The Experts below are selected from a list of 75 Experts worldwide ranked by ideXlab platform
Olivier Theodoly - One of the best experts on this subject based on the ideXlab platform.
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Lymphocytes can self-steer passively with Wind vane uropods
Nature communications, 2014Co-Authors: Marie-pierre Valignat, Paulin Nègre, Sophie Cadra, Annemarie C. Lellouch, François Gallet, Sylvie Hénon, Olivier TheodolyAbstract:Lymphocytes crawl on blood vessels against the flow of blood, but the mechanism for this directed migration is not known. Here, Valignat et al. show that lymphocytes can use their uropods as Wind Vanes to passively steer their migration in the presence of fluid flow, without the need for internal guidance cues.
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Lymphocytes can self-steer passively with Wind vane uropods
Nature Communications, 2014Co-Authors: Marie-pierre Valignat, Paulin Nègre, Sophie Cadra, Annemarie C. Lellouch, François Gallet, Sylvie Hénon, Olivier TheodolyAbstract:A wide variety of cells migrate directionally in response to chemical or mechanical cues, however the mechanisms involved in cue detection and translation into directed movement are debatable. Here, we investigate a model of lymphocyte migration on the inner surface of blood vessels. Cells orient their migration against fluid flow, suggesting the existence of an adaptive mechano-tranduction mechanism. We find that flow detection may not require molecular mechano-sensors of shear stress and detection of flow direction can be achieved by the orientation in the flow of the non-adherent cell rear, the uropod. Uropods act as microscopic Wind Vanes that can transmit detection of flow direction into cell steering via the on-going machinery of polarity maintenance, without need for novel internal guidance signalling triggered by flow. Contrary to chemotaxis, which implies active regulation of cue-dependant signalling, upstream flow mechanotaxis of lymphocytes may only rely on a passive self-steering mechanism.
Marie-pierre Valignat - One of the best experts on this subject based on the ideXlab platform.
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Lymphocytes can self-steer passively with Wind vane uropods
Nature communications, 2014Co-Authors: Marie-pierre Valignat, Paulin Nègre, Sophie Cadra, Annemarie C. Lellouch, François Gallet, Sylvie Hénon, Olivier TheodolyAbstract:Lymphocytes crawl on blood vessels against the flow of blood, but the mechanism for this directed migration is not known. Here, Valignat et al. show that lymphocytes can use their uropods as Wind Vanes to passively steer their migration in the presence of fluid flow, without the need for internal guidance cues.
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Lymphocytes can self-steer passively with Wind vane uropods
Nature Communications, 2014Co-Authors: Marie-pierre Valignat, Paulin Nègre, Sophie Cadra, Annemarie C. Lellouch, François Gallet, Sylvie Hénon, Olivier TheodolyAbstract:A wide variety of cells migrate directionally in response to chemical or mechanical cues, however the mechanisms involved in cue detection and translation into directed movement are debatable. Here, we investigate a model of lymphocyte migration on the inner surface of blood vessels. Cells orient their migration against fluid flow, suggesting the existence of an adaptive mechano-tranduction mechanism. We find that flow detection may not require molecular mechano-sensors of shear stress and detection of flow direction can be achieved by the orientation in the flow of the non-adherent cell rear, the uropod. Uropods act as microscopic Wind Vanes that can transmit detection of flow direction into cell steering via the on-going machinery of polarity maintenance, without need for novel internal guidance signalling triggered by flow. Contrary to chemotaxis, which implies active regulation of cue-dependant signalling, upstream flow mechanotaxis of lymphocytes may only rely on a passive self-steering mechanism.
François Gallet - One of the best experts on this subject based on the ideXlab platform.
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Lymphocytes can self-steer passively with Wind vane uropods
Nature communications, 2014Co-Authors: Marie-pierre Valignat, Paulin Nègre, Sophie Cadra, Annemarie C. Lellouch, François Gallet, Sylvie Hénon, Olivier TheodolyAbstract:Lymphocytes crawl on blood vessels against the flow of blood, but the mechanism for this directed migration is not known. Here, Valignat et al. show that lymphocytes can use their uropods as Wind Vanes to passively steer their migration in the presence of fluid flow, without the need for internal guidance cues.
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Lymphocytes can self-steer passively with Wind vane uropods
Nature Communications, 2014Co-Authors: Marie-pierre Valignat, Paulin Nègre, Sophie Cadra, Annemarie C. Lellouch, François Gallet, Sylvie Hénon, Olivier TheodolyAbstract:A wide variety of cells migrate directionally in response to chemical or mechanical cues, however the mechanisms involved in cue detection and translation into directed movement are debatable. Here, we investigate a model of lymphocyte migration on the inner surface of blood vessels. Cells orient their migration against fluid flow, suggesting the existence of an adaptive mechano-tranduction mechanism. We find that flow detection may not require molecular mechano-sensors of shear stress and detection of flow direction can be achieved by the orientation in the flow of the non-adherent cell rear, the uropod. Uropods act as microscopic Wind Vanes that can transmit detection of flow direction into cell steering via the on-going machinery of polarity maintenance, without need for novel internal guidance signalling triggered by flow. Contrary to chemotaxis, which implies active regulation of cue-dependant signalling, upstream flow mechanotaxis of lymphocytes may only rely on a passive self-steering mechanism.
Sophie Cadra - One of the best experts on this subject based on the ideXlab platform.
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Lymphocytes can self-steer passively with Wind vane uropods
Nature communications, 2014Co-Authors: Marie-pierre Valignat, Paulin Nègre, Sophie Cadra, Annemarie C. Lellouch, François Gallet, Sylvie Hénon, Olivier TheodolyAbstract:Lymphocytes crawl on blood vessels against the flow of blood, but the mechanism for this directed migration is not known. Here, Valignat et al. show that lymphocytes can use their uropods as Wind Vanes to passively steer their migration in the presence of fluid flow, without the need for internal guidance cues.
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Lymphocytes can self-steer passively with Wind vane uropods
Nature Communications, 2014Co-Authors: Marie-pierre Valignat, Paulin Nègre, Sophie Cadra, Annemarie C. Lellouch, François Gallet, Sylvie Hénon, Olivier TheodolyAbstract:A wide variety of cells migrate directionally in response to chemical or mechanical cues, however the mechanisms involved in cue detection and translation into directed movement are debatable. Here, we investigate a model of lymphocyte migration on the inner surface of blood vessels. Cells orient their migration against fluid flow, suggesting the existence of an adaptive mechano-tranduction mechanism. We find that flow detection may not require molecular mechano-sensors of shear stress and detection of flow direction can be achieved by the orientation in the flow of the non-adherent cell rear, the uropod. Uropods act as microscopic Wind Vanes that can transmit detection of flow direction into cell steering via the on-going machinery of polarity maintenance, without need for novel internal guidance signalling triggered by flow. Contrary to chemotaxis, which implies active regulation of cue-dependant signalling, upstream flow mechanotaxis of lymphocytes may only rely on a passive self-steering mechanism.
Sylvie Hénon - One of the best experts on this subject based on the ideXlab platform.
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Lymphocytes can self-steer passively with Wind vane uropods
Nature communications, 2014Co-Authors: Marie-pierre Valignat, Paulin Nègre, Sophie Cadra, Annemarie C. Lellouch, François Gallet, Sylvie Hénon, Olivier TheodolyAbstract:Lymphocytes crawl on blood vessels against the flow of blood, but the mechanism for this directed migration is not known. Here, Valignat et al. show that lymphocytes can use their uropods as Wind Vanes to passively steer their migration in the presence of fluid flow, without the need for internal guidance cues.
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Lymphocytes can self-steer passively with Wind vane uropods
Nature Communications, 2014Co-Authors: Marie-pierre Valignat, Paulin Nègre, Sophie Cadra, Annemarie C. Lellouch, François Gallet, Sylvie Hénon, Olivier TheodolyAbstract:A wide variety of cells migrate directionally in response to chemical or mechanical cues, however the mechanisms involved in cue detection and translation into directed movement are debatable. Here, we investigate a model of lymphocyte migration on the inner surface of blood vessels. Cells orient their migration against fluid flow, suggesting the existence of an adaptive mechano-tranduction mechanism. We find that flow detection may not require molecular mechano-sensors of shear stress and detection of flow direction can be achieved by the orientation in the flow of the non-adherent cell rear, the uropod. Uropods act as microscopic Wind Vanes that can transmit detection of flow direction into cell steering via the on-going machinery of polarity maintenance, without need for novel internal guidance signalling triggered by flow. Contrary to chemotaxis, which implies active regulation of cue-dependant signalling, upstream flow mechanotaxis of lymphocytes may only rely on a passive self-steering mechanism.
