The Experts below are selected from a list of 246 Experts worldwide ranked by ideXlab platform
Dayna G. Diven - One of the best experts on this subject based on the ideXlab platform.
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A Pilot Study to Investigate the Efficacy of Tobramycin–Dexamethasone Ointment in Promoting Wound Healing
Dermatology and Therapy, 2012Co-Authors: Rachel Andrew, Gwendolyn Luecke, Susan Dozier, Dayna G. DivenAbstract:Introduction The standard postsurgical treatment of wounds after dermatologic procedures is currently limited. Topical corticosteroids have been used successfully in postoperative management of ophthalmologic surgeries that involve the skin of the eyelid. In particular, tobramycin 0.3%/dexamethasone 0.1% ophthalmic ointment is considered the “gold standard” of steroid-antibiotic fixed combinations and is marketed worldwide as an agent used to control postsurgical inflammation and prevent postsurgical infection. The purpose of this study is to evaluate both the efficacy and safety of tobramycin–dexamethasone ointment for the postsurgical management of Mohs or dermatologic surgery in comparison to White Petrolatum. Methods The authors employed a half-scar study in which patients who underwent skin cancer removal surgery were given tobramycin–dexamethasone ointment and White Petrolatum to apply to each half of their wound for 2 weeks. The study was double blinded, and physicians and the patients independently evaluated the scars for cosmetic appearance at 2 and 6 weeks postoperatively. The evaluation criteria included judging which side of the wound looked better based on color, thickness, and discomfort. Results Eighteen patients were enrolled, of which 13 patients completed the three phases of the study. After 6 weeks the wounds did not show a statistically significant difference in color, thickness, or discomfort on either side. Conclusion Results obtained to date suggest that the application of tobramycin–dexamethasone ointment to wounds after dermatologic surgery does not promote better wound healing than White Petrolatum. These findings indicate that a topical steroid and antibiotic ointment may not be an effective intervention in improving postoperative outcomes in dermatologic surgeries.
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A Pilot Study to Investigate the Efficacy of Tobramycin–Dexamethasone Ointment in Promoting Wound Healing
Dermatology and therapy, 2012Co-Authors: Rachel Andrew, Gwendolyn Luecke, Susan E. Dozier, Dayna G. DivenAbstract:Introduction The standard postsurgical treatment of wounds after dermatologic procedures is currently limited. Topical corticosteroids have been used successfully in postoperative management of ophthalmologic surgeries that involve the skin of the eyelid. In particular, tobramycin 0.3%/dexamethasone 0.1% ophthalmic ointment is considered the “gold standard” of steroid-antibiotic fixed combinations and is marketed worldwide as an agent used to control postsurgical inflammation and prevent postsurgical infection. The purpose of this study is to evaluate both the efficacy and safety of tobramycin–dexamethasone ointment for the postsurgical management of Mohs or dermatologic surgery in comparison to White Petrolatum.
Fernando Bacanelli - One of the best experts on this subject based on the ideXlab platform.
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Coupling agents in therapeutic ultrasound: acoustic and thermal behavior.
Archives of physical medicine and rehabilitation, 2004Co-Authors: Raquel Aparecida Casarotto, Julio Cesar Adamowski, Flávio Fallopa, Fernando BacanelliAbstract:Abstract Casarotto RA, Adamowski JC, Fallopa F, Bacanelli F. Coupling agents in therapeutic ultrasound: acoustic and thermal behavior. Arch Phys Med Rehabil 2004;85:162–5. Objective To compare transmissivity data and thermal behavior of 4 coupling media. Design Experimental. Setting Postgraduate rehabilitation program in Brazil. Specimens Four coupling media: gel, mineral oil, White Petrolatum, and degassed water. Interventions Not applicable. Main outcome measures The transmission, attenuation, reflection coefficient, and acoustic impedance of gel, mineral oil, White Petrolatum, and degassed water were measured with a density measurement cell. The temperature variation in the therapeutic ultrasound transducer was measured with a thermocouple. Results The transmissivity data showed that the water and gel presented the highest transmission coefficient, the lowest reflection, and an attenuation coefficient and acoustic impedance close to that of the skin. The thermal data revealed the highest heating in the transducer during the insonation with White Petrolatum and mineral oil, resulting from the thermal conductivity features of each medium. Conclusions Transmissivity data obtained showed that water and gel present the best acoustic features. In ultrasound therapy, with the direct contact technique using thin layers of coupling agents, any product may be used, because the effect of the attenuation coefficient does not play a significant role when layers are as thin as those used in this experiment.
Rachel Andrew - One of the best experts on this subject based on the ideXlab platform.
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A Pilot Study to Investigate the Efficacy of Tobramycin–Dexamethasone Ointment in Promoting Wound Healing
Dermatology and Therapy, 2012Co-Authors: Rachel Andrew, Gwendolyn Luecke, Susan Dozier, Dayna G. DivenAbstract:Introduction The standard postsurgical treatment of wounds after dermatologic procedures is currently limited. Topical corticosteroids have been used successfully in postoperative management of ophthalmologic surgeries that involve the skin of the eyelid. In particular, tobramycin 0.3%/dexamethasone 0.1% ophthalmic ointment is considered the “gold standard” of steroid-antibiotic fixed combinations and is marketed worldwide as an agent used to control postsurgical inflammation and prevent postsurgical infection. The purpose of this study is to evaluate both the efficacy and safety of tobramycin–dexamethasone ointment for the postsurgical management of Mohs or dermatologic surgery in comparison to White Petrolatum. Methods The authors employed a half-scar study in which patients who underwent skin cancer removal surgery were given tobramycin–dexamethasone ointment and White Petrolatum to apply to each half of their wound for 2 weeks. The study was double blinded, and physicians and the patients independently evaluated the scars for cosmetic appearance at 2 and 6 weeks postoperatively. The evaluation criteria included judging which side of the wound looked better based on color, thickness, and discomfort. Results Eighteen patients were enrolled, of which 13 patients completed the three phases of the study. After 6 weeks the wounds did not show a statistically significant difference in color, thickness, or discomfort on either side. Conclusion Results obtained to date suggest that the application of tobramycin–dexamethasone ointment to wounds after dermatologic surgery does not promote better wound healing than White Petrolatum. These findings indicate that a topical steroid and antibiotic ointment may not be an effective intervention in improving postoperative outcomes in dermatologic surgeries.
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A Pilot Study to Investigate the Efficacy of Tobramycin–Dexamethasone Ointment in Promoting Wound Healing
Dermatology and therapy, 2012Co-Authors: Rachel Andrew, Gwendolyn Luecke, Susan E. Dozier, Dayna G. DivenAbstract:Introduction The standard postsurgical treatment of wounds after dermatologic procedures is currently limited. Topical corticosteroids have been used successfully in postoperative management of ophthalmologic surgeries that involve the skin of the eyelid. In particular, tobramycin 0.3%/dexamethasone 0.1% ophthalmic ointment is considered the “gold standard” of steroid-antibiotic fixed combinations and is marketed worldwide as an agent used to control postsurgical inflammation and prevent postsurgical infection. The purpose of this study is to evaluate both the efficacy and safety of tobramycin–dexamethasone ointment for the postsurgical management of Mohs or dermatologic surgery in comparison to White Petrolatum.
Murad Alam - One of the best experts on this subject based on the ideXlab platform.
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accelerated resolution of laser induced bruising with topical 20 arnica a rater blinded randomized controlled trial
British Journal of Dermatology, 2010Co-Authors: S Leu, Jillian Havey, Lucile E White, N Martin, Simon S Yoo, Alfred W Rademaker, Murad AlamAbstract:Summary Background Dermatological procedures can result in disfiguring bruises that resolve slowly. Objectives To assess the comparative utility of topical formulations in hastening the resolution of skin bruising. Methods Healthy volunteers, age range 21–65 years, were enrolled for this double (patient and rater) blinded randomized controlled trial. For each subject, four standard bruises of 7 mm diameter each were created on the bilateral upper inner arms, 5 cm apart, two per arm, using a 595-nm pulsed-dye laser (Vbeam; Candela Corp., Wayland, MA, U.S.A.). Randomization was used to assign one topical agent (5% vitamin K, 1% vitamin K and 0·3% retinol, 20% arnica, or White Petrolatum) to exactly one bruise per subject, which was then treated under occlusion twice a day for 2 weeks. A dermatologist not involved with subject assignment rated bruises [visual analogue scale, 0 (least)–10 (most)] in standardized photographs immediately after bruise creation and at week 2. Results There was significant difference in the change in the rater bruising score associated with the four treatments (anova, P = 0·016). Pairwise comparisons indicated that the mean improvement associated with 20% arnica was greater than with White Petrolatum (P = 0·003), and the improvement with arnica was greater than with the mixture of 1% vitamin K and 0·3% retinol (P = 0·01). Improvement with arnica was not greater than with 5% vitamin K cream, however. Conclusions Topical 20% arnica ointment may be able to reduce bruising more effectively than placebo and more effectively than low-concentration vitamin K formulations, such as 1% vitamin K with 0·3% retinol.
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Accelerated resolution of laser-induced bruising with topical 20% arnica: a rater-blinded randomized controlled trial.
The British journal of dermatology, 2010Co-Authors: S Leu, Jillian Havey, Lucile E White, N Martin, Simon S Yoo, Alfred W Rademaker, Murad AlamAbstract:Summary Background Dermatological procedures can result in disfiguring bruises that resolve slowly. Objectives To assess the comparative utility of topical formulations in hastening the resolution of skin bruising. Methods Healthy volunteers, age range 21–65 years, were enrolled for this double (patient and rater) blinded randomized controlled trial. For each subject, four standard bruises of 7 mm diameter each were created on the bilateral upper inner arms, 5 cm apart, two per arm, using a 595-nm pulsed-dye laser (Vbeam; Candela Corp., Wayland, MA, U.S.A.). Randomization was used to assign one topical agent (5% vitamin K, 1% vitamin K and 0·3% retinol, 20% arnica, or White Petrolatum) to exactly one bruise per subject, which was then treated under occlusion twice a day for 2 weeks. A dermatologist not involved with subject assignment rated bruises [visual analogue scale, 0 (least)–10 (most)] in standardized photographs immediately after bruise creation and at week 2. Results There was significant difference in the change in the rater bruising score associated with the four treatments (anova, P = 0·016). Pairwise comparisons indicated that the mean improvement associated with 20% arnica was greater than with White Petrolatum (P = 0·003), and the improvement with arnica was greater than with the mixture of 1% vitamin K and 0·3% retinol (P = 0·01). Improvement with arnica was not greater than with 5% vitamin K cream, however. Conclusions Topical 20% arnica ointment may be able to reduce bruising more effectively than placebo and more effectively than low-concentration vitamin K formulations, such as 1% vitamin K with 0·3% retinol.
Raquel Aparecida Casarotto - One of the best experts on this subject based on the ideXlab platform.
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Coupling agents in therapeutic ultrasound: acoustic and thermal behavior.
Archives of physical medicine and rehabilitation, 2004Co-Authors: Raquel Aparecida Casarotto, Julio Cesar Adamowski, Flávio Fallopa, Fernando BacanelliAbstract:Abstract Casarotto RA, Adamowski JC, Fallopa F, Bacanelli F. Coupling agents in therapeutic ultrasound: acoustic and thermal behavior. Arch Phys Med Rehabil 2004;85:162–5. Objective To compare transmissivity data and thermal behavior of 4 coupling media. Design Experimental. Setting Postgraduate rehabilitation program in Brazil. Specimens Four coupling media: gel, mineral oil, White Petrolatum, and degassed water. Interventions Not applicable. Main outcome measures The transmission, attenuation, reflection coefficient, and acoustic impedance of gel, mineral oil, White Petrolatum, and degassed water were measured with a density measurement cell. The temperature variation in the therapeutic ultrasound transducer was measured with a thermocouple. Results The transmissivity data showed that the water and gel presented the highest transmission coefficient, the lowest reflection, and an attenuation coefficient and acoustic impedance close to that of the skin. The thermal data revealed the highest heating in the transducer during the insonation with White Petrolatum and mineral oil, resulting from the thermal conductivity features of each medium. Conclusions Transmissivity data obtained showed that water and gel present the best acoustic features. In ultrasound therapy, with the direct contact technique using thin layers of coupling agents, any product may be used, because the effect of the attenuation coefficient does not play a significant role when layers are as thin as those used in this experiment.
