natural history of eczema, Wheeze, and rhinitis during childhood. We propose that this paradigm arose from cross-sectional analyses of longitudinal studies, and may reflect a population pattern that may not predominate at the individual level. METHODS AND FINDINGS: Data from 9,801 children in two population-based birth cohorts were used to determine individual profiles of eczema, Wheeze, and rhinitis and whether the manifestations of these symptoms followed an atopic march pattern. Children were assessed at ages 1, 3, 5, 8, and 11 y. We used Bayesian machine learning methods to identify distinct latent classes based on individual profiles of eczema, Wheeze, and rhinitis. This approach allowed us to identify groups of children with similar patterns of eczema, Wheeze, and rhinitis over time. Using a latent disease profile model, the data were best described by eight latent classes: no disease (51.3%), atopic march (3.1%), persistent eczema and Wheeze (2.7%), persistent eczema with later-onset rhinitis (4.7%), persistent Wheeze with later-onset rhinitis (5.7%), transient Wheeze (7.7%), eczema only (15.3%), and rhinitis only (9.6%). When latent variable modelling was carried out separately for the two cohorts, similar results were obtained. Highly concordant patterns of sensitisation were associated with different profiles of eczema, rhinitis, and Wheeze. The main limitation of this study was the difference in wording of the questions used to ascertain the presence of eczema, Wheeze, and rhinitis in the two cohorts. CONCLUSIONS: The developmental profiles of eczema, Wheeze, and rhinitis are heterogeneous; only a small proportion of children (? 7% of those with symptoms) follow trajectory profiles resembling the atopic march. Please see later in the article for the Editors' Summary.

  • developmental profiles of eczema Wheeze and rhinitis two population based birth cohort studies
    PLOS Medicine, 2014
    Co-Authors: Danielle Belgrave, John Guiver, John A Henderson, Christopher M. Bishop, Angela Simpson, Raquel Granell, Iain Buchan, Adnan Custovic
    Abstract:

    BACKGROUND: The term "atopic march" has been used to imply a natural progression of a cascade of symptoms from eczema to asthma and rhinitis through childhood. We hypothesize that this expression does not adequately describe the natural history of eczema, Wheeze, and rhinitis during childhood. We propose that this paradigm arose from cross-sectional analyses of longitudinal studies, and may reflect a population pattern that may not predominate at the individual level. METHODS AND FINDINGS: Data from 9,801 children in two population-based birth cohorts were used to determine individual profiles of eczema, Wheeze, and rhinitis and whether the manifestations of these symptoms followed an atopic march pattern. Children were assessed at ages 1, 3, 5, 8, and 11 y. We used Bayesian machine learning methods to identify distinct latent classes based on individual profiles of eczema, Wheeze, and rhinitis. This approach allowed us to identify groups of children with similar patterns of eczema, Wheeze, and rhinitis over time. Using a latent disease profile model, the data were best described by eight latent classes: no disease (51.3%), atopic march (3.1%), persistent eczema and Wheeze (2.7%), persistent eczema with later-onset rhinitis (4.7%), persistent Wheeze with later-onset rhinitis (5.7%), transient Wheeze (7.7%), eczema only (15.3%), and rhinitis only (9.6%). When latent variable modelling was carried out separately for the two cohorts, similar results were obtained. Highly concordant patterns of sensitisation were associated with different profiles of eczema, rhinitis, and Wheeze. The main limitation of this study was the difference in wording of the questions used to ascertain the presence of eczema, Wheeze, and rhinitis in the two cohorts. CONCLUSIONS: The developmental profiles of eczema, Wheeze, and rhinitis are heterogeneous; only a small proportion of children (? 7% of those with symptoms) follow trajectory profiles resembling the atopic march. Please see later in the article for the Editors' Summary.

  • joint modeling of parentally reported and physician confirmed Wheeze identifies children with persistent troublesome wheezing
    The Journal of Allergy and Clinical Immunology, 2013
    Co-Authors: Danielle Belgrave, Angela Simpson, Iain Buchan, Aida Semicjusufagic, Clare S Murray, Andrew Pickles, Adnan Custovic
    Abstract:

    Background Previous studies have suggested the presence of different childhood Wheeze phenotypes through statistical modeling based on parentally reported wheezing. Objective We sought to investigate whether joint modeling of observations from both medical records and parental reports helps to more accurately define wheezing disorders during childhood and whether incorporating information from medical records better characterizes severity. Methods In a population-based birth cohort (n = 1184), we analyzed data from 2 sources (parentally reported current Wheeze at 4 follow-ups and physician-confirmed Wheeze from medical records in each year from birth to age 8 years) to determine classes of children who differ in Wheeze trajectories. We tested the validity of these classes by examining their relationships with objective outcomes (lung function, airway hyperreactivity, and atopy), asthma medication, and severe exacerbations. Results Longitudinal latent class modeling identified a 5-class model that best described the data. We assigned classes as follows: no wheezing (53.3%), transient early Wheeze (13.7%), late-onset Wheeze (16.7%), persistent controlled Wheeze (13.1%), and persistent troublesome Wheeze (PTW; 3.2%). Longitudinal trajectories of atopy and lung function differed significantly between classes. Patients in the PTW class had diminished lung function and more hyperreactive airways compared with all other classes. We observed striking differences in exacerbations, hospitalizations, and unscheduled visits, all of which were markedly higher in patients in the PTW class compared with those in the other classes. For example, the risk of exacerbation was much higher in patients in the PTW class compared with patients with persistent controlled Wheeze (odds ratio [OR], 3.58; 95% CI, 1.27-10.09), late-onset Wheeze (OR, 15.92; 95% CI, 5.61-45.15), and transient early Wheeze (OR, 12.24; 95% CI, 4.28-35.03). Conclusion We identified a novel group of children with persistent troublesome wheezing, who have markedly different outcomes compared with persistent Wheezers with controlled disease.

  • definition assessment and treatment of wheezing disorders in preschool children an evidence based approach
    European Respiratory Journal, 2008
    Co-Authors: Paul L P Brand, Adnan Custovic, Hans Bisgaard, Jose A Castrorodriguez, Eugenio Baraldi, A L Boner, J De Blic, J C De Jongste, Ernst Eber, Mark L Everard
    Abstract:

    There is poor agreement on definitions of different phenotypes of preschool wheezing disorders. The present Task Force proposes to use the terms episodic (viral) Wheeze to describe children who Wheeze intermittently and are well between episodes, and multiple-trigger Wheeze for children who Wheeze both during and outside discrete episodes. Investigations are only needed when in doubt about the diagnosis. Based on the limited evidence available, inhaled short-acting beta(2)-agonists by metered-dose inhaler/spacer combination are recommended for symptomatic relief. Educating parents regarding causative factors and treatment is useful. Exposure to tobacco smoke should be avoided; allergen avoidance may be considered when sensitisation has been established. Maintenance treatment with inhaled corticosteroids is recommended for multiple-trigger Wheeze; benefits are often small. Montelukast is recommended for the treatment of episodic (viral) Wheeze and can be started when symptoms of a viral cold develop. Given the large overlap in phenotypes, and the fact that patients can move from one phenotype to another, inhaled corticosteroids and montelukast may be considered on a trial basis in almost any preschool child with recurrent Wheeze, but should be discontinued if there is no clear clinical benefit. Large well-designed randomised controlled trials with clear descriptions of patients are needed to improve the present recommendations on the treatment of these common syndromes.

  • secondary prevention of asthma by the use of inhaled fluticasone propionate in wheezy infants ifwin double blind randomised controlled study
    The Lancet, 2006
    Co-Authors: Clare S Murray, Ashley Woodcock, Stephen J Langley, Julie Morris, Adnan Custovic
    Abstract:

    Summary Background Wheezing and asthma often begins in early childhood, but it is difficult to predict whether or not a wheezy infant will develop asthma. Some researchers suggest that treatment with inhaled corticosteroids at the first signs of wheezing in childhood could prevent the development of asthma later in life. However, other investigators have reported that although such treatment could help control symptoms, the benefits can disappear within months of stopping treatment. We tested our hypothesis that to prevent loss of lung function and worsening asthma later in childhood, anti-inflammatory treatment needs to be started early in life. Methods We did a randomised, double-blind, controlled study of inhaled fluticasone propionate 100 μg twice daily in young children who were followed prospectively and randomised after either one prolonged (>1 month) or two medically confirmed wheezy episodes. The dose of study drug was reduced every 3 months to the minimum needed. If the symptoms were not under control by 3 months, open-label fluticasone propionate 100 μg twice daily was added to the treatment. Children were followed-up to 5 years of age, at which point we gave their parents or guardians questionnaires, and measured the children's lung function (specific airways resistance [sR aw ], forced expiratory volume in 1s [FEV 1 ]) and airway reactivity (eucapnic voluntary hyperventilation [EVH] challenge). This study is registered as an International Standard Randomised Controlled Trial, number ISRCTN86717853. Findings We followed 1073 children prospectively, of whom 333 were eligible, and 200 of these began treatment (130 male, median age 1·2 years [range 0·5–4·9]; 101 placebo, 99 treatment); 173 (85 treatment, 88 placebo) completed the follow-up at age five years. The groups did not differ significantly in the proportion of children with current Wheeze, physician-diagnosed asthma or use of asthma medication, lung function, or airway reactivity (percentage change in FEV 1 , adjusted mean for placebo 5·5% [95% CI −2·5 to 13·4]) vs for treatment 5·0% [−2·2 to 12·2], p=0·87). There were no differences in the results after adjustment for open-label fluticasone propionate, nor between the two groups in the time before the open-label drug was added (estimated hazard ratio 1·12 [95% CI 0·73–1·73], p=0·60), or the proportion needing the open-label drug (43 [42·57%] placebo, 41 [41·41%] treatment). Interpretation The early use of inhaled fluticasone propionate for wheezing in preschool children had no effect on the natural history of asthma or Wheeze later in childhood, and did not prevent lung function decline or reduce airway reactivity.

Fernando D. Martinez - One of the best experts on this subject based on the ideXlab platform.

  • factors influencing the relation of infant feeding to asthma and recurrent Wheeze in childhood
    Thorax, 2001
    Co-Authors: Anne L. Wright, Lynn M. Taussig, Catharine J Holberg, Fernando D. Martinez
    Abstract:

    BACKGROUND The relationship between infant feeding and childhood asthma is controversial. This study tested the hypothesis that the relation between breast feeding and childhood asthma is altered by the presence of maternal asthma. METHODS Healthy non-selected newborn infants (n=1246) were enrolled at birth. Asthma was defined as a physician diagnosis of asthma plus asthma symptoms reported on ⩾2 questionnaires at 6, 9, 11 or 13 years. Recurrent Wheeze (⩾4 episodes in the past year) was reported by questionnaire at seven ages in the first 13 years of life. Duration of exclusive breast feeding was based on prospective physician reports or parental questionnaires completed at 18 months. Atopy was assessed by skin test responses at the age of 6 years. RESULTS The relationship between breast feeding, asthma, and Wheeze differed with the presence or absence of maternal asthma and atopy in the child. After adjusting for confounders, children with asthmatic mothers were significantly more likely to have asthma if they had been exclusively breast fed (OR 8.7, 95% CI 3.4 to 22.2). This relationship was only evident for atopic children and persisted after adjusting for confounders. In contrast, the relation between recurrent Wheeze and breast feeding was age dependent. In the first 2 years of life exclusive breast feeding was associated with significantly lower rates of recurrent Wheeze (OR 0.45, 95% CI 0.2 to 0.9), regardless of the presence or absence of maternal asthma or atopy in the child. Beginning at the age of 6 years, exclusive breast feeding was unrelated to prevalence of recurrent Wheeze, except for children with asthmatic mothers in whom it was associated with a higher odds ratio for Wheeze (OR 5.7, 95% CI 2.3 to 14.1), especially if the child was atopic. CONCLUSION The relationship between breast feeding and asthma or recurrent Wheeze varies with the age of the child and the presence or absence of maternal asthma and atopy in the child. While associated with protection against recurrent Wheeze early in life, breast feeding is associated with an increased risk of asthma and recurrent Wheeze beginning at the age of 6 years, but only for atopic children with asthmatic mothers.

  • relation of two different subtypes of croup before age three to wheezing atopy and pulmonary function during childhood a prospective study
    Pediatrics, 2001
    Co-Authors: Jose A Castrorodriguez, Anne L. Wright, Marilyn Halonen, Lynn M. Taussig, Catharine J Holberg, Wayne J. Morgan, Fernando D. Martinez
    Abstract:

    Objective. Some retrospective evidence suggests that children with a history of croup may be at increased risk of subsequently developing asthma, atopy, and diminished pulmonary function. The objec- tive of this study was to determine the long-term out- come of croup (as diagnosed by a physician) in early life. Methods. Lower respiratory illnesses (LRIs) in the first 3 years of life were assessed in 884 children who were enrolled in a large longitudinal study of airway diseases at birth. Pulmonary function tests, markers of atopy, and wheezing episodes were studied at different ages between birth and 13 years. Results. Ten percent of children had croup with Wheeze (Croup/Wheeze), 5% had croup without Wheeze (Croup/No Wheeze), 36% had another LRI (Other LRI), and 48% had no LRI. Respiratory syncytial virus was more frequently isolated in children with Croup/Wheeze and Other LRI than in those with Croup/No Wheeze. There was no association between croup in early life and markers of atopy measured during the school years. Only children with Croup/Wheeze and with Other LRI had a significant risk of subsequent persistent Wheeze later in life. Significantly lower levels of indices of intrapulmo- nary airway function were observed at ages <1 (before any LRI), 6, and 11 years in children with Croup/Wheeze and Other LRI compared with children with No LRI. Conversely, inspiratory resistance before any LRI epi- sode was significantly higher in infants who later devel- oped Croup/No Wheeze than in the other 3 groups. Conclusions. We distinguish 2 manifestations of croup with and without wheezing. Children who present with croup may or may not be at increased risk of sub- sequent recurrent lower airway obstruction, depending on the initial lower airway involvement, and preillness and postillness abnormalities in lung function associated with this condition. Pediatrics 2001;170:512-518; croup, wheezing, atopy, pulmonary function, children.

  • Recurrent cough in childhood and its relation to asthma
    American Journal of Respiratory and Critical Care Medicine, 1996
    Co-Authors: Anne L. Wright, Marilyn Halonen, Lynn M. Taussig, Catharine J Holberg, Wayne J. Morgan, Fernando D. Martinez
    Abstract:

    Risk factors for recurrent cough (RC) in childhood, and its relation to asthma were investigated as part of the prospective, longitudinal Tucson Children's Respiratory Study. RC, defined as > or = 2 episodes of cough without a cold in the past year, was assessed by questionnaire in 987 children at age 6. Children having RC without Wheeze (n = 154) did not differ from children with neither symptom (n = 610) in serum IgE levels, skin test response, size-corrected forced expiratory flow, or percentage of decline following cold air challenge. In contrast, children with both RC and Wheeze (n = 116) had significantly more respiratory illness, more atopy, lower flow at end-tidal expiration (V'maxFRC), and greater declines in lung function following cold air challenge than children with neither symptom. Current parental smoking was a risk for RC without Wheeze, whereas male gender, maternal allergy, wheezing lower respiratory tract illness (LRI) in early life, and high IgE were significant risks for RC with Wheeze, compared with children having neither symptom. RC early in life resolved in the majority of children, between ages 2-3 yr and age 6, and between age 6 and age 11. High IgE and positive skin prick test were associated with persistence of RC to age 6 among children who Wheezed, and markers of allergy were associated with persistence of RC between 6 and 11 yr. These findings suggest that recurrent cough in the absence of Wheeze differs in important respects from classic asthma, and using the same label to refer to these distinct syndromes may obscure their diverse pathophysiologies.

Patrick G Holt - One of the best experts on this subject based on the ideXlab platform.

  • developmental regulation of type 1 and type 3 interferon production and risk for infant infections and asthma development
    The Journal of Allergy and Clinical Immunology, 2019
    Co-Authors: Patrick G Holt, Danny Mok, Debasis Panda, Lynnsey A Renn, Giulia Fabozzi, N Deklerk, Merci M H Kusel, Michael Serralha, Elysia M Hollams, Barbara J Holt
    Abstract:

    Background Virus-associated febrile lower respiratory tract infections (fLRIs) during infancy have been identified as risk factors for persistent Wheeze development. We hypothesized that variations in innate immune defense capacity during this period, as exemplified by production of type 1 and 3 interferons (T1/3IFNs), might be an underlying determinant of risk. Objective We sought to investigate relationships between postnatal development of innate interferon response capacity and susceptibility to early infections and persistent Wheeze. Methods We studied a subset of subjects from a birth cohort at high risk for asthma/allergy and determined the capacity of cord blood cells (n = 151) to produce any of a panel of 17 T1/3IFNs in response to the viral mimic polyinosinic-polycytidylic acid using a sensitive PCR assay. We investigated relationships between neonatal interferon responses and lower respiratory tract infection history during infancy, wheezing history to 5 age years, and ensuing maturation of innate immune capacity by age 4 years (n = 160) and 10 years (n = 125). Results Although cohort subjects produced an average of 2.6 ± 0.3 of the 17 innate interferons tested at birth, 24% showed no T1/3IFN production. This nonproducer subgroup showed increased risk for infant fLRIs (odds ratio, 2.62; 95% CI, 1.14-6.06; P = .024) and persistent Wheeze (odds ratio, 4.24; 95% CI, 1.60-11.24; P = .004) at age 5 years relative to those producing 1 or more T1/3IFNs, whereas risk for infant wheezy lower respiratory tract infections or "transient early Wheeze" was unaffected. Moreover, infants who experienced fLRIs subsequently demonstrated accelerated development of T1/3IFN response capacity between 1 and 4 years of age. Conclusions T1/3IFN response capacity appears strongly developmentally constrained at birth. Infants in whom this negative regulation is strongest manifest increased risk for severe respiratory tract infections during infancy and subsequent persistent Wheeze.

  • febrile respiratory illnesses in infancy and atopy are risk factors for persistent asthma and Wheeze
    European Respiratory Journal, 2012
    Co-Authors: Merci Kusel, Tatiana Kebadze, Sebastian L Johnston, Patrick G Holt
    Abstract:

    Severe viral respiratory illnesses and atopy are risk factors for childhood wheezing and asthma. To explore associations between severe respiratory infections and atopy in early childhood with Wheeze and asthma persisting into later childhood. 147 children at high atopic risk were followed from birth to 10years. Data on all respiratory infections occurring in infancy were collected prospectively and viral etiology ascertained. Atopy was measured by skin prick tests at 6months, 2 and 5years. History of Wheeze and doctor-diagnosed eczema and asthma was collected regularly until 10years of age. At 10years 60% of the cohort was atopic, 25.9% had current eczema, 18.4% current asthma and 20.4% persistent Wheeze. 35.8% experienced ≥one lower respiratory infection (LRI) associated with fever and/or Wheeze in year1. Children who had wheezy, or in particular, febrile LRI in infancy and were atopic by 2years, were significantly more likely to have persistent Wheeze (RR3.51; 95%CI 1.83-6.70; p<0.001) and current asthma (RR4.92; 95%CI 2.59-9.36; p<0.001) at 10years. Severe viral respiratory infections in infancy and early atopy are risk factors for persistent Wheeze and asthma. The strongest marker of the asthmatogenic potential of early life infections was concurrent fever. The occurrence of fever during respiratory illnesses is an important marker of risk for Wheeze and asthma later in childhood, suggesting it should be measured in prospective studies of asthma aetiology.

  • early life respiratory viral infections atopic sensitization and risk of subsequent development of persistent asthma
    The Journal of Allergy and Clinical Immunology, 2007
    Co-Authors: Merci Kusel, Tatiana Kebadze, Sebastian L Johnston, Patrick G Holt, Nicholas De Klerk, Vaike Vohma, Peter D Sly
    Abstract:

    Background: Severe lower respiratory infections (LRIs) and atopic sensitization have been identified as independent risk factors for asthma. Objective: The nature of potential interactions between these risk factors was the subject of this study. Methods: A community-based cohort of 198 children at high atopic risk was followed from birth to 5 years. All episodes of acute respiratory illness in the first year were recorded and postnasal aspirates were collected for viral identification. History of Wheeze and asthma was collected annually, and atopy was assessed at 6 months, 2 years, and 5 years. Results: A total of 815 episodes of acute respiratory illness were reported, and 33% were LRIs. Viruses were detected in 69% of aspirates, most commonly rhinoviruses (48.3%) and respiratory syncytial virus (10.9%). At 5 years, 28.3%(n = 56) had current Wheeze, and this was associated with wheezy [odds ratio (OR), 3.4 (1.2-9.7); P = .02] and/or febrile LRI [OR, 3.9 (1.4-10.5); P = .007], in particular those caused by respiratory syncytial virus or rhinoviruses [OR, 4.1 (1.3-12.6); P = .02]. Comparable findings were made for current asthma. Strikingly these associations were restricted to children who displayed early sensitization (≤2 years old) and not observed in nonatopic patients or those sensitized later. Conclusion: These data suggest viral infections interact with atopy in infancy to promote later asthma. Notably the occurrence of both of these events during this narrow developmental window is associated with maximal risk for subsequent asthma, which suggests a contribution from both classes of inflammatory insults to disease pathogenesis. Clinical implications: Protection of "high-risk" children against the effects of severe respiratory infections during infancy may represent an effective strategy for primary asthma prevention. The potential benefits of these strategies merit more careful evaluation in this age group.

Gerard H Koppelman - One of the best experts on this subject based on the ideXlab platform.

  • nocturnal dry cough in the first 7 years of life is associated with asthma at school age
    Pediatric Pulmonology, 2015
    Co-Authors: Ilse M Boudewijn, Gerard H Koppelman, Johan C De Jongste, Ulrike Gehring, Olga Savenije, Alet H Wijga, Henriette A Smit, Dirkje S Postma, Marjan Kerkhof
    Abstract:

    BACKGROUND: Childhood Wheeze is an important, well-known risk factor for asthma, yet little is known about the contribution of nocturnal dry cough. We investigated the association of nocturnal dry cough at ages 1-7 years with doctor-diagnosed asthma at 8 years of age, both in the presence and absence of Wheeze. METHODS: Data of 3,252 children from the PIAMA birth cohort were studied. Parents reported the presence of nocturnal dry cough, Wheeze, and doctor-diagnosed asthma in the past 12 months yearly, from birth up to the age of 8 years. RESULTS: Nocturnal dry cough without Wheeze was significantly associated with doctor-diagnosed asthma at age 8, except for age 1 (range of Relative Risks (RR) at ages 2-7: 1.8 (age 5) - 7.1 (age 7), all P-values <0.048). As expected, Wheeze without nocturnal dry cough was strongly associated with doctor-diagnosed asthma at age 8 (range of RR: 2.0 (age 1) - 22.2 (age 7), all P-values <0.003). Of interest, nocturnal dry cough with Wheeze showed the strongest association with doctor-diagnosed asthma at age 8 (range of RR: 3.7 (age 1) - 26.0 (age 7), all P-values <0.001). The relative excess risk of asthma at age 8 due to interaction of nocturnal dry cough with Wheeze at age 1 year was 1.8 (0.1-3.6, P < 0.01). CONCLUSION: Nocturnal dry cough and Wheeze in early childhood are both independently associated with asthma at school age. The presence of both nocturnal dry cough and Wheeze at age 1 almost doubles the risk of asthma at age 8 compared to Wheeze alone. Pediatr Pulmonol. © 2014 Wiley Periodicals, Inc.

  • an adam33 polymorphism associates with progression of preschool Wheeze into childhood asthma a prospective case control study with replication in a birth cohort study
    PLOS ONE, 2015
    Co-Authors: Ester M M Klaassen, Gerard H Koppelman, John Penders, Quirijn Jobsis, Kim D G Van De Kant, Carel Thijs, Monique Mommers, Constant P Van Schayck, Guillaume J J M Van Eys, Edward Dompeling
    Abstract:

    Background The influence of asthma candidate genes on the development from Wheeze to asthma in young children still needs to be defined. Objective To link genetic variants in asthma candidate genes to progression of Wheeze to persistent Wheeze into childhood asthma. Materials and Methods In a prospective study, children with recurrent Wheeze from the ADEM (Asthma DEtection and Monitoring) study were followed until the age of six. At that age a classification (transient Wheeze or asthma) was based on symptoms, lung function and medication use. In 198 children the relationship between this classification and 30 polymorphisms in 16 asthma candidate genes was assessed by logistic regression. In case of an association based on a p Results In the ADEM study, the minor alleles of ADAM33 rs511898 and rs528557 and the ORMDL3/GSDMB rs7216389 polymorphisms were negatively associated, whereas the minor alleles of IL4 rs2243250 and rs2070874 polymorphisms were positively associated with childhood asthma. When replicated in the KOALA study, ADAM33 rs528557 showed a negative association of the CG/GG-genotype with progression of recurrent Wheeze into childhood asthma (0.50 (0.26-0.97) p = 0.04) and no association with preschool Wheeze. Conclusion Polymorphisms in ADAM33, ORMDL3/GSDMB and IL4 were associated with childhood asthma in a group of children with recurrent Wheeze. The replication of the negative association of the CG/GG-genotype of rs528557 ADAM33 with childhood asthma in an independent birth cohort study confirms that a compromised ADAM33 gene may be implicated in the progression of Wheeze into childhood asthma.

  • nocturnal dry cough in early childhood is a risk for the development of asthma
    European Respiratory Journal, 2011
    Co-Authors: Ilse M Boudewijn, Gerard H Koppelman, Olga Savenije, Alet H Wijga, Henriette A Smit, Marjan Kerkhof, Dirkje S Postma
    Abstract:

    Background: Wheeze in young children is an established predictor of the development of asthma later in life. Cough frequently occurs in childhood as well. So far, little is known about the role of nocturnal dry cough (NDC) in the development of asthma. Objective: The aim of this study was to investigate the association of NDC at ages 1-7 years, in the presence or absence of Wheeze, with doctor-diagnosed asthma at 8 years of age. Methods: Data from the Prevalence and Incidence of Asthma and Mite Allergy (PIAMA) birth cohort were used, which consists of 3963 children born in The Netherlands. Children were followed from birth up to 8 years of age. Presence of NDC without having a cold, Wheeze, and a doctor's diagnosis of asthma ever with symptoms of asthma in the past 12 months (DDA) was reported yearly by the parents. Results: The prevalence of NDC at age 1 to 7 years varied from 15.0% at age 7, to 23.3% at age 5. NDC without Wheeze was significantly associated with DDA at age 8, except for the age of 1 year (range of Odds Ratios (OR) at age 2 to age 7: 1.82 (age 5) to 7.65 (age 7), range of p-values <0.001-<0.048). NDC combined with Wheeze showed the most strong association with DDA at age 8 (range of OR at age 1 to age 7: 3.96 (age 1) to 35.96 (age 7), all p-values < 0.000). Wheeze without NDC was also strongly associated with DDA at age 8 (range of OR at age 1 to age 7: 2.06 (age 1) to 29.12 (age 7), range of p-values <0.001-<0.003). Conclusion: These results show that NDC in early childhood is an independent risk factor for the development of asthma. The presence of NDC even increases the risk for asthma in children with Wheeze.

Marjan Kerkhof - One of the best experts on this subject based on the ideXlab platform.

  • nocturnal dry cough in the first 7 years of life is associated with asthma at school age
    Pediatric Pulmonology, 2015
    Co-Authors: Ilse M Boudewijn, Gerard H Koppelman, Johan C De Jongste, Ulrike Gehring, Olga Savenije, Alet H Wijga, Henriette A Smit, Dirkje S Postma, Marjan Kerkhof
    Abstract:

    BACKGROUND: Childhood Wheeze is an important, well-known risk factor for asthma, yet little is known about the contribution of nocturnal dry cough. We investigated the association of nocturnal dry cough at ages 1-7 years with doctor-diagnosed asthma at 8 years of age, both in the presence and absence of Wheeze. METHODS: Data of 3,252 children from the PIAMA birth cohort were studied. Parents reported the presence of nocturnal dry cough, Wheeze, and doctor-diagnosed asthma in the past 12 months yearly, from birth up to the age of 8 years. RESULTS: Nocturnal dry cough without Wheeze was significantly associated with doctor-diagnosed asthma at age 8, except for age 1 (range of Relative Risks (RR) at ages 2-7: 1.8 (age 5) - 7.1 (age 7), all P-values <0.048). As expected, Wheeze without nocturnal dry cough was strongly associated with doctor-diagnosed asthma at age 8 (range of RR: 2.0 (age 1) - 22.2 (age 7), all P-values <0.003). Of interest, nocturnal dry cough with Wheeze showed the strongest association with doctor-diagnosed asthma at age 8 (range of RR: 3.7 (age 1) - 26.0 (age 7), all P-values <0.001). The relative excess risk of asthma at age 8 due to interaction of nocturnal dry cough with Wheeze at age 1 year was 1.8 (0.1-3.6, P < 0.01). CONCLUSION: Nocturnal dry cough and Wheeze in early childhood are both independently associated with asthma at school age. The presence of both nocturnal dry cough and Wheeze at age 1 almost doubles the risk of asthma at age 8 compared to Wheeze alone. Pediatr Pulmonol. © 2014 Wiley Periodicals, Inc.

  • nocturnal dry cough in early childhood is a risk for the development of asthma
    European Respiratory Journal, 2011
    Co-Authors: Ilse M Boudewijn, Gerard H Koppelman, Olga Savenije, Alet H Wijga, Henriette A Smit, Marjan Kerkhof, Dirkje S Postma
    Abstract:

    Background: Wheeze in young children is an established predictor of the development of asthma later in life. Cough frequently occurs in childhood as well. So far, little is known about the role of nocturnal dry cough (NDC) in the development of asthma. Objective: The aim of this study was to investigate the association of NDC at ages 1-7 years, in the presence or absence of Wheeze, with doctor-diagnosed asthma at 8 years of age. Methods: Data from the Prevalence and Incidence of Asthma and Mite Allergy (PIAMA) birth cohort were used, which consists of 3963 children born in The Netherlands. Children were followed from birth up to 8 years of age. Presence of NDC without having a cold, Wheeze, and a doctor's diagnosis of asthma ever with symptoms of asthma in the past 12 months (DDA) was reported yearly by the parents. Results: The prevalence of NDC at age 1 to 7 years varied from 15.0% at age 7, to 23.3% at age 5. NDC without Wheeze was significantly associated with DDA at age 8, except for the age of 1 year (range of Odds Ratios (OR) at age 2 to age 7: 1.82 (age 5) to 7.65 (age 7), range of p-values <0.001-<0.048). NDC combined with Wheeze showed the most strong association with DDA at age 8 (range of OR at age 1 to age 7: 3.96 (age 1) to 35.96 (age 7), all p-values < 0.000). Wheeze without NDC was also strongly associated with DDA at age 8 (range of OR at age 1 to age 7: 2.06 (age 1) to 29.12 (age 7), range of p-values <0.001-<0.003). Conclusion: These results show that NDC in early childhood is an independent risk factor for the development of asthma. The presence of NDC even increases the risk for asthma in children with Wheeze.