Wolff-Parkinson-White Syndrome

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Fred Morady - One of the best experts on this subject based on the ideXlab platform.

  • Supraventricular tachyarrhythmia
    Current Treatment Options in Cardiovascular Medicine, 2000
    Co-Authors: Bradley P. Knight, Fred Morady
    Abstract:

    The main treatment modalities for supraventricular tachycardia are medications and catheter ablation. Ablation is appropriate therapy for paroxysmal supraventricular tachycardia in patients who have a preference for ablation over medications, symptoms that are refractory to medications, severe symptoms, Wolff-Parkinson-White Syndrome, or incessant tachycardia. Ablation also is reasonable as first-line therapy in patients with recurrent typical atrial flutter.

  • electrogram criteria for identification of appropriate target sites for radiofrequency catheter ablation of accessory atrioventricular connections
    Circulation, 1992
    Co-Authors: Hugh Calkins, Steve Schmaltz, Joao Sousa, Rafel Elatassi, Angel Leon, Alan H Kadish, Jonathan J Langberg, Fred Morady
    Abstract:

    BACKGROUNDCatheter ablation of accessory atrioventricular (AV) connections using radiofrequency current has been demonstrated to be effective in the majority of patients with the Wolff-Parkinson-White Syndrome or paroxysmal supraventricular tachycardia involving a concealed accessory AV connection. However, electrogram criteria have not been established to guide attempts at radiofrequency catheter ablation.METHODS AND RESULTSThe characteristics of local electrograms recorded at successful and unsuccessful sites of radiofrequency catheter ablation were determined in 132 patients. Electrograms recorded at a total of 438 sites were analyzed: 338 recorded during ablation of 90 manifest accessory AV connections and 100 recorded during ablation of 44 concealed accessory AV connections. During ablation of manifest accessory AV connections, the independent predictors of outcome were electrogram stability (p less than 0.001), the interval between activation of the ventricular electrogram and onset of the QRS compl...

G J Klein - One of the best experts on this subject based on the ideXlab platform.

Abdel J Fuenmayor - One of the best experts on this subject based on the ideXlab platform.

Christopher S Snyder - One of the best experts on this subject based on the ideXlab platform.

  • intraoperative radiofrequency ablation of the atrium effectiveness for treatment of supraventricular tachycardia in congenital heart surgery
    The Annals of Thoracic Surgery, 2002
    Co-Authors: Gary S Kopf, Dennis M Mello, Katherine M Kenney, Jose Moltedo, Nancy R Rollinson, Christopher S Snyder
    Abstract:

    Abstract Background . Supraventricular tachycardia (SVT) is common in surgical patients with congenital heart disease. Ablation and maze operations have been shown to be effective in treating SVT, but these procedures can be complex and time-consuming because of variable anatomy and a thickened right atrium. To simplify and shorten these procedures, we used a long, flexible radiofrequency probe capable of producing long ablation lines quickly and effectively. We report the initial results with this procedure. Methods . Six patients aged 6 weeks to 40 years with refractory SVT were referred for reoperation for repair of complex congenital heart disease (transposition of the great vessels, Ebstein's anomaly, single ventricle, tetralogy of fallot). Intraoperative radiofrequency ablation was performed in the right atrium for refractory SVT as an adjunct to surgical reconstruction (redo Fontan, right atrial reduction plasty, right ventricular outflow tract reconstruction, tricuspid repair). Lesions were made with a radiofrequency probe using temperatures of 70°C for 60 seconds. Lesions were placed between the coronary sinus and the tricuspid valve, between the tricuspid valve and the inferior vena cava, between the atrial septal defect and the superior and inferior vena cava in patients with intraatrial reentry tachycardia/atrial flutter, and at the location of the accessory pathway in a patient with Wolff-Parkinson-White Syndrome. The long, flexible probe has multiple independently controlled segments allowing ablation lesions that conform to the atrial morphology. Results . An average of five intraoperative radiofrequency ablation lesions per patient were made. Average time for ablation was 14 minutes. With up to 25 months' follow-up, 5 patients are in sinus rhythm, and 1 is in a paced atrial rhythm. The patient with Wolff-Parkinson-White Syndrome showed no preexcitation after operation. No complications resulting from intraoperative radiofrequency ablation were encountered. Conclusions . Intraoperative radiofrequency ablation in the atrium is a safe, effective, and expeditious procedure for control of SVT in patients undergoing reoperation for congenital heart disease with refractory SVT.

Warren M Jackman - One of the best experts on this subject based on the ideXlab platform.

  • catheter ablation of accessory atrioventricular pathways wolff parkinson white Syndrome by radiofrequency current
    The New England Journal of Medicine, 1991
    Co-Authors: Warren M Jackman, Xunzhang Wang, Karen J Friday, C A Roman, Kriegh Moulton, Karen J Beckman, James H Mcclelland, Nicholas Twidale, H A Hazlitt, Michael Prior
    Abstract:

    Abstract Background. Surgical or catheter ablation of accessory pathways by means of high-energy shocks serves as definitive therapy for patients with Wolff—Parkinson—White Syndrome but has substantial associated morbidity and mortality. Radiofrequency current, an alternative energy source for ablation, produces smaller lesions without adverse effects remote from the site where current is delivered. We conducted this study to develop catheter techniques for delivering radiofrequency current to reduce morbidity and mortality associated with accessory-pathway ablation. Methods. Radiofrequency current (mean power, 30.9±5.3 W) was applied through a catheter electrode positioned against the mitral or tricuspid annulus or a branch of the coronary sinus; when possible, delivery was guided by catheter recordings of accessory-pathway activation. Ablation was attempted in 166 patients with 177 accessory pathways (106 pathways in the left free wall, 13 in the anteroseptal region, 43 in the posteroseptal region, and ...

  • catheter ablation of accessory atrioventricular pathways wolff parkinson white Syndrome by radiofrequency current
    The New England Journal of Medicine, 1991
    Co-Authors: Warren M Jackman, Xunzhang Wang, Karen J Friday, C A Roman, Kriegh Moulton, Karen J Beckman, James H Mcclelland, Nicholas Twidale, H A Hazlitt, M I Prior
    Abstract:

    Background Surgical or catheter ablation of accessory pathways by means of high-energy shocks serves as definitive therapy for patients with Wolff-Parkinson-White Syndrome but has substantial associated morbidity and mortality. Radiofrequency current, an alternative energy source for ablation, produces smaller lesions without adverse effects remote from the site where current is delivered. We conducted this study to develop catheter techniques for delivering radiofrequency current to reduce morbidity and mortality associated with accessory-pathway ablation. Methods Radiofrequency current (mean power, 30.9 +/- 5.3 W) was applied through a catheter electrode positioned against the mitral or tricuspid annulus or a branch of the coronary sinus; when possible, delivery was guided by catheter recordings of accessory-pathway activation. Ablation was attempted in 166 patients with 177 accessory pathways (106 pathways in the left free wall, 13 in the anteroseptal region, 43 in the posteroseptal region, and 15 in the right free wall). Results Accessory-pathway conduction was eliminated in 164 of 166 patients (99 percent) by a median of three applications of radiofrequency current. During a mean follow-up (+/- SD) of 8.0 +/- 5.4 months, preexcitation or atrioventricular reentrant tachycardia returned in 15 patients (9 percent). All underwent a second, successful ablation. Electrophysiologic study 3.1 +/- 1.9 months after ablation in 75 patients verified the absence of accessory-pathway conduction in all. Complications of radiofrequency-current application occurred in three patients (1.8 percent): atrioventricular block (one patient), pericarditis (one), and cardiac tamponade (one) after radiofrequency current was applied in a small branch of the coronary sinus. Conclusions Radiofrequency current is highly effective in ablating accessory pathways, with low morbidity and no mortality.